S Majumdar

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls--data from the osteoarthritis initiative
    Gabby B Joseph
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Suite 203, San Francisco, CA 94107, USA
    Arthritis Res Ther 13:R153. 2011
  2. ncbi Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy study
    Ehsan Saadat
    Department of Bioengineering, University of California, Berkeley, 459 Evans Hall #1762 Berkeley, CA 94720-1762, USA
    Arthritis Res Ther 8:R147. 2006
  3. ncbi In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women
    Janet Goldenstein
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Ann Biomed Eng 38:235-46. 2010
  4. ncbi Magnetic resonance imaging of trabecular bone structure
    Sharmila Majumdar
    Department of Radiology, Magnetic Resonance Science Center, University of California-San Francisco, Box 1290, 1 Irving Street, San Francisco, CA 94143, USA
    Top Magn Reson Imaging 13:323-34. 2002
  5. ncbi Magnetic resonance imaging for osteoporosis
    Sharmila Majumdar
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, QB3 Building, 2nd Floor, Suite 203 1700, 4th Street, Campus Box 2520, San Francisco, CA 94158, USA
    Skeletal Radiol 37:95-7. 2008
  6. ncbi Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure
    Sharmila Majumdar
    Department of Radiology, University of California, San Francisco, CA 94143, USA
    Eur Radiol 14:1440-8. 2004
  7. ncbi MR imaging and early cartilage degeneration and strategies for monitoring regeneration
    S Majumdar
    Musculoskeletal and Quantitative Imaging Research (MQIR, University of California, San Francisco, CA 94158, USA
    J Musculoskelet Neuronal Interact 6:382-4. 2006
  8. ncbi Magnetic resonance imaging and spectroscopy of the intervertebral disc
    S Majumdar
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94158, USA
    NMR Biomed 19:894-903. 2006
  9. ncbi High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties
    S Majumdar
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    Bone 22:445-54. 1998
  10. ncbi Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations
    P Augat
    Department of Radiology, University of California, San Francisco 94143, USA
    Med Eng Phys 20:124-31. 1998

Research Grants

  1. Vertebral Fracture: Trabecular Bone Structure Assessment
    Sharmila Majumdar; Fiscal Year: 2006
  2. Cartilage-Bone Interactions in Osteoarthritis
    Sharmila Majumdar; Fiscal Year: 2007
  3. Morphological and functional Musculo-Skeletal Imaging
    Sharmila Majumdar; Fiscal Year: 2007
  4. Instrument Development for the Osteoarthritis Initiative
    Sharmila Majumdar; Fiscal Year: 2007
  5. Cartilage-Bone Interactions in Osteoarthritis
    Sharmila Majumdar; Fiscal Year: 2010
  6. SPECTROSCOPIC MARKERS OF DISC DEGENERATION
    Sharmila Majumdar; Fiscal Year: 2005
  7. MRI TO STUDY CARTILAGE-BONE INTERACTIONS
    Sharmila Majumdar; Fiscal Year: 2003
  8. Morphological and Functional Musko-Skeletal Imaging
    Sharmila Majumdar; Fiscal Year: 2010

Collaborators

Detail Information

Publications131 found, 100 shown here

  1. ncbi Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls--data from the osteoarthritis initiative
    Gabby B Joseph
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Suite 203, San Francisco, CA 94107, USA
    Arthritis Res Ther 13:R153. 2011
    ....
  2. ncbi Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy study
    Ehsan Saadat
    Department of Bioengineering, University of California, Berkeley, 459 Evans Hall #1762 Berkeley, CA 94720-1762, USA
    Arthritis Res Ther 8:R147. 2006
    ..Furthermore, stimulation is localized to cartilage regions of high hydrostatic pressure. These data may be useful in developing interventions to prevent overuse injuries or in developing therapies to improve joint function...
  3. ncbi In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women
    Janet Goldenstein
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Ann Biomed Eng 38:235-46. 2010
    ..not containing marrow, varied highly between subjects. The results suggest that cortical pore spaces contain components of varying composition, and that there may be more than one mechanism for the development of cortical porosity...
  4. ncbi Magnetic resonance imaging of trabecular bone structure
    Sharmila Majumdar
    Department of Radiology, Magnetic Resonance Science Center, University of California-San Francisco, Box 1290, 1 Irving Street, San Francisco, CA 94143, USA
    Top Magn Reson Imaging 13:323-34. 2002
  5. ncbi Magnetic resonance imaging for osteoporosis
    Sharmila Majumdar
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, QB3 Building, 2nd Floor, Suite 203 1700, 4th Street, Campus Box 2520, San Francisco, CA 94158, USA
    Skeletal Radiol 37:95-7. 2008
  6. ncbi Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure
    Sharmila Majumdar
    Department of Radiology, University of California, San Francisco, CA 94143, USA
    Eur Radiol 14:1440-8. 2004
    ..These data reflect the ability of X-ray based emerging technologies to depict cartilage-bone interactions in joint degeneration...
