STEVEN MAIER

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
    Mol Pain 1:9. 2005
  2. ncbi Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition
    S F Maier
    Department of Psychology, University of Colorado, Boulder 80309 0345, USA
    Psychol Rev 105:83-107. 1998
  3. ncbi Bi-directional immune-brain communication: Implications for understanding stress, pain, and cognition
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus box 345 80309 0345, Boulder, CO, USA
    Brain Behav Immun 17:69-85. 2003
  4. ncbi Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder 80309 0345, USA
    Brain Behav Immun 17:S125-31. 2003
  5. ncbi Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Neurosci Biobehav Rev 29:829-41. 2005
  6. ncbi The role of the vagus nerve in cytokine-to-brain communication
    S F Maier
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Ann N Y Acad Sci 840:289-300. 1998
  7. ncbi Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007
  8. ncbi Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
  9. ncbi Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression
    Abigail B Ginsberg
    Center for Neuroscience and Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309-0345, USA
    Neuroendocrinology 80:252-63. 2004
  10. ncbi A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine
    Ian N Johnston
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:7353-65. 2004

Research Grants

  1. Stressor Controllability: The Role of the mPFC in Producing Resiliency
    STEVEN MAIER; Fiscal Year: 2009
  2. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    STEVEN MAIER; Fiscal Year: 2009
  3. Neuroinflammation, Inflammatory Challenge, and Memory
    STEVEN MAIER; Fiscal Year: 2009
  4. Stressor Controllability: The Role of the mPFC in Producing Resiliency
    Steven F Maier; Fiscal Year: 2010
  5. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    Steven F Maier; Fiscal Year: 2010
  6. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    STEVEN MAIER; Fiscal Year: 2007
  7. Neuroinflammation, Inflammatory Challenge, and Memory
    STEVEN MAIER; Fiscal Year: 2007
  8. Stressor Controllability: The Role of the mPFC in Producing Resiliency
    STEVEN MAIER; Fiscal Year: 2007
  9. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    STEVEN MAIER; Fiscal Year: 2005
  10. Neuroinflammation, Inflammatory Challenge, and Memory
    Steven F Maier; Fiscal Year: 2010

Collaborators

Detail Information

Publications85

  1. ncbi Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
    Mol Pain 1:9. 2005
    ..Taken together, these data provide initial support that intrathecal gene therapy to drive the production of IL-10 may prove to be an efficacious treatment for neuropathic pain...
  2. ncbi Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition
    S F Maier
    Department of Psychology, University of Colorado, Boulder 80309 0345, USA
    Psychol Rev 105:83-107. 1998
    ..Finally, it is argued that activation of immune-brain pathways is important for understanding diverse phenomena related to stress such as depression and suppression of specific immunity...
  3. ncbi Bi-directional immune-brain communication: Implications for understanding stress, pain, and cognition
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus box 345 80309 0345, Boulder, CO, USA
    Brain Behav Immun 17:69-85. 2003
    ..Finally, these phenomena are placed in an evolutionary perspective...
  4. ncbi Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder 80309 0345, USA
    Brain Behav Immun 17:S125-31. 2003
    ....
  5. ncbi Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Neurosci Biobehav Rev 29:829-41. 2005
    ..Finally, implications for the general role of corticotropin-releasing hormone in stress-related phenomena and for the learned helplessness paradigm as an animal model of either depression or anxiety are discussed...
  6. ncbi The role of the vagus nerve in cytokine-to-brain communication
    S F Maier
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Ann N Y Acad Sci 840:289-300. 1998
    ..Data extending this analysis to TNF-alpha and intravenous routes will be described...
  7. ncbi Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007
    ..We propose that targeting the production of proinflammatory cytokines by intrathecal IL-10 gene therapy may be a promising therapeutic strategy for the relief of paclitaxel-induced neuropathic pain...
  8. ncbi Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
    ..These data implicate multiple opioid-induced spinal proinflammatory cytokines in opposing both acute and chronic opioid analgesia, and provide a novel mechanism for the opposition of acute opioid analgesia...
