MAHIN MAINES

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C
    Peter E M Gibbs
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry Rochester, NY, USA
    Front Pharmacol 3:31. 2012
  2. ncbi request reprint Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Curr Drug Targets 11:1586-94. 2010
  3. ncbi request reprint Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Antioxid Redox Signal 9:2187-95. 2007
  4. ncbi request reprint Human biliverdin reductase, a previously unknown activator of protein kinase C betaII
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14624, USA
    J Biol Chem 282:8110-22. 2007
  5. ncbi request reprint The heme oxygenase system: update 2005
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14624, USA
    Antioxid Redox Signal 7:1761-6. 2005
  6. ncbi request reprint New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York, USA
    Physiology (Bethesda) 20:382-9. 2005
  7. ncbi request reprint 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events
    Mahin D Maines
    University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Avenue Rochester, NY 14624, USA
    Biochem Biophys Res Commun 338:568-77. 2005
  8. ncbi request reprint Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury
    M D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642 0001, USA
    J Pharmacol Exp Ther 291:911-9. 1999
  9. ncbi request reprint The heme oxygenase system and its functions in the brain
    M D Maines
    University of Rochester Medical Center, Department of Biochemistry Biophysics, New York 14642, USA
    Cell Mol Biol (Noisy-le-grand) 46:573-85. 2000
  10. ncbi request reprint Bile pigments: newcomers to the cell signaling arena
    Mahin D Maines
    University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Ave, Box 712, Rochester, NY 14620 2945, USA
    Toxicol Sci 71:9-10. 2003

Collaborators

  • V Calabrese
  • D A Butterfield
  • John D Phillips
  • Giovanni Scapagnini
  • Peter E M Gibbs
  • Tihomir Miralem
  • Nicole Lerner-Marmarosh
  • Cicerone Tudor
  • Michael D Torno
  • Zhenbo Hu
  • Anatoliy Kravets
  • Bo Ding
  • Robert D Mayer
  • Zulfiqar Ahmad
  • Frank G Whitby
  • Paul S Brookes
  • Fernando Revert
  • Juan Saus
  • Yves Engelborghs
  • Katherine M Lelli
  • Jenny Shen
  • Xiaojun Wang
  • William McCoubrey
  • Mohammad Salim
  • Christopher P Hill