  7. ncbi MR imaging and early cartilage degeneration and strategies for monitoring regeneration
    S Majumdar
    Musculoskeletal and Quantitative Imaging Research (MQIR, University of California, San Francisco, CA 94158, USA
    J Musculoskelet Neuronal Interact 6:382-4. 2006
  8. ncbi Magnetic resonance imaging and spectroscopy of the intervertebral disc
    S Majumdar
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94158, USA
    NMR Biomed 19:894-903. 2006
    ..With the potential for gaining morphological and biochemical information, MRI shows promise for quantitative assessment of disc health...
  9. ncbi High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties
    S Majumdar
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    Bone 22:445-54. 1998
    ..Further studies are clearly warranted to establish the role of architecture in predicting overall bone quality, and the role of trabecular architecture measures in clinical practice. (ABSTRACT TRUNCATED)..
  10. ncbi Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations
    P Augat
    Department of Radiology, University of California, San Francisco 94143, USA
    Med Eng Phys 20:124-31. 1998
    ..The data suggest that BMD can be most successfully applied to determine the mechanical properties in the principal loading direction, which from a clinical perspective may be most relevant...
  11. ncbi 3.0 vs 1.5 T MRI in the detection of focal cartilage pathology--ROC analysis in an experimental model
    T M Link
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Osteoarthritis Cartilage 14:63-70. 2006
    ..To use receiver operator characteristics (ROC) analysis for assessing the diagnostic performance of three cartilage-specific MR sequences at 1.5 and 3 T in detecting cartilage lesions created in porcine knees...
  12. ncbi Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group
    S Majumdar
    Department of Radiology, and Department of Internal Medicine, University of California, San Francisco, California, USA
    Osteoporos Int 10:231-9. 1999
    ..87) when radius and calcaneus structure was included. Measures of trabecular architecture derived from MR images combined with BMD measures improve the discrimination between subjects with hip fractures and normal age-matched controls...
  13. ncbi Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo
    R Krug
    Department of Radiology, University of California, San Francisco, CA, USA
    Osteoporos Int 19:653-61. 2008
    ..Comparing HR-pQCT with MRI, we found that both modalities are capable of offering meaningful information on trabecular structure...
  14. ncbi The feasibility of characterizing the spatial distribution of cartilage T(2) using texture analysis
    G Blumenkrantz
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Osteoarthritis Cartilage 16:584-90. 2008
    ....
  15. ncbi Fractal analysis of radiographs: assessment of trabecular bone structure and prediction of elastic modulus and strength
    S Majumdar
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143, USA
    Med Phys 26:1330-40. 1999
    ..Thus, fractal based texture analysis of radiographs are technique dependent, but may be used to quantify trabecular structure and have a potentially valuable impact in the study of osteoporosis...
  16. ncbi In vivo assessment of trabecular bone structure using fractal analysis of distal radius radiographs
    S Majumdar
    Department of Radiology, University of California, San Francisco 94143 1290, USA
    Med Phys 27:2594-9. 2000
    ....
  17. ncbi High resolution MRI of small joints: impact of spatial resolution on diagnostic performance and SNR
    T M Link
    Magnetic Resonance Science Center and Musculoskeletal Radiology, Department of Radiology, UCSF, San Francisco, CA, USA
    Magn Reson Imaging 16:147-55. 1998
    ..In conclusion this study shows that increasing spatial resolution improves diagnostic performance in cartilage lesions, though SNR decreases substantially. Assessment of correct lesion size and depth still is limited...
  18. ncbi In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
    X Li
    Musculo skeletal Quantitative Imaging Research, Department of Radiology, University of California at San Francisco, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 15:789-97. 2007
    ..The objective of this study was to determine the ability of MR T1rho (T(1rho)) and T(2) mapping to detect cartilage matrix degeneration between normal and early OA patients...
  19. ncbi MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up
    R Stahl
    Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
    Osteoarthritis Cartilage 15:1225-34. 2007
    ....
  20. ncbi Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment
    Jan S Bauer
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California in San Francisco, San Francisco, CA, USA
    Calcif Tissue Int 80:366-73. 2007
    ..Even though ST scatter compromises image quality substantially, the major characteristics of the trabecular network can still be appreciated and quantified...