  9. ncbi Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression
    Abigail B Ginsberg
    Center for Neuroscience and Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309-0345, USA
    Neuroendocrinology 80:252-63. 2004
    ..These data suggest that the ultimate source of the IS-induced sensitization is not the anterior pituitary and implicate an increased drive on the anterior pituitary from the pPVN...
  10. ncbi A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine
    Ian N Johnston
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:7353-65. 2004
    ..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates...
  11. ncbi Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 23:1026-40. 2003
    ..These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions...
  12. ncbi Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:240-50. 2009
    ..Hence, suppression of glial proinflammatory responses can significantly reduce opioid withdrawal, while improving analgesia...
  13. ncbi Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia
    Mark R Hutchinson
    Department of Psychology, The Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1248-56. 2008
    ....
  14. ncbi The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 22:1020-6. 2002
    ..The potential role of the caudal DRN in states of anxiety is discussed...
  15. ncbi Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120
    Diana K Schoeniger-Skinner
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 30809 0345, USA
    Brain Behav Immun 21:660-7. 2007
    ..These results would suggest that IL-6 induces pain facilitation, and may do so in part by stimulating the production and release of other pro-inflammatory cytokines...
  16. ncbi Evidence that opioids may have toll-like receptor 4 and MD-2 effects
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:83-95. 2010
    ..These data provide evidence that select opioids may non-stereoselectively influence TLR4 signaling and have behavioral consequences resulting, in part, via TLR4 signaling...
  17. ncbi Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain
    Sondra T Bland
    Department of Psychology, University of Colorado, Denver, CO 80204, USA
    Brain Behav Immun 24:329-38. 2010
    ..These changes include marked alterations in glia, as well as influences on neurogenesis in brain regions important for cognition...
  18. ncbi Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain
    Linda R Watkins
    Department of Psychology, Center for Neurosciences, University of Colorado at Boulder, USA
    Adv Exp Med Biol 521:1-21. 2003
    ..The take-home message is that drugs that target glia and the chemical substances that these glia release are predicted to be powerful remedies for pain problems in people...
  19. ncbi Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons
    Benjamin N Greenwood
    Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309-0354, USA
    J Neurosci 23:2889-98. 2003
    ..An increase in 5-HT1A inhibitory autoreceptor expression may contribute to the attenuation of DRN 5-HT activity and the prevention of LH in physically active rats...
  20. ncbi Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress
    Michael V Baratta
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 30:1111-6. 2009
    ..These results suggest that the PL selectively responds to behavioral control and utilizes such information to regulate the brainstem response to ongoing and subsequent stressors...
  21. ncbi Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 28:20-9. 2008
    ..Thus, these data suggest that (+)-opioid antagonists such as (+)-naloxone may be useful clinically to suppress glial activation, yet (-)-opioid agonists suppress pain...
  22. ncbi Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1
    Timothy R Chapman
    Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 30:7598-603. 2010
    ....
  23. ncbi Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309-0345, USA
    Pain 115:71-83. 2005
    ..Taken together these data highlight the importance of microglial activation in the development of exaggerated pain states...
  24. ncbi Spinal gap junctions: potential involvement in pain facilitation
    Leah E Spataro
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 90309-0345, USA
    J Pain 5:392-405. 2004
    ..In addition, it decreased gp120-induced proinflammatory cytokines. This suggests gap junction activation might lead to proinflammatory cytokine release by distantly activated glia...
  25. ncbi The cortical innate immune response increases local neuronal excitability leading to seizures
    Krista M Rodgers
    Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309, USA
    Brain 132:2478-86. 2009
    ....
  26. ncbi Stressor exposure produces long-term reductions in antigen-specific T and B cell responses
    Lawrence S Gazda
    Department of Psychology, University of Colorado at Boulder, CO 80309-0354, USA
    Stress 6:259-67. 2003
    ....
  27. ncbi Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta
    Adelina Holguin
    Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Neurosci Methods 161:265-72. 2007
    ..This IL-1beta response was also temporo-spatially dependent. Thus, the pro-inflammatory sequelae of intracranial cannulation should be considered when designing studies of neuroinflammatory processes...
  28. ncbi Role of the medial prefrontal cortex in coping and resilience
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Res 1355:52-60. 2010
    ..e., stressor resistance. This controllability-induced proactive stressor resistance generalizes across very different stressors and may be involved in determining individual difference in reactions to traumatic events...
