Al Malkinson

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene
    A M Malkinson
    Department of Pharmaceutical Sciences, School of Pharmacy, Colorado Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Cancer Res 57:2832-4. 1997
  2. ncbi Role of inflammation in mouse lung tumorigenesis: a review
    Alvin M Malkinson
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver CO 80262, USA
    Exp Lung Res 31:57-82. 2005
  3. ncbi Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice
    Alvin M Malkinson
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Carcinogenesis 23:411-7. 2002
  4. ncbi Quantitative trait loci that regulate susceptibility to both butylated hydroxytoluene-induced pulmonary inflammation and lung tumor promotion in CXB recombinant inbred mice
    Al Malkinson
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:82S. 2002
  5. ncbi Evidence that inflammation encourages pulmonary adenocarcinoma formation in mice: clinical implications
    Alvin M Malkinson
    University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 125:154S-5S. 2004
  6. ncbi Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung
    A M Malkinson
    Department of Pharmaceutical Sciences and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Lung Cancer 32:265-79. 2001
  7. ncbi Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone)
    A M Malkinson
    Department of Pharmaceutical Sciences, School of Pharmacy and Colorado Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Carcinogenesis 19:1353-6. 1998
  8. ncbi Molecular comparison of human and mouse pulmonary adenocarcinomas
    A M Malkinson
    Department of Pharmaceutical Sciences, School of Pharmacy and Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, USA
    Exp Lung Res 24:541-55. 1998
  9. ncbi Proteomic analysis of mouse lung neoplasia
    Katherine Peebles
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:28S. 2002
  10. ncbi Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing
    Laura K Zerbe
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 802262, USA
    Mol Carcinog 41:187-96. 2004

