Ronald Maier

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Seattle's Harborview Medical Center, 1877-2003
    Ronald V Maier
    Department of Surgery, Harborview Medical Center, Seattle, Wash 98104 2499, USA
    Arch Surg 139:14-5. 2004
  2. ncbi request reprint Hypertonic saline modulates innate immunity in a model of systemic inflammation
    Kristan L Staudenmayer
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    Shock 23:459-63. 2005
  3. ncbi request reprint Ethanol abuse and the trauma patient
    R V Maier
    Department of Surgery, University of Washington and Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Surg Infect (Larchmt) 2:133-41; discussion 141-4. 2001
  4. ncbi request reprint Pathogenesis of multiple organ dysfunction syndrome--endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species
    R V Maier
    University of Washington Harborview Medical Center, Seattle, Washington, USA
    Surg Infect (Larchmt) 1:197-204; discussion 204-5. 2000
  5. ncbi request reprint What the surgeon of tomorrow needs to know about evidence-based surgery
    Ronald V Maier
    Division of Trauma and General Surgery, Harborview Medical Center, and Department of Surgery, University of Washington, Seattle, USA
    Arch Surg 141:317-23. 2006
  6. ncbi request reprint Controlling alcohol problems among hospitalized trauma patients
    Ronald V Maier
    University of Washington Harborview Medical Center, Seattle, WA 98104 2499, USA
    J Trauma 59:S1-2. 2005
  7. ncbi request reprint Trauma: the paradigm for medical care in the 21st century
    Ronald V Maier
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, 98104, USA
    J Trauma 54:803-13. 2003
  8. ncbi request reprint Modulation of endotoxin-induced endothelial activity by microtubule depolymerization
    Joseph Cuschieri
    Department of Surgery, Division of Trauma Critical Care, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
    J Trauma 54:104-12; discussion 112-3. 2003
  9. ncbi request reprint Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 20:176-82. 2003
  10. ncbi request reprint Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 21:182-8. 2004

Research Grants

Detail Information

Publications81

  1. ncbi request reprint Seattle's Harborview Medical Center, 1877-2003
    Ronald V Maier
    Department of Surgery, Harborview Medical Center, Seattle, Wash 98104 2499, USA
    Arch Surg 139:14-5. 2004
  2. ncbi request reprint Hypertonic saline modulates innate immunity in a model of systemic inflammation
    Kristan L Staudenmayer
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    Shock 23:459-63. 2005
    ..In vivo HTS prevents excessive AM activation during systemic inflammation. This suppression is mediated through alternate pathways and does not induce the classic MAPK signaling cascade...
  3. ncbi request reprint Ethanol abuse and the trauma patient
    R V Maier
    Department of Surgery, University of Washington and Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Surg Infect (Larchmt) 2:133-41; discussion 141-4. 2001
    ..Alcohol intoxication has long been associated with an increased risk of injury from a number of mechanisms and with trauma recidivism. It is less certain whether alcohol abuse is associated with worse outcomes for a given degree of injury...
  4. ncbi request reprint Pathogenesis of multiple organ dysfunction syndrome--endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species
    R V Maier
    University of Washington Harborview Medical Center, Seattle, Washington, USA
    Surg Infect (Larchmt) 1:197-204; discussion 204-5. 2000
    ....
  5. ncbi request reprint What the surgeon of tomorrow needs to know about evidence-based surgery
    Ronald V Maier
    Division of Trauma and General Surgery, Harborview Medical Center, and Department of Surgery, University of Washington, Seattle, USA
    Arch Surg 141:317-23. 2006
  6. ncbi request reprint Controlling alcohol problems among hospitalized trauma patients
    Ronald V Maier
    University of Washington Harborview Medical Center, Seattle, WA 98104 2499, USA
    J Trauma 59:S1-2. 2005
  7. ncbi request reprint Trauma: the paradigm for medical care in the 21st century
    Ronald V Maier
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, 98104, USA
    J Trauma 54:803-13. 2003
  8. ncbi request reprint Modulation of endotoxin-induced endothelial activity by microtubule depolymerization
    Joseph Cuschieri
    Department of Surgery, Division of Trauma Critical Care, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
    J Trauma 54:104-12; discussion 112-3. 2003
    ..The potential role of this polymerization event, however, is unknown...
