JACQUELYN MAHER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis
    Jacquelyn J Maher
    Department of Medicine, University of California, San Francisco, CA, USA
    Hepatology 48:670-8. 2008
  2. ncbi request reprint Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo
    J J Maher
    Liver Center, University of California, San Francisco, USA
    Biochem Pharmacol 53:637-41. 1997
  3. pmc DAMPs ramp up drug toxicity
    Jacquelyn J Maher
    Department of Medicine and Liver Center, UCSF, San Francisco, California, USA
    J Clin Invest 119:246-9. 2009
  4. ncbi request reprint Alcoholic steatohepatitis: management and prognosis
    Jacquelyn J Maher
    Rice Liver Center Laboratory, San Francisco General Hospital, 1001 Potrero Avenue, Building 40, Room 4102, San Francisco, CA 94110, USA
    Curr Gastroenterol Rep 9:39-46. 2007
  5. pmc New insights from rodent models of fatty liver disease
    Jacquelyn J Maher
    Liver Center and Department of Medicine, University of California, San Francisco San Francisco, California, USA
    Antioxid Redox Signal 15:535-50. 2011
  6. ncbi request reprint Treatment of alcoholic hepatitis
    Jacquelyn J Maher
    Liver Center Laboratory, Department of Medicine, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Gastroenterol Hepatol 17:448-55. 2002
  7. ncbi request reprint Alcoholic steatosis and steatohepatitis
    Jacquelyn J Maher
    Liver Center Laboratory, University of California, San Francisco General Hospital, 94110, USA
    Semin Gastrointest Dis 13:31-9. 2002
  8. ncbi request reprint Leukocytes as modulators of stellate cell activation
    J J Maher
    Liver Center and Department of Medicine, University of California San Francisco, 94110, USA
    Alcohol Clin Exp Res 23:917-21. 1999
  9. ncbi request reprint Interactions between hepatic stellate cells and the immune system
    J J Maher
    Liver Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
    Semin Liver Dis 21:417-26. 2001
  10. pmc Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
    R Wang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 153:1023-34. 2001

Research Grants

  1. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2003
  2. Dietary factors in the pathogenesis of steatohepatitis
    JACQUELYN MAHER; Fiscal Year: 2007
  3. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2007
  4. NRSA Hepatology Training Grant
    JACQUELYN MAHER; Fiscal Year: 2007
  5. LIVER CENTER
    JACQUELYN MAHER; Fiscal Year: 2006
  6. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2006
  7. Dietary factors in the pathogenesis of steatohepatitis
    Jacquelyn J Maher; Fiscal Year: 2010

Collaborators

  • Rennian Wang
  • Richard Rippe
  • Claus U Niemann
  • John Paul Roberts
  • Natalie J Serkova
  • Jan Hirsch
  • THOMAS BADGER
  • S M Turner
  • Matthias Behrends
  • Anne Beigneux
  • M O Bergo
  • Gene S Lee
  • Jim Yan
  • Gizem Rizki
  • Jennifer C Hanson
  • Betty Y Y Tam
  • Gene Lee
  • Junquan Xu
  • Johan Bj√∂rkegren
  • S Faouzi
  • Sanjay Kakar
  • Jim S Yan
  • Raymond K Ng
  • Bianca Gabrielli
  • Grace Wu
  • Jeng Shin Lee
  • Carson B Campe
  • Randall S Johnson
  • George D Yancopoulos
  • Kevin Wei
  • Calvin J Kuo
  • Joseph A Garcia
  • Shelly Jiang
  • Joceyln Holash
  • Ray K Ng
  • Frans A Kuypers
  • Robert E Pitas
  • Cecile Chartier
  • Richard C Mulligan
  • Colleen Hefner
  • Lisa Ma
  • Stanley L Schrier
  • Jana Hoffman
  • Nihar R Nayak
  • John S Rudge
  • Nihar R Niyak
  • Sang Ki Park
  • Michele K Bostick
  • Pratima Kodali
  • Jenny Yuan
  • Uma Sundram
  • Lorenzo Arnaboldi
  • Haimei Wang
  • John M Vierling
  • Stephen G Young
  • L W Schrum
  • J C Hanson
  • C B Campe
  • B E Burckhardt

