Peter Mancuso

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Obesity and respiratory infections: does excess adiposity weigh down host defense?
    Peter Mancuso
    Department of Environmental Health Sciences and the Graduate Program in Immunology, 109 S Observatory Street, School of Public Health, University of Michigan, 6627 SPH1A, Ann Arbor, MI 48109 2029, USA
    Pulm Pharmacol Ther 26:412-9. 2013
  2. pmc Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 189:867-75. 2012
  3. ncbi request reprint Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 168:4018-24. 2002
  4. pmc Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:1081-90. 2011
  5. pmc Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Infect Immun 78:2264-71. 2010
  6. pmc Obesity and lung inflammation
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, SPH IA Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    J Appl Physiol (1985) 108:722-8. 2010
  7. ncbi request reprint Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences SPH II, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Am J Respir Crit Care Med 173:212-8. 2006
  8. ncbi request reprint Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    Peter Mancuso
    Dept of Environmental Health Sciences, Univ of Michigan, 1420 Washington Hts, SPH II, Ann Arbor, MI 48109 2029, USA
    Am J Physiol Lung Cell Mol Physiol 287:L497-502. 2004
  9. pmc E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection
    David M Aronoff
    Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 183:2642-9. 2009
  10. pmc Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae
    John C Phipps
    Program in Toxicology, Department of Environmental Health Sciences, University of Michigan Health System, Ann Arbor, Michigan 48109 2029, USA
    Infect Immun 78:1214-20. 2010

Research Grants

  1. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2006
  2. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2007
  3. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2009
  4. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010

