Amit Maity

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint 2-Deoxyglucose and radiosensitization: teaching an old DOG new tricks?
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 5:824-6. 2006
  2. ncbi request reprint Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years' experience in a single center
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 58:1165-70. 2004
  3. doi request reprint Modulating the tumor microenvironment to improve radiotherapy
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Retina 29:S32-3. 2009
  4. ncbi request reprint Testicular seminoma 16 years after treatment for CNS germinoma
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Neurooncol 70:83-5. 2004
  5. ncbi request reprint Treatment of pediatric intracranial arteriovenous malformations with linear-accelerator-based stereotactic radiosurgery: the University of Pennsylvania experience
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Neurosurg 40:207-14. 2004
  6. ncbi request reprint Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir
    Zibin Jiang
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 67:4467-73. 2007
  7. ncbi request reprint Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 66:9252-9. 2006
  8. pmc HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neoplasia 8:889-95. 2006
  9. pmc Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy
    George J Cerniglia
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e6539. 2009
  10. ncbi request reprint Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Mol Cancer Res 4:471-9. 2006

Collaborators

Detail Information

Publications43

  1. ncbi request reprint 2-Deoxyglucose and radiosensitization: teaching an old DOG new tricks?
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 5:824-6. 2006
  2. ncbi request reprint Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years' experience in a single center
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 58:1165-70. 2004
    ..The optimal treatment for intracranial germinomas remains controversial. We report on our 25-year experience using craniospinal irradiation (CSI) for this disease...
  3. doi request reprint Modulating the tumor microenvironment to improve radiotherapy
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Retina 29:S32-3. 2009
    ..Progress with such combinations in oncology may be relevant to parallel strategies for treating and containing neovascularization in AMD and other retinal diseases...
  4. ncbi request reprint Testicular seminoma 16 years after treatment for CNS germinoma
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Neurooncol 70:83-5. 2004
    ..These patients require lifelong medical follow-up and should be encouraged to perform testicular self-examination at the appropriate age...
  5. ncbi request reprint Treatment of pediatric intracranial arteriovenous malformations with linear-accelerator-based stereotactic radiosurgery: the University of Pennsylvania experience
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Neurosurg 40:207-14. 2004
    ..Linear-accelerator-based SRS is effective in obliterating most AVMs in children; however, the potential for late effects exists, especially for those patients with larger target volumes...
  6. ncbi request reprint Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir
    Zibin Jiang
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 67:4467-73. 2007
    ..These results support the clinical investigation of nelfinavir in combination with radiation and temozolomide in future clinical trials for patients with glioblastomas...
  7. ncbi request reprint Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 66:9252-9. 2006
    ..These data support the use of nelfinavir in combination with radiation in future clinical trials...
  8. pmc HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neoplasia 8:889-95. 2006
    ..Our results support further research into these protease inhibitors for use in future clinical trials for patients with glioblastoma multiformes...
  9. pmc Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy
    George J Cerniglia
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e6539. 2009
    ..Hypothesizing that this might normalize tumor vasculature, we examined the effects of the EGFR inhibitor erlotinib on tumor vascular function, tumor microenvironment (TME) and chemotherapy and radiotherapy sensitivity...
  10. ncbi request reprint Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Mol Cancer Res 4:471-9. 2006
    ..We did find that rapamycin could decrease HIF-1alpha expression when cells were cultured in low serum, but this seems to represent a different pathway...
  11. ncbi request reprint Near complete surgical resection predicts a favorable outcome in pediatric patients with nonbrainstem, malignant gliomas: results from a single center in the magnetic resonance imaging era
    Mary Kara Bucci
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer 101:817-24. 2004
    ..Because few reports on outcome in patients with pediatric malignant gliomas during the magnetic resonance imaging era were available, the authors studied the outcomes of children with these tumors at their institution...
  12. pmc Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
    George J Cerniglia
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Pharmacol 82:1230-40. 2012
    ..Our data offer a rationale for combining NVP-BEZ235 along with an autophagy inhibitor (i.e., chloroquine) and radiation in future clinical trials...
  13. pmc Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation
    Gary D Kao
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:21206-12. 2007
    ..These results together support a direct link between Akt activation, repair of DNA damage, and radioresistance in glioblastoma. Targeting the PI3K/Akt pathway may modulate DNA repair to improve the efficacy of radiation therapy...
