Robert Mallet

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. doi request reprint Normobaric, intermittent hypoxia conditioning is cardio- and vasoprotective in rats
    Eugenia B Manukhina
    Laboratory of Adaptation, Institute for General Pathology and Pathophysiology, Moscow 125315, Russian Federation
    Exp Biol Med (Maywood) 238:1413-20. 2013
  2. ncbi request reprint Beta1-Adrenergic receptor antagonism abrogates cardioprotective effects of intermittent hypoxia
    Robert T Mallet
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Basic Res Cardiol 101:436-46. 2006
  3. ncbi request reprint Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics
    R T Mallet
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Cardiovasc Res 42:149-61. 1999
  4. ncbi request reprint Metabolic cardioprotection by pyruvate: recent progress
    Robert T Mallet
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Exp Biol Med (Maywood) 230:435-43. 2005
  5. ncbi request reprint Antioxidant properties of myocardial fuels
    Robert T Mallet
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Mol Cell Biochem 253:103-11. 2003
  6. ncbi request reprint Pyruvate: metabolic protector of cardiac performance
    R T Mallet
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Proc Soc Exp Biol Med 223:136-48. 2000
  7. ncbi request reprint Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium
    Robert T Mallet
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Mol Cell Cardiol 34:1173-84. 2002
  8. pmc Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass
    Myoung Gwi Ryou
    Department of Integrative Physiology, University of North Texas, Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Am J Physiol Heart Circ Physiol 297:H1914-22. 2009
  9. ncbi request reprint Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium
    E Marty Knott
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Am J Physiol Heart Circ Physiol 289:H1123-30. 2005
  10. ncbi request reprint Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism
    Jeffrey E Squires
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Am J Physiol Heart Circ Physiol 284:H1340-7. 2003

Research Grants

  1. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2002
  2. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2003
  3. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2004
  4. Cardioprotective Adaptation to Intermittent Hypoxia
    Robert Mallet; Fiscal Year: 2007

