JAMES MALTER

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid
    J S Malter
    Department of Pathology, Waisman Center for Developmental Disabilities, UWMadison, WI, USA
    Curr Alzheimer Res 7:200-6. 2010
  2. pmc The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, The Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Nat Immunol 10:257-65. 2009
  3. pmc Pin1 modulates the type 1 immune response
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e226. 2007
  4. pmc The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model
    Shannon Reese
    Departments of Medicine and Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Fibrogenesis Tissue Repair 3:1. 2010
  5. pmc The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
    Peter K Todd
    Department of Pathology, Neuroscience Training Program, and Waisman Center for Developmental Disabilities, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 100:14374-8. 2003
  6. ncbi request reprint Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells
    Zhong Jian Shen
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    Exp Cell Res 313:1415-25. 2007
  7. pmc Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, USA
    Blood 112:3088-98. 2008
  8. ncbi request reprint Anti-Abeta: The good, the bad, and the unforeseen
    Oleg Broytman
    Waisman Center for Human Development and Developmental Disabilities, Department of Pathology and Laboratory Medicine and the Neuroscience Training Program, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
    J Neurosci Res 75:301-6. 2004
  9. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
  10. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009

Research Grants

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid
    J S Malter
    Department of Pathology, Waisman Center for Developmental Disabilities, UWMadison, WI, USA
    Curr Alzheimer Res 7:200-6. 2010
    ..Thus seemingly disparate neurologic diseases may share a common pathologic instigator and be treatable with a common, currently available class of therapeutics...
  2. pmc The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, The Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Nat Immunol 10:257-65. 2009
    ..Our findings indicate that Pin1 is a key mediator of prosurvival signaling and is a regulator of Bax function...
  3. pmc Pin1 modulates the type 1 immune response
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e226. 2007
    ..Signalling molecules downstream of CD28 which are essential for the stabilization of cytokine mRNAs are largely unknown...
  4. pmc The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model
    Shannon Reese
    Departments of Medicine and Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Fibrogenesis Tissue Repair 3:1. 2010
    ....
  5. pmc The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
    Peter K Todd
    Department of Pathology, Neuroscience Training Program, and Waisman Center for Developmental Disabilities, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 100:14374-8. 2003
    ..Taken together, these studies suggest that FMRP is required for mGluR-dependent translation of PSD-95 and provide insights into the pathophysiology of FXS...
  6. ncbi request reprint Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells
    Zhong Jian Shen
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    Exp Cell Res 313:1415-25. 2007
    ..These data suggest autocrine TGF-beta1 antagonizes BMP signaling through modulation of inducible Smad6 and the activity of BMP specific Smad1/5...
  7. pmc Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, USA
    Blood 112:3088-98. 2008
    ..This study shows the prognostic importance of mutations in the TP53 DNA-binding domains in patients with DLBCL...
  8. ncbi request reprint Anti-Abeta: The good, the bad, and the unforeseen
    Oleg Broytman
    Waisman Center for Human Development and Developmental Disabilities, Department of Pathology and Laboratory Medicine and the Neuroscience Training Program, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
    J Neurosci Res 75:301-6. 2004
    ..Thus, vaccination appears to activate both beneficial and deleterious anti-Abeta immunity, suggesting that the vaccine can have potent clinical utility if an appropriate immunologic response can be generated...
  9. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
    ..Our data strongly implicates AbetaPP or a catabolite in seizure susceptibility and suggests that mGluR5 mediates this response...
  10. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009
    ..These data suggest that Abeta contributes to seizure incidence and may be an appropriate therapeutic target to lessen seizure pathology in FXS, Alzheimer's disease (AD) and Down syndrome (DS) patients...
  11. ncbi request reprint Serum and low-density lipoprotein enhance interleukin-8 secretion by airway epithelial cells
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53792 9988, USA
    Am J Respir Cell Mol Biol 29:483-9. 2003
    ..This effect may represent an innate mechanism for the recruitment of neutrophils to the airway in response to noxious stimuli, such as viral infections, that increase vascular permeability...
  12. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