  29. ncbi The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats
    Andre Der-Avakian
    Department of Psychology and Center for Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 191:899-907. 2007
    ..However, prior work suggests that IS might sensitize nonopioid drug responding if the drug were to be preceded by a mild stressor...
  30. ncbi Behavioral control, the medial prefrontal cortex, and resilience
    Steven F Maier
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Colorado 80309 0345, USA
    Dialogues Clin Neurosci 8:397-406. 2006
    ..The general implications of these results for understanding resilience in the face of adversity are discussed...
  31. ncbi Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat
    John P Christianson
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Stress 12:445-50. 2009
    ..The relationship between the vmPFC, dorsal raphé nucleus, and other structures mediating stress-induced anxiety are discussed...
  32. ncbi Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:131-46. 2007
    ....
  33. ncbi Activation of the infralimbic cortex in a fear context enhances extinction learning
    Brittany M Thompson
    Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309 0345, USA
    Learn Mem 17:591-9. 2010
    ..The results indicate a novel persisting control of fear induced by activation of the IL and suggest that IL activation induces changes in extinction-related circuitry that prime extinction learning...
  34. ncbi Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood
    Staci D Bilbo
    Department of Psychology, Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:332-42. 2007
    ..Taken together, these data suggest that maternal care may profoundly influence neuroinflammatory processes in adulthood, and that infection may also prevent maternal care influences on cognition later in life...
  35. ncbi Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:47-59. 2007
    ..The present results suggest that stress can activate microglia, thereby sensitizing the pro-inflammatory reactivity of microglia to immunogenic stimuli...
  36. ncbi Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain
    Lisa C Loram
    Department of Psychology and Center for Neurosciences, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    J Neurosci 29:14015-25. 2009
    ..Activation of A(2A)Rs after intrathecal administration may be a novel, therapeutic approach for the treatment of neuropathic pain by increasing IL-10 in the immunocompetent cells of the CNS...
  37. ncbi Below level central pain induced by discrete dorsal spinal cord injury
    Julie Wieseler
    Department of Psychology and Neuroscience and the Center for Neurosciences, Campus Box 345, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurotrauma 27:1697-707. 2010
    ..The new model described here is the first to use discrete dorsal horn damage by dorsal root avulsion to create below-level bilateral central neuropathic pain...
  38. ncbi Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:46-54. 2009
    ..These data suggest that the exaggerated and prolonged elevation of IL-1 beta, specifically in the hippocampus, may be responsible for hippocampal-dependent memory impairments observed in aging rats following a bacterial infection...
  39. ncbi The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control
    John P Christianson
    Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 28:13703-11. 2008
    ..These results indicate that stressor-modulators can recruit distinct neural circuitry and imply a critical role of the sensory insula in safety learning...
  40. ncbi Characterization of the sickness response in young and aging rats following E. coli infection
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado, Campus Box 345, Boulder, CO 80309, USA
    Brain Behav Immun 23:450-4. 2009
    ....
  41. ncbi The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release
    Sondra T Bland
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:492-7. 2009
    ..These results indicate that glial activation contributes to the effects of morphine on NAc DA, which is associated with somatic signs of precipitated withdrawal...
  42. ncbi The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration
    John P Christianson
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Behav Brain Res 193:87-93. 2008
    ..We argue that DRN-5-HT activation mediates a state of generalized anxiety produced by uncontrollable stress and that juvenile social exploration is a useful behavioral endpoint in stressor controllability studies...
  43. ncbi The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress
    Robert R Rozeske
    Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Neuropsychopharmacology 34:834-43. 2009
    ....
  44. ncbi "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids
    Linda R Watkins
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res Rev 56:148-69. 2007
    ..Such changes in neuronal function would be expected to occur wherever immune-derived substances come in close contact with neurons...
  45. ncbi A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats
    Julie Wieseler
    Department of Psychology and Center for Neurosciences, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    J Neurosci Methods 185:236-45. 2010
    ..This model allows time- and dose-dependent assessment of the relationship between changes in meningeal inflammation and corresponding exaggerated pain behaviors...
