Pauline Maki

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi request reprint The timing of estrogen therapy after ovariectomy--implications for neurocognitive function
    Pauline M Maki
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, USA
    Nat Clin Pract Endocrinol Metab 4:494-5. 2008
  2. pmc Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 20:695-709. 2013
  3. pmc Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 19:1215-23. 2012
  4. doi request reprint Minireview: effects of different HT formulations on cognition
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago College of Medicine, 912 South Wood Street, Chicago Illinois 60612, USA
    Endocrinology 153:3564-70. 2012
  5. doi request reprint Mechanisms of action of estrogen in the brain: insights from human neuroimaging and psychopharmacologic studies
    Pauline M Maki
    Departments of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Semin Reprod Med 27:250-9. 2009
  6. ncbi request reprint Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function
    Pauline M Maki
    Center for Cognitive Medicine, Neuropsychiatric Institute MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 92:4107-14. 2007
  7. pmc HIV, cognition and women
    Pauline M Maki
    Departments of Psychiatry and Psychology, University of Illinois at Chicago, Chicago, IL 60605, USA
    Neuropsychol Rev 19:204-14. 2009
  8. pmc Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women: a preliminary study
    P M Maki
    Departments of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurology 72:1661-8. 2009
  9. pmc Hormone therapy and cognitive function
    Pauline M Maki
    Neuropsychiatric Institute, MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, USA
    Hum Reprod Update 15:667-81. 2009
  10. pmc Effects of botanicals and combined hormone therapy on cognition in postmenopausal women
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 16:1167-77. 2009