    ..Our data indicate that postsynaptic FMRP binds to and regulates the translation of APP mRNA through metabotropic glutamate receptor activation and suggests a possible link between Alzheimer disease and fragile X syndrome...
  13. ncbi request reprint HuR mRNA ligands expressed after seizure
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neuropathol Exp Neurol 64:1037-45. 2005
    ..These results demonstrate a biochemical approach to identify and characterize the diverse repertoire of ligands for HuR and other regulatory mRNA-binding proteins...
  14. pmc Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells
    Rui Wang
    Department of Pathology, School of Medicine and Public Health, University of Wisconsin, Madison, USA
    J Neurochem 108:1072-82. 2009
    ..This study demonstrates that NEP can be inactivated by HNE-adduction, which is associated with, at least partly, reduced Abeta cleavage and enhanced Abeta accumulation...
  15. ncbi request reprint RhoB mRNA is stabilized by HuR after UV light
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Oncogene 24:502-11. 2005
    ..Therefore, we propose a model in which UVL induces stress-activated signal transduction leading to nuclear/cytoplasmic shuttling of HuR and subsequent stabilization of RhoB mRNA...
  16. ncbi request reprint The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine, Madison, WI 53705, USA
    J Immunol 177:6999-7006. 2006
    ..Mechanistically, Pin1 mediated the association of the AU-rich element-binding protein, AUF1, with GM-CSF mRNA, which determined the rate of decay by the exosome...
  17. ncbi request reprint Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors
    Peter K Todd
    Department of Pathology, University of Wisconsin at Madison, Madison, WI, USA
    Brain Res Mol Brain Res 110:267-78. 2003
    ..Taken together, these studies show that experience regulates FMRP production in vivo at the level of translation and supports a role for FMRP in metabotropic glutamate receptor mediated synaptic plasticity...
  18. ncbi request reprint Circadian changes in granulocyte-macrophage colony-stimulating factor message in circulating eosinophils
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Madison, Wisconsin, USA
    Ann Allergy Asthma Immunol 98:75-82. 2007
    ..Although eosinophil recruitment and enhanced survival have been associated with nocturnal asthma (NA), the contribution of GM-CSF to NA is unknown...
  19. ncbi request reprint Fragile X mental retardation protein in plasticity and disease
    Peter K Todd
    Department of Pathology, Medical Scientist and Neuroscience Training Program, University of Wisconsin, 600 Highland Drive, Madison, WI 53792, USA
    J Neurosci Res 70:623-30. 2002
    ....
  20. ncbi request reprint Ets-1 regulates TNF-alpha-induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts
    Yutaka Nakamura
    Department of Medicine Pulmonary and Critical Care Section, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 172:1945-52. 2004
    ..Taken together, these data demonstrate that TNF-alpha increases MMP-9 and tenascin expression in bronchial fibroblasts via the transcription factor Ets-1, and suggest a role for Ets-1 in airway remodeling in asthma...
  21. ncbi request reprint The significance of Pin1 in the development of Alzheimer's disease
    Suqing Wang
    Department of Pathology and Laboratory Medicine, and Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine, Madison, WI 53705, USA
    J Alzheimers Dis 11:13-23. 2007
    ....
  22. ncbi request reprint Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Neuroscience Training Program, Waisman Center for Developmental Disabilities and Institute on Aging, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Neurobiol Aging 27:787-96. 2006
    ....
  23. ncbi request reprint Dendritic cell-based immunotherapy for cancer and relevant challenges for transfusion medicine
    Ching Y Voss
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 53705, USA
    Transfus Med Rev 18:189-202. 2004
    ..The potential challenges for blood banking/transfusion medicine involving both technical and regulatory issues are discussed...
  24. doi request reprint Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent
    Stephane Esnault
    J Allergy Clin Immunol 121:1289-90. 2008
  25. ncbi request reprint Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 171:6780-7. 2003
    ....
  26. ncbi request reprint Expression of interleukin-5- and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophils
    Mary E Bates
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Am J Respir Cell Mol Biol 30:736-43. 2004
    ..e., lymphotoxin beta and CD24). These studies have identified several transcriptional targets of IL-5 and GM-CSF in human eosinophils and suggest that a number of protein products are critical to the responsiveness of airway eosinophils...
  27. ncbi request reprint Extracellular signal-regulated kinase mediates granulocyte-macrophage colony-stimulating factor messenger RNA stabilization in tumor necrosis factor-alpha plus fibronectin-activated peripheral blood eosinophils
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53792, USA
    Blood 99:4048-52. 2002
    ..These data are in contradistinction to the c-Jun NH(2)-terminal kinase-mediated regulation of interleukin 2 and 3 mRNAs and suggest unique regulatory features for GM-CSF mRNA in eosinophils...

