Research Topics
Genomes and GenesSpecies | Ronald MaierSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Hypertonic saline modulates innate immunity in a model of systemic inflammationKristan L Staudenmayer
Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
Shock 23:459-63. 2005..In vivo HTS prevents excessive AM activation during systemic inflammation. This suppression is mediated through alternate pathways and does not induce the classic MAPK signaling cascade...- Seattle's Harborview Medical Center, 1877-2003Ronald V Maier
Department of Surgery, Harborview Medical Center, Seattle, Wash 98104-2499, USA
Arch Surg 139:14-5. 2004 - What the surgeon of tomorrow needs to know about evidence-based surgeryRonald V Maier
Division of Trauma and General Surgery, Harborview Medical Center, and Department of Surgery, University of Washington, Seattle, USA
Arch Surg 141:317-23. 2006 - Pathogenesis of multiple organ dysfunction syndrome--endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen speciesR V Maier
University of Washington Harborview Medical Center, Seattle, Washington, USA
Surg Infect (Larchmt) 1:197-204; discussion 204-5. 2000.... - Controlling alcohol problems among hospitalized trauma patientsRonald V Maier
University of Washington Harborview Medical Center, Seattle, WA 98104-2499, USA
J Trauma 59:S1-2. 2005 - Ethanol abuse and the trauma patientR V Maier
Department of Surgery, University of Washington and Harborview Medical Center, Seattle, Washington 98104 2499, USA
Surg Infect (Larchmt) 2:133-41; discussion 141-4. 2001..Alcohol intoxication has long been associated with an increased risk of injury from a number of mechanisms and with trauma recidivism. It is less certain whether alcohol abuse is associated with worse outcomes for a given degree of injury... - Trauma: the paradigm for medical care in the 21st centuryRonald V Maier
Department of Surgery, University of Washington, Harborview Medical Center, Seattle, 98104, USA
J Trauma 54:803-13. 2003 - Modulation of endotoxin-induced endothelial activity by microtubule depolymerizationJoseph Cuschieri
Department of Surgery, Division of Trauma Critical Care, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
J Trauma 54:104-12; discussion 112-3. 2003..The potential role of this polymerization event, however, is unknown... - Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinaseJoseph Cuschieri
Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
Shock 20:176-82. 2003..Therefore, CaMK inhibition of endothelial cells, characteristic of sustained increases in intracellular calcium, appears to result in a dysregulated proadhesive phenotype... - Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic responseRobert D Winfield
Department of Surgery, Laboratory of Inflammation Biology and Surgical Science, University of Florida College of Medicine, Gainesville, FL, USA
Crit Care Med 38:51-8. 2010..The effect of obesity on severely injured patients, however, remains incompletely defined. We sought to unravel potential physiologic and genomic alterations induced by obesity in severely injured blunt trauma patients... - Male gender is associated with excessive IL-6 expression following severe injuryJason L Sperry
Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma 64:572-8; discussion 578-9. 2008.... - Platelet-activating factor priming of inflammatory cell activity requires cellular adherenceJoseph Cuschieri
Department of Surgery, University of Cincinnati, Ohio 45267-0558, USA
Surgery 132:157-66. 2002..This, therefore, would limit PAF-induced priming in vivo to foci of stimulated adherent inflammatory cells with little effect systemically on circulating cells... - Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulationJoseph Cuschieri
Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
Shock 21:182-8. 2004..Therefore, IRAK-1 appears to be the central kinase involved in the activation of the macrophage at distant sites during septic shock but is not necessary for activation in areas of local infection... - Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?Jason L Sperry
Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Crit Care Med 36:1838-45. 2008..old, >52 yrs of age) in a cohort of severely injured trauma patients for which significant variation in postinjury care is minimized... - A comparison of prehospital and hospital data in trauma patientsSaman Arbabi
Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
J Trauma 56:1029-32. 2004..We hypothesized that ED and Fd physiologic parameters are equally valid predictors of outcomes. In addition, we hypothesized that early field intubation will improve survival compared with later ED intubation... - Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsivenessJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington 98104, USA
J Trauma 52:434-42. 2002..This study investigates the possible intracellular mechanisms responsible for calcium antagonist protection in tissue-fixed macrophages, a central modulator of the proinflammatory phenotype... - Endotoxin-induced endothelial cell proinflammatory phenotypic differentiation requires stress fiber polymerizationJoseph Cuschleri
Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