Detail Information

Publications31

  1. doi request reprint The timing of estrogen therapy after ovariectomy--implications for neurocognitive function
    Pauline M Maki
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, USA
    Nat Clin Pract Endocrinol Metab 4:494-5. 2008
  2. pmc Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 20:695-709. 2013
    ..This article reviews clinical studies that bear on this hypothesis...
  3. pmc Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 19:1215-23. 2012
    ..In a cross-sectional analysis, we evaluated the association of menopausal stage and vasomotor symptoms with depressive symptoms in an ethnically diverse cohort of women with a high prevalence of HIV...
  4. doi request reprint Minireview: effects of different HT formulations on cognition
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago College of Medicine, 912 South Wood Street, Chicago Illinois 60612, USA
    Endocrinology 153:3564-70. 2012
    ..Small RCT show neutral or beneficial effects of other progestins on memory. Overall, RCT indicate that type of progestogen is a more important determinant of the effects of HT on memory than type of estrogen...
  5. doi request reprint Mechanisms of action of estrogen in the brain: insights from human neuroimaging and psychopharmacologic studies
    Pauline M Maki
    Departments of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Semin Reprod Med 27:250-9. 2009
    ..Overall, we conclude that estrogen interacts with cholinergic and serotonergic systems to affect hippocampal and frontal cortical brain areas and thereby enhance memory, particularly at the retrieval stage...
  6. ncbi request reprint Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function
    Pauline M Maki
    Center for Cognitive Medicine, Neuropsychiatric Institute MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 92:4107-14. 2007
    ..Recent clinical trials of im testosterone in eugonadal men suggest positive effects on verbal memory, but other studies find no effect...
  7. pmc HIV, cognition and women
    Pauline M Maki
    Departments of Psychiatry and Psychology, University of Illinois at Chicago, Chicago, IL 60605, USA
    Neuropsychol Rev 19:204-14. 2009
    ..Such studies will also address questions regarding involvement of the hippocampus and verbal memory, which may be of particular significance among HIV+ women...
  8. pmc Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women: a preliminary study
    P M Maki
    Departments of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurology 72:1661-8. 2009
    ..Our aim was to conduct a preliminary investigation of episodic memory and its neural correlates in HIV-infected and at-risk uninfected women...
  9. pmc Hormone therapy and cognitive function
    Pauline M Maki
    Neuropsychiatric Institute, MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, USA
    Hum Reprod Update 15:667-81. 2009
    ..This issue is clinically relevant because declines in verbal memory are the earliest predictor of Alzheimer's disease and declines in executive function are central to some theories of normal, age-related changes in cognition...
  10. pmc Effects of botanicals and combined hormone therapy on cognition in postmenopausal women
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 16:1167-77. 2009
    ..The aim of this study was to characterize the effects of red clover, black cohosh, and combined hormone therapy on cognitive function in comparison to placebo in women with moderate to severe vasomotor symptoms...
  11. ncbi request reprint Hormone therapy and cognitive function: is there a critical period for benefit?
    P M Maki
    Department of Psychiatry, Center for Cognitive Medicine, Neuropsychiatric Institute MC913, University of Illinois at Chicago, 60612, USA
    Neuroscience 138:1027-30. 2006
    ..Other forms of hormone therapy, other cognitive domains, and cyclic hormone regimens may not conform to this "critical period hypothesis." Further research is needed to test the validity and limits of this hypothesis...
  12. pmc Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition
    Pauline M Maki
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Menopause 17:815-22. 2010
    ....
  13. ncbi request reprint A systematic review of clinical trials of hormone therapy on cognitive function: effects of age at initiation and progestin use
    Pauline M Maki
    Department of Psychiatry, Center for Cognitive Medicine, Neuropsychiatric Institute MC913, University of Illinois at Chicago, 912 S Wood St, Chicago, IL 60612, USA
    Ann N Y Acad Sci 1052:182-97. 2005
    ..Without firm evidence of benefit to younger women, it is prudent to caution early postmenopausal women about the cognitive risks observed in WHI, recognizing the low likelihood of dementia at that age...
  14. pmc Perimenopausal use of hormone therapy is associated with enhanced memory and hippocampal function later in life
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Brain Res 1379:232-43. 2011
    ..These results suggest that perimenopausal use of HT might confer long-term benefits to verbal memory and the brain systems underlying verbal memory. More generally, the results support the critical window hypothesis...
  15. pmc Objective hot flashes are negatively related to verbal memory performance in midlife women
    Pauline M Maki
    Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Menopause 15:848-56. 2008
    ..To test the hypothesis that hot flashes specifically relate to verbal memory performance by examining the relationship between objective hot flashes and cognitive test performance in women with moderate to severe vasomotor symptoms...
  16. ncbi request reprint Hormone therapy in menopausal women with cognitive complaints: a randomized, double-blind trial
    P M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Neurology 69:1322-30. 2007