Detail Information

Publications26

  1. pmc Obesity and respiratory infections: does excess adiposity weigh down host defense?
    Peter Mancuso
    Department of Environmental Health Sciences and the Graduate Program in Immunology, 109 S Observatory Street, School of Public Health, University of Michigan, 6627 SPH1A, Ann Arbor, MI 48109 2029, USA
    Pulm Pharmacol Ther 26:412-9. 2013
    ..Additional clinical and animal studies are needed to clarify the relationship between increased adiposity and susceptibility to community-acquired and nosocomial pneumonia...
  2. pmc Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 189:867-75. 2012
    ..These results demonstrate that leptin receptor-mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions...
  3. ncbi request reprint Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 168:4018-24. 2002
    ..This study demonstrates for the first time that leptin-deficient mice display impaired host defense in bacterial pneumonia that may be due to a defect in alveolar macrophage phagocytosis and leukotriene synthesis...
  4. pmc Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:1081-90. 2011
    ..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia...
  5. pmc Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Infect Immun 78:2264-71. 2010
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  6. pmc Obesity and lung inflammation
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, SPH IA Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    J Appl Physiol (1985) 108:722-8. 2010
    ..An increased understanding of the mechanisms by which obesity influences pulmonary inflammation may facilitate the development of novel therapeutic interventions for the treatment of lung disease...
  7. ncbi request reprint Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences SPH II, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Am J Respir Crit Care Med 173:212-8. 2006
    ..Previously, we employed leptin-deficient (ob/ob) mice to identify an important role for leptin in the host defense against Klebsiella pneumonia...
  8. ncbi request reprint Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    Peter Mancuso
    Dept of Environmental Health Sciences, Univ of Michigan, 1420 Washington Hts, SPH II, Ann Arbor, MI 48109 2029, USA
    Am J Physiol Lung Cell Mol Physiol 287:L497-502. 2004
    ....
  9. pmc E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection
    David M Aronoff
    Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 183:2642-9. 2009
    ..Pharmacological targeting of the PGE(2)-EP3 axis represents a novel area warranting greater investigative interest in the prevention and/or treatment of infectious diseases...
  10. pmc Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae
    John C Phipps
    Program in Toxicology, Department of Environmental Health Sciences, University of Michigan Health System, Ann Arbor, Michigan 48109 2029, USA
    Infect Immun 78:1214-20. 2010
    ..This murine model provides robust additional support to the hypothesis that cigarette smoke exposure increases the risk of pneumococcal pneumonia and defines a novel cellular mechanism to help explain this immunosuppressive effect...
  11. pmc Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase
    Carlos H C Serezani
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Blood 106:1067-75. 2005
    ..Our results demonstrate that LTs, especially LTB4, enhanceAM microbicidal activity through the PKC-delta-dependent activation of NADPH oxidase...
  12. pmc The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women
    Carrie A Karvonen-Gutierrez
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Ann Rheum Dis 73:883-9. 2014
    ..Serum leptin measures are associated with radiographic knee osteoarthritis, but no studies have examined leptin levels with respect to different measures of knee joint damage from MRI...
  13. ncbi request reprint Leukotrienes: underappreciated mediators of innate immune responses
    Marc Peters-Golden
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor 48109, USA
    J Immunol 174:589-94. 2005
    ..The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity...
  14. pmc E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae
    David M Aronoff
    Divisions of Infectious Diseases, The University of Michigan, Ann Arbor, MI 48109 5680, United States
    Prostaglandins Other Lipid Mediat 98:23-30. 2012
    ..These data suggest that PGE(2)-EP2 signaling may provide a novel pharmacological target for treating pneumococcal pneumonia in combination with antimicrobials...
  15. ncbi request reprint Lipopolysaccharide O-antigen promotes persistent murine bacteremia
    Joanelle Z Lugo
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Shock 27:186-91. 2007
    ....
  16. pmc Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae
    Sharlene I Moore
    Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA
    Infect Immun 71:4182-5. 2003
    ..These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria...
  17. ncbi request reprint Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins
    Thomas G Brock
    Department of Internal Medicine, University of Michigan, 6301 MSRB III, Ann Arbor, MI 48109 0642, USA
    Prostaglandins Other Lipid Mediat 71:131-45. 2003
    ..The shift in mediator profile, to one that minimizes leukotrienes and emphasizes prostacyclin, prostaglandin E2 and NO, provides a signal that reduces leukocyte function, as indicated by impaired killing of Gram-negative bacteria...
  18. pmc Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis
    Mary K McCarthy
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e77628. 2013
    ..Thus, while PGE2 promotes the expression of a variety of cytokines in response to acute MAV-1 infection, PGE2 synthesis does not appear to be essential for generating pulmonary immunity. ..
  19. pmc Change in adipocytokines and ghrelin with menopause
    MaryFran R Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, United States
    Maturitas 59:149-57. 2008
    ....
  20. pmc Perinatal bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course
    Olivia S Anderson
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    FASEB J 27:1784-92. 2013
    ..Variability across studies may be attributable to differential exposure duration and timing, dietary fat and phytoestrogen content, or lack of sophisticated phenotyping across the life course...
  21. pmc Perinatal bisphenol A exposures increase production of pro-inflammatory mediators in bone marrow-derived mast cells of adult mice
    Edmund O'Brien
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    J Immunotoxicol 11:205-12. 2014
    ....
  22. pmc Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice
    Shyamala Ganesan
    Department of Pediatrics and Communicable Diseases, University of Michigan, 1150 W, Medical Center Dr, Ann Arbor, MI 48109 5688, USA
    Respir Res 15:11. 2014
    ..Therefore, CS may interact with other factors, particularly respiratory infections, in the pathogenesis of airway remodeling in COPD...
  23. pmc Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells
    Edmund O'Brien
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    J Immunotoxicol 11:84-9. 2014
    ..These data suggest that exposure to BPA at levels relevant to human exposure may provoke an acute inflammatory response in atopic individuals via enhanced mast cell activation...
  24. pmc Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women
    Carrie A Karvonen-Gutierrez
    School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Arthritis Care Res (Hoboken) 65:936-44. 2013
    ..To relate serum leptin levels to prevalent and incident radiographic knee osteoarthritis (OA) and to determine if patterns of change in longitudinal serum leptin measures differ by knee OA status over a 10-year period...
  25. doi request reprint Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A
    Shyamala Ganesan
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 5688, USA
    Thorax 68:131-41. 2013
    ..Here, we examined the mechanisms underlying decreased FoxO3A activation and its modulation by quercetin in COPD human airway epithelial cells and in a COPD mouse model...
  26. ncbi request reprint 1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin
    Peter Mancuso
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cardiovasc Pharmacol 51:559-64. 2008
    ..These studies suggest that 1,25(OH)2D3 treatment may prevent the development of cardiac hypertrophy, an important contributing factor in the progression of congestive heart failure...

Research Grants5

  1. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2006
    ....
  2. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2007
    ....
  3. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2009
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  4. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..