Shock 19:433-9. 2003..These findings support the necessity of stress fiber polymerization for optimal recruitment of neutrophils during sepsis... - Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stressEileen M Bulger
Department of Surgery, University of Washington, Seattle, WA, USA
Surgery 134:146-52. 2003..We hypothesized that the induction of HO-1 protein would attenuate the proinflammatory response of endothelial cells to lipopolysaccharide and oxidant stress... - Timing of intubation and ventilator-associated pneumonia following injuryHeather L Evans
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, 98104, USA
Arch Surg 145:1041-6. 2010.... - Variations in rates of tracheostomy in the critically ill trauma patientAvery B Nathens
Harborview Injury Prevention and Research Center, Seattle, WA, USA
Crit Care Med 34:2919-24. 2006..The variation provides evidence of equipoise and emphasizes the need for a well-conducted randomized controlled trial to evaluate the utility of this procedure... - The macrophage response to endotoxin requires platelet activating factorEileen M Bulger
Department of Surgery, University of Washington, Seattle, USA
Shock 17:173-9. 2002..Macrophage cytokine production in response to endotoxin is PAF dependent. This effect involves the inhibition of TNF gene transcription and concomitant inhibition of NF-kappaB... - An argument for Vitamin E supplementation in the management of systemic inflammatory response syndromeEileen M Bulger
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
Shock 19:99-103. 2003.... - Intracellular antioxidant activity is necessary to modulate the macrophage response to endotoxinEileen M Bulger
University of Washington, Department of Surgery, Seattle 98104, USA
Shock 18:58-63. 2002.... - The actin cytoskeleton: an essential component for enhanced TNFalpha production by adherent monocytesMatthew R Rosengart
Department of Surgery, University of Washington, Seattle 98104, USA
Shock 17:109-13. 2002..In conclusion, the actin cytoskeleton is integral in the reprogramming of the monocyte for enhanced cytokine production and in maintaining this "primed" state... - Patient outcomes in academic medical centers: influence of fellowship programs and in-house on-call attending surgeonSaman Arbabi
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
Arch Surg 138:47-51; discussion 51. 2003..We were interested in 2 such policies or characteristics that are commonly implemented in academic centers: an in-house on-call attending physician policy and the existence of postgraduate medical education... - Implications of proteasome inhibition: an enhanced macrophage phenotypeJoseph Cuschieri
Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 558 Cincinnati, OH 45267 0558, USA
Cell Immunol 227:140-7. 2004..Thus, this study demonstrates that cellular proteasome is critical to regulation of LPS-induced signaling within the macrophage, and inhibition of the proteasome results in a conversion to an anti-inflammatory phenotype... - Overview of the Essential Trauma Care ProjectCharles Mock
Department of Surgery, University of Washington, Seattle, Washington 98104, USA
World J Surg 30:919-29. 2006..Future efforts need to emphasize more on-the-ground implementation in individual countries, greater linkages with prehospital care, and wider political endorsement, such as by passage of a World Health Assembly resolution... - Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysisMatthew D Neal
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 67:476-82; discussion 482-4. 2009..We sought to determine whether preinjury statin (PIS) use was associated with improved outcome in severely injured blunt trauma patients... - Timing of femur fracture fixation: effect on outcome in patients with thoracic and head injuriesSusan I Brundage
Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
J Trauma 52:299-307. 2002..Optimal timing of femur fracture fixation remains controversial. This study examines the association between the timing of femur fracture fixation and outcome in patients with concomitant chest and head injuries... - Inclusive trauma systems: do they improve triage or outcomes of the severely injured?Garth H Utter
Department of Surgery, Harborview Medical Center, and the Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, USA
J Trauma 60:529-35; discussion 535-37. 2006..We postulate that inclusive systems assure that severely injured patients are more likely to be triaged to a level I or II regional trauma center, and this greater degree of participation would lead to lower mortality... - Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivoEileen M Bulger
Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
Shock 20:17-22. 2003..This effect of PAF-AH may be mediated by the inhibition of intracellular signaling via inhibition of ERK kinase and NF-kappaB activation... - Characterization of persistent hyperglycemia: what does it mean postinjury?Jason L Sperry
Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 66:1076-82. 2009.... - Complication rates among trauma centersDarwin N Ang
Department of Surgery, University of Washington, Seattle, WA
J Am Coll Surg 209:595-602. 2009..The goal of this study was to examine the association between patient complications and admission to Level I trauma centers (TC) compared with nontrauma centers (NTC)... - The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathwayValerie Schaeffer
Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
Shock 27:623-30. 2007..On the contrary, in PBMCs, C5a activates the p38 cascade, and this pathway plays a major role in the C5a enhancement of LPS-induced IL-6 and TNF-alpha production... - Acid sphingomyelinase is required for lipid Raft TLR4 complex formationJoseph Cuschieri
Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
Surg Infect (Larchmt) 8:91-106. 2007..However, the mechanism responsible for these events remains unknown... - Vitamin E inhibits endotoxin-mediated transport of phosphatases to lipid raftsJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington, USA
Shock 27:19-24. 2007..Antioxidant exposure in the form of vitamin E seems to attenuate endotoxin-mediated SHIP activation resulting in increased AKT activity, and attenuated MAPK activation and TNF-alpha production... - Do trauma centers have the capacity to respond to disasters?Frederick P Rivara
Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington 98104, USA
J Trauma 61:949-53. 2006..Our objective was to examine the capacity of current centers to handle an increased load from a mass casualty disaster... - The impact of an intensivist-model ICU on trauma-related mortalityAvery B Nathens
Department of Surgery, University of Washington and Harborview Injury Prevention and Research Center, Seattle, WA, USA
Ann Surg 244:545-54. 2006..To evaluate the effect of an intensivist-model of critical care delivery on the risk of death following injury... - Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patientsHeather L Evans
Department of Surgery, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
Arch Surg 145:240-6. 2010..To demonstrate whether daily bathing with cloths impregnated with 2% chlorhexidine gluconate will decrease colonization of resistant bacteria and reduce the rates of health care-associated infections in critically injured patients... - Oxidative stress, lipid rafts, and macrophage reprogrammingJoseph Cuschieri
University of Washington, Department of Surgery, Seattle, Washington 98104, USA
Antioxid Redox Signal 9:1485-97. 2007..Within this review, the complexity of oxidant-induced reprogramming within the tissue fixed macrophage as currently understood is explained... - Oxidant alterations in CD16 expression are cytoskeletal inducedJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington, USA
Shock 32:572-7. 2009.... - Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trialEileen M Bulger
Department of Surgery, Campus Box 359796, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
Arch Surg 143:139-48; discussion 149. 2008..The purpose of this study was to evaluate the effect of hypertonicity on organ injury after blunt trauma... - Early elevation in random plasma IL-6 after severe injury is associated with development of organ failureJoseph Cuschieri
Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
Shock 34:346-51. 2010..This measurement may be useful as a biomarker for prognosis and serve to identify patients at higher risk of adverse outcome that would benefit from novel therapeutic interventions... - Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patientsMichael A West
Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
J Trauma 65:1511-9. 2008..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative... - Gossypiboma: tales of lost sponges and lessons learnedLisa K McIntyre
Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
Arch Surg 145:770-5. 2010..To review the details surrounding cases of patients found to have retained laparotomy sponges after surgical procedures and share policy changes that have led to process improvements at one academic medical center... - Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patientJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington, USA
J Trauma 65:944-50. 2008 - Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patientsMatthew J Sena
Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA
J Am Coll Surg 207:459-67. 2008..The purpose of this study is to determine whether early administration of parenteral nutrition is associated with an increased risk for infection after severe injury... - Effect of immediate enteral feeding on trauma patients with an open abdomen: protection from nosocomial infectionsSharmila Dissanaike
Department of Surgery, University of Washington, Seattle, WA 98104, USA
J Am Coll Surg 207:690-7. 2008..Despite increased use, uncertainty exists about the safety and timing of enteral nutrition. The purpose of this study was to determine the safety and effect of immediate enteral nutrition... - Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shockEileen M Bulger
Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
Ann Surg 245:635-41. 2007..To determine the effect of resuscitation with hypertonic saline/dextran (HSD) on the innate immune response after injury... - Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activationJoseph Cuschieri
University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359796, Seattle, WA 98104, USA