    ..To evaluate the effects of hormone therapy (HT) on cognition and subjective quality of life (QoL) in recently postmenopausal women with cognitive complaints...
  17. pmc HIV+ men and women show different performance patterns on procedural learning tasks
    Eileen Martin
    University of Illinois College of Medicine Chicago, Chicago, IL 60612, USA
    J Clin Exp Neuropsychol 33:112-20. 2011
    ..Additional studies are needed to address directly the possibility of sex differences in HAND and the possibility that women might be more vulnerable to the effects of HIV and substance dependence on some neurocognitive functions...
  18. ncbi request reprint Hormone therapy and risk for dementia: where do we go from here?
    P M Maki
    Department of Psychiatry and Psychology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Gynecol Endocrinol 19:354-9. 2004
    ..Additional clinical studies are needed to understand the external generalizability of the WHIMS results to populations of women for whom HT remains an indication...
  19. ncbi request reprint Effects of combination estrogen plus progestin hormone treatment on cognition and affect
    Susan M Resnick
    National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Clin Endocrinol Metab 91:1802-10. 2006
    ..Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory...
  20. ncbi request reprint Re: Prospective assessment of estrogen replacement therapy and cognitive functioning: atherosclerosis risk in communities study
    Pauline M Maki
    Am J Epidemiol 156:785; author reply 785. 2002
  21. ncbi request reprint Implicit memory varies across the menstrual cycle: estrogen effects in young women
    Pauline M Maki
    Gerontology Research Center Box 03, Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropsychologia 40:518-29. 2002
    ..Mood did not vary across the cycle phases. Overall, the findings suggest that estrogen may facilitate the automatic activation of verbal representations in memory...
  22. ncbi request reprint Nulliparity and late menopause are associated with decreased cognitive decline
    Robert N McLay
    Department of Psychiatry, Naval Medical Center San Diego, California, USA
    J Neuropsychiatry Clin Neurosci 15:161-7. 2003
    ..These results suggest that greater lifetime exposure to endogenous estrogen may be associated with less age-related cognitive decline...
  23. ncbi request reprint Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies
    Judith L Turgeon
    Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California Davis, Davis, California 95616, USA
    Endocr Rev 27:575-605. 2006
    ..Only then will we have a better understanding of what hormonal compounds should be used in which populations of women and at what stages of menopausal/postmenopausal life...
  24. ncbi request reprint Potential importance of early initiation of hormone therapy for cognitive benefit
    Pauline M Maki
    Menopause 13:6-7. 2006
  25. ncbi request reprint The Women's Health Initiative Memory Study: findings and implications for treatment
    Michael C Craig
    Psychological Medicine, Institute of Psychiatry, London, UK
    Lancet Neurol 4:190-4. 2005
    ..There has been extensive media coverage of these trials and many doctors are asked whether HT improves or worsens brain function in younger women who are prescribed HT for the treatment of menopausal symptoms...
  26. ncbi request reprint Estrogen effects on the hippocampus and frontal lobes
    Pauline M Maki
    University of Illinois at Chicago, Department of Psychiatry, Center for Cognitive Medicine, Neuropsychiatric Institute, Illinois 60612, USA
    Int J Fertil Womens Med 50:67-71. 2005
    ..Serotonin might play a critical role in these potential indirect benefits, and therapies that target these symptoms, even those without estrogenic actions, might have indirect benefits on cognition...
  27. ncbi request reprint The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    Clin Trials 1:440-50. 2004
    ....
  28. doi request reprint Effects of menstrual cycle phase and oral contraceptive use on verbal memory
    Kristen L Mordecai
    Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Horm Behav 54:286-93. 2008
    ..Overall, these results suggest that verbal memory performance in premenopausal women varies across the cycle with OC use, but does not vary systematically with changes in endogenous estradiol...
  29. ncbi request reprint Sex difference in cognitive response to antipsychotic treatment in first episode schizophrenia
    Leah H Rubin
    Department of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:290-7. 2008
    ..Future studies of the neurocognitive effects of antipsychotic treatment may need to take potential sex differences in cognitive response into account...
  30. doi request reprint A study of visuospatial working memory pre- and post-Gonadotropin Hormone Releasing Hormone agonists (GnRHa) in young women
    Michael C Craig
    Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Horm Behav 54:47-59. 2008
    ..Our study suggests that acute ovarian hormone withdrawal following GnRHa, and perhaps at other times, (e.g. following surgical menopause and postpartum) alters the neural circuitry underlying performance of VWM...
  31. ncbi request reprint Gonadotropin hormone releasing hormone agonists alter prefrontal function during verbal encoding in young women
    Michael C Craig
    Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, 16 De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Psychoneuroendocrinology 32:1116-27. 2007
    ....

Research Grants4

  1. Effects of Botanicals on Cognition in Midlife Women
    Pauline Maki; Fiscal Year: 2005
    ..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
  2. Botanical Menopausal Therapies Mechanisms of CNS Action
    Pauline Maki; Fiscal Year: 2007
    ....
  3. Effects of Estradiol & Phytoestrogens on Stress Responsivity
    Pauline Maki; Fiscal Year: 2009
    ....
  4. Effects of Estradiol & Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2010
    ....