Marilyn J Manco-Johnson

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint A new global assay of coagulation and fibrinolysis
    Neil A Goldenberg
    Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Health Sciences Center The Children s Hospital, Denver, CO, USA
    Thromb Res 116:345-56. 2005
  2. pmc How I treat venous thrombosis in children
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, PO Box 6507, MS F416, Aurora, CO 80045 0507, USA
    Blood 107:21-9. 2006
  3. ncbi request reprint Etiopathogenesis of pediatric thrombosis
    Marilyn J Manco-Johnson
    University of Colorado Denver and the Health Sciences Center, Denver, CO, USA
    Hematology 10:167-70. 2005
  4. ncbi request reprint Postthrombotic syndrome in children
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80045 0507, USA
    Acta Haematol 115:207-13. 2006
  5. pmc Pharmacokinetics of protein C and antithrombin in the fetal lamb: a model to predict human neonatal replacement dosing
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
    Neonatology 95:279-85. 2009
  6. ncbi request reprint Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
    Marilyn J Manco-Johnson
    University of Colorado and Health Sciences Center, Denver, USA
    N Engl J Med 357:535-44. 2007
  7. ncbi request reprint Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice
    M Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado, Denver and Health Sciences Center, Denver, Colorado, USA
    Haemophilia 13:4-9. 2007
  8. doi request reprint When the cause of clotting is not in the blood--it may be the vessel!
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, Colorado 80045 0507, USA
    Pediatr Blood Cancer 51:161-2. 2008
  9. ncbi request reprint Hemophilia management: optimizing treatment based on patient needs
    Marilyn Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
    Curr Opin Pediatr 17:3-6. 2005
  10. ncbi request reprint Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions
    M J Manco-Johnson
    Department of Pediatrics, Mountain States Regional Hemophilia and Thrombosis Centre, University of Colorado Health Sciences Centre, Denver, Colorado 800445 0507, USA
    Haemophilia 10:88-93. 2004

Collaborators

Detail Information

Publications46

  1. ncbi request reprint A new global assay of coagulation and fibrinolysis
    Neil A Goldenberg
    Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Health Sciences Center The Children s Hospital, Denver, CO, USA
    Thromb Res 116:345-56. 2005
    ..In this research, a global assay that measures both coagulation and fibrinolytic capacities was developed and investigated...
  2. pmc How I treat venous thrombosis in children
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, PO Box 6507, MS F416, Aurora, CO 80045 0507, USA
    Blood 107:21-9. 2006
  3. ncbi request reprint Etiopathogenesis of pediatric thrombosis
    Marilyn J Manco-Johnson
    University of Colorado Denver and the Health Sciences Center, Denver, CO, USA
    Hematology 10:167-70. 2005
  4. ncbi request reprint Postthrombotic syndrome in children
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80045 0507, USA
    Acta Haematol 115:207-13. 2006
    ....
  5. pmc Pharmacokinetics of protein C and antithrombin in the fetal lamb: a model to predict human neonatal replacement dosing
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO 80045 0507, USA
    Neonatology 95:279-85. 2009
    ..The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data are lacking...
  6. ncbi request reprint Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
    Marilyn J Manco-Johnson
    University of Colorado and Health Sciences Center, Denver, USA
    N Engl J Med 357:535-44. 2007
    ..Effective ways to prevent arthropathy in severe hemophilia are unknown...
  7. ncbi request reprint Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice
    M Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado, Denver and Health Sciences Center, Denver, Colorado, USA
    Haemophilia 13:4-9. 2007
    ..Data from these studies will provide objective evidence for the prevention of haemarthroses and arthropathy in children with severe haemophilia A...
  8. doi request reprint When the cause of clotting is not in the blood--it may be the vessel!
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, Colorado 80045 0507, USA
    Pediatr Blood Cancer 51:161-2. 2008
  9. ncbi request reprint Hemophilia management: optimizing treatment based on patient needs
    Marilyn Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
    Curr Opin Pediatr 17:3-6. 2005
    ..Progress in hemophilia management over the past year has focused on improving understanding of the most common complications of genetic bleeding disorders and building upon available therapeutic strategies...
  10. ncbi request reprint Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions
    M J Manco-Johnson
    Department of Pediatrics, Mountain States Regional Hemophilia and Thrombosis Centre, University of Colorado Health Sciences Centre, Denver, Colorado 800445 0507, USA
    Haemophilia 10:88-93. 2004
    ..88 and 0.87; test-retest reliability was 0.92 and 0.93. These new PT and MRI scales promise to improve outcome assessment in children on early preventive treatment regimens...