  46. ncbi Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2
    Sondra T Bland
    Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, 80309 0345, USA
    Neuroreport 17:593-7. 2006
    ..Thus, stressor controllability modulates stress-induced decreases in neurogenesis and increases in fibroblast growth factor-2...
  47. ncbi The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine
    Andre Der-Avakian
    Department of Psychology and Center for Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 31:653-63. 2006
    ....
  48. ncbi The consequences of uncontrollable stress are sensitive to duration of prior wheel running
    Benjamin N Greenwood
    Department of Integrative Physiology, University of Colorado, Boulder, 80309-0354, USA
    Brain Res 1033:164-78. 2005
    ..The potential role of the BNST in the prevention of LH by wheel running is discussed...
  49. ncbi HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)
    Adelina Holguin
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Pain 110:517-30. 2004
    ..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines...
  50. ncbi Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    Heidi E W Day
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Comp Neurol 474:364-78. 2004
    ..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
  51. ncbi Glial activation and pathological pain
    Julie Wieseler-Frank
    Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Neurochem Int 45:389-95. 2004
    ..Moreover, the glial-neuronal interactions discussed here are likely not exclusive to pain, but rather are likely to play significant roles in other behavioral phenomena...
  52. ncbi Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects
    Kevin A O'Connor
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Cytokine 24:254-65. 2003
    ..Nonetheless, these data suggest that HMGB1 may play a role as an endogenous pyrogen and support the concept that HMGB1 has proinflammatory characteristics within the central nervous system...
  53. ncbi Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex
    Sondra T Bland
    Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Neuropsychopharmacology 28:1589-96. 2003
    ..No changes in DA efflux were observed after morphine. Thus, 5-HT and DA in the mPFC may be involved in stressor controllability effects, and the sensitization of 5-HT neurons by IS extends to the mPFC and to morphine as a challenge...
  54. ncbi Effects of prior stress on LPS-induced cytokine and sickness responses
    John D Johnson
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0345, USA
    Am J Physiol Regul Integr Comp Physiol 284:R422-32. 2003
    ..These data suggest that enhanced proinflammatory cytokine responses are not necessary to observe enhanced HPA or fever responses...
  55. ncbi Beyond neurons: evidence that immune and glial cells contribute to pathological pain states
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado
    Physiol Rev 82:981-1011. 2002
    ..Indeed, all nerves and neurons regardless of modality or function are likely affected by immune and glial activation in the ways described for pain...
  56. ncbi Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus
    Ruth M Barrientos
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, CB345, Boulder, CO 80309, USA
    Behav Brain Res 134:291-8. 2002
    ..At this time the mechanisms responsible for this impairment are not understood, but may involve late-phase protein synthesis processes associated with LTP, because later consolidation processes are being disrupted...
  57. ncbi Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex
    Jose Amat
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 26:13264-72. 2006
    ..Moreover, the mPFCv may be a site of storage or plasticity concerning controllability information. These results are consistent with recent research in other domains that explore the functions of the mPFCv...
  58. ncbi Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats
    Andre Der-Avakian
    Department of Psychology and Center for Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 179:409-17. 2005
    ..We have previously shown that an acute uncontrollable stressor (inescapable shock, IS) potentiates the rewarding effects of morphine using conditioned place preference (CPP)...
  59. ncbi Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress
    Sondra T Bland
    Department of Psychology, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Res 1051:90-9. 2005
    ..These results reveal sex differences in inescapable stress-induced gene expression that may have implications for differences in vulnerability to stress-related disorders...
  60. ncbi A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats
    Staci D Bilbo
    Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Behav Brain Res 169:39-47. 2006
    ..Taken together, we have demonstrated that neonatal infection results in robust hippocampal-dependent memory impairment following an immune challenge in adulthood using a number of conditioning paradigms...
  61. ncbi Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    Annemarie Ledeboer
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 22:1977-86. 2005
    ..Together, these results demonstrate that spinal cord NF-kappaB activation is involved, at least in part, in exaggerated pain states...