  21. ncbi MRI analysis of in vivo meniscal and tibiofemoral kinematics in ACL-deficient and normal knees
    Sandra J Shefelbine
    Department of Orthopaedic Surgery, University of California, San Francisco, 500 Parnassus Avenue, MU 320W, San Francisco, California 94143-0728, USA
    J Orthop Res 24:1208-17. 2006
    ..These results help explain the increased risk of meniscal tears and osteoarthritis in chronic ACL deficient knees...
  22. ncbi Fuzzy logic structure analysis of trabecular bone of the calcaneus to estimate proximal femur fracture load and discriminate subjects with and without vertebral fractures using high-resolution magnetic resonance imaging at 1.5 T and 3 T
    Priyesh V Patel
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Calcif Tissue Int 81:294-304. 2007
    ..Local femoral measurements are still needed to estimate femoral bone strength. Overall, parameters obtained at 3.0 T performed better than those at 1.5 T...
  23. ncbi Contribution of inter-site variations in architecture to trabecular bone apparent yield strains
    Elise F Morgan
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA
    J Biomech 37:1413-20. 2004
    ..These findings indicate the importance of incorporating large deformation capabilities in computational analyses of trabecular bone. This may be critical when investigating the biomechanical consequences of trabecular thinning and loss...
  24. ncbi Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T
    Suchandrima Banerjee
    Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:1319-25. 2009
    ..Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans...
  25. ncbi Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: reproducibility of structural measures and micro-finite element analysis derived mechanical properties
    D C Newitt
    MRSC, Department of Radiology, University of California, San Francisco 94143 1290, USA
    Osteoporos Int 13:278-87. 2002
    ....
  26. ncbi Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur
    Roland Krug
    MQIR, Department of Radiology, University of California, San Francisco, CA, USA
    Osteoporos Int 16:1307-14. 2005
    ..This feasibility study establishes the potential of MRI as a means of imaging proximal femur structure, and improvements in technique and resolution enhancements are warranted...
  27. ncbi Noninvasive assessment of bone density and structure using computed tomography and magnetic resonance
    T Lang
    Department of Radiology, University of California, San Francisco, 94143 1250, USA
    Bone 22:149S-153S. 1998
    ..High resolution MR measurements may be employed for assessment of the trabecular texture at a range of peripheral sites, including the calcaneus, distal radius, and phalanges...
  28. ncbi Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs
    M B Huber
    Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143, USA
    Med Phys 36:5089-98. 2009
    ..The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength...
  29. ncbi Autocalibrating parallel imaging of in vivo trabecular bone microarchitecture at 3 Tesla
    S Banerjee
    Department of Radiology, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 56:1075-84. 2006
    ..The results also demonstrated the potential of PPI for increasing the signal-to-noise ratio (SNR) efficiency of multiple-acquisition b-SSFP imaging protocols...
  30. ncbi Normalized cuts in 3-D for spinal MRI segmentation
    Julio Carballido-Gamio
    Joint Graduate Group in Bioengineering, University of California, San Francisco, 94143-1290, USA
    IEEE Trans Med Imaging 23:36-44. 2004
    ..Results of the segmentation as well as limitations and challenges in this area are presented...
  31. ncbi Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading
    Benjamin M Boudignon
    Division of Endocrinology, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, California, USA
    J Appl Physiol 103:125-31. 2007
    ....
  32. ncbi Three-dimensional image registration of MR proximal femur images for the analysis of trabecular bone parameters
    Janet Blumenfeld
    Department of Radiology and UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, California 94107, USA
    Med Phys 35:4630-9. 2008
    ....
  33. ncbi Association of MR relaxation and cartilage deformation in knee osteoarthritis
    K Subburaj
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158, USA
    J Orthop Res 30:919-26. 2012
    ....
  34. ncbi Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture
    J B Pialat
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    Bone 50:111-8. 2012
    ..These results provide estimates of the error in bone quality measures due to motion artifacts and provide an initial framework for developing standardized quality control criteria for cross-sectional and longitudinal HR-pQCT studies...
  35. ncbi T1rho relaxation time of the meniscus and its relationship with T1rho of adjacent cartilage in knees with acute ACL injuries at 3 T
    R I Bolbos
    Musculo skeletal Quantitative Imaging Research MQIR, Department of Radiology, University of California, San Francisco UCSF, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 17:12-8. 2009
    ....
  36. ncbi New model-independent measures of trabecular bone structure applied to in vivo high-resolution MR images
    A Laib
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143-1290, USA
    Osteoporos Int 13:130-6. 2002
    ..003). We conclude that in vivo high-resolution MRI not only has the potential of imaging trabecular bone, but in combination with novel metrics may offer new insight into the structural changes occurring in postmenopausal women...