Collaborators

Detail Information

Publications39

  1. ncbi Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene
    A M Malkinson
    Department of Pharmaceutical Sciences, School of Pharmacy, Colorado Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Cancer Res 57:2832-4. 1997
    ..This low-dose MCA/BHT model in BALB mice will facilitate the identification of genes regulating susceptibility to lung tumor promotion and pulmonary chemopreventative agents that act at a postinitiation site...
  2. ncbi Role of inflammation in mouse lung tumorigenesis: a review
    Alvin M Malkinson
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver CO 80262, USA
    Exp Lung Res 31:57-82. 2005
    ..Promising drug candidates include synthetic glucocorticoids such as budesonide and the sulfone derivative of sulindac, apotosyn...
  3. ncbi Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice
    Alvin M Malkinson
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Carcinogenesis 23:411-7. 2002
    ..The fact that common chromosomal locations regulate both inflammation and carcinogenesis suggests a pathogenic role of inflammatory mediators in tumor development that may be exploited for chemoprevention of lung cancer...
  4. ncbi Quantitative trait loci that regulate susceptibility to both butylated hydroxytoluene-induced pulmonary inflammation and lung tumor promotion in CXB recombinant inbred mice
    Al Malkinson
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:82S. 2002
  5. ncbi Evidence that inflammation encourages pulmonary adenocarcinoma formation in mice: clinical implications
    Alvin M Malkinson
    University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 125:154S-5S. 2004
  6. ncbi Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung
    A M Malkinson
    Department of Pharmaceutical Sciences and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Lung Cancer 32:265-79. 2001
    ....
  7. ncbi Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone)
    A M Malkinson
    Department of Pharmaceutical Sciences, School of Pharmacy and Colorado Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Carcinogenesis 19:1353-6. 1998
    ....
  8. ncbi Molecular comparison of human and mouse pulmonary adenocarcinomas
    A M Malkinson
    Department of Pharmaceutical Sciences, School of Pharmacy and Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, USA
    Exp Lung Res 24:541-55. 1998
    ..Similarly, EGF-receptor content often increases in human lung adenocarcinomas but decreases in the mouse tumors. In general, however, the nature of the molecular changes is quite similar...
  9. ncbi Proteomic analysis of mouse lung neoplasia
    Katherine Peebles
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:28S. 2002
  10. ncbi Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing
    Laura K Zerbe
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 802262, USA
    Mol Carcinog 41:187-96. 2004
    ..These changes are influenced by tumor histology and may be associated with production of variant CD44 mRNA isoforms...
  11. ncbi Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
    Lori D Dwyer-Nield
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Carcinogenesis 26:1196-206. 2005
    ....
  12. pmc Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model
    Robert S Stearman
    Department of Medicine Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Pathol 167:1763-75. 2005
    ..Thus, the A/J mouse-urethane model reflects significant molecular details of human lung AC, and comparison of changes in orthologous gene expression may provide novel insights into lung carcinogenesis...
  13. ncbi Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis
    Alison K Bauer
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 97:1778-81. 2005
    ..To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis...
  14. ncbi Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis
    E Paul O'Donnell
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Box C238, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cancer Lett 241:197-202. 2006
    ..The formation of microscopic lesions is thus genetically dependent, but whether they continue to grow or regress depends on how they were induced...
  15. ncbi Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice
    Amy M Meyer
    University of Colorado Health Sciences Center, School of Pharmacy, Box C238, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1260-6. 2006
    ....
  16. ncbi Effect of silibinin on the growth and progression of primary lung tumors in mice
    Rana P Singh
    4200 E 9th Ave, Box C238, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Cancer Center, Denver, CO 80262, USA
    J Natl Cancer Inst 98:846-55. 2006
    ..Silibinin, a flavanone from milk thistle, inhibits the growth of tumors in several rodent models. We examined the effects of dietary silibinin on the growth, progression, and angiogenesis of urethane-induced lung tumors in mice...
  17. ncbi Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis
    Robert L Keith
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, CO 80220, USA
    Anticancer Res 26:2857-61. 2006
    ..Elevated PGI2 production prevents murine lung cancer, while decreasing PGE2 content protects against colon cancer. PGE2 receptor subtype 2 (EP2) -deficient mice were hypothesized to be resistant to lung tumorigenesis...
  18. pmc Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice
    Elizabeth F Redente
    University of Colorado at Denver and Health Sciences Center, Department of Pharmaceutical Sciences, Box C238, East Ninth Ave, Denver, CO 80262, USA
    Am J Pathol 170:693-708. 2007
    ..These biochemical markers of macrophage activation states would have diagnostic and/or therapeutic value if analogous systemic shifts occur in humans...
  19. ncbi BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models
    David C Christiani
    Harvard University Schools of Medicine and Public Health, Boston, MA, USA
    J Thorac Oncol 1:S2-7. 2006
    ..However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative...
  20. ncbi Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia
    Katherine A Peebles
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80215, USA
    Mol Carcinog 46:887-900. 2007
    ....
  21. ncbi Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice
    Laura K Zerbe
    Department of Pharmaceutical Sciences, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C238, Denver, CO, 80262, USA