J Leukoc Biol 80:1289-97. 2006..Thus, endotoxin tolerance appears to be induced through attenuated TLR4 formation following LPS stimulation. This complex formation appears to be PKC-dependent, and restoration of PKC activity reverses tolerance... - Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid raftsJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, USA
Surgery 138:158-64. 2005.... - The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injuryEileen M Bulger
Departments of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
J Trauma 58:718-23; discussion 723-4. 2005..We sought to determine the effect of the use of NMBAs to facilitate prehospital intubation on outcome after TBI... - Calcium/calmodulin-dependent kinase II is required for platelet-activating factor primingJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, WA 98104, USA
Shock 23:99-106. 2005..This priming event is mediated in part by modulation of ERK 1/2, JNK/SAPK, NF-kappaB, and AP-1 activation. CaMK IV, on the other hand, is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events... - Centers for Disease Control and Prevention injury research agenda: identification of acute care research topics of interest to the Centers for disease Control and Prevention--National Center for Injury Prevention and ControlGregory J Jurkovich
Harborview Injury Prevention and Research Center, American Association for the Surgery of Trauma, Seattle, Washington, USA
J Trauma 56:1166-70. 2004..The purpose of this report is to identify the most important research questions pertaining to the acute care of the injured patient using a Web-based Delphi technique to achieve expert opinion consensus... - Development of trauma systems and effect on outcomes after injuryAvery B Nathens
Division of General and Trauma Surgery, Harborview Medical Center, Department of Surgery, University of Washington, Seattle 98104 2499, USA
Lancet 363:1794-801. 2004.... - The effect of interfacility transfer on outcome in an urban trauma systemAvery B Nathens
Division of General and Trauma Surgery, Harborview Medical Center, and Department of Surgery, University of Washington, Seattle, 98104 2499, USA
J Trauma 55:444-9. 2003..We set out to evaluate whether patients initially assessed at these centers and then transferred to a Level I facility were adversely affected by delays to definitive care... - Hypertonic preconditioning inhibits macrophage responsiveness to endotoxinJoseph Cuschieri
Department of Surgery, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
J Immunol 168:1389-96. 2002..e., urea) had no significant effect. Hypertonic saline or mannitol resuscitation, therefore, may help protect against multiple-organ dysfunction syndrome as a result of this reduced proinflammatory responsiveness... - Management of the injured patient: identification of research topics for systematic review using the delphi techniqueAvery B Nathens
Department of Surgery, Harborview Injury Prevention and Research Center, University of Washington, Seattle, 98104, USA
J Trauma 54:595-601. 2003..This study identifies the most important research questions pertaining to the acute care of the injured patient using a Web-based Delphi technique to achieve consensus of expert opinion... - Mitogen-activated protein kinases in the intensive care unit: prognostic potentialMatthew R Rosengart
Department of Surgery, University of Washington, Seattle, USA
Ann Surg 237:94-100. 2003..To evaluate the prognostic significance of the activational status of p38, specifically progression to multiple organ dysfunction syndrome (MODS), in a group of severely injured trauma patients... - Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activationRichard P Darveau
Department of Periodontics, University of Washington, Seattle, Washington 98181, USA
Infect Immun 70:1867-73. 2002..These data also suggest that although LPS is generally considered a bacterial component that alerts the host to infection, LPS from P. gingivalis may selectively modify the host response as a means to facilitate colonization... - Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patientAvery B Nathens
Department of Surgery, University of Washington, Seattle, Washington, USA
J Trauma 59:764-9. 2005 - Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (Joseph P Minei
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9158, USA
J Trauma 60:1106-13; discussion 1113. 2006 - Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14Joseph Cuschieri
Department of Surgery, University of Washington, Seattle, WA, USA
J Leukoc Biol 80:407-14. 2006..This study demonstrates that TLR4 assembly and activation following LPS exposure require the production of ceramide by PC-PLC, which appears to be CD14-dependent... - The delivery of critical care services in US trauma centers: is the standard being met?Avery B Nathens
Division of Trauma and General Surgery, Harborview Medical Center, Seattle, WA 98104, USA
J Trauma 60:773-83; disucssion 783-4. 2006..We set out to evaluate how critical care is delivered in Level I and II trauma centers and the extent to which these centers implement evidence-based patient care practices known to improve outcome... - Oxandrolone does not improve outcome of ventilator dependent surgical patientsEileen M Bulger
Department of Surgery, University of Washington, Seattle 98104, USA