  62. ncbi Central proinflammatory cytokines and pain enhancement
    Julie Wieseler-Frank
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, CO 80309 0345, USA
    Neurosignals 14:166-74. 2005
    ..Gene therapy to augment the endogenous anti-inflammatory cytokine, interleukin-10, is one of the more promising therapies currently under study...
  63. ncbi mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:717-22. 2006
    ..The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS...
  64. ncbi Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition
    Staci D Bilbo
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 25:8000-9. 2005
    ..These data implicate IL-1beta in the set of immune/inflammatory events that occur in the brain as a result of neonatal infection, which likely contribute to cognitive alterations in adulthood...
  65. ncbi Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide
    Marucia Chacur
    Instituto Butantan, Sao Paolo, Brazil
    Pain 108:180-91. 2004
    ..As a variety of immune cells also produce and release sPLA2s during inflammatory states, the data may have general implications for the understanding of inflammatory pain...
  66. ncbi Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychiatry, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Behav Brain Res 147:55-64. 2003
    ..In a separate experiment, the effective dose of CRH blocked the usual behavioral consequences of uncontrollable stress...
  67. ncbi Glia: a novel drug discovery target for clinical pain
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309-0345, USA
    Nat Rev Drug Discov 2:973-85. 2003
  68. ncbi Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders
    Stefania Bonaccorso
    Psychiatric Hospital, University La Sapienza, Rome, Italy
    J Affect Disord 77:143-8. 2003
    ..DISCUSSION: Acute and chronic administration of IL-1beta significantly increase the latency of escape to a foot shock, whereas repeated IL-1beta administration does not induce a sensitization of these behavioral responses...
  69. ncbi Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats
    Matthew J Will
    Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, WI 53719, USA
    Psychopharmacology (Berl) 171:191-8. 2004
    ..CONCLUSIONS: These data implicate alterations in DRN 5-HT neurons in the potentiation of morphine reward produced by uncontrollable stress...
  70. ncbi Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychiatry and Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:1019-25. 2003
    ..Ucn II was effective at doses 100-fold lower than those previously required for CRH. The relationship between CRH(2) receptors and DRN 5-HT is discussed...
  71. ncbi Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, 80309 0345, USA
    J Pain 7:757-67. 2006
    ..As such, this might represent the first evidence for pain facilitation occurring in the absence of glial involvement...
  72. ncbi Neonatal infection induces memory impairments following an immune challenge in adulthood
    Staci D Bilbo
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Behav Neurosci 119:293-301. 2005
    ..Infection during development appears to alter glia within the hippocampus, which may contribute to altered cytokine responses and memory impairment...
  73. ncbi Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression
    Matthew G Frank
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 32:376-84. 2007
    ..Exogenous CORT mimicked the effects of ES and IS on FGF-2, but not FGF-2-AS mRNA. The present study demonstrates that glucocorticoids mediate the effects of stress on FGF-2 and FGF-2-AS...
  74. ncbi A role for G protein-coupled receptor kinase 2 in mechanical allodynia
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Eur J Neurosci 25:1696-704. 2007
    ..We propose cytokine-induced down-regulation of spinal cord neuronal GRK2 expression as a novel mechanism that contributes to increased neuronal signalling in mechanical allodynia...
  75. ncbi Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization
    Carin M Twining
    Department of Psychology and the Center of Neuroscience, University of Colorado at Boulder, 80309, USA
    J Pain 6:174-83. 2005
    ..These data suggest that complement activation within the spinal cord might contribute to enhanced pain states and provide additional evidence for immune regulation of pain transmission...
  76. ncbi Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    ScientificWorldJournal 7:98-111. 2007
    ....
  77. ncbi Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Brain Behav Immun 22:451-5. 2008
    ..Taken together, these data indicate that early infection strongly influences the induction of IL-1beta and BDNF within distinct regions of the hippocampus, which likely contribute to observed memory impairments in adulthood...
  78. ncbi Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats
    Staci D Bilbo
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Psychoneuroendocrinology 33:261-9. 2008
    ....
  79. ncbi Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat
    Luiz F Takase
    Departmento de Anatomia, , , Brasil
    Behav Brain Res 162:299-306. 2005
    ..The relevance of these results for elucidating the neural bases of psychopathology is discussed...