  9. ncbi request reprint Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 20:176-82. 2003
    ..Therefore, CaMK inhibition of endothelial cells, characteristic of sustained increases in intracellular calcium, appears to result in a dysregulated proadhesive phenotype...
  10. ncbi request reprint Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 21:182-8. 2004
    ..Therefore, IRAK-1 appears to be the central kinase involved in the activation of the macrophage at distant sites during septic shock but is not necessary for activation in areas of local infection...
  11. doi request reprint Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
    ....
  12. doi request reprint Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?
    Jason L Sperry
    Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 36:1838-45. 2008
    ..old, >52 yrs of age) in a cohort of severely injured trauma patients for which significant variation in postinjury care is minimized...
  13. doi request reprint Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response
    Robert D Winfield
    Department of Surgery, Laboratory of Inflammation Biology and Surgical Science, University of Florida College of Medicine, Gainesville, FL, USA
    Crit Care Med 38:51-8. 2010
    ..The effect of obesity on severely injured patients, however, remains incompletely defined. We sought to unravel potential physiologic and genomic alterations induced by obesity in severely injured blunt trauma patients...
  14. ncbi request reprint Platelet-activating factor priming of inflammatory cell activity requires cellular adherence
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
    Surgery 132:157-66. 2002
    ..The purpose of this study was to investigate whether cellular adherence plays a role in PAF priming of inflammatory cells...
  15. ncbi request reprint A comparison of prehospital and hospital data in trauma patients
    Saman Arbabi
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Trauma 56:1029-32. 2004
    ..We hypothesized that ED and Fd physiologic parameters are equally valid predictors of outcomes. In addition, we hypothesized that early field intubation will improve survival compared with later ED intubation...
  16. ncbi request reprint Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington 98104, USA
    J Trauma 52:434-42. 2002
    ..This study investigates the possible intracellular mechanisms responsible for calcium antagonist protection in tissue-fixed macrophages, a central modulator of the proinflammatory phenotype...
  17. ncbi request reprint Endotoxin-induced endothelial cell proinflammatory phenotypic differentiation requires stress fiber polymerization
    Joseph Cuschleri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 19:433-9. 2003
    ..These findings support the necessity of stress fiber polymerization for optimal recruitment of neutrophils during sepsis...
  18. ncbi request reprint The macrophage response to endotoxin requires platelet activating factor
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    Shock 17:173-9. 2002
    ..Macrophage cytokine production in response to endotoxin is PAF dependent. This effect involves the inhibition of TNF gene transcription and concomitant inhibition of NF-kappaB...
  19. doi request reprint Timing of intubation and ventilator-associated pneumonia following injury
    Heather L Evans
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, 98104, USA
    Arch Surg 145:1041-6. 2010
    ....
  20. ncbi request reprint Variations in rates of tracheostomy in the critically ill trauma patient
    Avery B Nathens
    Harborview Injury Prevention and Research Center, Seattle, WA, USA
    Crit Care Med 34:2919-24. 2006
    ..Thus, we set out explore the extent and potential sources of this variation among injured patients cared for in trauma centers in the United States...
  21. ncbi request reprint Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stress
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, WA, USA
    Surgery 134:146-52. 2003
    ..We hypothesized that the induction of HO-1 protein would attenuate the proinflammatory response of endothelial cells to lipopolysaccharide and oxidant stress...
  22. ncbi request reprint Intracellular antioxidant activity is necessary to modulate the macrophage response to endotoxin
    Eileen M Bulger
    University of Washington, Department of Surgery, Seattle 98104, USA
    Shock 18:58-63. 2002
    ....
  23. ncbi request reprint Implications of proteasome inhibition: an enhanced macrophage phenotype
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 558 Cincinnati, OH 45267 0558, USA
    Cell Immunol 227:140-7. 2004
    ..Thus, this study demonstrates that cellular proteasome is critical to regulation of LPS-induced signaling within the macrophage, and inhibition of the proteasome results in a conversion to an anti-inflammatory phenotype...
  24. ncbi request reprint An argument for Vitamin E supplementation in the management of systemic inflammatory response syndrome
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Shock 19:99-103. 2003
    ....
