J S Malter

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Regulation of mRNA stability in the nervous system and beyond
    J S Malter
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neurosci Res 66:311-6. 2001
  2. ncbi request reprint Up-regulation of nucleolin mRNA and protein in peripheral blood mononuclear cells by extracellular-regulated kinase
    C J Westmark
    Institute on Aging and Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Biol Chem 276:1119-26. 2001
  3. pmc The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
    Peter K Todd
    Department of Pathology, Neuroscience Training Program, and Waisman Center for Developmental Disabilities, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 100:14374-8. 2003
  4. ncbi request reprint Minute quantities of granulocyte-macrophage colony-stimulating factor prolong eosinophil survival
    S Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792, USA
    J Interferon Cytokine Res 21:117-24. 2001
  5. ncbi request reprint Granulocyte macrophage colony-stimulating factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils
    S Bhattacharya
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Am J Respir Cell Mol Biol 24:312-6. 2001
  6. ncbi request reprint Granulocyte macrophage-colony-stimulating factor mRNA is stabilized in airway eosinophils and peripheral blood eosinophils activated by TNF-alpha plus fibronectin
    S Esnault
    Department of Pathology, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 166:4658-63. 2001
  7. ncbi request reprint Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid
    J S Malter
    Department of Pathology, Waisman Center for Developmental Disabilities, UWMadison, WI, USA
    Curr Alzheimer Res 7:200-6. 2010
  8. ncbi request reprint Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells
    Zhong Jian Shen
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    Exp Cell Res 313:1415-25. 2007
  9. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
  10. ncbi request reprint Anti-Abeta: The good, the bad, and the unforeseen
    Oleg Broytman
    Waisman Center for Human Development and Developmental Disabilities, Department of Pathology and Laboratory Medicine and the Neuroscience Training Program, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
    J Neurosci Res 75:301-6. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Regulation of mRNA stability in the nervous system and beyond
    J S Malter
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Neurosci Res 66:311-6. 2001
    ..This review discusses several examples of such posttranscriptional gene regulation...
  2. ncbi request reprint Up-regulation of nucleolin mRNA and protein in peripheral blood mononuclear cells by extracellular-regulated kinase
    C J Westmark
    Institute on Aging and Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Biol Chem 276:1119-26. 2001
    ..Supplementation of rabbit reticulocyte lysate with nucleolin decreased APP mRNA stability and protein production. These data suggest ERK up-regulates nucleolin posttranscriptionally thereby controlling APP production...
  3. pmc The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
    Peter K Todd
    Department of Pathology, Neuroscience Training Program, and Waisman Center for Developmental Disabilities, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 100:14374-8. 2003
    ..Taken together, these studies suggest that FMRP is required for mGluR-dependent translation of PSD-95 and provide insights into the pathophysiology of FXS...
  4. ncbi request reprint Minute quantities of granulocyte-macrophage colony-stimulating factor prolong eosinophil survival
    S Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792, USA
    J Interferon Cytokine Res 21:117-24. 2001
    ..Thus, autocrine production of low levels of GM-CSF by a minority of PBEo can block apoptosis of the entire culture by a minute but sustained GM-CSF release...
  5. ncbi request reprint Granulocyte macrophage colony-stimulating factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils
    S Bhattacharya
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Am J Respir Cell Mol Biol 24:312-6. 2001
    ..These data suggest that active nuclear STAT5 participates in the regulation of IL-5 and GM-CSF--inducible genes in stimulated human peripheral blood eosinophils...
  6. ncbi request reprint Granulocyte macrophage-colony-stimulating factor mRNA is stabilized in airway eosinophils and peripheral blood eosinophils activated by TNF-alpha plus fibronectin
    S Esnault
    Department of Pathology, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 166:4658-63. 2001
    ..These data suggest that TNF-alpha plus fibronectin may increase eosinophil survival in vivo by controlling GM-CSF production at a posttranscriptional level...
  7. ncbi request reprint Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid
    J S Malter
    Department of Pathology, Waisman Center for Developmental Disabilities, UWMadison, WI, USA
    Curr Alzheimer Res 7:200-6. 2010
    ..Thus seemingly disparate neurologic diseases may share a common pathologic instigator and be treatable with a common, currently available class of therapeutics...