Detail Information

Publications27

  1. pmc Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C
    Peter E M Gibbs
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry Rochester, NY, USA
    Front Pharmacol 3:31. 2012
    ..Presently, we have reviewed the function of hBVR in cell signaling with an emphasis on regulation of PKCδ activity...
  2. ncbi request reprint Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Curr Drug Targets 11:1586-94. 2010
    ..This, points to a realistic prospect of their use in clinical settings. The present review will briefly update cytoprotective activity and cytotoxicity of bile pigments and will focus on findings that link hBVR to cell signaling...
  3. ncbi request reprint Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Antioxid Redox Signal 9:2187-95. 2007
    ..Structural features of BVR and recent findings relevant to its function in cell-signaling pathways are reviewed here and are intended to complement a recent commentary on the role of BVR in linking heme metabolism and cell signaling...
  4. ncbi request reprint Human biliverdin reductase, a previously unknown activator of protein kinase C betaII
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14624, USA
    J Biol Chem 282:8110-22. 2007
    ..hBVR activation of PKC betaII underscores its potential function in propagation of signals relayed through PKCs...
  5. ncbi request reprint The heme oxygenase system: update 2005
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14624, USA
    Antioxid Redox Signal 7:1761-6. 2005
  6. ncbi request reprint New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York, USA
    Physiology (Bethesda) 20:382-9. 2005
    ..These, together with the protein's primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades...
  7. ncbi request reprint 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events
    Mahin D Maines
    University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Avenue Rochester, NY 14624, USA
    Biochem Biophys Res Commun 338:568-77. 2005
    ..This review is a compilation of certain older findings and recent events that together ensure placement of the HO system in the mainstream research for decades to come...
  8. ncbi request reprint Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury
    M D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642 0001, USA
    J Pharmacol Exp Ther 291:911-9. 1999
    ..We also suggest spin trap-mediated protection against ischemia/reperfusion injury is likely due to a sustained elevation of HO-1 gene expression by formation of stable radicals...
  9. ncbi request reprint The heme oxygenase system and its functions in the brain
    M D Maines
    University of Rochester Medical Center, Department of Biochemistry Biophysics, New York 14642, USA
    Cell Mol Biol (Noisy-le-grand) 46:573-85. 2000
    ..The present review is intended to highlight molecular properties of HO isozymes and their likely functions in the brain. Extended reviews of the system are found in Maines (1992, 1997)...
  10. ncbi request reprint Bile pigments: newcomers to the cell signaling arena
    Mahin D Maines
    University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Ave, Box 712, Rochester, NY 14620 2945, USA
    Toxicol Sci 71:9-10. 2003
    ..Tuomisto, Seppo Auriola, Raimo Pohjanvirta, Paula Syrjälä, Ulla Simanainen, Matti Viluksela, and Jouko Tuomisto (pp. 112-123)...
  11. ncbi request reprint Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1
    M D Maines
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Pharmacol Exp Ther 296:1091-7. 2001
    ....
  12. ncbi request reprint Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells
    Tihomir Miralem
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14624, USA
    J Biol Chem 280:17084-92. 2005
    ..The findings describe the function of BVR in HO-1 oxidative response and, demonstrate, for the first time, not only that BVR advances the role of HO-1 in cytoprotection but also affords cytoprotection independent of heme degradation...
  13. pmc Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
    Nicole Lerner-Marmarosh
    University of Rochester School of Medicine, Department of Biochemistry and Biophysics, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 105:6870-5. 2008
    ....
  14. pmc Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB
    Peter E M Gibbs
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    FASEB J 24:3239-54. 2010
    ....
  15. ncbi request reprint Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase
    Peter E M Gibbs
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 121:2567-74. 2007
    ..On the other hand, by increasing BVR levels beneficial functions of NF-kappaB might be augmented...
  16. ncbi request reprint Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
    Anatoliy Kravets
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 279:19916-23. 2004
    ..We propose that increased expression of the protein can be used to alter the gene expression profile in the cell...
  17. ncbi request reprint Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase
    Nicole Lerner-Marmarosh
    University of Rochester School of Medicine and Dentistry, Department of Biochemistry and Biophysics, 601 Elmwood Avenue, Rochester, NY 14642, USA
    FASEB J 21:3949-62. 2007
    ..The findings are of potential significance for development of modulators of PKC-zeta activity and cellular response to cytokines...
  18. pmc Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
    Nicole Lerner-Marmarosh
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14624, USA
    Proc Natl Acad Sci U S A 102:7109-14. 2005
    ....
  19. pmc Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression
    Tihomir Miralem
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 285:12551-8. 2010
    ..Collectively, our data reveal that hBVR is a regulator of the TNF-alpha-GPBP-collagen type IV signaling cascade and uncover a novel biological interaction that may be of relevance in autoimmune pathogenesis...
  20. ncbi request reprint Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress
    Zulfiqar Ahmad
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 277:9226-32. 2002
    ..We propose a role for BVR in the signaling cascade for AP-1 complex activation necessary for HO-1 oxidative stress response...
  21. pmc The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction
    Bo Ding
    University of Rochester School of Medicine and Dentistry, Department of Biochemistry and Biophysics, Rochester, NY 14642, USA
    FASEB J 25:301-13. 2011
    ..Finding that BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by small human BVR-based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions...
  22. ncbi request reprint Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase
    Robert D Mayer
    Department of Urology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Pharmacol Exp Ther 306:43-50. 2003
    ..Inhibition of NOS is potentially useful for sustained induction of HO-1 in organs that will be subjected to oxidative-stress insult...
  23. pmc Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin
    Cicerone Tudor
    Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, Leuven, Belgium
    Biochem J 413:405-16. 2008
    ..Because gene regulation is energy-dependent and haematin regulates gene expression, our data suggest that hBVR functions as an essential component of the regulatory mechanisms for haem-responsive transcriptional activation...
  24. ncbi request reprint Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex
    Frank G Whitby
    Department of Biochemistry, University of Utah School of Medicine, 50 N Medical Drive, Salt Lake City 84132, USA
    J Mol Biol 319:1199-210. 2002
    ..This finding suggests that the dominant role in catalysis may be performed by hydride transfer from the cofactor, a process that may be promoted by proximity of the invariant residues Glu96, Glu123, and Glu126, to the nicotinamide ring...
  25. ncbi request reprint Antiaging medicine: antioxidants and aging
    Vittorio Calabrese
    Antioxid Redox Signal 8:362-4. 2006
  26. ncbi request reprint Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 8:444-77. 2006
    ....
  27. ncbi request reprint The heme oxygenase system: past, present, and future
    Mahin D Maines
    Antioxid Redox Signal 6:797-801. 2004