  25. ncbi request reprint The actin cytoskeleton: an essential component for enhanced TNFalpha production by adherent monocytes
    Matthew R Rosengart
    Department of Surgery, University of Washington, Seattle 98104, USA
    Shock 17:109-13. 2002
    ..In conclusion, the actin cytoskeleton is integral in the reprogramming of the monocyte for enhanced cytokine production and in maintaining this "primed" state...
  26. ncbi request reprint Patient outcomes in academic medical centers: influence of fellowship programs and in-house on-call attending surgeon
    Saman Arbabi
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    Arch Surg 138:47-51; discussion 51. 2003
    ..We were interested in 2 such policies or characteristics that are commonly implemented in academic centers: an in-house on-call attending physician policy and the existence of postgraduate medical education...
  27. pmc Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
    Crit Care Med 41:399-404. 2013
    ..To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients...
  28. ncbi request reprint Overview of the Essential Trauma Care Project
    Charles Mock
    Department of Surgery, University of Washington, Seattle, Washington 98104, USA
    World J Surg 30:919-29. 2006
    ..Future efforts need to emphasize more on-the-ground implementation in individual countries, greater linkages with prehospital care, and wider political endorsement, such as by passage of a World Health Assembly resolution...
  29. doi request reprint Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:476-82; discussion 482-4. 2009
    ..We sought to determine whether preinjury statin (PIS) use was associated with improved outcome in severely injured blunt trauma patients...
  30. ncbi request reprint Timing of femur fracture fixation: effect on outcome in patients with thoracic and head injuries
    Susan I Brundage
    Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Trauma 52:299-307. 2002
    ..Optimal timing of femur fracture fixation remains controversial. This study examines the association between the timing of femur fracture fixation and outcome in patients with concomitant chest and head injuries...
  31. doi request reprint Characterization of persistent hyperglycemia: what does it mean postinjury?
    Jason L Sperry
    Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 66:1076-82. 2009
    ....
  32. ncbi request reprint Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Shock 20:17-22. 2003
    ..This effect of PAF-AH may be mediated by the inhibition of intracellular signaling via inhibition of ERK kinase and NF-kappaB activation...
  33. pmc Complication rates among trauma centers
    Darwin N Ang
    Department of Surgery, University of Washington, Seattle, WA
    J Am Coll Surg 209:595-602. 2009
    ..The goal of this study was to examine the association between patient complications and admission to Level I trauma centers (TC) compared with nontrauma centers (NTC)...
  34. ncbi request reprint Inclusive trauma systems: do they improve triage or outcomes of the severely injured?
    Garth H Utter
    Department of Surgery, Harborview Medical Center, and the Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, USA
    J Trauma 60:529-35; discussion 535-37. 2006
    ..We postulate that inclusive systems assure that severely injured patients are more likely to be triaged to a level I or II regional trauma center, and this greater degree of participation would lead to lower mortality...
  35. ncbi request reprint The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway
    Valerie Schaeffer
    Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
    Shock 27:623-30. 2007
    ..On the contrary, in PBMCs, C5a activates the p38 cascade, and this pathway plays a major role in the C5a enhancement of LPS-induced IL-6 and TNF-alpha production...
  36. ncbi request reprint Oxidative stress, lipid rafts, and macrophage reprogramming
    Joseph Cuschieri
    University of Washington, Department of Surgery, Seattle, Washington 98104, USA
    Antioxid Redox Signal 9:1485-97. 2007
    ..Within this review, the complexity of oxidant-induced reprogramming within the tissue fixed macrophage as currently understood is explained...
  37. pmc Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Ann Surg 245:635-41. 2007
    ..To determine the effect of resuscitation with hypertonic saline/dextran (HSD) on the innate immune response after injury...
  38. doi request reprint Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients
    Heather L Evans
    Department of Surgery, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
    Arch Surg 145:240-6. 2010
    ..To demonstrate whether daily bathing with cloths impregnated with 2% chlorhexidine gluconate will decrease colonization of resistant bacteria and reduce the rates of health care-associated infections in critically injured patients...
  39. ncbi request reprint Acid sphingomyelinase is required for lipid Raft TLR4 complex formation
    Joseph Cuschieri
    Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Surg Infect (Larchmt) 8:91-106. 2007
    ..However, the mechanism responsible for these events remains unknown...