  37. ncbi Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor
    G J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94107, USA
    Calcif Tissue Int 89:10-20. 2011
    ..Our findings suggest that bone tissue quality may be an important contributor to increased fracture risk in fibrous dysplasia patients...
  38. ncbi The temporal changes of trabecular architecture in ovariectomized rats assessed by MicroCT
    A Laib
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143-0686, USA
    Osteoporos Int 12:936-41. 2001
    ....
  39. ncbi Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography
    A J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, 1700 4th St, San Francisco, CA 94158, USA
    Osteoporos Int 20:2017-24. 2009
    ..This technique represents a useful reference to gauge the utility of novel 3D quantification methods applied to HR-pQCT in multi-center clinical studies and potentially negates the need for separate forearm DXA measurements...
  40. ncbi Teriparatide in bisphosphonate-resistant osteoporosis: microarchitectural changes and clinical results after 6 and 18 months
    B Jobke
    Department of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group, University of California San Francisco, CA, USA
    Calcif Tissue Int 89:130-9. 2011
    ..The overall results indicate a positive ceiling effect of teriparatide on bone microarchitecture and bone markers after 6 and 12 months for lumbar spine BMD, with no additional gain until M18 in bisphosphonate nonresponders...
  41. ncbi Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements
    G J Kazakia
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, California 94158, USA
    Med Phys 35:3170-9. 2008
    ..Our results indicate that muCT mineralization measures are underestimated but well-correlated with SRmuCT and gravimetric data, particularly when volume fraction groups are considered individually...
  42. ncbi Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I
    Yongmei Wang
    Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
    J Endocrinol 189:279-87. 2006
    ..These effects are more evident in the male mouse. These differences between male and female mice may reflect the greater response to PTH of IGF-I and IGF-IR gene expression in males enhancing the anabolic effect on cortical bone...
  43. ncbi Magnetic resonance imaging of patellofemoral kinematics with weight-bearing
    Vikas V Patel
    Department of Orthopaedic Surgery, University of California, 400 Parnassus, ACC-3, San Francisco, CA 94117, USA
    J Bone Joint Surg Am 85:2419-24. 2003
    ..Therefore, we believe that lateral patellar tilt and subluxation observed during arthroscopy of the extended knee may not represent a pathological condition...
  44. ncbi Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae
    Ahi Sema Issever
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143-1290, USA
    Spine 28:123-8. 2003
    ..These observations may be helpful in understanding the pathologic processes and the chronology of degenerative spinal conditions...
  45. ncbi Quantification of articular cartilage in the knee with pulsed saturation transfer subtraction and fat-suppressed MR imaging: optimization and validation
    C G Peterfy
    Department of Radiology, University of California, San Francisco 94143 0628
    Radiology 192:485-91. 1994
    ....
  46. ncbi Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla
    R Krug
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California San Francisco, San Francisco, California, USA
    Magn Reson Med 56:1033-40. 2006
    ..Comparisons of structural bone parameters revealed a difference of less than 3% for all structural parameters between parallel and conventional imaging...
  47. ncbi In vivo application of 3D-line skeleton graph analysis (LSGA) technique with high-resolution magnetic resonance imaging of trabecular bone structure
    Laurent Pothuaud
    Department of Radiology, Magnetic Resonance Science Center, University of California San Francisco, 1 Irving Street, Room AC-109, San Francisco, CA 94143-1290, USA
    Osteoporos Int 15:411-9. 2004
    ..However, this paper demonstrated the feasibility of using 3D-LSGA based evaluation coupled with in vivo high-resolution MR imaging as a complementary approach for the monitoring of trabecular bone changes in individual subjects...
  48. ncbi Fast magnetic resonance spectroscopic imaging at 3 Tesla using autocalibrating parallel technique
    Suchandrima Banerjee
    Joint Graduate Group in Bioeng, California Univ, Berkeley, San Francisco, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1866-9. 2006
    ..Employing two fold undersampling in two phase-encoding directions, a four fold reduction in scantime was simulated. Metabolic parameters showed close agreement between the full and GRAPPA reconstructed spectral data...
  49. ncbi MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens
    Vikas Patel
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143-1290, USA
    J Orthop Res 21:6-13. 2003
    ..Severely arthritic bone changes are most prominent in the medial compartment of the tibia and bone structure is less sound in severe arthritis...
  50. ncbi Meniscal measurements of T1rho and T2 at MR imaging in healthy subjects and patients with osteoarthritis
    Isabel Rauscher
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Radiology 249:591-600. 2008
    ....