Research Grants22

  1. Pin1 in Synaptic Plasticity and Translation
    James S Malter; Fiscal Year: 2010
    ..As such our aims are to determine 1) the role of PKMz in regulating Pin1 and 2) further characterize PKMz function by identifying its downstream targets through chemical-genetics. ..
  2. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 2005
    ..In aggregate, these studies will help unravel how APP mRNA stability is regulated in cells and animal models. This knowledge may facilitate the development of anti-AP . ..
  3. CLONING OF EARLY RESPONSE GENES FROM THE NERVOUS SYSTEM
    JAMES MALTER; Fiscal Year: 2000
    ..In aggregate, these studies will identify heretofore unknown, ERGs induced by seizure and begin to characterize the temporal and spatial expression of these genes in the brain. ..
  4. Pin1 in Synaptic Plasticity and Translation
    JAMES MALTER; Fiscal Year: 2009
    ..As such our aims are to determine 1) the role of PKMz in regulating Pin1 and 2) further characterize PKMz function by identifying its downstream targets through chemical-genetics. ..
  5. APP MRNA DYSREGULATION AND ALZHEIMERS DISEASE
    JAMES MALTER; Fiscal Year: 2000
    ..Taken together, these studies will investigate the underlying mechanisms of APP mRNA posttranscriptional gene regulation and its consequences on APP and AB production. ..
  6. APP MRNA DYSREGULATION AND ALZHEIMERS DISEASE
    JAMES MALTER; Fiscal Year: 1999
    ..Taken together, these studies will investigate the underlying mechanisms of APP mRNA posttranscriptional gene regulation and its consequences on APP and AB production. ..
  7. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 2006
    ..In aggregate, these studies will help unravel how APP mRNA stability is regulated in cells and animal models. This knowledge may facilitate the development of anti-AP . ..
  8. Pin1 regulation of prosurvival signalling in eosinophils
    JAMES MALTER; Fiscal Year: 2009
    ..Such drugs could be useful for the treatment of chronic asthma. ..
  9. Pin1 regulation of prosurvival signalling in eosinophils
    James S Malter; Fiscal Year: 2010
    ..Such drugs could be useful for the treatment of chronic asthma. ..
  10. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 2004
    ..In aggregate, these studies will help unravel how APP mRNA stability is regulated in cells and animal models. This knowledge may facilitate the development of anti-AP . ..
  11. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 2003
    ..In aggregate, these studies will help unravel how APP mRNA stability is regulated in cells and animal models. This knowledge may facilitate the development of anti-AP . ..
  12. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 2002
    ..In aggregate, these studies will help unravel how APP mRNA stability is regulated in cells and animal models. This knowledge may facilitate the development of anti-AP . ..
  13. CLONING OF EARLY RESPONSE GENES FROM THE NERVOUS SYSTEM
    JAMES MALTER; Fiscal Year: 2001
    ..In aggregate, these studies will identify heretofore unknown, ERGs induced by seizure and begin to characterize the temporal and spatial expression of these genes in the brain. ..
  14. CLONING OF EARLY RESPONSE GENES FROM THE NERVOUS SYSTEM
    JAMES MALTER; Fiscal Year: 1999
    ..In aggregate, these studies will identify heretofore unknown, ERGs induced by seizure and begin to characterize the temporal and spatial expression of these genes in the brain. ..
  15. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 1993
    ..Cumulatively these studies will clarify the roles of posttranscriptional gene regulation and AUBF-B in the accumulation of APP mRNAs...
  16. APP MRNA DYSREGULATION AND ALZHEIMER'S DISEASE
    JAMES MALTER; Fiscal Year: 1992
    ..Cumulatively these studies will clarify the roles of posttranscriptional gene regulation and AUBF-B in the accumulation of APP mRNAs...