Research Topics
| D G MakiSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Conclusions: drotrecogin alfa (activated)--from bench to practical use at the bedsideDennis G Maki
University of Wisconsin Hospital and Clinics, 600 Highland Avenue, H4/572, Madison, WI 53792, USA
Am J Surg 184:S47-50. 2002
Engineering out the risk for infection with urinary cathetersD G Maki
University of Wisconsin Medical School, Madison, Wisconsin, USA
Emerg Infect Dis 7:342-7. 2001....- Massive rhabdomyolysis and multiple organ dysfunction syndrome caused by leptospirosisD B Coursin
Department of Anesthesiology, University of Wisconsin Medical School, Madison 53792, USA
Intensive Care Med 26:808-12. 2000..Appropriate antimicrobial therapy, with penicillin or doxycycline, can be life-saving... - The promise of novel technology for the prevention of intravascular device-related bloodstream infection. I. Pathogenesis and short-term devicesChristopher J Crnich
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Clin Infect Dis 34:1232-42. 2002..The challenge for the future will be to identify new preventative technologies and to begin to adapt more widely those technologies already shown to be efficacious and cost-effective... - A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective, randomized trialJeffery S Garland
Department of Pediatrics, St Joseph's Hospital, Milwaukee, Wisconsin, USA
Pediatrics 116:e198-205. 2005..The use of an anti-infective lock solution for prevention of CRBSI with long-term intravascular devices has achieved proof of principle and warrants selective application in clinical practice... - Prevalence, consequences, and solutionsDennis G Maki
Section of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Pharmacotherapy 27:121S-125S. 2007..Education of the patient and the prescriber, as well as antimicrobial stewardship programs, are necessary to avert a global antibiotic resistance catastrophe... - The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studiesDennis G Maki
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, USA
Mayo Clin Proc 81:1159-71. 2006.... 
In vitro studies of a novel antimicrobial luer-activated needleless connector for prevention of catheter-related bloodstream infectionDennis G Maki
Section of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health and the University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Clin Infect Dis 50:1580-7. 2010....- Cohort study of the pathogenesis and molecular epidemiology of catheter-related bloodstream infection in neonates with peripherally inserted central venous cathetersJeffery S Garland
Department of Pediatrics, Wheaton Franciscan Healthcare St Joseph, Milwaukee, Wisconsin, USA
Infect Control Hosp Epidemiol 29:243-9. 2008..To better define the pathogenesis of catheter-related bloodstream infection (BSI) in neonates with peripherally inserted central venous catheters (PICCs) to guide the development of more effective strategies for prevention... - Are antimicrobial-impregnated catheters effective? When does repetition reach the point of exhaustion?Christopher J Crnich
Department of Medicine, University of Wisconsin Hospital and Clinics, Medical School, Madison, WI 53792, USA
Clin Infect Dis 41:681-5. 2005 - Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trialsNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Clin Infect Dis 43:474-84. 2006..The use of an anti-infective lock solution warrants consideration for patients who require central access but who are at high risk of BSI, such as patients with malignancy or low-birthweight neonates... - The promise of novel technology for the prevention of intravascular device-related bloodstream infection. II. Long-term devicesChristopher J Crnich
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Clin Infect Dis 34:1362-8. 2002..The challenge for the future will be to identify new preventative technologies and to begin to more-widely adapt those technologies that have already been shown to be efficacious and cost effective... - Are antimicrobial-impregnated catheters effective? Don't throw out the baby with the bathwaterChristopher J Crnich
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
Clin Infect Dis 38:1287-92. 2004.... - The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous cathetersNasia Safdar
Section of Infectious Diseases, Department of Medicine, Medical School, University of Wisconsin, Madison, WI 53792, USA
Intensive Care Med 30:62-7. 2004..Strategies achieving successful suppression of cutaneous colonization can substantially reduce the risk of catheter-related BSI with short-term CVCs... - A review of risk factors for catheter-related bloodstream infection caused by percutaneously inserted, noncuffed central venous catheters: implications for preventive strategiesNasia Safdar
Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospitals and Clinics, Madison, 53792, USA
Medicine (Baltimore) 81:466-79. 2002.... - Comparative study of cefazolin, cefamandole, and vancomycin for surgical prophylaxis in cardiac and vascular operations. A double-blind randomized trialD G Maki
Department of Medicine, University of Wisconsin Medical School, Madison