  51. ncbi A three-dimensional MRI analysis of knee kinematics
    Vikas V Patel
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA
    J Orthop Res 22:283-92. 2004
    ..MR imaging allows excellent non-invasive evaluation of knee joint kinematics with weight bearing. This tool may potentially be used for assessing knee kinematics in patients with knee pathology...
  52. ncbi Combination of topological parameters and bone volume fraction better predicts the mechanical properties of trabecular bone
    Laurent Pothuaud
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, CA 94143-1290, USA
    J Biomech 35:1091-9. 2002
    ..Such formulations could potentially be used to increase the prediction of the mechanical properties of trabecular bone...
  53. ncbi Three-dimensional-line skeleton graph analysis of high-resolution magnetic resonance images: a validation study from 34-microm-resolution microcomputed tomography
    Laurent Pothuaud
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, 94143-1290, USA
    J Bone Miner Res 17:1883-95. 2002
    ..57-0.64 for morphological measurements. 3D-LSGA technique could be applied to in vivo high-resolution MRIs of trabecular bone structure, giving an indirect characterization of the microtrabecular bone network...
  54. ncbi Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees
    G J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Osteoarthritis Cartilage 21:94-101. 2013
    ..The aim of the present study was to evaluate bone structure and composition within bone marrow edema-like lesion (BMEL) regions associated with knee OA...
  55. ncbi Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro
    E J Chiu
    Department of Radiology, University of California, Berkeley San Francisco, California, USA
    Spine (Phila Pa 1976) 26:E437-44. 2001
    ..CONCLUSIONS: This study demonstrated that magnetic resonance imaging can be used to measure significant changes in T1, T2, or diffusion in intervertebral disc specimens by region, loading condition, or Thompson grade...
  56. ncbi Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia
    J Peng
    Endocrine Research Unit, Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, California 94121, USA
    Endocrinology 149:1329-37. 2008
    ..The skeletal phenotype in Ro1 mice bears some similarity to that produced by knockout of Gs-alpha expression in osteoblasts and thus may be due at least in part to Gi-mediated inhibition of adenylyl cyclase...
  57. ncbi Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee
    C T Lindsey
    Magnetic Resonance Science Center, University of California, CA, San Francisco, USA
    Osteoarthritis Cartilage 12:86-96. 2004
    ..To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA)...
  58. ncbi Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis
    G Blumenkrantz
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Eur Cell Mater 13:76-86. 2007
    ..The cross-sectional and longitudinal studies using these imaging techniques show promise for cartilage assessment and for the study of osteoarthritis...
  59. ncbi Advances in imaging: impact on studying craniofacial bone structure
    S Majumdar
    Department of Radiology, University of California, San Francisco, CA 94143, USA
    Orthod Craniofac Res 6:48-51. 2003
    ..Examples of in vitro and in vivo images are presented...
  60. ncbi Cartilage and meniscus assessment using T1rho and T2 measurements in healthy subjects and patients with osteoarthritis
    Z A Zarins
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Osteoarthritis Cartilage 18:1408-16. 2010
    ..The purpose of this study was to evaluate meniscal degeneration in healthy subjects and subjects with osteoarthritis (OA) using T(1ρ) and T(2) measurements and to examine the interrelationship between cartilage and meniscus abnormalities...
  61. ncbi A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging--data from the Osteoarthritis Initiative
    C Stehling
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 19:984-9. 2011
    ..59%) than for mean T(2) (1.57%) and laminar analysis (up to 2.17%). Due to these results, the novel DST can be recommended for T(2) measurements in large clinical trials like the OAI...
  62. ncbi In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms
    Gabrielle Blumenkrantz
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:1193-200. 2010
    ..This study suggests that T(1rho) may be sensitive to early degenerative changes (corroborating previous studies) and clinical symptoms in intervertebral disc degeneration...
  63. ncbi In vivo T1rho quantitative assessment of knee cartilage after anterior cruciate ligament injury using 3 Tesla magnetic resonance imaging
    Radu I Bolbos
    Musculo skeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, San Francisco, California 94107, USA
    Invest Radiol 43:782-8. 2008
    ....
  64. ncbi Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography
    Andrew J Burghardt
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Calcif Tissue Int 83:129-38. 2008
    ..80). In cortical bone specimens, the correlation was somewhat weaker when a global threshold was applied (R (2) = 0.67) compared to the local threshold method (R (2) = 0.78)...