    Cancer Chemother Pharmacol 62:605-20. 2008
    ..We evaluated whether erlotinib is also effective at an early stage of primary lung tumorigenesis in a carcinogen-induced lung tumor model in mice...
  22. doi A macrophage gene expression signature defines a field effect in the lung tumor microenvironment
    Robert S Stearman
    Department of Medicine Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Cancer Res 68:34-43. 2008
    ..This work suggests that TAMs generate a unique gene expression signature within the tumor microenvironment, and this signature could potentially be used for identifying lung cancer from BAL cells and/or fluid...
  23. ncbi Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities
    Alison K Bauer
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 287:L685-703. 2004
    ..These QTLs are described herein, candidate genes are suggested within these sites, and experimental evidence that inflammation enhances lung tumor development is provided...
  24. ncbi Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy
    Yingnian Lu
    GlobeImmune Inc, 12635 E Montview Boulevard, Aurora, CO 80010, USA
    Cancer Res 64:5084-8. 2004
    ..In combination with the genomic sequencing of tumors in patients, the yeast-based immunotherapeutic approach could be applied to treat Ras mutation-bearing human cancers...
  25. ncbi Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer
    Robert L Keith
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, CO 80220, USA
    Cancer Res 62:734-40. 2002
    ....
  26. ncbi Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: a comparison with human lung adenocarcinoma
    Linda M Sargent
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Toxicology and Molecular Biology Branch, Genetic Susceptibility Team, Morgantown, West Virginia 26505, USA
    Cancer Res 62:1152-7. 2002
    ..Similar linkage groups are altered in human lung adenocarcinoma, implying that the mouse is a valid genetic model for the study of human lung adenocarcinoma susceptibility...
  27. ncbi Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity
    Rene Kupfer
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chem Res Toxicol 15:1106-12. 2002
    ....
  28. ncbi Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice
    Lori R Kisley
    Department of Pharmaceutical Sciences, University of Colorado Cancer Center, Denver CO 80262, USA
    Carcinogenesis 23:1653-60. 2002
    ..As the production of eicosanoids in addition to PGE2 is also inhibited by celecoxib, and as celecoxib has COX-independent interactions, its effects on tumor formation may vary in different organ systems...
  29. ncbi Morphological assessment of apoptosis in human lung cells
    Lori D Dwyer-Nield
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Methods Mol Med 74:283-97. 2003
  30. ncbi Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis
    Lori R Kisley
    Department of Pharmaceutical Sciences, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver 80262, USA
    Cancer Res 62:6850-6. 2002
    ..The substantial (80%) reduction in lung tumor multiplicity in iNOS (-/-) mice strongly supports examining iNOS-specific inhibitors as potential lung cancer chemopreventive agents...
  31. pmc Misexpression of MIA disrupts lung morphogenesis and causes neonatal death
    Sui Lin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Dev Biol 316:441-55. 2008
    ..These results suggest that the silencing of Mia1 that occurs in late gestation may be required for maturation of the surfactant system...
  32. ncbi Responses of tumorigenic and non-tumorigenic mouse lung epithelial cell lines to electrophilic metabolites of the tumor promoter butylated hydroxytoluene
    Yude Sun
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East 9th Avenue Box C238, Denver, CO 80262, USA
    Chem Biol Interact 145:41-51. 2003
    ..Normal cells are destroyed more readily which allows neoplastic cells to expand their proliferation...
  33. ncbi Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines
    Min Wang
    Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Cancer Res 63:3317-24. 2003
    ..The Ak015530 carries an amino acid polymorphism, but this polymorphism does not cosegregate with mouse lung tumor susceptibility. Thus, these 4 genes are less likely candidates for the Pas1 locus...
  34. ncbi Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections
    York E Miller
    Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Section 111A, Denver Veterans Affairs Medical Center, 1055 Clermont St, Denver, CO 80220 3808, USA
    Cancer Lett 198:139-44. 2003
    ....
  35. ncbi Serum levels of surfactant protein D are increased in mice with lung tumors
    Feijie Zhang
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Cancer Res 63:5889-94. 2003
    ..In conclusion, serum SP-D concentration is increased in mice bearing lung tumors and generally reflects the tumor burden but is also elevated during lung inflammation...
  36. ncbi Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: gender-dependent modulation of IL-10 haploinsufficiency
    Heike Bernert
    Division of Human Cancer Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
    Mol Carcinog 38:117-23. 2003
    ..These studies support a role for inflammation in lung cancer susceptibility...
  37. ncbi Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2
    Amy M Meyer
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Carcinogenesis 25:1517-24. 2004
    ..These results demonstrate a role for cPLA2 in mouse lung tumorigenesis that may be mediated by decreased prostaglandin synthesis...
  38. ncbi Proteomic analysis of a neoplastic mouse lung epithelial cell line whose tumorigenicity has been abrogated by transfection with the gap junction structural gene for connexin 43, Gja1
    Katherine A Peebles
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver 80262, USA
    Carcinogenesis 24:651-7. 2003
    ..The PDI superfamily has multiple cellular roles including chaperoning assembled glycoproteins, regulating the activities of transcription factors, and regulating disulfide bond formation...
  39. ncbi Gap junctional intercellular communication in cells isolated from urethane-induced tumors in A/J mice
    Adina Vultur
    Department of Microbiology, Queen s University, Kingston, Ontario, Canada
    DNA Cell Biol 22:33-40. 2003
    ..Propagation of tumor cells in culture induces additional alterations that can lead to gap junction closure...