Ivan Maillard

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage
    Laleh Talebian
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Blood 109:11-21. 2007
  2. ncbi request reprint Regulation of lymphoid development, differentiation, and function by the Notch pathway
    Ivan Maillard
    Division of Hematology Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Annu Rev Immunol 23:945-74. 2005
  3. pmc The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
    Ivan Maillard
    Division of Hematology Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 203:2239-45. 2006
  4. ncbi request reprint Notch signaling controls the generation and differentiation of early T lineage progenitors
    Arivazhagan Sambandam
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:663-70. 2005
  5. pmc Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation
    Ivan Maillard
    611 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 107:3511-9. 2006
  6. ncbi request reprint Selective thymus settling regulated by cytokine and chemokine receptors
    Benjamin A Schwarz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:2008-17. 2007
  7. ncbi request reprint Immunology. Keeping a tight leash on Notch
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 316:840-2. 2007
  8. ncbi request reprint Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Blood 104:1696-702. 2004
  9. pmc Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
    Karen Keeshan
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Cell 10:401-11. 2006
  10. pmc Multiple prethymic defects underlie age-related loss of T progenitor competence
    Valerie P Zediak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 110:1161-7. 2007

Collaborators

Detail Information

Publications27

  1. pmc T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage
    Laleh Talebian
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Blood 109:11-21. 2007
    ..Our data define a critical CBFbeta threshold for normal T-cell development, and situate an essential role for core-binding factors during the earliest stages of T-cell development...
  2. ncbi request reprint Regulation of lymphoid development, differentiation, and function by the Notch pathway
    Ivan Maillard
    Division of Hematology Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Annu Rev Immunol 23:945-74. 2005
    ..Thus, the full spectrum of Notch effects is just beginning to be understood. In this review, we discuss this explosion of knowledge as well as current controversies and challenges in the field...
  3. pmc The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
    Ivan Maillard
    Division of Hematology Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 203:2239-45. 2006
    ..These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional activation by Notch via the CSL/RBP-J-MAML complex...
  4. ncbi request reprint Notch signaling controls the generation and differentiation of early T lineage progenitors
    Arivazhagan Sambandam
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:663-70. 2005
    ..In contrast, multipotent hematopoietic progenitors circulated in the blood even in the absence of Notch signaling, suggesting that critical Notch signals during early T lineage development are delivered early after thymic entry...
  5. pmc Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation
    Ivan Maillard
    611 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 107:3511-9. 2006
    ..Our data show plasticity of T-lineage commitment sites in the post-BMT environment and indicate that Notch-driven extrathymic Tlineage commitment from multipotent progenitors may contribute to early T-lineage reconstitution after BMT...
  6. ncbi request reprint Selective thymus settling regulated by cytokine and chemokine receptors
    Benjamin A Schwarz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:2008-17. 2007
    ..We conclude that fms-like tyrosine kinase receptor-3 signaling is required for the generation of T lineage-competent progenitors, which selectively express molecules, including CCR9, that allow them to settle within the thymus...
  7. ncbi request reprint Immunology. Keeping a tight leash on Notch
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 316:840-2. 2007
  8. ncbi request reprint Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Blood 104:1696-702. 2004
    ..These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members...
  9. pmc Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
    Karen Keeshan
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Cell 10:401-11. 2006
    ..Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha...
  10. pmc Multiple prethymic defects underlie age-related loss of T progenitor competence
    Valerie P Zediak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 110:1161-7. 2007
    ..These results identify T-compromised aged HSCs and define the nature and cellular sites of prethymic, age-related defects in T-lineage differentiation potential...
  11. ncbi request reprint Closer to the source: notch and the nature of thymus-settling cells
    Valerie P Zediak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunity 23:245-8. 2005
    ..Three new papers together show that for at least some thymus-settling precursors, the loss of B lineage potential occurs in the thymus, and Notch acts on multipotent progenitors early after thymic entry...
  12. ncbi request reprint From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    Immunity 18:587-9. 2003
    ..Thus, different Notch receptors have specific and nonoverlapping functions that influence multiple hematopoietic lineages at various stages of development...