  14. pmc Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT
    Anjali K Gupta
    Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Int J Radiat Oncol Biol Phys 74:928-33. 2009
    ..We are in the process of starting a clinical trial in H&N cancer patients using nelfinavir (NFV) (which inhibits Akt) and it would be important to know the effect of HPV on radiation response +/- NFV...
  15. pmc The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response
    Anjali K Gupta
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neoplasia 9:271-8. 2007
    ..These findings may have important implications in understanding how nelfinavir may increase radiation sensitivity and also result in downregulation of the PI3K/Akt pathway...
  16. ncbi request reprint Ionizing radiation inhibits tumor neovascularization by inducing ineffective angiogenesis
    Jeff H Tsai
    Biomedical Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 4:1395-1400. 2005
    ..Our studies further show that radiation impact on tumor vasculature extends beyond near-term induction of EC death to more prolonged effects on their ability to support angiogenesis...
  17. ncbi request reprint Childhood intracranial ependymoma: twenty-year experience from a single institution
    Hui Kuo G Shu
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 30322, USA
    Cancer 110:432-41. 2007
    ..In this article, they report their 20-year institutional experience with this disease...
  18. ncbi request reprint EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 66:3197-204. 2006
    ..Similar results were obtained with erlotinib in SQ20B and gefitinib in HSC3 squamous carcinoma cells. These results indicate that there are at least two separate mechanisms by which EGFR inhibitors decrease VEGF expression...
  19. ncbi request reprint Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia
    Stephen W Tuttle
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    J Biol Chem 282:36790-6. 2007
    ..Therefore, we conclude that the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia...
  20. ncbi request reprint Bortezomib sensitizes human head and neck carcinoma cells SQ20B to radiation
    Charles N Weber
    Department of Radiation Oncology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Cancer Biol Ther 6:156-9. 2007
    ..The dose of bortezomib is also 2 logs less as a sensitizer than that required for single agent efficacy. Further studies should be done to explore this model in vivo...
  21. pmc Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia
    Jayashree Karar
    Department of Radiation Oncology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
    Cancer Biol Ther 13:1102-11. 2012
    ..In conclusion, we have found that BEZ235 blocks HIF-1α induction by decreasing protein translation and increases cell killing under hypoxia, likely by increasing apoptosis...
  22. ncbi request reprint Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults
    Diana C H Stripp
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 58:714-20. 2004
    ..The optimal management of craniopharyngiomas remains controversial, especially in children and young adults. This study reports a single institution's experience with such patients...
  23. pmc Cellular responses to EGFR inhibitors and their relevance to cancer therapy
    Pinaki R Dutta
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Cancer Lett 254:165-77. 2007
    ..Unfortunately, many of the clinical trials reported so far have shown at best limited gains; therefore, understanding the actions of these agents is essential to improving their efficacy in the treatment of cancers...
  24. ncbi request reprint Modulating the tumor microenvironment to increase radiation responsiveness
    Jayashree Karar
    Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Cancer Biol Ther 8:1994-2001. 2009
    ..The challenge remains to obtain clinical data from patients showing that modulation of the TME is an important mechanism by which biological agents can radiosensitize tumors and then to utilize this information to optimize therapy...
  25. pmc Modulating tumor vasculature through signaling inhibition to improve cytotoxic therapy
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 70:2141-5. 2010
    ..Recent work has shown that changes in the tumor vasculature can be achieved by inhibiting tumor cell signaling, resulting in enhanced tumor oxygenation. These changes could promote responses to both chemo- and radiation therapy...
  26. pmc Regulation of histone deacetylase 4 expression by the SP family of transcription factors
    Fang Liu
    Department of Radiation Oncology, Philadelphia Veterans Affairs Medical Center, PA 19104, USA
    Mol Biol Cell 17:585-97. 2006
    ..These studies together characterize for the first time the activity of the HDAC4 promoter, through which Sp1 and Sp3 modulates expression of HDAC4 and which may contribute to tissue or cell-line-specific expression of HDAC4...
  27. pmc Aiding and ABT'ing Treatment for Glioblastoma
    Elaine Y Chung
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6051, USA
    Cancer Biol Ther 6:802-4. 2007
  28. ncbi request reprint The chemokine receptor CXCR4: a homing device for hypoxic cancer cells?
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 5:1563-5. 2006
  29. pmc Sirolimus as a potential radiosensitizer in squamous cell cancer of the head and neck
    Eric T Shinohara
    Department of Radiation Oncology, Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Head Neck 31:406-11. 2009
    ..Radiation is commonly used to treat these patients. Preclinical studies have suggested that sirolimus may be an effective radiosensitizer in HNSCC...
