Research Topics
Genomes and GenesSpecies | Marilyn J Manco-JohnsonSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
A new global assay of coagulation and fibrinolysisNeil A Goldenberg
Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Health Sciences Center The Children s Hospital, Denver, CO, USA
Thromb Res 116:345-56. 2005..In this research, a global assay that measures both coagulation and fibrinolytic capacities was developed and investigated...
How I treat venous thrombosis in childrenMarilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, PO Box 6507, MS F416, Aurora, CO 80045-0507, USA
Blood 107:21-9. 2006- Etiopathogenesis of pediatric thrombosisMarilyn J Manco-Johnson
University of Colorado Denver and the Health Sciences Center, Denver, CO, USA
Hematology 10:167-70. 2005 - Postthrombotic syndrome in childrenMarilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80045 0507, USA
Acta Haematol 115:207-13. 2006.... - Joint evaluation instruments for children and adults with haemophiliaM J Manco-Johnson
Department of Paediatrics, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, CO 80045 0507, USA
Haemophilia 6:649-57. 2000..35) and this instrument had better overall statistical performance. This instrument should be studied further in prospective, longitudinal clinical trials of young children... - Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practiceM Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado, Denver and Health Sciences Center, Denver, Colorado, USA
Haemophilia 13:4-9. 2007..Data from these studies will provide objective evidence for the prevention of haemarthroses and arthropathy in children with severe haemophilia A... - Hemophilia management: optimizing treatment based on patient needsMarilyn Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
Curr Opin Pediatr 17:3-6. 2005..Progress in hemophilia management over the past year has focused on improving understanding of the most common complications of genetic bleeding disorders and building upon available therapeutic strategies... - Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directionsM J Manco-Johnson
Department of Pediatrics, Mountain States Regional Hemophilia and Thrombosis Centre, University of Colorado Health Sciences Centre, Denver, Colorado 800445 0507, USA
Haemophilia 10:88-93. 2004..88 and 0.87; test-retest reliability was 0.92 and 0.93. These new PT and MRI scales promise to improve outcome assessment in children on early preventive treatment regimens... - Advances in care of children with hemophiliaMarilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
Semin Thromb Hemost 29:585-94. 2003..The future of hemophilia promises a cure with gene therapy. Given the past accomplishments in hemophilia, a long-term solution to replacement of the genetically deficient protein lies on the horizon... - Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiencyMarilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, P O Box 6507, Mail Stop F 416, Aurora, CO 80045 0507, USA
J Pediatr Hematol Oncol 26:25-7. 2004..At the end of the APC infusion all skin lesions of PF were resolved. There were no adverse reactions to APC. APC was safe and effective for treatment of PF in severe genetic protein C deficiency... - Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophiliaMarilyn J Manco-Johnson
University of Colorado and Health Sciences Center, Denver, USA
N Engl J Med 357:535-44. 2007..Effective ways to prevent arthropathy in severe hemophilia are unknown... - When the cause of clotting is not in the blood--it may be the vessel!Marilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children's Hospital, Aurora, Colorado 80045-0507, USA
Pediatr Blood Cancer 51:161-2. 2008 
Pharmacokinetics of protein C and antithrombin in the fetal lamb: a model to predict human neonatal replacement dosingMarilyn J Manco-Johnson
Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
Neonatology 95:279-85. 2009..The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data are lacking...- North American prophylaxis studies for persons with severe haemophilia: background, rationale and designM J Manco-Johnson
The Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
Haemophilia 9:44-8; discussion 49. 2003..Both of these studies will contribute valuable information regarding optimal therapy and will help establish evidence-based medicine for the management of severe haemophilia... - 32P Radiosynoviorthesis in children with hemophiliaMarilyn J Manco-Johnson
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
J Pediatr Hematol Oncol 24:534-9. 2002..This study was performed to prospectively evaluate the safety, efficacy, and cost of injecting P-colloid into joints of children with hemophilia and synovitis to decrease the rate of joint bleeding... - Development of coagulation regulatory proteins in the fetal and neonatal lambMarilyn J Manco-Johnson
Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