J Thorac Cardiovasc Surg 104:1423-34. 1992..Guidelines for dosing and administration of vancomycin for cardiovascular surgical prophylaxis are provided... - Meta-analysis: methods for diagnosing intravascular device-related bloodstream infectionNasia Safdar
University of Wisconsin Medical School, Madison, Wisconsin, USA
Ann Intern Med 142:451-66. 2005..The positive predictive value of all tests increased greatly with high pretest clinical probability. Catheters should not be cultured routinely but rather only if IVD-related bloodstream infection is suspected clinically... - Nosocomial infection with vancomycin-dependent enterococciPaul A Tambyah
University of Wisconsin Medical School, Madison, USA
Emerg Infect Dis 10:1277-81. 2004..While antimicrobial pressure promotes nosocomial colonization by VRE, prolonged exposure to vancomycin may foster the transition from vancomycin resistance to dependence... - Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysisNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, USA
Lancet Infect Dis 4:519-27. 2004.... - The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for preventionNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, University of Wisconsin Center for Health Sciences, Madison WI, USA
Respir Care 50:725-39; discussion 739-41. 2005..Routine surveillance of VAP, to track endemic VAPs and facilitate early detection of outbreaks, is mandatory... - Effectiveness of preemptive barrier precautions in controlling nosocomial colonization and infection by methicillin-resistant Staphylococcus aureus in a burn unitNasia Safdar
Infectious Diseases, Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
Am J Infect Control 34:476-83. 2006..Use of clean gloves, with or without a gown, bears consideration for all high-risk hospitalized patients to prevent cross transmission of all multiresistant nosocomial pathogens... - Risk of catheter-related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patientsNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, USA
Chest 128:489-95. 2005..Moreover, PICCs are not advisable in patients with renal failure and impending need for dialysis, in whom preservation of upper-extremity veins is needed for fistula or graft implantation... - Inflammation at the insertion site is not predictive of catheter-related bloodstream infection with short-term, noncuffed central venous cathetersNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Crit Care Med 30:2632-5. 2002.... - The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and CandidaNasia Safdar
Department of Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, H4/572, Madison, WI 53792, USA
Ann Intern Med 136:834-44. 2002.... - The use of antiseptics for handwashing by medical personnelD G Maki
Department of Medicine, University of Wisconsin Medical School, Madison
J Chemother 1:3-11. 1989..001). Novel approaches are needed to improve the frequency of hygienic handwashing.(ABSTRACT TRUNCATED AT 250 WORDS).. - Double-blind, randomized trial of scheduled use of a novel barrier cream and an oil-containing lotion for protecting the hands of health care workersR D McCormick
Infection Control Department, University of Wisconsin Hospital and Clinics, Madison, WI 53792 5158, USA
Am J Infect Control 28:302-10. 2000.... - The effects of prolonged ethanol exposure on the mechanical properties of polyurethane and silicone catheters used for intravascular accessChristopher J Crnich
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Hospital and Medical School, Madison, Wisconsin, USA
Infect Control Hosp Epidemiol 26:708-14. 2005.... - Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysisNasia Safdar
Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospital and Clinics, Madison, WI 53792-5158, USA
JAMA 288:996-1001. 2002..A randomized trial of adequate power, with multiple distinct strains of E coli O157:H7 represented, is needed to conclusively determine whether antibiotic treatment of E coli O157:H7 enteritis increases the risk of HUS... - The direct costs of nosocomial catheter-associated urinary tract infection in the era of managed carePaul A Tambyah
Department of Medicine, University of Wisconsin Medical School, University of Wisconsin, Madison, USA
Infect Control Hosp Epidemiol 23:27-31. 2002.... - The role of the intensive care unit environment in the pathogenesis and prevention of ventilator-associated pneumoniaChristopher J Crnich
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, University of Wisconsin Center for Health Sciences, Madison WI, USA
Respir Care 50:813-36; discussion 836-8. 2005..This review examines strategies to prevent transmission of environmental pathogens to the vulnerable mechanically-ventilated patient... - Infected bilomas in liver transplant recipients, incidence, risk factors and implications for preventionAdnan Said
Section of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, USA
Am J Transplant 4:574-82. 2004..T-tube drainage post-transplantation bears reassessment. The protective effect of ursodeoxycholic acid found in this study warrants confirmation in a prospective multicenter, randomized trial... - Severe Ehrlichia chaffeensis infection in a lung transplant recipient: a review of ehrlichiosis in the immunocompromised patientNasia Safdar