Collaborators

Detail Information

Publications27

  1. doi request reprint Normobaric, intermittent hypoxia conditioning is cardio- and vasoprotective in rats
    Eugenia B Manukhina
    Laboratory of Adaptation, Institute for General Pathology and Pathophysiology, Moscow 125315, Russian Federation
    Exp Biol Med (Maywood) 238:1413-20. 2013
    ..Similar findings were found for the coronary circulations of isolated hearts. These findings support the hypothesis that moderate, normobaric IHC is cardio- and vasoprotective in a rat model of IR. ..
  2. ncbi request reprint Beta1-Adrenergic receptor antagonism abrogates cardioprotective effects of intermittent hypoxia
    Robert T Mallet
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Basic Res Cardiol 101:436-46. 2006
    ..Thus, episodic beta1-adrenergic activation during IHC evokes progressive development of powerful resistance to myocardial ischemia...
  3. ncbi request reprint Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics
    R T Mallet
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Cardiovasc Res 42:149-61. 1999
    ....
  4. ncbi request reprint Metabolic cardioprotection by pyruvate: recent progress
    Robert T Mallet
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Exp Biol Med (Maywood) 230:435-43. 2005
    ....
  5. ncbi request reprint Antioxidant properties of myocardial fuels
    Robert T Mallet
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Mol Cell Biochem 253:103-11. 2003
    ..These findings reveal novel, energy-independent mechanisms for enhancement of post-ischemic cardiac performance by metabolic fuels...
  6. ncbi request reprint Pyruvate: metabolic protector of cardiac performance
    R T Mallet
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Proc Soc Exp Biol Med 223:136-48. 2000
    ..This review aims to summarize evidence for each of these mechanisms and to consider the potential utility of pyruvate as a therapeutic intervention for clinical management of cardiac insufficiency...
  7. ncbi request reprint Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium
    Robert T Mallet
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Mol Cell Cardiol 34:1173-84. 2002
    ....
  8. pmc Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass
    Myoung Gwi Ryou
    Department of Integrative Physiology, University of North Texas, Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Am J Physiol Heart Circ Physiol 297:H1914-22. 2009
    ..By stabilizing HIF-1alpha, pyruvate-fortified cardioplegia may evoke sustained activation of EPO's cardioprotective signaling cascade in myocardium...
  9. ncbi request reprint Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium
    E Marty Knott
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Am J Physiol Heart Circ Physiol 289:H1123-30. 2005
    ..Pyruvate cardioplegia doubled [PCr]/([Cr][P(i)]) versus control and lactate cardioplegia after reperfusion. Pyruvate cardioplegia mitigates oxidative stress during cardioplegic arrest and enhances myocardial energy state on reperfusion...
  10. ncbi request reprint Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism
    Jeffrey E Squires
    Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Am J Physiol Heart Circ Physiol 284:H1340-7. 2003
    ..Thus acetoacetate increased contractile performance and potentiated beta-adrenergic inotropism in stunned myocardium without increasing energy reserves, suggesting its antioxidant character is central to its beneficial actions...
  11. doi request reprint Hypoxic conditioning suppresses nitric oxide production upon myocardial reperfusion
    Myoung Gwi Ryou
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Exp Biol Med (Maywood) 233:766-74. 2008
    ..Attenuation of the NOS/NO system may contribute to IHC-induced protection of myocardium from ischemia-reperfusion injury...
  12. doi request reprint Pyruvate-enriched cardioplegia suppresses cardiopulmonary bypass-induced myocardial inflammation
    Myoung Gwi Ryou
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Ann Thorac Surg 90:1529-35. 2010
    ..This study tested whether cardioplegia enriched with the intermediary metabolite and antioxidant pyruvate dampens postbypass myocardial inflammation...
  13. ncbi request reprint Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation
    Arti B Sharma
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Resuscitation 66:71-81. 2005
    ..In conclusion, intravenous pyruvate therapy increases energy reserves and antioxidant defenses of resuscitated myocardium. These temporary metabolic improvements support post-arrest recovery of cardiac electromechanical performance...
  14. ncbi request reprint Vagal modulation of heart rate variability during atrial fibrillation in pigs
    Christina F Kneip
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, 76107 2699, USA
    Exp Biol Med (Maywood) 235:1007-14. 2010
    ..15 Hz (P < 0.05). These results indicate that: (1) power spectral analysis may be used to assess parasympathetic regulation during AF, and (2) vagal oscillations produce an entrainment of the ventricular rhythm during AF in pigs...
  15. ncbi request reprint Pyruvate mitigates oxidative stress during reperfusion of cardioplegia-arrested myocardium
    E Marty Knott
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Ann Thorac Surg 81:928-34. 2006
    ....
  16. ncbi request reprint Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypass
    Albert H Olivencia-Yurvati
    Department of Surgery, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    J Cardiothorac Vasc Anesth 17:715-20. 2003
    ....
  17. ncbi request reprint Leukocyte filtration and aprotinin: synergistic anti-inflammatory protection
    Albert H Olivencia-Yurvati
    Department of Surgery, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Perfusion 19:S13-9. 2004
    ..8%). These findings suggest that combining mechanical and pharmacologic suppression of the systemic inflammatory response could mitigate its deleterious arrhythmic and pulmonary complications...
  18. ncbi request reprint Intermittent hypoxic training protects canine myocardium from infarction
    Pu Zong
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    Exp Biol Med (Maywood) 229:806-12. 2004
    ..The mechanism responsible for this potent cardioprotection merits further study...
  19. pmc Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation
    Arti B Sharma
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Resuscitation 76:108-19. 2008
    ..This study tested whether acute pyruvate treatment during cardiopulmonary resuscitation can prevent neurological dysfunction and cerebral injury following cardiac arrest...
  20. pmc Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Appl Physiol (1985) 105:510-7. 2008
    ..We conclude that IH conditioning during chronic ethanol consumption attenuates oxidative damage to the brain and mitigates behavioral abnormalities during subsequent EW. IH-induced ROS may evoke this powerful protection...
  21. pmc Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1132:1-9. 2007
    ..Collectively, these results suggest that pyruvate protects neuronal cells through its antioxidant actions on mitochondria...
  22. ncbi request reprint Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock
    Devin C Flaherty
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mil Med 175:166-72. 2010
    ..conventional lactate Ringer's (LR) more effectively stabilizes mean arterial pressure (MAP) and suppresses myocardial inflammation postresuscitation...
  23. ncbi request reprint A putative mitochondrial mechanism for antioxidative cytoprotection by 17beta-estradiol
    Andrea N Moor
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Exp Eye Res 78:933-44. 2004
    ....
  24. ncbi request reprint Oxidative stress reversibly inactivates myocardial enzymes during cardiac arrest
    Arti B Sharma
    Dept of Integrative Physiology, Univ of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Am J Physiol Heart Circ Physiol 292:H198-206. 2007
    ..In conclusion, cardiac arrest reversibly inactivates several important myocardial metabolic enzymes. Antioxidant protection of these enzymes implicates oxidative stress as a principal mechanism of enzyme inactivation during arrest...
  25. doi request reprint Intermittent hypoxia: cause of or therapy for systemic hypertension?
    Tatiana V Serebrovskaya
    Bogomoletz Institute of Physiology, 4 Bogomoletz St, Kiev 01024, Ukraine
    Exp Biol Med (Maywood) 233:627-50. 2008
    ..Also reviewed is evidence regarding mechanisms of the pro- and anti-hypertensive effects of intermittent hypoxia...
  26. ncbi request reprint Hypoxic modulation of cardiac L-type Ca2+ current: interaction of reactive oxygen species and beta-adrenergic signaling
    Robert T Mallet
    Cardiovasc Res 67:578-80. 2005
  27. ncbi request reprint Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia
    Eugenia B Manukhina
    Institute of General Pathology and Pathophysiology, Moscow, Russia
    Exp Biol Med (Maywood) 231:343-65. 2006
    ..Understanding the role of NO in mechanisms of adaptation to hypoxia will support development of therapies to prevent and treat hypoxic or ischemic damage to organs and cells and to increase adaptive capabilities of the organism...

Research Grants4

  1. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2002
    ....
  2. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2003
    ....
  3. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2004
    ....
  4. Cardioprotective Adaptation to Intermittent Hypoxia
    Robert Mallet; Fiscal Year: 2007
    ..Information on hypoxia-evoked cardioprotection resulting from this investigation will establish an empirical foundation to support eventual clinical application of this powerful cardioprotective phenomenon. ..