Marcus Mall

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
    Marcus Mall
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, 7011 Thurston Bowles Building, Chapel Hill, North Carolina 27599 7248, USA
    Nat Med 10:487-93. 2004
  2. ncbi Activation of ion secretion via proteinase-activated receptor-2 in human colon
    Marcus Mall
    Universitäts Kinderklinik, Albert Ludwigs Universitat Freiburg, 79106 Freiburg, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G200-10. 2002
  3. ncbi Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia
    Marcus Mall
    Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Freiburg, Germany
    Pediatr Res 53:608-18. 2003
  4. ncbi Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis
    Marcus Mall
    Department of Pediatrics III, Pediatric Pulmonology and Infectious Diseases, University of Heidelberg, lm Neuenheimer Feld 153, Heidelberg D 69120, Germany
    J Cyst Fibros 3:165-9. 2004
  5. pmc Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Mol Biol Cell 16:2154-67. 2005
  6. ncbi CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis
    Stephanie Hirtz
    Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Freiburg, Germany
    Gastroenterology 127:1085-95. 2004
  7. ncbi The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon
    Marcus Mall
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Gastroenterology 126:32-41. 2004
  8. ncbi Correction of the CF defect by curcumin: hypes and disappointments
    Marcus Mall
    Department of Pediatrics III, University of Heidelberg, Germany
    Bioessays 27:9-13. 2005
  9. pmc Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment
    Alessandra Livraghi
    University of North Carolina at Chapel Hill, Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248 Thurston Bowles Bldg, Room 6029, Chapel Hill, NC 27599, USA
    Am J Respir Cell Mol Biol 38:423-34. 2008
  10. ncbi Pharmacotherapy of the ion transport defect in cystic fibrosis: role of purinergic receptor agonists and other potential therapeutics
    Karl Kunzelmann
    Physiologisches Institut, Universitäts Regensburg, Regensburg, Germany
    Am J Respir Med 2:299-309. 2003

Collaborators

Detail Information

Publications14

  1. ncbi Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
    Marcus Mall
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, 7011 Thurston Bowles Building, Chapel Hill, North Carolina 27599 7248, USA
    Nat Med 10:487-93. 2004
    ..We conclude that increasing airway Na(+) absorption initiates cystic fibrosis-like lung disease and produces a model for the study of the pathogenesis and therapy of this disease...
  2. ncbi Activation of ion secretion via proteinase-activated receptor-2 in human colon
    Marcus Mall
    Universitäts Kinderklinik, Albert Ludwigs Universitat Freiburg, 79106 Freiburg, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G200-10. 2002
    ....
  3. ncbi Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia
    Marcus Mall
    Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Freiburg, Germany
    Pediatr Res 53:608-18. 2003
    ..Co-activation of hKvLQT1 improves CaCC-mediated Cl- secretion in native CF airway epithelia, and may have a therapeutic effect in the treatment of CF lung disease...
  4. ncbi Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis
    Marcus Mall
    Department of Pediatrics III, Pediatric Pulmonology and Infectious Diseases, University of Heidelberg, lm Neuenheimer Feld 153, Heidelberg D 69120, Germany
    J Cyst Fibros 3:165-9. 2004
    ..Together with sweat testing and genetic analyses, these functional measurements may aid in establishing a diagnosis of CF...
  5. pmc Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Mol Biol Cell 16:2154-67. 2005
    ..In sum, our data demonstrate that WT CFTR is predominantly expressed in ciliated cells, and deltaF508 CFTR pathogenesis in native tissues, like heterologous cells, reflects loss of normal protein processing...
  6. ncbi CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis
    Stephanie Hirtz
    Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Freiburg, Germany
    Gastroenterology 127:1085-95. 2004
    ..Residual Cl- channel function was shown for selected PS mutations in heterologous cells. However, the functional consequences of most CFTR mutations in native epithelia are not well established...
  7. ncbi The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon
    Marcus Mall
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Gastroenterology 126:32-41. 2004
    ..However, data with respect to the processing block of DeltaF508 protein in native epithelia are limited and conflicting...
  8. ncbi Correction of the CF defect by curcumin: hypes and disappointments
    Marcus Mall
    Department of Pediatrics III, University of Heidelberg, Germany
    Bioessays 27:9-13. 2005
    ..Thus, although herbal medicines and dietary supplements can be desirable alternatives to classical pharmacological compounds, their efficacy needs careful evaluation both in vivo and ex vivo...
  9. pmc Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment
    Alessandra Livraghi
    University of North Carolina at Chapel Hill, Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248 Thurston Bowles Bldg, Room 6029, Chapel Hill, NC 27599, USA
    Am J Respir Cell Mol Biol 38:423-34. 2008
    ..We conclude that mucosal Nys treatment of HBEs provides a simple in vitro model to recapitulate the Na(+) and volume hyperabsorptive features of CF airway epithelia...
  10. ncbi Pharmacotherapy of the ion transport defect in cystic fibrosis: role of purinergic receptor agonists and other potential therapeutics
    Karl Kunzelmann
    Physiologisches Institut, Universitäts Regensburg, Regensburg, Germany
    Am J Respir Med 2:299-309. 2003
    ....
  11. ncbi Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways
    Karl Kunzelmann
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Cell Biochem Biophys 36:209-14. 2002
    ..We postulate that these receptors play a significant role in the regulation of electrolyte transport, which might be important during inflammatory diseases of airways and intestine...
  12. ncbi Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR-2)
    Karl Kunzelmann
    Institut fur Physiologie, Universitat Regensburg, Regensburg, Germany
    FASEB J 19:969-70. 2005
    ....
  13. ncbi Electrolyte transport in the mammalian colon: mechanisms and implications for disease
    Karl Kunzelmann
    Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland, Brisbane, Australia
    Physiol Rev 82:245-89. 2002
    ..It will also lead to a better understanding of the pathophysiological events during inflammatory bowel disease and development of colonic carcinoma...
  14. ncbi Assessment of CFTR function in native epithelia for the diagnosis of cystic fibrosis
    Celeste Barreto
    Cystic Fibrosis Centre, Paediatrics Department, University Hospital of Santa Maria, Lisboa, Portugal
    Pediatr Pulmonol Suppl 26:243. 2004