  65. ncbi Quantitative assessment of bone marrow edema-like lesion and overlying cartilage in knees with osteoarthritis and anterior cruciate ligament tear using MR imaging and spectroscopic imaging at 3 Tesla
    Xiaojuan Li
    Musculo skeletal Quantitative Imaging Research MQIR, Department of Radiology, University of California, San Francisco UCSF, San Francisco, California 94107, USA
    J Magn Reson Imaging 28:453-61. 2008
    ..To quantitatively assess bone marrow edema-like lesion (BMEL) and the overlying cartilage in osteoarthritis (OA) or anterior cruciate ligament (ACL)-injured knees using magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI)...
  66. ncbi High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, San Francisco, California 94158, USA
    J Clin Endocrinol Metab 95:5045-55. 2010
    ..Cross-sectional epidemiological studies have found that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal or elevated bone mineral density (BMD)...
  67. ncbi A comparative study at 3 T of sequence dependence of T2 quantitation in the knee
    Alex Pai
    Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA
    Magn Reson Imaging 26:1215-20. 2008
    ..However, the derivation of these times may vary from sequence to sequence. This study seeks to evaluate the sequence-dependent differences in T2 quantitation of cartilage, muscle, fat and bone marrow in the knee joint at 3 T...
  68. ncbi Prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison with physically active subjects-a 3.0 T magnetic resonance imaging study
    Robert Stahl
    Musculoskeletal and Quantitative Imaging Group, Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
    Skeletal Radiol 37:627-38. 2008
    ..To compare the diagnostic performance of cartilage-dedicated magnetic resonance imaging (MRI) sequences at 3.0 T...
  69. ncbi Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT--correlation with biomechanical strength measurement
    Markus B Huber
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
    Radiology 247:472-81. 2008
    ....
  70. ncbi Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
    R I Bolbos
    Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California San Francisco, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 16:1150-9. 2008
    ..To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3Tesla (3T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging...
  71. ncbi Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 93:2166-72. 2008
    ..Daily PTH administration increases bone mineral density (BMD) and reduces fracture risk. However, cost and compliance significantly limit clinical use...
  72. ncbi Geodesic topological analysis of trabecular bone microarchitecture from high-spatial resolution magnetic resonance images
    Julio Carballido-Gamio
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 61:448-56. 2009
    ..95; p < 0.001). Results indicate that GTA can substantially contribute in studies of osteoporosis involving imaging of the trabecular bone microarchitecture...
  73. ncbi Comparison of quantitative imaging of cartilage for osteoarthritis: T2, T1rho, dGEMRIC and contrast-enhanced computed tomography
    Carmen Taylor
    Department of Radiology, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:779-84. 2009
    ..Together, these results indicate that T1rho, T2 and contrast-enhanced techniques may provide complementary information about the molecular environment in cartilage during the evolution of OA...
  74. ncbi Assessment of cartilage-dedicated sequences at ultra-high-field MRI: comparison of imaging performance and diagnostic confidence between 3.0 and 7.0 T with respect to osteoarthritis-induced changes at the knee joint
    Robert Stahl
    Musculoskeletal and Quantitative Imaging Group, Department of Radiology, University of California, San Francisco, CA 94107 0946, USA
    Skeletal Radiol 38:771-83. 2009
    ..0 T ultra-high-field (UHF) magnetic resonance imaging (MRI) and to compare imaging performance and diagnostic confidence concerning osteoarthritis (OA)-induced changes at 7.0 and 3.0 T MRI...
  75. ncbi Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    Bone 46:1652-60. 2010
    ..Therefore, a combined approach of investigating the entire region, each subregion, and the cortical compartment may offer more complete information...
  76. ncbi Local bone enhancement fuzzy clustering for segmentation of MR trabecular bone images
    Jenny Folkesson
    Department of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group MQIR, University of California, San Francisco, California 94158, USA
    Med Phys 37:295-302. 2010
    ..This approach is meant to allow for a soft segmentation that accounts for partial volume effects while suppressing the influence of noise...
  77. ncbi Quantitative analysis of spatial distortions of diffusion techniques at 3T
    Duan Xu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    Magn Reson Imaging 28:451-4. 2010
    ..These methods have confirmed the SSFSE based diffusion method is less distorted than the EPI based one, which is generally accepted through visual inspection...
  78. ncbi Spatial analysis of magnetic resonance T1rho and T2 relaxation times improves classification between subjects with and without osteoarthritis
    Julio Carballido-Gamio
    Grupo Tecnológico Santa Fe, S A de C V, Mexico City 06140, Mexico
    Med Phys 36:4059-67. 2009
    ....