  80. ncbi Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine
    Sondra T Bland
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado, Boulder, CO 80309 0345, USA
    Neuroreport 15:2637-41. 2004
    ..Morphine produced an enhanced increase in DA in the Stress-Sham group that was completely blocked by 5,7-DHT lesions, suggesting that 5-HT in the medial prefrontal cortex mediates this potentiation...
  81. ncbi Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators
    Marucia Chacur
    , Instituto Butantan, Av. Vital Brazil, 1500, , SP, Brazil
    Pain 111:65-76. 2004
    ..Lastly, celecoxib, an inhibitor of cyclooxygenase-2, attenuated sPLA2 actions. These data provide the first evidence of spinal mediators involved in pain facilitation induced by subcutaneous venoms...
  82. ncbi The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats
    Andre Der-Avakian
    Department of Psychology and Center for Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 191:909-17. 2007
    ..However, this persistent, trans-situational enhancement did not occur to amphetamine CPP...
  83. ncbi Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats
    Carin M Twining
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345. Boulder, CO 80309-0345, USA
    Pain 110:299-309. 2004
    ..Thus these immune-derived substances can markedly alter sensory nerve function at mid-axon...
  84. ncbi Inescapable shock activates serotonergic neurons in all raphe nuclei of rat
    Luiz F Takase
    Departmento de Anatomia, , Universidade de Sao Paulo, Sao Paulo SP, Brazil
    Behav Brain Res 153:233-9. 2004
    ..This stimulus exerted a consistent and strong activation of the entire midline brain stem system of serotonergic neurons. The implications of these findings for animal models of human psychopathology are discussed...
  85. ncbi Elevated IL-1beta contributes to antibody suppression produced by stress
    Albert Moraska
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309, USA
    J Appl Physiol 93:207-15. 2002
    ..These data support the hypothesis that stress-induced increases in innate immunity (i.e., IL-1beta) may contribute to stress-induced suppression in acquired immunity (i.e., anti-KLH Ig)...

Research Grants23

  1. Stressor Controllability: The Role of the mPFC in Producing Resiliency
    STEVEN MAIER; Fiscal Year: 2009
    ..g.. escape behavior) to processes regulated by other structures also innervated bv the PFC? ..
  2. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    STEVEN MAIER; Fiscal Year: 2009
    ....
  3. Neuroinflammation, Inflammatory Challenge, and Memory
    STEVEN MAIER; Fiscal Year: 2009
    ..The third Aim investigates whether a manipulation that is known prevent age-related glial priming, namely dietary restriction (DR), will prevent age-related exaggeration of brain PIC responses and challenge-induced memory impairments. ..
  4. Stressor Controllability: The Role of the mPFC in Producing Resiliency
    Steven F Maier; Fiscal Year: 2010
    ..g.. escape behavior) to processes regulated by other structures also innervated bv the PFC? ..
  5. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    Steven F Maier; Fiscal Year: 2010
    ....
  6. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    STEVEN MAIER; Fiscal Year: 2007
    ....
  7. Neuroinflammation, Inflammatory Challenge, and Memory
    STEVEN MAIER; Fiscal Year: 2007
    ..The third Aim investigates whether a manipulation that is known prevent age-related glial priming, namely dietary restriction (DR), will prevent age-related exaggeration of brain PIC responses and challenge-induced memory impairments. ..
  8. Stressor Controllability: The Role of the mPFC in Producing Resiliency
    STEVEN MAIER; Fiscal Year: 2007
    ..g.. escape behavior) to processes regulated by other structures also innervated bv the PFC? ..
  9. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    STEVEN MAIER; Fiscal Year: 2005
    ..Conditioned place preference and locomotor activation are the behaviors to be examined, and morphine, amphetamine, heroin, nicotine, cocaine, and ethanol are the drugs that will be tested. ..
  10. Neuroinflammation, Inflammatory Challenge, and Memory
    Steven F Maier; Fiscal Year: 2010
    ..The third Aim investigates whether a manipulation that is known prevent age-related glial priming, namely dietary restriction (DR), will prevent age-related exaggeration of brain PIC responses and challenge-induced memory impairments. ..