  30. pmc In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection
    Diane Marotta
    Department of Radiation Oncology, University of Pennsylvania, Pennsylvania, USA
    Cancer Res 71:779-89. 2011
    ....
  31. doi request reprint General principles of radiation and chemoradiation
    Stephen M Hahn
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Retina 29:S30-1. 2009
    ..In AMD, the most significant challenge for radiotherapy may be precise delivery to the target and avoidance of damage to surrounding tissues...
  32. ncbi request reprint Ionizing radiation inhibits tumor neovascularization by inducing ineffective angiogenesis
    Jeff H Tsai
    Biomedical Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 4:1395-1400. 2005
    ..Our studies further show that radiation impact on tumor vasculature extends beyond near-term induction of EC death to more prolonged effects on their ability to support angiogenesis...
  33. ncbi request reprint Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature
    Yuquan Shi
    Department of Radiation Oncology, University of Pennsylvania, 195 John Morgan Building, 37th and Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Head Neck 27:362-9. 2005
    ..Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth...
  34. ncbi request reprint Volumetric considerations in radiotherapy for pediatric parameningeal rhabdomyosarcomas
    Changhu Chen
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 55:1294-9. 2003
    ..To assess the influence of radiation volume on outcome in pediatric parameningeal rhabdomyosarcomas (PM-RMSs)...
  35. pmc Location, location, location-makes all the difference for hypoxia in lung tumors
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6072, USA
    Clin Cancer Res 16:4685-7. 2010
    ..Here, we describe how different animal tumor models of lung cancer can yield surprisingly different hypoxic profiles...
  36. doi request reprint A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme
    Michelle Alonso-Basanta
    Department of Radiation Oncology, Smilow Center for Translational Research 8 135, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA, 19104, USA
    J Neurooncol 116:365-72. 2014
    ..NFV (1,250 mg bid) concurrent with temozolomide and radiotherapy is tolerated in most patients with glioblastoma. At the 1,250 mg bid dose level, patients should be monitored for hepatotoxicity and GI side effects. ..
  37. pmc Onset of mandible and tibia osteoradionecrosis: a comparative pilot study in the rat
    Monika Damek-Poprawa
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 115:201-11. 2013
    ..Osteoradionecrosis (ORN) is common in the jaws after radiotherapy. We hypothesized that the mandible is more susceptible to ORN than the tibia, based on site disparity in hypoxic, hypocellular, and hypovascular tissue breakdown...
  38. pmc ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
    Lori S Hart
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 5156, USA
    J Clin Invest 122:4621-34. 2012
    ..Our findings establish a role for UPR as an enhancer of c-Myc-induced transformation and suggest that UPR inhibition may be particularly effective against malignancies characterized by c-Myc overexpression...
  39. ncbi request reprint HIF and MIF--a nifty way to delay senescence?
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 20:3337-41. 2006
  40. ncbi request reprint Pulmonary function abnormalities in children treated with whole lung irradiation
    Daniel J Weiner
    Department of Pediatrics, Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 46:222-7. 2006
    ..We sought to determine the prevalence of abnormal pulmonary function tests (PFTs) in a cohort of children who had received whole lung irradiation (WLI) for treatment of metastatic disease...
  41. pmc Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19004, USA
    Mol Biol Cell 15:4841-53. 2004
    ..Others have proposed that the PI3K/Akt pathway can increase VEGF expression via the hypoxia-inducible factor 1 (HIF-1); however, our results suggest an alternative mechanism can also operate...
  42. pmc PI3K/AKT/mTOR Pathway in Angiogenesis
    Jayashree Karar
    Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania Philadelphia, PA, USA
    Front Mol Neurosci 4:51. 2011
    ..Hence, the PI3K pathway plays an important role in regulating angiogenesis both in normal tissues and in cancers...
  43. ncbi request reprint PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter
    Nabendu Pore
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:236-41. 2003
    ..Therefore, in human glioblastoma cells, PTEN mutation can cooperate with EGFR activation to increase VEGF mRNA levels by transcriptionally up-regulating the proximal VEGF promoter via the PI3K/Akt pathway...

Research Grants9

  1. Regulation of VEGF in Tumors by Ras, EGF and PTEN
    Amit Maity; Fiscal Year: 2005
    ..These experiments will lead to a better understanding of HIF-1 alpha regulation, mechanisms of VEGF overexpression in cancers, and the effects of EGFR activation and Ras and PTEN mutations on gene expression. ..
  2. Regulation of VEGF/HIF-1 by AKT: Implications for Radiotherapy
    Amit Maity; Fiscal Year: 2007
    ..Increased oxygenation should make tumors more sensitive to radiation; therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..
  3. Regulation of VEGF/HIF-1 by AKT: Implications for Radiotherapy
    Amit Maity; Fiscal Year: 2009
    ..Increased oxygenation should make tumors more sensitive to radiation; therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..
  4. Regulation of VEGF/HIF-1 by AKT: Implications for Radiotherapy
    Amit Maity; Fiscal Year: 2010
    ..Increased oxygenation should make tumors more sensitive to radiation;therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..