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Genomes and Genes | Ivan MaillardSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosageLaleh Talebian
Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Blood 109:11-21. 2007..Our data define a critical CBFbeta threshold for normal T-cell development, and situate an essential role for core-binding factors during the earliest stages of T-cell development...- Regulation of lymphoid development, differentiation, and function by the Notch pathwayIvan Maillard
Division of Hematology Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
Annu Rev Immunol 23:945-74. 2005..Thus, the full spectrum of Notch effects is just beginning to be understood. In this review, we discuss this explosion of knowledge as well as current controversies and challenges in the field... - The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptorIvan Maillard
Division of Hematology Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 203:2239-45. 2006..These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional activation by Notch via the CSL/RBP-J-MAML complex... - Notch signaling controls the generation and differentiation of early T lineage progenitorsArivazhagan Sambandam
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 6:663-70. 2005..In contrast, multipotent hematopoietic progenitors circulated in the blood even in the absence of Notch signaling, suggesting that critical Notch signals during early T lineage development are delivered early after thymic entry... - Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantationIvan Maillard
611 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
Blood 107:3511-9. 2006..Our data show plasticity of T-lineage commitment sites in the post-BMT environment and indicate that Notch-driven extrathymic Tlineage commitment from multipotent progenitors may contribute to early T-lineage reconstitution after BMT... - Immunology. Keeping a tight leash on NotchIvan Maillard
Division of Hematology-Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Science 316:840-2. 2007 - Selective thymus settling regulated by cytokine and chemokine receptorsBenjamin A Schwarz
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 178:2008-17. 2007..We conclude that fms-like tyrosine kinase receptor-3 signaling is required for the generation of T lineage-competent progenitors, which selectively express molecules, including CCR9, that allow them to settle within the thymus... - Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemiaKaren Keeshan
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Cell 10:401-11. 2006..Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha... - Mastermind critically regulates Notch-mediated lymphoid cell fate decisionsIvan Maillard
Division of Hematology Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Blood 104:1696-702. 2004..These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members... - Multiple prethymic defects underlie age-related loss of T progenitor competenceValerie P Zediak
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Blood 110:1161-7. 2007..These results identify T-compromised aged HSCs and define the nature and cellular sites of prethymic, age-related defects in T-lineage differentiation potential... - Closer to the source: notch and the nature of thymus-settling cellsValerie P Zediak
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Immunity 23:245-8. 2005..Three new papers together show that for at least some thymus-settling precursors, the loss of B lineage potential occurs in the thymus, and Notch acts on multipotent progenitors early after thymic entry... - From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesisIvan Maillard
Division of Hematology-Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
Immunity 18:587-9. 2003..Thus, different Notch receptors have specific and nonoverlapping functions that influence multiple hematopoietic lineages at various stages of development... - Use of iodine 131I-tositumomab radioimmunotherapy in a patient with Waldenstrom's macroglobulinemiaDonald E Tsai
Bone Marrow and Stem Cell Transplant Program, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania 19104, USA
Leuk Lymphoma 45:591-5. 2004..The patient had a complete response to the treatment, including disappearance of any detectable IgM paraprotein. This case report demonstrates the potential for radioimmunotherapy in CD20 positive B-cell malignancies... - Notch and the immune systemIvan Maillard
Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 19:781-91. 2003..In this review, we critically assess recent findings regarding the function of Notch in the hematolymphoid system... - Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activationMatthew Thomas
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
Blood 109:3342-50. 2007..These data suggest that the BCR and CD40 signaling pathways collaborate with the Notch pathway to optimize B-cell activation... - Notch and cancer: best to avoid the ups and downsIvan Maillard
Division of Hematology Oncology, Institute for Medicine and Engineering, University of Pennsylvania, 611 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Cell 3:203-5. 2003.... - Utility of fluorodeoxyglucose-PET imaging in the management of patients with Hodgkin's and non-Hodgkin's lymphomasRakesh Kumar
Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 110 Donner Building, Philadelphia, PA 19104, USA
Radiol Clin North Am 42:1083-100. 2004..In addition, a baseline PET scan will help detect relapse or residual disease, because relapse occurs most often in the region of previous disease... - Increased Expression of PcG Protein YY1 Negatively Regulates B Cell Development while Allowing Accumulation of Myeloid Cells and LT-HSC CellsXuan Pan
Department of Animal Biology, School of Veterinary, University of Pennsylvania, Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 7:e30656. 2012..B cell apoptosis and LT-HSC enrichment induced by YY1 suggest that novel strategies to induce YY1 expression could have beneficial effects in the treatment of B lineage malignancies while preserving normal HSCs... - Notch signaling is an important regulator of type 2 immunityLiLi Tu
Department of Pathology and Laboratory Medicine, School of Veterinary Medicine, Philadelphia, PA 19104, USA
J Exp Med 202:1037-42. 2005..In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity... - Use of ibritumomab tiuxetan anti-CD20 radioimmunotherapy in a non-Hodgkin's lymphoma patient previously treated with a yttrium-90-labeled anti-CD22 monoclonal antibodyDonald E Tsai
Bone Marrow and Stem Cell Transplant Program, University of Pennsylvania Cancer Center, Philadelphia, 19104, USA
Clin Lymphoma 4:56-9. 2003..This case report demonstrates the potential for repeated treatments with radioimmunotherapy agents in patients with chemotherapy-refractory non-Hodgkin's lymphoma... - Notch signaling in cancerEric J Allenspach
Departments of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Biol Ther 1:466-76. 2002..Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway... - The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell developmentLizi Wu
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Blood 110:3618-23. 2007..Moreover, the number of MZB cells correlated with Maml1 gene dosage. Since all 3 Maml genes were expressed in MZB cells and their precursors, these results suggest that Maml1 is specifically required for Notch2 signaling in MZB cells... - Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cellsMargarida Almeida Santos
Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
Proc Natl Acad Sci U S A 104:15454-9. 2007..These results indicate that Notch ligands participate in the definition of the mature B cell microenvironment that influences their terminal differentiation... - Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specificationYalin Guo
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
Blood 112:480-92. 2008..Therefore, the ability of the prethymic cell to respond appropriately to Notch is dependent on CBFbeta, and both signals converge to activate the T-cell developmental program... - Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cellsIvan Maillard
Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Cell Stem Cell 2:356-66. 2008..Furthermore, Notch target genes were expressed at low levels in primitive hematopoietic progenitors. Taken together, these results rule out an essential physiological role for cell-autonomous canonical Notch signals in HSC maintenance... - Notch signaling specifies megakaryocyte development from hematopoietic stem cellsThomas Mercher
Department of Medicine, Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 20115, USA
Cell Stem Cell 3:314-26. 2008..These findings indicate that Notch is a positive regulator of megakaryopoiesis and plays a more complex role in cell-fate decisions among myeloid progenitors than previously appreciated...