  40. ncbi request reprint Vitamin E inhibits endotoxin-mediated transport of phosphatases to lipid rafts
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 27:19-24. 2007
    ..Antioxidant exposure in the form of vitamin E seems to attenuate endotoxin-mediated SHIP activation resulting in increased AKT activity, and attenuated MAPK activation and TNF-alpha production...
  41. pmc Mitogen-activated protein kinases in the intensive care unit: prognostic potential
    Matthew R Rosengart
    Department of Surgery, University of Washington, Seattle, USA
    Ann Surg 237:94-100. 2003
    ..To evaluate the prognostic significance of the activational status of p38, specifically progression to multiple organ dysfunction syndrome (MODS), in a group of severely injured trauma patients...
  42. doi request reprint Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...
  43. doi request reprint Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, Campus Box 359796, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    Arch Surg 143:139-48; discussion 149. 2008
    ..The purpose of this study was to evaluate the effect of hypertonicity on organ injury after blunt trauma...
  44. pmc Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure
    Joseph Cuschieri
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Shock 34:346-51. 2010
    ..This measurement may be useful as a biomarker for prognosis and serve to identify patients at higher risk of adverse outcome that would benefit from novel therapeutic interventions...
  45. doi request reprint Gossypiboma: tales of lost sponges and lessons learned
    Lisa K McIntyre
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    Arch Surg 145:770-5. 2010
    ..To review the details surrounding cases of patients found to have retained laparotomy sponges after surgical procedures and share policy changes that have led to process improvements at one academic medical center...
  46. pmc Oxidant alterations in CD16 expression are cytoskeletal induced
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 32:572-7. 2009
    ....
  47. doi request reprint Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 65:944-50. 2008
  48. doi request reprint Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients
    Matthew J Sena
    Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA
    J Am Coll Surg 207:459-67. 2008
    ..The purpose of this study is to determine whether early administration of parenteral nutrition is associated with an increased risk for infection after severe injury...
  49. doi request reprint Effect of immediate enteral feeding on trauma patients with an open abdomen: protection from nosocomial infections
    Sharmila Dissanaike
    Department of Surgery, University of Washington, Seattle, WA 98104, USA
    J Am Coll Surg 207:690-7. 2008
    ..Despite increased use, uncertainty exists about the safety and timing of enteral nutrition. The purpose of this study was to determine the safety and effect of immediate enteral nutrition...
  50. ncbi request reprint Do trauma centers have the capacity to respond to disasters?
    Frederick P Rivara
    Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington 98104, USA
    J Trauma 61:949-53. 2006
    ..Our objective was to examine the capacity of current centers to handle an increased load from a mass casualty disaster...
  51. ncbi request reprint Effect of patient load on trauma outcomes in a Level I trauma center
    Saman Arbabi
    Department of Surgery, University of Michigan, Ann Arbor, USA
    J Trauma 59:815-8; discussion 819-20. 2005
    ..The goal of the study was to see whether trauma patients admitted during 'high' patient-load periods, at night, or on weekends had worse outcomes...
  52. ncbi request reprint Centers for Disease Control and Prevention injury research agenda: identification of acute care research topics of interest to the Centers for disease Control and Prevention--National Center for Injury Prevention and Control
    Gregory J Jurkovich
    Harborview Injury Prevention and Research Center, American Association for the Surgery of Trauma, Seattle, Washington, USA
    J Trauma 56:1166-70. 2004
    ..The purpose of this report is to identify the most important research questions pertaining to the acute care of the injured patient using a Web-based Delphi technique to achieve expert opinion consensus...
  53. ncbi request reprint Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA 98104, USA
    Shock 23:99-106. 2005
    ..This priming event is mediated in part by modulation of ERK 1/2, JNK/SAPK, NF-kappaB, and AP-1 activation. CaMK IV, on the other hand, is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events...
  54. ncbi request reprint The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injury
    Eileen M Bulger
    Departments of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    J Trauma 58:718-23; discussion 723-4. 2005
    ..We sought to determine the effect of the use of NMBAs to facilitate prehospital intubation on outcome after TBI...
