J W Mandell

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
    J W Mandell
    Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Glia 34:283-95. 2001
  2. pmc In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
    J W Mandell
    Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Pathol 153:1411-23. 1998
  3. ncbi request reprint A green fluorescent protein kinase substrate allowing detection and localization of intracellular ERK/MAP kinase activity
    J W Mandell
    Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Anal Biochem 293:264-8. 2001

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
    J W Mandell
    Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Glia 34:283-95. 2001
    ..Finally, we demonstrated that focal lesioning of adult rat cortex induces a rapid activation and spreading of astroglial ERK/MAPK, suggesting that similar mechanisms may operate in astroglial activation following acute brain injury...
  2. pmc In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms
    J W Mandell
    Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Pathol 153:1411-23. 1998
    ..Although ERK/MAPK activation was not restricted to neoplastic glia, consistent patterns of selective activation in tumor cells suggests that sustained activation may contribute to the neoplastic glial phenotype...
  3. ncbi request reprint A green fluorescent protein kinase substrate allowing detection and localization of intracellular ERK/MAP kinase activity
    J W Mandell
    Department of Pathology Neuropathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Anal Biochem 293:264-8. 2001
    ..The approach described should be generally applicable to the intracellular analysis of many specific protein kinase substrates for which phospho-specific antibodies have been produced...