  8. ncbi request reprint Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells
    Zhong Jian Shen
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Korea
    Exp Cell Res 313:1415-25. 2007
    ..These data suggest autocrine TGF-beta1 antagonizes BMP signaling through modulation of inducible Smad6 and the activity of BMP specific Smad1/5...
  9. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
    ..Our data indicate that postsynaptic FMRP binds to and regulates the translation of APP mRNA through metabotropic glutamate receptor activation and suggests a possible link between Alzheimer disease and fragile X syndrome...
  10. ncbi request reprint Anti-Abeta: The good, the bad, and the unforeseen
    Oleg Broytman
    Waisman Center for Human Development and Developmental Disabilities, Department of Pathology and Laboratory Medicine and the Neuroscience Training Program, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
    J Neurosci Res 75:301-6. 2004
    ..Thus, vaccination appears to activate both beneficial and deleterious anti-Abeta immunity, suggesting that the vaccine can have potent clinical utility if an appropriate immunologic response can be generated...
  11. ncbi request reprint Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Neuroscience Training Program, Waisman Center for Developmental Disabilities and Institute on Aging, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Neurobiol Aging 27:787-96. 2006
    ....
  12. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
    ..Our data strongly implicates AbetaPP or a catabolite in seizure susceptibility and suggests that mGluR5 mediates this response...
  13. ncbi request reprint Serum and low-density lipoprotein enhance interleukin-8 secretion by airway epithelial cells
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53792 9988, USA
    Am J Respir Cell Mol Biol 29:483-9. 2003
    ..This effect may represent an innate mechanism for the recruitment of neutrophils to the airway in response to noxious stimuli, such as viral infections, that increase vascular permeability...
  14. pmc Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, USA
    Blood 112:3088-98. 2008
    ..This study shows the prognostic importance of mutations in the TP53 DNA-binding domains in patients with DLBCL...
  15. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009
    ..These data suggest that Abeta contributes to seizure incidence and may be an appropriate therapeutic target to lessen seizure pathology in FXS, Alzheimer's disease (AD) and Down syndrome (DS) patients...
  16. pmc The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model
    Shannon Reese
    Departments of Medicine and Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Fibrogenesis Tissue Repair 3:1. 2010
    ....
  17. ncbi request reprint The significance of Pin1 in the development of Alzheimer's disease
    Suqing Wang
    Department of Pathology and Laboratory Medicine, and Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine, Madison, WI 53705, USA
    J Alzheimers Dis 11:13-23. 2007
    ....
  18. pmc Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines
    Oleg Broytman
    Department of Pathology and Laboratory Medicine, Neuroscience Training Program, Waisman Center for Developmental Disabilities and Institute on Aging, University of Wisconsin, Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Neurobiol Aging 30:1962-74. 2009
    ..These findings suggest a novel mechanism for post-transcriptional regulation of APP mRNA...
  19. ncbi request reprint HuR mRNA ligands expressed after seizure
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neuropathol Exp Neurol 64:1037-45. 2005
    ..These results demonstrate a biochemical approach to identify and characterize the diverse repertoire of ligands for HuR and other regulatory mRNA-binding proteins...
  20. ncbi request reprint Multiple proteins interact at a unique cis-element in the 3'-untranslated region of amyloid precursor protein mRNA
    S H Zaidi
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792 2472
    J Biol Chem 269:24000-6. 1994
    ..269, 24007-24013) we show that this 29-base element in the 3'-untranslated region regulates the stability of APP mRNA. Cumulatively these data suggest that steady-state APP mRNA levels are modulated by cytosolic protein-RNA interactions...
  21. ncbi request reprint Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay
    C J Westmark
    Institute on Aging and Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    Brain Res Mol Brain Res 90:193-201. 2001
    ..We attribute the initial rapid loss of APP mRNA to the helicase activity associated with nucleolin and later stabilization to hnRNP C binding to the 29 base instability element in the 3'-UTR of APP mRNA...
  22. pmc Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells
    Rui Wang
    Department of Pathology, School of Medicine and Public Health, University of Wisconsin, Madison, USA
    J Neurochem 108:1072-82. 2009
    ..This study demonstrates that NEP can be inactivated by HNE-adduction, which is associated with, at least partly, reduced Abeta cleavage and enhanced Abeta accumulation...
