Affiliation: University of North Carolina
- Parkinson's disease and D1 dopamine receptorsR Mailman
Department of Pharmacology, and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Curr Opin Investig Drugs 2:1582-91. 2001..These examples suggest that it is highly likely that the immense therapeutic potential of D1 agonists will be realized both in PD and several other important CNS disorders before the end of the decade...
- Amygdaloid D1 receptors are not linked to stimulation of adenylate cyclaseSarah K Leonard
Neuroscience Center, Departments of Psychiatry and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7250, USA
Synapse 50:320-33. 2003....
- Lower low-density lipoprotein cholesterol levels are associated with Parkinson's diseaseXuemei Huang
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Mov Disord 22:377-81. 2007..Thus, our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation...
- GPCR functional selectivity has therapeutic impactRichard B Mailman
Neurosciences Hospital, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Trends Pharmacol Sci 28:390-6. 2007..Together, these data provide support for the hypothesis that compounds with functionally selective properties in vitro are likely to have novel actions in vivo, opening doors to new avenues of drug discovery...
- Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging StudyXuemei Huang
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
Mov Disord 23:1013-8. 2008..2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD...
- Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugsCandace Andersson
Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA
Neuropsychopharmacology 27:143-51. 2002..The current data suggests that such differential responses may be due to both the pharmacological properties and the relative doses of the atypical agents...
- Functional selectivity and classical concepts of quantitative pharmacologyJonathan D Urban
Curriculum in Toxicology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
J Pharmacol Exp Ther 320:1-13. 2007..It also may be timely to revise classic concepts in quantitative pharmacology and relevant pharmacological conventions to incorporate these new concepts...
- Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: application in GPCR-mediated adenylate cyclase assaysJustin T Brown
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States
J Neurosci Methods 177:261-6. 2009..Use of aspects of this method can also improve throughput in other radioimmunoassays...
- Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in ratsStephanie Padilla
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 88:161-71. 2005..These data indicate that, although chronic feeding with or without intermittent spiked dosages with CPF produces substantial biochemical changes in a dose- and tissue-related manner, there are no persistent biochemical changes...
- A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophreniaMark S George
Brain Stimulation Laboratory BSL, Psychiatry Department, Medical University of South Carolina MUSC 29425, United States
Schizophr Res 93:42-50. 2007..No medication interactions were seen. Thus, a single subcutaneous dose of dihydrexidine is tolerated and safe in patients with schizophrenia and does not produce delayed clinical or neuropsychological improvements...
- A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophreniaQiwen Mu
Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
Schizophr Res 94:332-41. 2007..These data are consistent with the hypothesis formulated from studies of non-human primates that dihydrexidine and other D1 agonists may be able to modulate prefrontal dopaminergic function...
- Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligandsAmjad M Qandil
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, USA
Bioorg Med Chem 11:1451-64. 2003..Moreover, as rigid ligands in which small substituents can cause significant changes in selectivity, they are important tools for deriving 'differential' SARs of the dopamine receptor isoforms...