  13. ncbi request reprint Use of iodine 131I-tositumomab radioimmunotherapy in a patient with Waldenstrom's macroglobulinemia
    Donald E Tsai
    Bone Marrow and Stem Cell Transplant Program, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Leuk Lymphoma 45:591-5. 2004
    ..The patient had a complete response to the treatment, including disappearance of any detectable IgM paraprotein. This case report demonstrates the potential for radioimmunotherapy in CD20 positive B-cell malignancies...
  14. ncbi request reprint Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation
    Matthew Thomas
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Blood 109:3342-50. 2007
    ..These data suggest that the BCR and CD40 signaling pathways collaborate with the Notch pathway to optimize B-cell activation...
  15. ncbi request reprint Notch and the immune system
    Ivan Maillard
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 19:781-91. 2003
    ..In this review, we critically assess recent findings regarding the function of Notch in the hematolymphoid system...
  16. pmc Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias
    Lesley A Rakowski
    Division of Hematology Oncology, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 73:930-41. 2013
    ..They also raise new inquiries into potential NOTCH-ZMIZ1 collaboration in a variety of C-MYC-driven cancers...
  17. ncbi request reprint Utility of fluorodeoxyglucose-PET imaging in the management of patients with Hodgkin's and non-Hodgkin's lymphomas
    Rakesh Kumar
    Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 110 Donner Building, Philadelphia, PA 19104, USA
    Radiol Clin North Am 42:1083-100. 2004
    ..In addition, a baseline PET scan will help detect relapse or residual disease, because relapse occurs most often in the region of previous disease...
  18. ncbi request reprint Notch and cancer: best to avoid the ups and downs
    Ivan Maillard
    Division of Hematology Oncology, Institute for Medicine and Engineering, University of Pennsylvania, 611 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Cell 3:203-5. 2003
    ....
  19. pmc Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells
    Xuan Pan
    Department of Animal Biology, School of Veterinary, University of Pennsylvania, Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e30656. 2012
    ..B cell apoptosis and LT-HSC enrichment induced by YY1 suggest that novel strategies to induce YY1 expression could have beneficial effects in the treatment of B lineage malignancies while preserving normal HSCs...
  20. pmc Notch signaling is an important regulator of type 2 immunity
    LiLi Tu
    Department of Pathology and Laboratory Medicine, School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 202:1037-42. 2005
    ..In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity...
  21. ncbi request reprint Notch signaling in cancer
    Eric J Allenspach
    Departments of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Biol Ther 1:466-76. 2002
    ..Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway...
  22. ncbi request reprint Use of ibritumomab tiuxetan anti-CD20 radioimmunotherapy in a non-Hodgkin's lymphoma patient previously treated with a yttrium-90-labeled anti-CD22 monoclonal antibody
    Donald E Tsai
    Bone Marrow and Stem Cell Transplant Program, University of Pennsylvania Cancer Center, Philadelphia, 19104, USA
    Clin Lymphoma 4:56-9. 2003
    ..This case report demonstrates the potential for repeated treatments with radioimmunotherapy agents in patients with chemotherapy-refractory non-Hodgkin's lymphoma...
  23. pmc The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development
    Lizi Wu
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:3618-23. 2007
    ..Moreover, the number of MZB cells correlated with Maml1 gene dosage. Since all 3 Maml genes were expressed in MZB cells and their precursors, these results suggest that Maml1 is specifically required for Notch2 signaling in MZB cells...
  24. pmc Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification
    Yalin Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Blood 112:480-92. 2008
    ..Therefore, the ability of the prethymic cell to respond appropriately to Notch is dependent on CBFbeta, and both signals converge to activate the T-cell developmental program...
  25. pmc Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells
    Margarida Almeida Santos
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    Proc Natl Acad Sci U S A 104:15454-9. 2007
    ..These results indicate that Notch ligands participate in the definition of the mature B cell microenvironment that influences their terminal differentiation...
  26. pmc Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells
    Ivan Maillard
    Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 2:356-66. 2008
    ..Furthermore, Notch target genes were expressed at low levels in primitive hematopoietic progenitors. Taken together, these results rule out an essential physiological role for cell-autonomous canonical Notch signals in HSC maintenance...
  27. doi request reprint Notch signaling specifies megakaryocyte development from hematopoietic stem cells
    Thomas Mercher
    Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 20115, USA
    Cell Stem Cell 3:314-26. 2008
    ..These findings indicate that Notch is a positive regulator of megakaryopoiesis and plays a more complex role in cell-fate decisions among myeloid progenitors than previously appreciated...