  11. ncbi request reprint Advances in care of children with hemophilia
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
    Semin Thromb Hemost 29:585-94. 2003
    ..The future of hemophilia promises a cure with gene therapy. Given the past accomplishments in hemophilia, a long-term solution to replacement of the genetically deficient protein lies on the horizon...
  12. ncbi request reprint Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency
    Marilyn J Manco-Johnson
    Mountain States Regional Hemophilia and Thrombosis Center, P O Box 6507, Mail Stop F 416, Aurora, CO 80045 0507, USA
    J Pediatr Hematol Oncol 26:25-7. 2004
    ..At the end of the APC infusion all skin lesions of PF were resolved. There were no adverse reactions to APC. APC was safe and effective for treatment of PF in severe genetic protein C deficiency...
  13. ncbi request reprint Development of coagulation regulatory proteins in the fetal and neonatal lamb
    Marilyn J Manco-Johnson
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
    Pediatr Res 52:580-8. 2002
    ..05). This study suggests that fetal regulation of coagulation proteins follows characteristic patterns relative to the vitamin K dependence of the protein rather than its role as a procoagulant versus regulatory protein...
  14. ncbi request reprint Joint evaluation instruments for children and adults with haemophilia
    M J Manco-Johnson
    Department of Paediatrics, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, CO 80045 0507, USA
    Haemophilia 6:649-57. 2000
    ..35) and this instrument had better overall statistical performance. This instrument should be studied further in prospective, longitudinal clinical trials of young children...
  15. ncbi request reprint 32P Radiosynoviorthesis in children with hemophilia
    Marilyn J Manco-Johnson
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    J Pediatr Hematol Oncol 24:534-9. 2002
    ..This study was performed to prospectively evaluate the safety, efficacy, and cost of injecting P-colloid into joints of children with hemophilia and synovitis to decrease the rate of joint bleeding...
  16. ncbi request reprint North American prophylaxis studies for persons with severe haemophilia: background, rationale and design
    M J Manco-Johnson
    The Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado, USA
    Haemophilia 9:44-8; discussion 49. 2003
    ..Both of these studies will contribute valuable information regarding optimal therapy and will help establish evidence-based medicine for the management of severe haemophilia...
  17. doi request reprint The "parallel-cohort RCT": Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism
    Neil A Goldenberg
    Dept of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and Mountain States Regional Hemophilia and Thrombosis Center, Univ of Colorado Denver and The Children s Hospital, Aurora, CO, USA
    Contemp Clin Trials 31:131-3. 2010
    ....
  18. doi request reprint Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study
    Hayley S Hancock
    Department of Pediatrics, University of Colorado School of Medicine, Children s Hospital Colorado, Aurora, Colorado 80045, USA
    Cardiol Young 23:344-52. 2013
    ..Right ventricular dysfunction was rare in follow-up. These data indicate that acute heart strain is common, but chronic cardiac dysfunction is rare, following aggressive management of acute pulmonary embolism in children...
  19. pmc The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, Colorado, USA
    Thromb Res 127:6-12. 2011
    ..Consensus-based guidelines have been developed, but future research must emphasize identification of additional prognostic factors and the initiation of cooperative randomized controlled clinical trials...
  20. doi request reprint Biomarkers of hypercoagulability and inflammation in childhood-onset arterial ischemic stroke
    Timothy J Bernard
    Department of Pediatrics, Section of Child Neurology, Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO 80045 0507, USA
    J Pediatr 156:651-6. 2010
    ....
  21. ncbi request reprint Lemierre's and Lemierre's-like syndromes in children: survival and thromboembolic outcomes
    Neil A Goldenberg
    Department of Pediatrics, University of Colorado Health Sciences Center, The Children s Hospital, Denver, Colorado, USA
    Pediatrics 116:e543-8. 2005
    ....
  22. ncbi request reprint Elevated plasma factor VIII and D-dimer levels as predictors of poor outcomes of thrombosis in children
    Neil A Goldenberg
    Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Health Sciences Center and The Children s Hospital, 1056 E 19th Ave, B 115, Denver, CO 80218, USA
    N Engl J Med 351:1081-8. 2004
    ....