Ann Surg 240:472-8; discussion 478-80. 2004..Oxandrolone is an anabolic steroid that attenuates loss of lean body mass and improves wound healing in burn patients. We hypothesized that oxandrolone would improve outcome for ventilator-dependent surgical patients... - Effect of patient load on trauma outcomes in a Level I trauma centerSaman Arbabi
Department of Surgery, University of Michigan, Ann Arbor, USA
J Trauma 59:815-8; discussion 819-20. 2005..The goal of the study was to see whether trauma patients admitted during 'high' patient-load periods, at night, or on weekends had worse outcomes... - Randomized, prospective trial of antioxidant supplementation in critically ill surgical patientsAvery B Nathens
Division of Trauma and General Surgery, Harborview Medical Center and the Department of Surgery, University of Washington, Seattle, Washington, USA
Ann Surg 236:814-22. 2002..To determine the effectiveness of early, routine antioxidant supplementation using alpha-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction in critically ill surgical patients... - Insulin regulates macrophage activation through activin AJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, Washington, USA
Shock 29:285-90. 2008..As a result, we set out to investigate the role and means of activation of this pathway by insulin on endotoxin-mediated activation of tissue-fixed macrophages... - Prehospital care of the injured: what's newEileen M Bulger
Department of Surgery, University of Washington, Harborview Medical Center, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
Surg Clin North Am 87:37-53, vi. 2007..Through additional research, the best practice and optimal EMS system design will continue to be defined... - Scoop and run to the trauma center or stay and play at the local hospital: hospital transfer's effect on mortalityRam Nirula
Section of Burns Trauma Critical Care, Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA
J Trauma 69:595-9; discussion 599-601. 2010..We sought to analyze whether initial triage of critically injured patients to a nontrauma center (NTC) is associated with increased mortality... - Mechanistic analysis of macrophage response to IRAK-1 gene knockdown by a smart polymer-antisense oligonucleotide therapeuticRachel E Johns
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
J Biomater Sci Polym Ed 19:1333-46. 2008..These results provide a larger mechanistic picture of IRAK-1 knockdown by this polymer therapeutic in macrophage-like cells... - Survey of national usage of trauma response charge codes: an opportunity for enhanced trauma center revenueSamir M Fakhry
Department of Surgery, National Foundation for Trauma Care Trauma Center Association of America, Las Cruces, New Mexico, USA
J Trauma 67:1352-8. 2009..Potential over- and underutilization of these enhanced reimbursements was assessed... - Strengthening trauma systems globally: the Essential Trauma Care ProjectCharles Mock
University of Washington, Seattle, Washington, USA
J Trauma 59:1243-6. 2005 - Outcomes after ruptured abdominal aortic aneurysms: the "halo effect" of trauma center designationGarth H Utter
Department of Surgery, Harborview Medical Center, Seattle, WA, USA
J Am Coll Surg 203:498-505. 2006..We set out to determine whether patients hospitalized with ruptured abdominal aortic aneurysms experience lower morbidity and mortality at regional trauma centers than at other acute care hospitals... - An analysis of advanced prehospital airway managementEileen M Bulger
Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
J Emerg Med 23:183-9. 2002..In this study, only 1.1% of patients required a surgical airway. We attribute this low rate to the use of paralytic agents. The availability of paralytic agents also allows expansion of the indications for prehospital airway control... - Profile: Ronald V. Maier, M.D. Interview by Vicki GlaserRonald V Maier
Surg Infect (Larchmt) 3:43-7. 2002 - Early use of vasopressors after injury: caution before constrictionJason L Sperry
Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 64:9-14. 2008..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients... - High dynamic range characterization of the trauma patient plasma proteomeTao Liu
Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, USA
Mol Cell Proteomics 5:1899-913. 2006.... - Evaluation of hyaluronan from different sources: Streptococcus zooepidemicus, rooster comb, bovine vitreous, and human umbilical cordAviva Shiedlin
Genzyme Corporation, Cambridge, Massachusetts 02139, USA
Biomacromolecules 5:2122-7. 2004..These results indicate that the source of HA should be considered due to differences in the amounts and types of contaminants that could lead to widely different behaviors in vitro and in vivo... - Early hyperglycemia predicts multiple organ failure and mortality but not infectionJason L Sperry
Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 63:487-93; discussion 493-4. 2007..We sought to characterize the clinical outcomes associated with EH in a cohort of severely injured trauma patients, when a strict glycemic control protocol was used...
Research Grants
- IMMUNOMODULATION OF MACROPHAGES FOLLOWING TRAUMARonald Maier; Fiscal Year: 2002....
- IMMUNOMODULATION OF MACROPHAGES FOLLOWING TRAUMARonald Maier; Fiscal Year: 1993....
- IMMUNOMODULATION OF MACROPHAGES FOLLOWING TRAUMARonald Maier; Fiscal Year: 2006....