Pediatr Res 52:580-8. 2002..05). This study suggests that fetal regulation of coagulation proteins follows characteristic patterns relative to the vitamin K dependence of the protein rather than its role as a procoagulant versus regulatory protein... - The "parallel-cohort RCT": Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolismNeil A Goldenberg
Dept of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and Mountain States Regional Hemophilia and Thrombosis Center, Univ of Colorado Denver and The Children s Hospital, Aurora, CO, USA
Contemp Clin Trials 31:131-3. 2010.... - The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic strokeTimothy J Bernard
Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, Colorado, USA
Thromb Res 127:6-12. 2011..Consensus-based guidelines have been developed, but future research must emphasize identification of additional prognostic factors and the initiation of cooperative randomized controlled clinical trials... - Biomarkers of hypercoagulability and inflammation in childhood-onset arterial ischemic strokeTimothy J Bernard
Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO 80045 0507, USA
J Pediatr 156:651-6. 2010.... - Lemierre's and Lemierre's-like syndromes in children: survival and thromboembolic outcomesNeil A Goldenberg
Department of Pediatrics, University of Colorado Health Sciences Center, The Children s Hospital, Denver, Colorado, USA
Pediatrics 116:e543-8. 2005.... - Elevated plasma factor VIII and D-dimer levels as predictors of poor outcomes of thrombosis in childrenNeil A Goldenberg
Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Health Sciences Center and The Children s Hospital, 1056 E 19th Ave, B 115, Denver, CO 80218, USA
N Engl J Med 351:1081-8. 2004.... - Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adultsMindy L Simpson
Rush University Medical Center, Department of Pediatrics, Section of Hematology Oncology, Chicago, IL 60612, USA
Thromb Res 127:317-23. 2011..Plasma coagulative and fibrinolytic potentials in normal children and adults, and in representative pathologically altered hemostatic states, were evaluated via simultaneous assessment of thrombin and plasmin generation... - Percutaneous mechanical and pharmacomechanical thrombolysis for occlusive deep vein thrombosis of the proximal limb in adolescent subjects: findings from an institution-based prospective inception cohort study of pediatric venous thromboembolismNeil A Goldenberg
Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, Aurora, Colorado 80045, USA
J Vasc Interv Radiol 22:121-32. 2011..The present report is an evaluation of experience with adjunctive percutaneous mechanical thrombolysis (PMT) and/or percutaneous pharmacomechanical thrombolysis (PPMT) in such patients... - Monitoring hypercoagulability and hypofibrinolysis following acute venous Thromboembolism in children: application of the CloFAL assay in a prospective inception cohort studyChristopher Bombardier
Department of Pediatrics, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 80045, USA
Thromb Res 130:343-9. 2012..These findings indicate the utility of the CloFAL assay in monitoring plasma coagulative and fibrinolytic capacities in children with VTE. Studies of its potential role in outcome prediction are ongoing... - Towards a consensus-based classification of childhood arterial ischemic strokeTimothy J Bernard
Sections of Child Neurology and Hemophilia and Thrombosis Center, Department of Pediatrics, School of Public Health, University of Colorado, Aurora, CO, USA
Stroke 43:371-7. 2012..In contrast, current classification and nomenclature in childhood AIS are often overlapping or contradictory. Our purpose was to develop a comprehensive consensus-based classification system for childhood AIS... - A thrombolytic regimen for high-risk deep venous thrombosis may substantially reduce the risk of postthrombotic syndrome in childrenNeil A Goldenberg
University of Colorado at Denver and Health Sciences Center, Department of Pediatrics, Section of Hematology, Center for Cancer and Blood Disorders, The Children s Hospital, Denver, CO 80045, USA
Blood 110:45-53. 2007..These findings suggest that the use of a thrombolysis regimen may safely and substantially reduce the risk of PTS in children with occlusive lower-extremity acute DVT, providing the basis for a future clinical trial... - Update on treatment regimens: prophylaxis versus on-demand therapyMarilyn J Manco-Johnson
Department of Pediatrics, University of Colorado, Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO, USA
Semin Hematol 40:3-9. 2003..A need exists for validated and standardized outcome measures in future research, as well as for research into factors that affect families' adherence to prophylactic regimens for their children... - Treatment, survival, and thromboembolic outcomes of thrombotic storm in childrenMarilyn J Manco-Johnson
Department of Pediatrics, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Pediatr 161:682-8.e1. 2012..To describe the course and management of thrombotic storm in 8 children... - Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factorsNeil A Goldenberg
Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and the Mountain States Regional Hemophilia and Thrombosis Center, Univ of Colorado Denver and The Children s Hospital, Aurora, CO 80045, USA
Haematologica 95:1952-9. 2010..This systematic review was conducted to critically evaluate pediatric evidence on frequency of occurrence, validity of outcome measures, and prognostic indicators of post-thrombotic syndrome... - Central venous access device infections in children with hemophilia: a comparison of prophylaxis and episodic therapyMichele R Hacker
Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, Denver, USA
J Pediatr Hematol Oncol 29:458-64. 2007..Given the need for CVADs in some children and the benefits of prophylaxis, we conclude there is no reason to recommend against prophylaxis on the basis of existing knowledge of CVAD-related infection risk... - Athletic participation in severe hemophilia: bleeding and joint outcomes in children on prophylaxisCassie Ross
Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and Children s Hospital, Aurora, Colorado 80045 0507, USA
Pediatrics 124:1267-72. 2009.... - Brief communication: duration of platelet dysfunction after a 7-day course of IbuprofenNeil A Goldenberg
Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045 0507, USA
Ann Intern Med 142:506-9. 2005..Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures... - High prevalence of thrombophilic traits in children with family history of thromboembolismMeghan J Calhoon
Section of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO 80045, USA
J Pediatr 157:485-9. 2010.... - Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: findings from the Colorado and German (COAG) collaborationTimothy J Bernard
Pediatric Neurology, B155, The Children s Hospital, Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA
Stroke 40:2869-71. 2009..We sought to investigate the safety of extended anticoagulation in childhood arterial ischemic stroke with nonmoyamoya arteriopathy, for which the risk of recurrent stroke is high... - Thrombosis during infancy and childhood: what we know and what we do not knowJanna M Journeycake
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas TX, 75390 9063, USA
Hematol Oncol Clin North Am 18:1315-38, viii-ix. 2004..There still are many unanswered questions and clinical trials are being designed to help study these important issues... - Validation of upper extremity post-thrombotic syndrome outcome measurement in childrenNeil A Goldenberg
Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and the Mountain States Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO, USA
J Pediatr 157:852-5. 2010..Interrater reliability in an independent validation cohort (n = 38) of children with or without upper extremity deep venous thrombosis was 97%-100%... - A new euglobulin clot lysis assay for global fibrinolysisAmy A Smith
Department of Pediatrics, Section of Hematology, University of Colorado Health Sciences Center, Denver, CO USA
Thromb Res 112:329-37. 2003..These observations are interesting, but at this time, it cannot be said that any of the test parameters are better than lysis time in distinguishing between these normal physiologic states... - Pediatric hemostasis and use of plasma componentsNeil A Goldenberg
Section of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
Best Pract Res Clin Haematol 19:143-55. 2006..This chapter reviews evidence to support the use of plasma and plasma derivatives for pediatric patients... - Laboratory testing for thrombophilia in pediatric patients. On behalf of the Subcommittee for Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis (ISTH)Marilyn J Manco-Johnson
Mountain States Hemophilia Center, Aurora, CO, USA
Thromb Haemost 88:155-6. 2002 - Recommendations for tPA thrombolysis in children. On behalf of the Scientific Subcommittee on Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and HaemostasisMarilyn J Manco-Johnson
Mountain States Hemophilia Center, Aurora, CO, USA
Thromb Haemost 88:157-8. 2002 - Low-dose tissue plasminogen activator thrombolysis in childrenMichael Wang
Department of Pediatrics, Children's Hospital, University of Colorado Health Sciences Center, Denver, USA
J Pediatr Hematol Oncol 25:379-86. 2003..CONCLUSIONS: TPA in very low doses appears to be safe and effective for thrombolysis of acute thromboses in most children, given appropriate patient selection... - Protein C pathway in infants and childrenJari Petaja
Department of Pediatrics, Helsinki University Central Hospital, Jorvi Hospital, Helsinki, Finland
Semin Thromb Hemost 29:349-62. 2003..Clinical implications of the protein C pathway defects in pediatric venous thromboembolism as well as acquired disturbances of protein C pathway during sepsis are discussed... - Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survivalSandra L Haberichter
Department of Pediatrics Hematology Oncology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Blood 108:3344-51. 2006..This phenotype may require an altered clinical therapeutic approach, and we propose to refer to this phenotype as type-1C VWD...