  23. doi request reprint Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults
    Mindy L Simpson
    Rush University Medical Center, Department of Pediatrics, Section of Hematology Oncology, Chicago, IL 60612, USA
    Thromb Res 127:317-23. 2011
    ..Plasma coagulative and fibrinolytic potentials in normal children and adults, and in representative pathologically altered hemostatic states, were evaluated via simultaneous assessment of thrombin and plasmin generation...
  24. pmc Percutaneous mechanical and pharmacomechanical thrombolysis for occlusive deep vein thrombosis of the proximal limb in adolescent subjects: findings from an institution-based prospective inception cohort study of pediatric venous thromboembolism
    Neil A Goldenberg
    Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, Aurora, Colorado 80045, USA
    J Vasc Interv Radiol 22:121-32. 2011
    ..The present report is an evaluation of experience with adjunctive percutaneous mechanical thrombolysis (PMT) and/or percutaneous pharmacomechanical thrombolysis (PPMT) in such patients...
  25. doi request reprint Monitoring hypercoagulability and hypofibrinolysis following acute venous Thromboembolism in children: application of the CloFAL assay in a prospective inception cohort study
    Christopher Bombardier
    Department of Pediatrics, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 80045, USA
    Thromb Res 130:343-9. 2012
    ..These findings indicate the utility of the CloFAL assay in monitoring plasma coagulative and fibrinolytic capacities in children with VTE. Studies of its potential role in outcome prediction are ongoing...
  26. pmc Towards a consensus-based classification of childhood arterial ischemic stroke
    Timothy J Bernard
    Sections of Child Neurology and Hemophilia and Thrombosis Center, Department of Pediatrics, School of Public Health, University of Colorado, Aurora, CO, USA
    Stroke 43:371-7. 2012
    ..In contrast, current classification and nomenclature in childhood AIS are often overlapping or contradictory. Our purpose was to develop a comprehensive consensus-based classification system for childhood AIS...
  27. pmc A thrombolytic regimen for high-risk deep venous thrombosis may substantially reduce the risk of postthrombotic syndrome in children
    Neil A Goldenberg
    University of Colorado at Denver and Health Sciences Center, Department of Pediatrics, Section of Hematology, Center for Cancer and Blood Disorders, The Children s Hospital, Denver, CO 80045, USA
    Blood 110:45-53. 2007
    ..These findings suggest that the use of a thrombolysis regimen may safely and substantially reduce the risk of PTS in children with occlusive lower-extremity acute DVT, providing the basis for a future clinical trial...
  28. ncbi request reprint Update on treatment regimens: prophylaxis versus on-demand therapy
    Marilyn J Manco-Johnson
    Department of Pediatrics, University of Colorado, Mountain States Regional Hemophilia and Thrombosis Center, Aurora, CO, USA
    Semin Hematol 40:3-9. 2003
    ..A need exists for validated and standardized outcome measures in future research, as well as for research into factors that affect families' adherence to prophylactic regimens for their children...
  29. pmc Overweight and obesity are increased in childhood-onset cerebrovascular disease
    Virginia Pearson
    School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Child Neurol 28:517-9. 2013
    ..In conclusion, the prevalence of overweight/obese was significantly increased in cerebral sinovenous thrombosis patients as compared to both national and local controls. Results should be evaluated in a larger multi-institutional cohort...
  30. doi request reprint Treatment, survival, and thromboembolic outcomes of thrombotic storm in children
    Marilyn J Manco-Johnson
    Department of Pediatrics, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Pediatr 161:682-8.e1. 2012
    ..To describe the course and management of thrombotic storm in 8 children...
  31. ncbi request reprint Central venous access device infections in children with hemophilia: a comparison of prophylaxis and episodic therapy
    Michele R Hacker
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado, Denver, USA
    J Pediatr Hematol Oncol 29:458-64. 2007
    ..Given the need for CVADs in some children and the benefits of prophylaxis, we conclude there is no reason to recommend against prophylaxis on the basis of existing knowledge of CVAD-related infection risk...
  32. pmc Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors
    Neil A Goldenberg
    Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and the Mountain States Regional Hemophilia and Thrombosis Center, Univ of Colorado Denver and The Children s Hospital, Aurora, CO 80045, USA
    Haematologica 95:1952-9. 2010
    ..This systematic review was conducted to critically evaluate pediatric evidence on frequency of occurrence, validity of outcome measures, and prognostic indicators of post-thrombotic syndrome...