Section of Infectious Diseases, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Emerg Infect Dis 8:320-3. 2002..Of 23 reported cases of ehrlichiosis in immunocompromised patients, organ failure occurred in all patients and 6 (25%) died... - Case study and panel discussionDennis G Maki
Section of Infectious Diseases, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
Pharmacotherapy 27:136S-143S. 2007 - Microbiologic assessment of disposable sterile endoscopic sheaths to replace high-level disinfection in reprocessing: a prospective clinical trial with nasopharygoscopesCarla J Alvarado
Center for Quality and Productivity Improvement, Systems Engineering Initiative for Patient Safety, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Am J Infect Control 37:408-13. 2009.... - Device-associated nosocomial infections in 55 intensive care units of 8 developing countriesVictor D Rosenthal
Medical College of Buenos Aires, Buenos Aires, Argentina
Ann Intern Med 145:582-91. 2006..0 per 1000 CVC days, 5.4 per 1000 mechanical ventilator days, and 3.9 per Foley catheter days, respectively... - Lost in translationNasia Safdar
Infect Control Hosp Epidemiol 27:3-7. 2006 - Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated)Steven M Opal
Brown University School of Medicine, Providence, RI, USA
Clin Infect Dis 37:50-8. 2003..Results demonstrate that DrotAA, administered as an adjunct to standard anti-infective therapy, can improve the rate of survival for patients who develop severe sepsis regardless of causative microorganism... - Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee, Center for Disese Control and Prevention, u.sMary Alexander
National Institutes of Health, Department of Critical Care Medicine, Bethesda, Maryland 20892, USA
Pediatrics 110:e51. 2002..These guidelines also identify performance indicators that can be used locally by health-care institutions or organizations to monitor their success in implementing these evidence-based recommendations... - Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS studyPierre-Francois Laterre
Head of Intensive Care Unit, Cliniques Universitaires Saint-Luc Service des Urgences et des Soins Intensifs, UCL, Brussels, Belgium
Crit Care Med 33:952-61. 2005..In patients with severe sepsis resulting from CAP, a readily identifiable disease, DrotAA, improved survival compared with placebo... - Guidelines for the prevention of intravascular catheter-related infectionsMary Alexander
Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Infect Control Hosp Epidemiol 23:759-69. 2002..CONCLUSION: Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection... - Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trialMark E Rupp
University of Nebraska Medical Center, Omaha, Nebraska, USA
Ann Intern Med 143:570-80. 2005..Central venous catheter-related infections are a significant medical problem. Improved preventive measures are needed... - Quality of care and satisfaction among patients isolated for infection controlNasia Safdar
JAMA 291:420-1; author reply 421-2. 2004 - Improving the safety of peripheral intravenous cathetersDennis G Maki
BMJ 337:a630. 2008 - Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of AmericaNAOMI P O'GRADY
National Institutes of Health, Bethesda, MD, USA
Crit Care Med 36:1330-49. 2008..To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice... - Prospective study of the impact of open and closed infusion systems on rates of central venous catheter-associated bacteremiaVictor D Rosenthal
Infection Control and Infectious Diseases Department, Bernal Medical Center and Colegiales Medical Center, Arengreen 1366, 1405 Buenos Aires, Argentina
Am J Infect Control 32:135-41. 2004.... - Guidelines for the prevention of intravascular catheter-related infectionsMary Alexander
Clinical Center, National Institutes of Health, Bethesda, MD, USA
Am J Infect Control 30:476-89. 2002..CONCLUSION: Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection... - The 2002 Hospital Infection Control Practices Advisory Committee Centers for Disease Control and Prevention guideline for prevention of intravascular device-related infectionJeffery S Garland
Department of Pediatrics, St Joseph's Regional Medical Center, Milwaukee, WI 53210, USA
Pediatrics 110:1009-13. 2002 - Disinfection of needleless catheter connectors and access ports with alcohol may not prevent microbial entry: the promise of a novel antiseptic-barrier capSteve Z Menyhay
Menhay Medical, Fresno, California, USA
Infect Control Hosp Epidemiol 27:23-7. 2006..In contrast, the antiseptic-barrier cap provided a high level of protection, even in the presence of very heavy contamination. This novel technology deserves to be studied in a clinical trial... - Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and PreventionMary Alexander
National Institutes of Health, Bethesda, Maryland, USA
MMWR Recomm Rep 51:1-29. 2002..These guidelines also identify performance indicators that can be used locally by health-care institutions or organizations to monitor their success in implementing these evidence-based recommendations... - History forgotten is history relived: nosocomial infection control is also essential in the outpatient settingDennis G Maki
Arch Intern Med 165:2565-7. 2005