  23. ncbi request reprint RhoB mRNA is stabilized by HuR after UV light
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Oncogene 24:502-11. 2005
    ..Therefore, we propose a model in which UVL induces stress-activated signal transduction leading to nuclear/cytoplasmic shuttling of HuR and subsequent stabilization of RhoB mRNA...
  24. ncbi request reprint Ets-1 regulates TNF-alpha-induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts
    Yutaka Nakamura
    Department of Medicine Pulmonary and Critical Care Section, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 172:1945-52. 2004
    ..Taken together, these data demonstrate that TNF-alpha increases MMP-9 and tenascin expression in bronchial fibroblasts via the transcription factor Ets-1, and suggest a role for Ets-1 in airway remodeling in asthma...
  25. ncbi request reprint Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA
    E E Capowski
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 167:5970-6. 2001
    ..Thus, we propose a model whereby activation of eosinophils leads to YB-1 binding to and stabilization of GM-CSF mRNA, ultimately resulting in GM-CSF release and prolonged eosinophil survival...
  26. pmc Pin1 modulates the type 1 immune response
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e226. 2007
    ..Signalling molecules downstream of CD28 which are essential for the stabilization of cytokine mRNAs are largely unknown...
  27. ncbi request reprint The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine, Madison, WI 53705, USA
    J Immunol 177:6999-7006. 2006
    ..Mechanistically, Pin1 mediated the association of the AU-rich element-binding protein, AUF1, with GM-CSF mRNA, which determined the rate of decay by the exosome...
  28. ncbi request reprint Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors
    Peter K Todd
    Department of Pathology, University of Wisconsin at Madison, Madison, WI, USA
    Brain Res Mol Brain Res 110:267-78. 2003
    ..Taken together, these studies show that experience regulates FMRP production in vivo at the level of translation and supports a role for FMRP in metabotropic glutamate receptor mediated synaptic plasticity...
  29. ncbi request reprint Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 171:6780-7. 2003
    ....
  30. ncbi request reprint Circadian changes in granulocyte-macrophage colony-stimulating factor message in circulating eosinophils
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Madison, Wisconsin, USA
    Ann Allergy Asthma Immunol 98:75-82. 2007
    ..Although eosinophil recruitment and enhanced survival have been associated with nocturnal asthma (NA), the contribution of GM-CSF to NA is unknown...
  31. ncbi request reprint Fragile X mental retardation protein in plasticity and disease
    Peter K Todd
    Department of Pathology, Medical Scientist and Neuroscience Training Program, University of Wisconsin, 600 Highland Drive, Madison, WI 53792, USA
    J Neurosci Res 70:623-30. 2002
    ....
  32. ncbi request reprint Expression of interleukin-5- and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophils
    Mary E Bates
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Am J Respir Cell Mol Biol 30:736-43. 2004
    ..e., lymphotoxin beta and CD24). These studies have identified several transcriptional targets of IL-5 and GM-CSF in human eosinophils and suggest that a number of protein products are critical to the responsiveness of airway eosinophils...
  33. pmc Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells
    Rui Wang
    Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    J Alzheimers Dis 17:489-501. 2009
    ..The results demonstrated for the first time that both ECE-1 and IDE are substrates of HNE modification induced by Abeta. In addition, the results suggest complex mechanisms underlying the regulation of their enzymatic activity...
  34. ncbi request reprint Extracellular signal-regulated kinase mediates granulocyte-macrophage colony-stimulating factor messenger RNA stabilization in tumor necrosis factor-alpha plus fibronectin-activated peripheral blood eosinophils
    Stephane Esnault
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53792, USA
    Blood 99:4048-52. 2002
    ..These data are in contradistinction to the c-Jun NH(2)-terminal kinase-mediated regulation of interleukin 2 and 3 mRNAs and suggest unique regulatory features for GM-CSF mRNA in eosinophils...
  35. ncbi request reprint Dendritic cell-based immunotherapy for cancer and relevant challenges for transfusion medicine
    Ching Y Voss
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 53705, USA
    Transfus Med Rev 18:189-202. 2004
    ..The potential challenges for blood banking/transfusion medicine involving both technical and regulatory issues are discussed...
  36. pmc The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, The Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Nat Immunol 10:257-65. 2009
    ..Our findings indicate that Pin1 is a key mediator of prosurvival signaling and is a regulator of Bax function...
  37. doi request reprint Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent
    Stephane Esnault
    J Allergy Clin Immunol 121:1289-90. 2008