  79. ncbi Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy
    Jin Zuo
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA
    Magn Reson Med 62:1140-6. 2009
    ..0039). This study demonstrates for the first time that short-echo PRESS on a clinical 3T MR scanner can be used to noninvasively and can reproducibly quantify metabolic changes associated with degeneration of intervertebral discs...
  80. ncbi Imaging of the musculoskeletal system in vivo using ultra-high field magnetic resonance at 7 T
    Roland Krug
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    Invest Radiol 44:613-8. 2009
    ..Imaging of more central body parts such as the spine at 7 T is still in its infancy and dedicated coils have to be developed...
  81. ncbi A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 25:2558-71. 2010
    ..48, p < .05). These findings suggest a more pronounced response to ALN in the tibia than in the radius, driven by trabecular and endocortical changes...
  82. ncbi Magnetic resonance imaging of 3-dimensional in vivo tibiofemoral kinematics in anterior cruciate ligament-reconstructed knees
    R Dana Carpenter
    Department of Radiology, University of California, San Francisco, California 94143, USA
    Arthroscopy 25:760-6. 2009
    ..The purpose of this study was to use magnetic resonance imaging (MRI) to determine 3-dimensional knee kinematics after anterior cruciate ligament (ACL) reconstruction...
  83. ncbi High-resolution imaging techniques for the assessment of osteoporosis
    Roland Krug
    MQIR, Department of Radiology and Biomedical Imaging, University of California San Francisco, UCSF China Basin Landing, 185 Berry Street, San Francisco, CA 94107, USA
    Radiol Clin North Am 48:601-21. 2010
    ..Details regarding imaging protocols as well as image postprocessing methods for bone structure quantification are discussed...
  84. ncbi Spatial distribution and relationship of T1rho and T2 relaxation times in knee cartilage with osteoarthritis
    Xiaojuan Li
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, San Francisco, California 94107, USA
    Magn Reson Med 61:1310-8. 2009
    ..T(1rho) and T(2) values show different spatial distributions and may provide complementary information regarding cartilage degeneration in OA...
  85. ncbi Lactic acid and proteoglycans as metabolic markers for discogenic back pain
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94158 2330, USA
    Spine (Phila Pa 1976) 33:312-7. 2008
    ..These samples were then analyzed using ex vivo proton high resolution magic angle spinning (HR-MAS) NMR spectroscopy to produce metabolic profiles for comparison between the 2 patient groups...
  86. ncbi Resolution dependence of the non-metric trabecular structure indices
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
    Bone 42:728-36. 2008
    ..g. relative resolution, the size of the treatment effect to detect, and specimen type). The results of this study provide an upper bound for the accuracy of the non-metric indices under limited resolution scenarios...
  87. ncbi Partially parallel MR spectroscopic imaging of gliomas at 3T
    Esin Ozturk
    UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:493-6. 2006
    ....
  88. ncbi Characterization of trabecular bone structure from high-resolution magnetic resonance images using fuzzy logic
    Julio Carballido-Gamio
    MQIR, Department of Radiology, University of California, San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 24:1023-9. 2006
    ..85; P<.001) and good agreements based on Bland-Altman analysis, suggesting that the level of fuzziness in high-resolution magnetic resonance images could be related to the trabecular bone structure...
  89. ncbi Magnetic resonance imaging of in vivo kinematics after total knee arthroplasty
    Keh Yang Lee
    Department of Radiology, University of California at San Francisco, San Francisco, California 94143 0946, USA
    J Magn Reson Imaging 21:172-8. 2005
    ....
  90. ncbi Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements
    Roland Krug
    MQIR, Department of Radiology, University of California, San Francisco, CA 94143 2520, USA
    Magn Reson Imaging 25:392-8. 2007
    ....
  91. ncbi MR imaging findings in the follow-up of patients with different stages of knee osteoarthritis and the correlation with clinical symptoms
    Catherine M Phan
    Department of Radiology, University of California San Francisco, 185 Berry Street, Suite 350, Box 0628, San Francisco, CA 94143 0946, USA
    Eur Radiol 16:608-18. 2006
    ..5-T MRI in patients with knee osteoarthritis and to correlate these findings with the clinical Western Ontario and McMaster University Osteoarthitis (WOMAC) score...
  92. ncbi Automatic prospective registration of high-resolution trabecular bone images of the tibia
    Janet Blumenfeld
    Department of Radiology, University of California, 1700 4th St, Suite 203, Box 2520, San Francisco, CA 94107, USA
    Ann Biomed Eng 35:1924-31. 2007
    ..5% range which are within values previously reported in the literature. Results suggest that this algorithm is robust enough to be used in different musculoskeletal imaging applications including the hip as well as the tibia...