  55. ncbi request reprint Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, USA
    Surgery 138:158-64. 2005
    ....
  56. ncbi request reprint Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patient
    Avery B Nathens
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 59:764-9. 2005
  57. ncbi request reprint The effect of interfacility transfer on outcome in an urban trauma system
    Avery B Nathens
    Division of General and Trauma Surgery, Harborview Medical Center, and Department of Surgery, University of Washington, Seattle, 98104 2499, USA
    J Trauma 55:444-9. 2003
    ..We set out to evaluate whether patients initially assessed at these centers and then transferred to a Level I facility were adversely affected by delays to definitive care...
  58. ncbi request reprint Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin
    Joseph Cuschieri
    Department of Surgery, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Immunol 168:1389-96. 2002
    ..e., urea) had no significant effect. Hypertonic saline or mannitol resuscitation, therefore, may help protect against multiple-organ dysfunction syndrome as a result of this reduced proinflammatory responsiveness...
  59. pmc Oxandrolone does not improve outcome of ventilator dependent surgical patients
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle 98104, USA
    Ann Surg 240:472-8; discussion 478-80. 2004
    ..Oxandrolone is an anabolic steroid that attenuates loss of lean body mass and improves wound healing in burn patients. We hypothesized that oxandrolone would improve outcome for ventilator-dependent surgical patients...
  60. ncbi request reprint Management of the injured patient: identification of research topics for systematic review using the delphi technique
    Avery B Nathens
    Department of Surgery, Harborview Injury Prevention and Research Center, University of Washington, Seattle, 98104, USA
    J Trauma 54:595-601. 2003
    ..This study identifies the most important research questions pertaining to the acute care of the injured patient using a Web-based Delphi technique to achieve consensus of expert opinion...
  61. ncbi request reprint Development of trauma systems and effect on outcomes after injury
    Avery B Nathens
    Division of General and Trauma Surgery, Harborview Medical Center, Department of Surgery, University of Washington, Seattle 98104 2499, USA
    Lancet 363:1794-801. 2004
    ....
  62. ncbi request reprint The delivery of critical care services in US trauma centers: is the standard being met?
    Avery B Nathens
    Division of Trauma and General Surgery, Harborview Medical Center, Seattle, WA 98104, USA
    J Trauma 60:773-83; disucssion 783-4. 2006
    ..We set out to evaluate how critical care is delivered in Level I and II trauma centers and the extent to which these centers implement evidence-based patient care practices known to improve outcome...
  63. pmc Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation
    Richard P Darveau
    Department of Periodontics, University of Washington, Seattle, Washington 98181, USA
    Infect Immun 70:1867-73. 2002
    ..These data also suggest that although LPS is generally considered a bacterial component that alerts the host to infection, LPS from P. gingivalis may selectively modify the host response as a means to facilitate colonization...
  64. ncbi request reprint Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (
    Joseph P Minei
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9158, USA
    J Trauma 60:1106-13; discussion 1113. 2006
  65. ncbi request reprint Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA, USA
    J Leukoc Biol 80:407-14. 2006
    ..This study demonstrates that TLR4 assembly and activation following LPS exposure require the production of ceramide by PC-PLC, which appears to be CD14-dependent...
  66. pmc The impact of an intensivist-model ICU on trauma-related mortality
    Avery B Nathens
    Department of Surgery, University of Washington and Harborview Injury Prevention and Research Center, Seattle, WA, USA
    Ann Surg 244:545-54. 2006
    ..To evaluate the effect of an intensivist-model of critical care delivery on the risk of death following injury...
  67. ncbi request reprint Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation
    Joseph Cuschieri
    University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359796, Seattle, WA 98104, USA
    J Leukoc Biol 80:1289-97. 2006
    ..Thus, endotoxin tolerance appears to be induced through attenuated TLR4 formation following LPS stimulation. This complex formation appears to be PKC-dependent, and restoration of PKC activity reverses tolerance...
  68. pmc Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients
    Avery B Nathens
    Division of Trauma and General Surgery, Harborview Medical Center and the Department of Surgery, University of Washington, Seattle, Washington, USA
    Ann Surg 236:814-22. 2002
    ..To determine the effectiveness of early, routine antioxidant supplementation using alpha-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction in critically ill surgical patients...
