J W Mandell

Summary

Affiliation: University of Virginia

Country: USA

Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
J W Mandell
Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Glia 34:283-95. 2001
In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
J W Mandell
Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville 22908, USA
Am J Pathol 153:1411-23. 1998
A green fluorescent protein kinase substrate allowing detection and localization of intracellular ERK/MAP kinase activity
J W Mandell
Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Anal Biochem 293:264-8. 2001

Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
J W Mandell
Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Glia 34:283-95. 2001
..Finally, we demonstrated that focal lesioning of adult rat cortex induces a rapid activation and spreading of astroglial ERK/MAPK, suggesting that similar mechanisms may operate in astroglial activation following acute brain injury...
In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
J W Mandell
Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville 22908, USA
Am J Pathol 153:1411-23. 1998
..Although ERK/MAPK activation was not restricted to neoplastic glia, consistent patterns of selective activation in tumor cells suggests that sustained activation may contribute to the neoplastic glial phenotype...
A green fluorescent protein kinase substrate allowing detection and localization of intracellular ERK/MAP kinase activity
J W Mandell
Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Anal Biochem 293:264-8. 2001
..The approach described should be generally applicable to the intracellular analysis of many specific protein kinase substrates for which phospho-specific antibodies have been produced...