Affiliation: University of California
- The placenta: transcriptional, epigenetic, and physiological integration during developmentEmin Maltepe
Department of Pediatrics, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, 513 Parnassus Ave HSE 1401, Box 1346, San Francisco, CA 94143 1346, USA
J Clin Invest 120:1016-25. 2010..Developing an understanding of these pathways contributes to an improvement of our models for studying trophoblast biology and sheds light on the etiology of pregnancy complications and the in utero programming of adult diseases...
- Oxygen, epigenetics and stem cell fateKelly Okazaki
University of California, Department of Cell and Tissue Biology, San Francisco, CA 94143, USA
Regen Med 1:71-83. 2006..Dissection of the pathways involved will provide novel insights into the metabolic as well as molecular determinants of the stem cell niches that allow self-renewal of progenitors in an undifferentiated state...
- ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangementHwa J Choi
Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
PLoS ONE 8:e56949. 2013..Thus, we find that HIF can integrate positional and metabolic cues from within the TSC niche to regulate placental development by modulating the cellular cytoskeleton via non-canonical gene expression...
- A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsiaNathan M Hunkapiller
Center for Reproductive Sciences, University of California San Francisco, CA 94143, USA
Development 138:2987-98. 2011..In pre-eclampsia, expression of the Notch ligand JAG1 was absent in perivascular and endovascular TBs. We conclude that Notch signaling is crucial for TB vascular invasion...
- Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal careAngela M Park
Department of Pediatrics, University of California, San Francisco, CA 94143 1346, USA
Semin Fetal Neonatal Med 15:196-202. 2010..The pharmacological stabilization of HIF family members may therefore have clinical utility in premature infants in whom this important morphogen has been inactivated by exposure to supraphysiological oxygen levels...
- Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentationKristy Red-Horse
Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California, USA
J Clin Invest 116:2643-52. 2006....
- The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryosFrancis Smith
Graduate Program in Oral and Craniofacial Sciences, The University of California San Francisco, School of Dentistry, San Francisco, CA 94143, USA
Dis Model Mech 6:915-24. 2013..These results indicate that hypoxia during early embryonic craniofacial development might induce cellular oxidative stress, leading to apoptosis of the neural crest progenitor cells that are crucial to normal craniofacial morphogenesis. ..
- Placental Syncytium Forms a Biophysical Barrier against Pathogen InvasionVarvara B Zeldovich
Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, California, United States of America
PLoS Pathog 9:e1003821. 2013..Moreover, murine TSCs are a genetically tractable model system for the investigation of specific pathways in syncytial host defenses. ..
- Impaired placental nutrient transport in mice generated by in vitro fertilizationEnrrico Bloise
Department of Obstetrics Gynecology and Reproductive Science, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0916, USA
Endocrinology 153:3457-67. 2012..05). We conclude that IVF alters both fetal and placental growth and, importantly, decreases placental transport efficiency in mice conceived by IVF...
- Oxygen in health and disease: regulation of oxygen homeostasis--clinical implicationsEmin Maltepe
Department of Pediatrics, University of California, San Francisco, California 94143, USA
Pediatr Res 65:261-8. 2009....
- Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placentaEmin Maltepe
Department of Pediatrics and Molecular Medicine Program, University of California, Parnassus Avenue, San Francisco, CA 94143, USA
Development 132:3393-403. 2005..Thus, the HIFs play important roles in modulating the developmental plasticity of stem cells by integrating physiological, transcriptional and epigenetic inputs...
- HIF Dependent Epigenetic Responses During Hypoxia and DifferentiationEmin Maltepe; Fiscal Year: 2007..This proposal seeks to explain these enigmatic associations in term of the molecular causes. (End of Abstract) ..