Nawajes A Mandal
Affiliation: University of Oklahoma Health Sciences Center
Stiles M, Qi H, Sun E, Tan J, Porter H, Allegood J, et al
. Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration. J Lipid Res. 2016;57:818-31 pubmed publisher
..S. Food and Drug Administration-approved drug FTY720 or related compounds that modulate sphingolipid metabolism could potentially delay the cell death. ..
Wilkerson J, Mandal N. Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. Methods Mol Biol. 2017;1609:267-276 pubmed publisher
..Here we describe an easy and affordable in vivo model of neovascularization by an alkali chemical burn to the cornea. This gives a consistent and easy way to quantitate methods for neovascularization. ..
Mandal M, Moiseyev G, Elliott M, Kasus Jacobi A, Li X, Chen H, et al
. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011;286:32491-501 pubmed publisher
..Thus, PBN inhibition of RPE65 catalytic action may provide therapeutic benefit for such retinal diseases. ..
Mandal N, Tran J, Saadi A, Rahman A, Huynh T, Klein W, et al
. Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene. Exp Eye Res. 2013;106:24-33 pubmed publisher
..Thus, CERKL may be important for the stress responses and protection of photoreceptor cells...