Affiliation: University of California
- Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitisJacquelyn J Maher
Department of Medicine, University of California, San Francisco, CA, USA
Hepatology 48:670-8. 2008..This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease...
- Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivoJ J Maher
Liver Center, University of California, San Francisco, USA
Biochem Pharmacol 53:637-41. 1997..This disparate behavior of stellate cells in culture and in vivo is unusual; the data suggest that stellate cells might respond variably to oxidants depending on their glutathione status...
- DAMPs ramp up drug toxicityJacquelyn J Maher
Department of Medicine and Liver Center, UCSF, San Francisco, California, USA
J Clin Invest 119:246-9. 2009....
- Alcoholic steatohepatitis: management and prognosisJacquelyn J Maher
Rice Liver Center Laboratory, San Francisco General Hospital, 1001 Potrero Avenue, Building 40, Room 4102, San Francisco, CA 94110, USA
Curr Gastroenterol Rep 9:39-46. 2007..A prompt decline in serum bilirubin indicates a favorable response to therapy. Patients who do not exhibit a reduction in serum bilirubin within 1 week are considered nonresponders and have a 6-month mortality rate of 50% or higher...
- New insights from rodent models of fatty liver diseaseJacquelyn J Maher
Liver Center and Department of Medicine, University of California, San Francisco San Francisco, California, USA
Antioxid Redox Signal 15:535-50. 2011..Numerous additional insights about hepatic lipid metabolism, which have been gained from genetically engineered mice, are also mentioned...
- Treatment of alcoholic hepatitisJacquelyn J Maher
Liver Center Laboratory, Department of Medicine, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
J Gastroenterol Hepatol 17:448-55. 2002..Anti-oxidants have received the greatest attention; drugs such as S-adenosyl-methionine may be of benefit. This and others are under active study...
- Alcoholic steatosis and steatohepatitisJacquelyn J Maher
Liver Center Laboratory, University of California, San Francisco General Hospital, 94110, USA
Semin Gastrointest Dis 13:31-9. 2002..Survival in this severely ill subgroup is improved with the short-term use of corticosteroids; patients who have contraindications to steroids may benefit from other forms of therapy, either pharmacologic, nutritional, or both...
- Leukocytes as modulators of stellate cell activationJ J Maher
Liver Center and Department of Medicine, University of California San Francisco, 94110, USA
Alcohol Clin Exp Res 23:917-21. 1999..The following data summarize recent investigations in this area that focus on neutrophils as well as mononuclear cells...
- Interactions between hepatic stellate cells and the immune systemJ J Maher
Liver Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
Semin Liver Dis 21:417-26. 2001..Both types of studies are required to develop a better understanding of the complex interplay between stellate cells and leukocytes...
- Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic miceR Wang
G W Hooper Foundation and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
J Cell Biol 153:1023-34. 2001....
- Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathwayS Faouzi
Liver Center and the Department of Medicine, University of California, San Francisco, California 94110, USA
J Biol Chem 276:49077-82. 2001..Inflammation does not arise from Fas-mediated signaling through NF-kappa B; rather, it represents an indirect effect, requiring activation of caspase-3 and nuclear translocation of AP-1...
- Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injuryJohan Björkegren
Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco 94110, USA
J Biol Chem 277:5476-83. 2002..Our results suggest that blocking lipoprotein secretion in the liver may increase the susceptibility of the liver to certain toxic challenges...
- Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusionClaus U Niemann
Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143 0648, USA
Surgery 140:404-12. 2006....
- Metabolic profiling of livers and blood from obese Zucker ratsNatalie J Serkova
Biomedical MRI NMR, Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
J Hepatol 44:956-62. 2006..Obesity frequently leads to changes in fatty acid metabolism with subsequent fatty infiltration in the liver...
- Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in ratsJan Hirsch
Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 0446, USA
Mol Cell Proteomics 5:979-86. 2006..The ability to simultaneously monitor several pathways involved in reperfusion stress may result in important mechanistic insight and possibly new treatment options...
- VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesisBetty Y Y Tam
Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, Stanford, California, 94305, USA
Nat Med 12:793-800. 2006....
- Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injuryGene S Lee
Liver Center, University of California, San Francisco, San Francisco, CA 94110, USA
J Lipid Res 48:1885-96. 2007..These findings emphasize that individual dietary nutrients can make specific contributions to steatohepatitis...
- Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicityJennifer C Hanson
Liver Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
J Hepatol 44:359-67. 2006..CXC chemokines function as survival factors for several types of cells. In this study, we investigated whether CXC chemokines promote survival of liver cells following an apoptotic stimulus in vivo...
- Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injuryJunquan Xu
Liver Center and Department of Medicine, University of California, San Francisco 94110, USA
Am J Physiol Gastrointest Liver Physiol 287:G734-41. 2004....
- Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1Gizem Rizki
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
J Lipid Res 47:2280-90. 2006..MCD feeding also induces hepatic steatosis, by an independent mechanism. Viewed together, these two disparate consequences of MCD feeding (weight loss and hepatic steatosis) give the appearance of an unusual form of lipodystrophy...