Research Grants48

  1. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2000
    ..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
  2. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2009
    ..Liver will serve as the non-target organ as control for the expression of the transgene. ..
  3. ACTIVITIES OF BILIVERDIN REDUCTASE-EFFECT OF NEPHROTOXIN
    MAHIN MAINES; Fiscal Year: 2001
    ..4) To isolate the human BVR gene, characterize its promoter region and analyze its regulation by various toxins and effector agents. ..
  4. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001
    ..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
  5. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2002
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  6. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2007
    ..Liver will serve as the non-target organ as control for the expression of the transgene. ..
  7. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2006
    ..H202 will be utilized as the generator of 02 radicals. COS cells transfected with adenoviral vectors of effectors or their mutated counterparts will be used as the experimental model. ..
  8. Regulation of Cell Signaling by Human Biliverdin Reductase
    MAHIN MAINES; Fiscal Year: 2006
    ..For this, mice null for BVR gene will be generated to examine effects of phenylhydrazine and As (III), which are diabetogenic and promote cell death, on glucose metabolism and apoptosis. ..
  9. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2004
    ..H202 will be utilized as the generator of 02 radicals. COS cells transfected with adenoviral vectors of effectors or their mutated counterparts will be used as the experimental model. ..
  10. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2004
    ..H202 will be utilized as the generator of 02 radicals. COS cells transfected with adenoviral vectors of effectors or their mutated counterparts will be used as the experimental model. ..
  11. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2005
    ..H202 will be utilized as the generator of 02 radicals. COS cells transfected with adenoviral vectors of effectors or their mutated counterparts will be used as the experimental model. ..
  12. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  13. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 1999
    ..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
  14. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2010
    ..For this, mice null for BVR gene will be generated to examine effects of phenylhydrazine and As (III), which are diabetogenic and promote cell death, on glucose metabolism and apoptosis. ..
  15. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2011
    ..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
  16. Regulation of Cell Signaling by Human Biliverdin Reductase
    MAHIN MAINES; Fiscal Year: 2009
    ..For this, mice null for BVR gene will be generated to examine effects of phenylhydrazine and As (III), which are diabetogenic and promote cell death, on glucose metabolism and apoptosis. ..
  17. BILIVERDIN REDUCTASE--MULTIPLICITY & CONTROL BY TOXINS
    MAHIN MAINES; Fiscal Year: 1990
    ..6) To examine whether the phenomenon of multiplicity extends to human tissues and other rat organs (brain and testes)...
  18. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2009
    ..Liver will serve as the non-target organ as control for the expression of the transgene. ..
  19. BILIVERDIN REDUCTASE: MULTIPLICITY & CONTROL BY TOXINS
    MAHIN MAINES; Fiscal Year: 1991
    ..6) To examine whether the phenomenon of multiplicity extends to human tissues and other rat organs (brain and testes)...
  20. BILIVERDIN REDUCTASE: MULTIPLICITY & CONTROL BY TOXINS
    MAHIN MAINES; Fiscal Year: 1993
    ..6) To examine whether the phenomenon of multiplicity extends to human tissues and other rat organs (brain and testes)...
  21. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2004
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  22. Regulation of Cell Signaling by Human Biliverdin Reductase
    MAHIN MAINES; Fiscal Year: 2007
    ..For this, mice null for BVR gene will be generated to examine effects of phenylhydrazine and As (III), which are diabetogenic and promote cell death, on glucose metabolism and apoptosis. ..
  23. Regulation of heme oxygenase-1 by biliverdin reductase
    Mahin D Maines; Fiscal Year: 2010
    ..Liver will serve as the non-target organ as control for the expression of the transgene. ..
  24. ACTIVITIES OF BILIVERDIN REDUCTASE-EFFECT OF NEPHROTOXIN
    MAHIN MAINES; Fiscal Year: 2004
    ..4) To isolate the human BVR gene, characterize its promoter region and analyze its regulation by various toxins and effector agents. ..
  25. BILIVERDIN REDUCTASE: MULTIPLICITY & CONTROL BY TOXINS
    MAHIN MAINES; Fiscal Year: 1992
    ..6) To examine whether the phenomenon of multiplicity extends to human tissues and other rat organs (brain and testes)...
  26. BILIVERDIN REDUCTASE--MULTIPLICITY AND CONTROL BY TOXIN
    MAHIN MAINES; Fiscal Year: 1999
    ..Isolated protein, macrophages, hippocampal slices, and intact rats will be used. ..
  27. ACTIVITIES OF BILIVERDIN REDUCTASE-EFFECT OF NEPHROTOXIN
    MAHIN MAINES; Fiscal Year: 2000
    ..4) To isolate the human BVR gene, characterize its promoter region and analyze its regulation by various toxins and effector agents. ..
  28. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2001
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  29. ACTIVITIES OF BILIVERDIN REDUCTASE-EFFECT OF NEPHROTOXIN
    MAHIN MAINES; Fiscal Year: 2002
    ..4) To isolate the human BVR gene, characterize its promoter region and analyze its regulation by various toxins and effector agents. ..
  30. Heme Oxygenase-Regulation, Function&Clinical Application
    MAHIN MAINES; Fiscal Year: 2003
    ....
  31. Regulation of heme oxygenase-1 by biliverdin reductase
    MAHIN MAINES; Fiscal Year: 2003
    ..H202 will be utilized as the generator of 02 radicals. COS cells transfected with adenoviral vectors of effectors or their mutated counterparts will be used as the experimental model. ..
  32. ACTIVITIES OF BILIVERDIN REDUCTASE-EFFECT OF NEPHROTOXIN
    MAHIN MAINES; Fiscal Year: 2003
    ..4) To isolate the human BVR gene, characterize its promoter region and analyze its regulation by various toxins and effector agents. ..
  33. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2003
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  34. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2004
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..