Research Topics
Genomes and Genes | Peter MancusoSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumoniaPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 189:867-75. 2012..These results demonstrate that leptin receptor-mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions...
Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumoniaPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 168:4018-24. 2002..This study demonstrates for the first time that leptin-deficient mice display impaired host defense in bacterial pneumonia that may be due to a defect in alveolar macrophage phagocytosis and leukotriene synthesis...- Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumoniaPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 186:1081-90. 2011..These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia... - Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumoniaPeter Mancuso
Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
Infect Immun 78:2264-71. 2010..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia... - Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expressionPeter Mancuso
Dept of Environmental Health Sciences, Univ of Michigan, 1420 Washington Hts, SPH II, Ann Arbor, MI 48109 2029, USA
Am J Physiol Lung Cell Mol Physiol 287:L497-502. 2004.... - Obesity and lung inflammationPeter Mancuso
Department of Environmental Health Sciences, School of Public Health, SPH IA Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
J Appl Physiol 108:722-8. 2010..An increased understanding of the mechanisms by which obesity influences pulmonary inflammation may facilitate the development of novel therapeutic interventions for the treatment of lung disease... - Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumoniaPeter Mancuso
Department of Environmental Health Sciences SPH II, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
Am J Respir Crit Care Med 173:212-8. 2006..Previously, we employed leptin-deficient (ob/ob) mice to identify an important role for leptin in the host defense against Klebsiella pneumonia... - Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniaeJohn C Phipps
Program in Toxicology, Department of Environmental Health Sciences, University of Michigan Health System, Ann Arbor, Michigan 48109 2029, USA
Infect Immun 78:1214-20. 2010..This murine model provides robust additional support to the hypothesis that cigarette smoke exposure increases the risk of pneumococcal pneumonia and defines a novel cellular mechanism to help explain this immunosuppressive effect... 
E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infectionDavid M Aronoff
Divisions of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Immunol 183:2642-9. 2009..Pharmacological targeting of the PGE(2)-EP3 axis represents a novel area warranting greater investigative interest in the prevention and/or treatment of infectious diseases...- Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidaseCarlos H C Serezani
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
Blood 106:1067-75. 2005..Our results demonstrate that LTs, especially LTB4, enhanceAM microbicidal activity through the PKC-delta-dependent activation of NADPH oxidase... - Leukotrienes: underappreciated mediators of innate immune responsesMarc Peters-Golden
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor 48109, USA
J Immunol 174:589-94. 2005..The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity... - E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniaeDavid M Aronoff
Divisions of Infectious Diseases, The University of Michigan, Ann Arbor, MI 48109 5680, United States
Prostaglandins Other Lipid Mediat 98:23-30. 2012..These data suggest that PGE(2)-EP2 signaling may provide a novel pharmacological target for treating pneumococcal pneumonia in combination with antimicrobials... - Lipopolysaccharide O-antigen promotes persistent murine bacteremiaJoanelle Z Lugo
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Shock 27:186-91. 2007.... - Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandinsThomas G Brock
Department of Internal Medicine, University of Michigan, 6301 MSRB III, Ann Arbor, MI 48109 0642, USA
Prostaglandins Other Lipid Mediat 71:131-45. 2003..The shift in mediator profile, to one that minimizes leukotrienes and emphasizes prostacyclin, prostaglandin E2 and NO, provides a signal that reduces leukocyte function, as indicated by impaired killing of Gram-negative bacteria... - Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniaeSharlene I Moore
Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA
Infect Immun 71:4182-5. 2003..These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria... - Change in adipocytokines and ghrelin with menopauseMaryFran R Sowers
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, United States
Maturitas 59:149-57. 2008.... - Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3AShyamala Ganesan
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 5688, USA
Thorax 68:131-41. 2013..Here, we examined the mechanisms underlying decreased FoxO3A activation and its modulation by quercetin in COPD human airway epithelial cells and in a COPD mouse model... - 1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptinPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
J Cardiovasc Pharmacol 51:559-64. 2008..These studies suggest that 1,25(OH)2D3 treatment may prevent the development of cardiac hypertrophy, an important contributing factor in the progression of congestive heart failure...
Research Grants
- Regulation of Pulmonary Host Defense by LeptinPeter Mancuso; Fiscal Year: 2007....
- Regulation of Pulmonary Host Defense by LeptinPeter Mancuso; Fiscal Year: 2009..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
- Regulation of Pulmonary Host Defense by LeptinPeter Mancuso; Fiscal Year: 2010..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..