  33. doi request reprint Athletic participation in severe hemophilia: bleeding and joint outcomes in children on prophylaxis
    Cassie Ross
    Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and Children s Hospital, Aurora, Colorado 80045 0507, USA
    Pediatrics 124:1267-72. 2009
    ....
  34. doi request reprint The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism
    Emily Joachim
    Department of Pediatrics and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children s Hospital Colorado, Aurora, CO, USA Department of Medicine and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado and Children s Hospital Colorado, Aurora, CO, USA
    Thromb Res 132:170-4. 2013
    ..The objectives of this study were to determine the prevalences of elevated tHcy and MTHFR variant in a pediatric population with VTE or arterial ischemic stroke (AIS), and to determine associations with thrombus outcomes...
  35. doi request reprint Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: findings from the Colorado and German (COAG) collaboration
    Timothy J Bernard
    Pediatric Neurology, B155, The Children s Hospital, Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA
    Stroke 40:2869-71. 2009
    ..We sought to investigate the safety of extended anticoagulation in childhood arterial ischemic stroke with nonmoyamoya arteriopathy, for which the risk of recurrent stroke is high...
  36. doi request reprint High prevalence of thrombophilic traits in children with family history of thromboembolism
    Meghan J Calhoon
    Section of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr 157:485-9. 2010
    ....
  37. ncbi request reprint Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen
    Neil A Goldenberg
    Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045 0507, USA
    Ann Intern Med 142:506-9. 2005
    ..Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures...
  38. ncbi request reprint A new euglobulin clot lysis assay for global fibrinolysis
    Amy A Smith
    Department of Pediatrics, Section of Hematology, University of Colorado Health Sciences Center, Denver, CO USA
    Thromb Res 112:329-37. 2003
    ..These observations are interesting, but at this time, it cannot be said that any of the test parameters are better than lysis time in distinguishing between these normal physiologic states...
  39. pmc Validation of upper extremity post-thrombotic syndrome outcome measurement in children
    Neil A Goldenberg
    Department of Pediatrics, Section of Hematology Oncology Bone Marrow Transplantation and the Mountain States Hemophilia and Thrombosis Center, University of Colorado Denver and The Children s Hospital, Aurora, CO, USA
    J Pediatr 157:852-5. 2010
    ..Interrater reliability in an independent validation cohort (n = 38) of children with or without upper extremity deep venous thrombosis was 97%-100%...
  40. ncbi request reprint Thrombosis during infancy and childhood: what we know and what we do not know
    Janna M Journeycake
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas TX, 75390 9063, USA
    Hematol Oncol Clin North Am 18:1315-38, viii-ix. 2004
    ..There still are many unanswered questions and clinical trials are being designed to help study these important issues...
  41. ncbi request reprint Pediatric hemostasis and use of plasma components
    Neil A Goldenberg
    Section of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Best Pract Res Clin Haematol 19:143-55. 2006
    ..This chapter reviews evidence to support the use of plasma and plasma derivatives for pediatric patients...
  42. ncbi request reprint Laboratory testing for thrombophilia in pediatric patients. On behalf of the Subcommittee for Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis (ISTH)
    Marilyn J Manco-Johnson
    Mountain States Hemophilia Center, Aurora, CO, USA
    Thromb Haemost 88:155-6. 2002
  43. ncbi request reprint Low-dose tissue plasminogen activator thrombolysis in children
    Michael Wang
    Department of Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, Denver, USA
    J Pediatr Hematol Oncol 25:379-86. 2003
    ..To compare results of low-dose tissue plasminogen activator (TPA) in children with arterial and venous thrombi relative to standard published dosing...
  44. ncbi request reprint Recommendations for tPA thrombolysis in children. On behalf of the Scientific Subcommittee on Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis
    Marilyn J Manco-Johnson
    Mountain States Hemophilia Center, Aurora, CO, USA
    Thromb Haemost 88:157-8. 2002
  45. ncbi request reprint Protein C pathway in infants and children
    Jari Petaja
    Department of Pediatrics, Helsinki University Central Hospital, Jorvi Hospital, Helsinki, Finland
    Semin Thromb Hemost 29:349-62. 2003
    ..Clinical implications of the protein C pathway defects in pediatric venous thromboembolism as well as acquired disturbances of protein C pathway during sepsis are discussed...
  46. pmc Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival
    Sandra L Haberichter
    Department of Pediatrics Hematology Oncology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Blood 108:3344-51. 2006
    ..This phenotype may require an altered clinical therapeutic approach, and we propose to refer to this phenotype as type-1C VWD...