Kalyaneswar Mandal

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods
    Kalyaneswar Mandal
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA
    Protein Sci 18:1146-54. 2009
  2. doi request reprint Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography
    Brad L Pentelute
    Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA
    Chem Commun (Camb) 46:8174-6. 2010
  3. doi request reprint Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site
    Vladimir Yu Torbeev
    Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Bioorg Med Chem Lett 18:4554-7. 2008
  4. pmc Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography
    James R Banigan
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA
    Protein Sci 19:1840-9. 2010
  5. ncbi request reprint Design, total chemical synthesis, and x-ray structure of a protein having a novel linear-loop polypeptide chain topology
    Kalyaneswar Mandal
    Department of Biochemistry and Molecular Biology, Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637 USA
    Angew Chem Int Ed Engl 51:1481-6. 2012
  6. pmc X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods
    Kalyaneswar Mandal
    Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Chem Soc 131:1362-3. 2009
  7. pmc Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography
    Michal Avital-Shmilovici
    Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Chem Soc 135:3173-85. 2013
  8. pmc Total chemical synthesis of biologically active vascular endothelial growth factor
    Kalyaneswar Mandal
    Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, IL 60637, USA
    Angew Chem Int Ed Engl 50:8029-33. 2011
  9. pmc Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography
    Kalyaneswar Mandal
    Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:14779-84. 2012
  10. doi request reprint Synthesis and comparative properties of two amide-generating resin linkers for use in solid phase peptide synthesis
    Fang Kun Deng
    Department of Chemistry, University of Chicago, Chicago, IL 60615, USA
    J Pept Sci 16:545-50. 2010

Collaborators

Detail Information

Publications14

  1. pmc Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods
    Kalyaneswar Mandal
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA
    Protein Sci 18:1146-54. 2009
    ..The structure of the plectasin molecule was well defined for all 40 amino acids and was generally similar to the previously determined NMR structure, suggesting minimal impact of the crystal packing on the plectasin conformation...
  2. doi request reprint Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography
    Brad L Pentelute
    Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA
    Chem Commun (Camb) 46:8174-6. 2010
    ..95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods...
  3. doi request reprint Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site
    Vladimir Yu Torbeev
    Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Bioorg Med Chem Lett 18:4554-7. 2008
    ..These data support the general acid-general base mechanism for HIV-1 protease catalysis...
  4. pmc Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography
    James R Banigan
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA
    Protein Sci 19:1840-9. 2010
    ..Racemic crystallography once again proved to be a valuable method for obtaining crystals of recalcitrant proteins and for determining high-resolution X-ray structures by direct methods...
  5. ncbi request reprint Design, total chemical synthesis, and x-ray structure of a protein having a novel linear-loop polypeptide chain topology
    Kalyaneswar Mandal
    Department of Biochemistry and Molecular Biology, Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637 USA
    Angew Chem Int Ed Engl 51:1481-6. 2012
    ..Lassoed at the other end: Original synthetic and structure determination methods were used to make a protein molecule with an unprecedented linear-loop polypeptide chain topology, and to characterize its X-ray structure...
  6. pmc X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods
    Kalyaneswar Mandal
    Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Chem Soc 131:1362-3. 2009
    ..This is the first example of a protein racemate that crystallized in space group I41/a...
  7. pmc Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography
    Michal Avital-Shmilovici
    Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Chem Soc 135:3173-85. 2013
    ..The structural basis of the lack of biological activity of ester insulin is discussed...
  8. pmc Total chemical synthesis of biologically active vascular endothelial growth factor
    Kalyaneswar Mandal
    Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, IL 60637, USA
    Angew Chem Int Ed Engl 50:8029-33. 2011
    ..The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography...
  9. pmc Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography
    Kalyaneswar Mandal
    Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:14779-84. 2012
    ....
  10. doi request reprint Synthesis and comparative properties of two amide-generating resin linkers for use in solid phase peptide synthesis
    Fang Kun Deng
    Department of Chemistry, University of Chicago, Chicago, IL 60615, USA
    J Pept Sci 16:545-50. 2010
    ..Then we have explored their comparative properties in SPPS. Use of sonication in reductive amination facilitated the synthesis of both benzhydrylamine (BHA) and MBHA linkers...
  11. doi request reprint Through the looking glass--a new world of proteins enabled by chemical synthesis
    Stephen Kent
    University of Chicago, Chicago, IL 60637, USA
    J Pept Sci 18:428-36. 2012
    ..The total chemical synthesis of proteins is now a practical reality and enables access to a new world of protein molecules...
  12. doi request reprint Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy
    Vladimir Yu Torbeev
    Institute for Biophysical Dynamics, Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Chem Soc 131:884-5. 2009
    ..Moreover, the distance distribution profile is significantly varied among the different inhibitors, which mimic different species on the reaction coordinate for enzyme catalyzed proteolysis...
  13. ncbi request reprint Total chemical synthesis and biological activities of glycosylated and non-glycosylated forms of the chemokines CCL1 and Ser-CCL1
    Ryo Okamoto
    Department of Biochemistry and Molecular Biology, Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637 USA Present address Department of Chemistry, Graduate School of Science, Osaka University, 1 1, Toyonaka, Osaka 5600043 Japan
    Angew Chem Int Ed Engl 53:5188-93. 2014
    ..To the best of our knowledge, these are the first investigations of the effect of glycosylation on the chemotactic activity of the chemokine (Ser-)CCL1 using homogeneous N-glycosylated protein molecules of defined covalent structure...
  14. pmc Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography
    Bobo Dang
    Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA
    J Am Chem Soc 135:11911-9. 2013
    ..The structure was solved by direct methods and showed significant differences from the previously reported NMR structures in some regions of the ShK protein molecule...