  69. ncbi request reprint Prehospital care of the injured: what's new
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
    Surg Clin North Am 87:37-53, vi. 2007
    ..Through additional research, the best practice and optimal EMS system design will continue to be defined...
  70. ncbi request reprint Insulin regulates macrophage activation through activin A
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 29:285-90. 2008
    ..As a result, we set out to investigate the role and means of activation of this pathway by insulin on endotoxin-mediated activation of tissue-fixed macrophages...
  71. doi request reprint Scoop and run to the trauma center or stay and play at the local hospital: hospital transfer's effect on mortality
    Ram Nirula
    Section of Burns Trauma Critical Care, Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Trauma 69:595-9; discussion 599-601. 2010
    ..We sought to analyze whether initial triage of critically injured patients to a nontrauma center (NTC) is associated with increased mortality...
  72. doi request reprint Mechanistic analysis of macrophage response to IRAK-1 gene knockdown by a smart polymer-antisense oligonucleotide therapeutic
    Rachel E Johns
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    J Biomater Sci Polym Ed 19:1333-46. 2008
    ..These results provide a larger mechanistic picture of IRAK-1 knockdown by this polymer therapeutic in macrophage-like cells...
  73. ncbi request reprint Strengthening trauma systems globally: the Essential Trauma Care Project
    Charles Mock
    University of Washington, Seattle, Washington, USA
    J Trauma 59:1243-6. 2005
  74. doi request reprint Survey of national usage of trauma response charge codes: an opportunity for enhanced trauma center revenue
    Samir M Fakhry
    Department of Surgery, National Foundation for Trauma Care Trauma Center Association of America, Las Cruces, New Mexico, USA
    J Trauma 67:1352-8. 2009
    ..Potential over- and underutilization of these enhanced reimbursements was assessed...
  75. ncbi request reprint An analysis of advanced prehospital airway management
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
    J Emerg Med 23:183-9. 2002
    ..In this study, only 1.1% of patients required a surgical airway. We attribute this low rate to the use of paralytic agents. The availability of paralytic agents also allows expansion of the indications for prehospital airway control...
  76. ncbi request reprint Profile: Ronald V. Maier, M.D. Interview by Vicki Glaser
    Ronald V Maier
    Surg Infect (Larchmt) 3:43-7. 2002
  77. ncbi request reprint Evaluation of hyaluronan from different sources: Streptococcus zooepidemicus, rooster comb, bovine vitreous, and human umbilical cord
    Aviva Shiedlin
    Genzyme Corporation, Cambridge, Massachusetts 02139, USA
    Biomacromolecules 5:2122-7. 2004
    ..These results indicate that the source of HA should be considered due to differences in the amounts and types of contaminants that could lead to widely different behaviors in vitro and in vivo...
  78. ncbi request reprint Outcomes after ruptured abdominal aortic aneurysms: the "halo effect" of trauma center designation
    Garth H Utter
    Department of Surgery, Harborview Medical Center, Seattle, WA, USA
    J Am Coll Surg 203:498-505. 2006
    ..We set out to determine whether patients hospitalized with ruptured abdominal aortic aneurysms experience lower morbidity and mortality at regional trauma centers than at other acute care hospitals...
  79. ncbi request reprint Early hyperglycemia predicts multiple organ failure and mortality but not infection
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 63:487-93; discussion 493-4. 2007
    ..We sought to characterize the clinical outcomes associated with EH in a cohort of severely injured trauma patients, when a strict glycemic control protocol was used...
  80. pmc High dynamic range characterization of the trauma patient plasma proteome
    Tao Liu
    Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    Mol Cell Proteomics 5:1899-913. 2006
    ....
  81. doi request reprint Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
    ..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients...

Research Grants16

  1. IMMUNOMODULATION OF MACROPHAGES FOLLOWING TRAUMA
    Ronald Maier; Fiscal Year: 2002
    ....
  2. IMMUNOMODULATION OF MACROPHAGES FOLLOWING TRAUMA
    Ronald Maier; Fiscal Year: 1993
    ....
  3. IMMUNOMODULATION OF MACROPHAGES FOLLOWING TRAUMA
    Ronald Maier; Fiscal Year: 2006
    ....