Research Topics
| Robert MalletSummaryAffiliation: University of North Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energeticsR T Mallet
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
Cardiovasc Res 42:149-61. 1999....- Beta1-Adrenergic receptor antagonism abrogates cardioprotective effects of intermittent hypoxiaRobert T Mallet
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Basic Res Cardiol 101:436-46. 2006..Thus, episodic beta1-adrenergic activation during IHC evokes progressive development of powerful resistance to myocardial ischemia... - Metabolic cardioprotection by pyruvate: recent progressRobert T Mallet
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Exp Biol Med (Maywood) 230:435-43. 2005.... - Antioxidant properties of myocardial fuelsRobert T Mallet
Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
Mol Cell Biochem 253:103-11. 2003..These findings reveal novel, energy-independent mechanisms for enhancement of post-ischemic cardiac performance by metabolic fuels... - Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardiumRobert T Mallet
Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
J Mol Cell Cardiol 34:1173-84. 2002.... - Pyruvate: metabolic protector of cardiac performanceR T Mallet
Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
Proc Soc Exp Biol Med 223:136-48. 2000..This review aims to summarize evidence for each of these mechanisms and to consider the potential utility of pyruvate as a therapeutic intervention for clinical management of cardiac insufficiency... - Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardiumE Marty Knott
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA
Am J Physiol Heart Circ Physiol 289:H1123-30. 2005..Pyruvate cardioplegia doubled [PCr]/([Cr][P(i)]) versus control and lactate cardioplegia after reperfusion. Pyruvate cardioplegia mitigates oxidative stress during cardioplegic arrest and enhances myocardial energy state on reperfusion... 
Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypassMyoung Gwi Ryou
Department of Integrative Physiology, University of North Texas, Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Am J Physiol Heart Circ Physiol 297:H1914-22. 2009..By stabilizing HIF-1alpha, pyruvate-fortified cardioplegia may evoke sustained activation of EPO's cardioprotective signaling cascade in myocardium...- Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanismJeffrey E Squires
Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699, USA
Am J Physiol Heart Circ Physiol 284:H1340-7. 2003..Thus acetoacetate increased contractile performance and potentiated beta-adrenergic inotropism in stunned myocardium without increasing energy reserves, suggesting its antioxidant character is central to its beneficial actions... 
Hypoxic conditioning suppresses nitric oxide production upon myocardial reperfusionMyoung Gwi Ryou
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Exp Biol Med (Maywood) 233:766-74. 2008..Attenuation of the NOS/NO system may contribute to IHC-induced protection of myocardium from ischemia-reperfusion injury...- Pyruvate-enriched cardioplegia suppresses cardiopulmonary bypass-induced myocardial inflammationMyoung Gwi Ryou
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
Ann Thorac Surg 90:1529-35. 2010..This study tested whether cardioplegia enriched with the intermediary metabolite and antioxidant pyruvate dampens postbypass myocardial inflammation... - Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitationArti B Sharma
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA
Resuscitation 66:71-81. 2005..In conclusion, intravenous pyruvate therapy increases energy reserves and antioxidant defenses of resuscitated myocardium. These temporary metabolic improvements support post-arrest recovery of cardiac electromechanical performance... - Vagal modulation of heart rate variability during atrial fibrillation in pigsChristina F Kneip
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, 76107 2699, USA
Exp Biol Med (Maywood) 235:1007-14. 2010..15 Hz (P < 0.05). These results indicate that: (1) power spectral analysis may be used to assess parasympathetic regulation during AF, and (2) vagal oscillations produce an entrainment of the ventricular rhythm during AF in pigs... - Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypassAlbert H Olivencia-Yurvati
Department of Surgery, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
J Cardiothorac Vasc Anesth 17:715-20. 2003.... - Pyruvate mitigates oxidative stress during reperfusion of cardioplegia-arrested myocardiumE Marty Knott
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699, USA
Ann Thorac Surg 81:928-34. 2006..These results support therapeutic application of pyruvate-enhanced reperfusion to prevent cardiac injury after cardioplegic arrest... - Leukocyte filtration and aprotinin: synergistic anti-inflammatory protectionAlbert H Olivencia-Yurvati
Department of Surgery, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
Perfusion 19:S13-9. 2004..8%). These findings suggest that combining mechanical and pharmacologic suppression of the systemic inflammatory response could mitigate its deleterious arrhythmic and pulmonary complications... - Intermittent hypoxic training protects canine myocardium from infarctionPu Zong
Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
Exp Biol Med (Maywood) 229:806-12. 2004..The mechanism responsible for this potent cardioprotection merits further study... - Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitationArti B Sharma
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Resuscitation 76:108-19. 2008..This study tested whether acute pyruvate treatment during cardiopulmonary resuscitation can prevent neurological dysfunction and cerebral injury following cardiac arrest... - Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shockDevin C Flaherty
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Mil Med 175:166-72. 2010..conventional lactate Ringer's (LR) more effectively stabilizes mean arterial pressure (MAP) and suppresses myocardial inflammation postresuscitation... - Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn ratsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
J Appl Physiol 105:510-7. 2008..We conclude that IH conditioning during chronic ethanol consumption attenuates oxidative damage to the brain and mitigates behavioral abnormalities during subsequent EW. IH-induced ROS may evoke this powerful protection... - Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cellsXiaofei Wang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Brain Res 1132:1-9. 2007..Collectively, these results suggest that pyruvate protects neuronal cells through its antioxidant actions on mitochondria... - A putative mitochondrial mechanism for antioxidative cytoprotection by 17beta-estradiolAndrea N Moor
Department of Cell Biology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Exp Eye Res 78:933-44. 2004.... - Oxidative stress reversibly inactivates myocardial enzymes during cardiac arrestArti B Sharma
Dept of Integrative Physiology, Univ of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Am J Physiol Heart Circ Physiol 292:H198-206. 2007..In conclusion, cardiac arrest reversibly inactivates several important myocardial metabolic enzymes. Antioxidant protection of these enzymes implicates oxidative stress as a principal mechanism of enzyme inactivation during arrest... - Intermittent hypoxia: cause of or therapy for systemic hypertension?Tatiana V Serebrovskaya
Bogomoletz Institute of Physiology, 4 Bogomoletz St, Kiev 01024, Ukraine
Exp Biol Med (Maywood) 233:627-50. 2008..Also reviewed is evidence regarding mechanisms of the pro- and anti-hypertensive effects of intermittent hypoxia... - Role of nitric oxide in cardiovascular adaptation to intermittent hypoxiaEugenia B Manukhina
Institute of General Pathology and Pathophysiology, Moscow, Russia
Exp Biol Med (Maywood) 231:343-65. 2006..Understanding the role of NO in mechanisms of adaptation to hypoxia will support development of therapies to prevent and treat hypoxic or ischemic damage to organs and cells and to increase adaptive capabilities of the organism... - Hypoxic modulation of cardiac L-type Ca2+ current: interaction of reactive oxygen species and beta-adrenergic signalingRobert T Mallet
Cardiovasc Res 67:578-80. 2005
Research Grants
- Pyruvate-enhanced cardiopulmonary resuscitationRobert Mallet; Fiscal Year: 2004....
- Cardioprotective Adaptation to Intermittent HypoxiaRobert Mallet; Fiscal Year: 2007..Information on hypoxia-evoked cardioprotection resulting from this investigation will establish an empirical foundation to support eventual clinical application of this powerful cardioprotective phenomenon. ..