  93. ncbi Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T
    Xiaojuan Li
    Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, CA 94107, USA
    Magn Reson Imaging 26:188-97. 2008
    ....
  94. ncbi Current diagnostic techniques in the evaluation of bone architecture
    Thomas M Link
    Department of Radiology, University of California, San Francisco, 400 Parnassus Avenue A 367, Box 0628, San Francisco, CA 94143, USA
    Curr Osteoporos Rep 2:47-52. 2004
    ..The methodologies described will include magnetic resonance imaging, clinical multislice spiral computed tomography, and micro-computed tomography, along with computerized analysis of radiographic patterns of trabecular bone...
  95. ncbi Reproducibility and dependence on diffusion weighting of line scan diffusion in the lumbar intervertebral discs
    David C Newitt
    Department of Radiology, University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 21:482-8. 2005
    ..To investigate the dependence of line scan diffusion imaging (LSDI) in the lumbar vertebral discs on diffusion weighting, fat suppression (FS), and postprocessing noise correction...
  96. ncbi A feasibility study of in vivo T1rho imaging of the intervertebral disc
    Gabrielle Blumenkrantz
    Department of Radiology, University of California San Francisco, QB3 Building, Box 2520, San Francisco, CA 94158, USA
    Magn Reson Imaging 24:1001-7. 2006
    ..The purpose of this study was to test the feasibility of quantifying T1rho relaxation time in phantoms and intervertebral discs of healthy volunteers using in vivo MR imaging at 3 T...
  97. ncbi Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94107, USA
    Spine (Phila Pa 1976) 30:2683-8. 2005
    ..A quantitative high-resolution magic angle spinning (HR-MAS) NMR study of human lumbar discs was conducted to determine biomarkers of disc degeneration...
  98. ncbi New techniques for cartilage magnetic resonance imaging relaxation time analysis: texture analysis of flattened cartilage and localized intra- and inter-subject comparisons
    Julio Carballido-Gamio
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 59:1472-7. 2008
    ..The results indicate that the presented techniques have potential in longitudinal and population studies of knee OA at different stages of the disease...
  99. ncbi Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, QB3 Byers Hall, Suite 203, 1700 4th Street, San Francisco, CA 94158, USA
    Bone 40:160-8. 2007
    ..The advantages unique to SR-microCT allow for 3D visualization and quantification of pre-natal bone microstructure and mineral density in mice which was not previously possible...
  100. ncbi Rapid in vivo musculoskeletal MR with parallel imaging at 7T
    Suchandrima Banerjee
    Radiology, University of California, San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 59:655-60. 2008
    ..Robust quantification of bone and cartilage metrics could be derived from accelerated ankle and knee acquisitions. PI can enhance the clinical feasibility of in vivo bone and cartilage HR-MRI for osteoporosis and osteoarthritis at 7T...
  101. ncbi Computer-aided quantification of focal cartilage lesions of osteoarthritic knee using MRI
    Keh Yang Lee
    Department of Radiology, University of California, San Francisco, San Francisco, California, USA
    Magn Reson Imaging 22:1105-15. 2004
    ....

Research Grants27

  1. Vertebral Fracture: Trabecular Bone Structure Assessment
    Sharmila Majumdar; Fiscal Year: 2006
    ..abstract_text> ..
  2. Cartilage-Bone Interactions in Osteoarthritis
    Sharmila Majumdar; Fiscal Year: 2007
    ..An additional cohort consisting of consist of patients with acute anterior cruciate ligament (ACL) injuries with associated osseous contusion (n=20) will also be followed. ..
  3. Morphological and functional Musculo-Skeletal Imaging
    Sharmila Majumdar; Fiscal Year: 2007
    ....
  4. Instrument Development for the Osteoarthritis Initiative
    Sharmila Majumdar; Fiscal Year: 2007
    ..The tools developed will then be disseminate to one or two interested investigators for further testing. ..
  5. Cartilage-Bone Interactions in Osteoarthritis
    Sharmila Majumdar; Fiscal Year: 2010
    ..An additional cohort consisting of consist of patients with acute anterior cruciate ligament (ACL) injuries with associated osseous contusion (n=20) will also be followed. ..
  6. SPECTROSCOPIC MARKERS OF DISC DEGENERATION
    Sharmila Majumdar; Fiscal Year: 2005
    ..abstract_text> ..
  7. MRI TO STUDY CARTILAGE-BONE INTERACTIONS
    Sharmila Majumdar; Fiscal Year: 2003
    ....
  8. Morphological and Functional Musko-Skeletal Imaging
    Sharmila Majumdar; Fiscal Year: 2010
    ....