Affiliation: University of Maryland
- Galantamine counteracts development of learning impairment in guinea pigs exposed to the organophosphorus poison soman: clinical significanceJacek Mamczarz
Division of Translational Toxicology, Department Epidemiology and Public Health, University of Maryland School of Medicine, 10 S Pine St Suite 900, Baltimore, MD 21210, USA
Neurotoxicology 32:785-98. 2011..In conclusion, learning impairment develops months after a single exposure to 1xLD50 soman, and galantamine prevents both the acute toxicity and the delayed cognitive deficits triggered by this OP poison...
- An acute exposure to a sub-lethal dose of soman triggers anxiety-related behavior in guinea pigs: interactions with acute restraintJacek Mamczarz
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Neurotoxicology 31:77-84. 2010..It is concluded that a single exposure to sub-lethal doses of soman triggers long-lasting anxiogenesis and decreased locomotor activity and that acute restraint stress modifies the magnitude of these effects...
- Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacyTadanobu Utsuki
Drug Design and Development Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Pharmacol Exp Ther 321:353-61. 2007..Particular benefits over oral therapies might include avoiding first-pass metabolic effects and improved dosing compliance...