Peter Mancuso

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. Mancuso P. Obesity and respiratory infections: does excess adiposity weigh down host defense?. Pulm Pharmacol Ther. 2013;26:412-9 pubmed publisher
    ..Additional clinical and animal studies are needed to clarify the relationship between increased adiposity and susceptibility to community-acquired and nosocomial pneumonia. ..
  2. Dolan J, Weinberg J, O Brien E, Abashian A, Procario M, Aronoff D, et al. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1111-20 pubmed publisher
    ..These results suggest that specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections. ..
  3. request reprint
    Mancuso P, Gottschalk A, Phare S, Peters Golden M, Lukacs N, Huffnagle G. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol. 2002;168:4018-24 pubmed
    ..This study demonstrates for the first time that leptin-deficient mice display impaired host defense in bacterial pneumonia that may be due to a defect in alveolar macrophage phagocytosis and leukotriene synthesis. ..
  4. Mancuso P, Lewis C, Serezani C, Goel D, Peters Golden M. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Infect Immun. 2010;78:2264-71 pubmed publisher
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  5. Mancuso P, Peters Golden M, Goel D, Goldberg J, Brock T, Greenwald Yarnell M, et al. Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol. 2011;186:1081-90 pubmed publisher
    ..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia. ..

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Detail Information

Publications5

  1. Mancuso P. Obesity and respiratory infections: does excess adiposity weigh down host defense?. Pulm Pharmacol Ther. 2013;26:412-9 pubmed publisher
    ..Additional clinical and animal studies are needed to clarify the relationship between increased adiposity and susceptibility to community-acquired and nosocomial pneumonia. ..
  2. Dolan J, Weinberg J, O Brien E, Abashian A, Procario M, Aronoff D, et al. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1111-20 pubmed publisher
    ..These results suggest that specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections. ..
  3. request reprint
    Mancuso P, Gottschalk A, Phare S, Peters Golden M, Lukacs N, Huffnagle G. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol. 2002;168:4018-24 pubmed
    ..This study demonstrates for the first time that leptin-deficient mice display impaired host defense in bacterial pneumonia that may be due to a defect in alveolar macrophage phagocytosis and leukotriene synthesis. ..
  4. Mancuso P, Lewis C, Serezani C, Goel D, Peters Golden M. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Infect Immun. 2010;78:2264-71 pubmed publisher
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  5. Mancuso P, Peters Golden M, Goel D, Goldberg J, Brock T, Greenwald Yarnell M, et al. Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol. 2011;186:1081-90 pubmed publisher
    ..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia. ..