Detail Information

Publications20

  1. pmc Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis
    Jacquelyn J Maher
    Department of Medicine, University of California, San Francisco, CA, USA
    Hepatology 48:670-8. 2008
    ..This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease...
  2. ncbi request reprint Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo
    J J Maher
    Liver Center, University of California, San Francisco, USA
    Biochem Pharmacol 53:637-41. 1997
    ..This disparate behavior of stellate cells in culture and in vivo is unusual; the data suggest that stellate cells might respond variably to oxidants depending on their glutathione status...
  3. pmc DAMPs ramp up drug toxicity
    Jacquelyn J Maher
    Department of Medicine and Liver Center, UCSF, San Francisco, California, USA
    J Clin Invest 119:246-9. 2009
    ....
  4. ncbi request reprint Alcoholic steatohepatitis: management and prognosis
    Jacquelyn J Maher
    Rice Liver Center Laboratory, San Francisco General Hospital, 1001 Potrero Avenue, Building 40, Room 4102, San Francisco, CA 94110, USA
    Curr Gastroenterol Rep 9:39-46. 2007
    ..A prompt decline in serum bilirubin indicates a favorable response to therapy. Patients who do not exhibit a reduction in serum bilirubin within 1 week are considered nonresponders and have a 6-month mortality rate of 50% or higher...
  5. pmc New insights from rodent models of fatty liver disease
    Jacquelyn J Maher
    Liver Center and Department of Medicine, University of California, San Francisco San Francisco, California, USA
    Antioxid Redox Signal 15:535-50. 2011
    ..Numerous additional insights about hepatic lipid metabolism, which have been gained from genetically engineered mice, are also mentioned...
  6. ncbi request reprint Treatment of alcoholic hepatitis
    Jacquelyn J Maher
    Liver Center Laboratory, Department of Medicine, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Gastroenterol Hepatol 17:448-55. 2002
    ..Anti-oxidants have received the greatest attention; drugs such as S-adenosyl-methionine may be of benefit. This and others are under active study...
  7. ncbi request reprint Alcoholic steatosis and steatohepatitis
    Jacquelyn J Maher
    Liver Center Laboratory, University of California, San Francisco General Hospital, 94110, USA
    Semin Gastrointest Dis 13:31-9. 2002
    ..Survival in this severely ill subgroup is improved with the short-term use of corticosteroids; patients who have contraindications to steroids may benefit from other forms of therapy, either pharmacologic, nutritional, or both...
  8. ncbi request reprint Leukocytes as modulators of stellate cell activation
    J J Maher
    Liver Center and Department of Medicine, University of California San Francisco, 94110, USA
    Alcohol Clin Exp Res 23:917-21. 1999
    ..The following data summarize recent investigations in this area that focus on neutrophils as well as mononuclear cells...
  9. ncbi request reprint Interactions between hepatic stellate cells and the immune system
    J J Maher
    Liver Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
    Semin Liver Dis 21:417-26. 2001
    ..Both types of studies are required to develop a better understanding of the complex interplay between stellate cells and leukocytes...
  10. pmc Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
    R Wang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 153:1023-34. 2001
    ....
  11. ncbi request reprint Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway
    S Faouzi
    Liver Center and the Department of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 276:49077-82. 2001
    ..Inflammation does not arise from Fas-mediated signaling through NF-kappa B; rather, it represents an indirect effect, requiring activation of caspase-3 and nuclear translocation of AP-1...
  12. ncbi request reprint Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury
    Johan Björkegren
    Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco 94110, USA
    J Biol Chem 277:5476-83. 2002
    ..Our results suggest that blocking lipoprotein secretion in the liver may increase the susceptibility of the liver to certain toxic challenges...
  13. ncbi request reprint Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion
    Claus U Niemann
    Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143 0648, USA
    Surgery 140:404-12. 2006
    ....
  14. ncbi request reprint Metabolic profiling of livers and blood from obese Zucker rats
    Natalie J Serkova
    Biomedical MRI NMR, Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    J Hepatol 44:956-62. 2006
    ..Obesity frequently leads to changes in fatty acid metabolism with subsequent fatty infiltration in the liver...
  15. ncbi request reprint Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats
    Jan Hirsch
    Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 0446, USA
    Mol Cell Proteomics 5:979-86. 2006
    ..The ability to simultaneously monitor several pathways involved in reperfusion stress may result in important mechanistic insight and possibly new treatment options...
  16. ncbi request reprint VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
    Betty Y Y Tam
    Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1155, Stanford, California, 94305, USA
    Nat Med 12:793-800. 2006
    ....
  17. ncbi request reprint Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury
    Gene S Lee
    Liver Center, University of California, San Francisco, San Francisco, CA 94110, USA
    J Lipid Res 48:1885-96. 2007
    ..These findings emphasize that individual dietary nutrients can make specific contributions to steatohepatitis...
  18. ncbi request reprint Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicity
    Jennifer C Hanson
    Liver Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    J Hepatol 44:359-67. 2006
    ..CXC chemokines function as survival factors for several types of cells. In this study, we investigated whether CXC chemokines promote survival of liver cells following an apoptotic stimulus in vivo...
  19. pmc Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury
    Junquan Xu
    Liver Center and Department of Medicine, University of California, San Francisco 94110, USA
    Am J Physiol Gastrointest Liver Physiol 287:G734-41. 2004
    ....
  20. ncbi request reprint Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    Gizem Rizki
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Lipid Res 47:2280-90. 2006
    ..MCD feeding also induces hepatic steatosis, by an independent mechanism. Viewed together, these two disparate consequences of MCD feeding (weight loss and hepatic steatosis) give the appearance of an unusual form of lipodystrophy...

Research Grants15

  1. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2003
    ..If chemokines have significant cytoprotective effects, then anti-chemokine therapy may be complicated by unwanted side effects. ..
  2. Dietary factors in the pathogenesis of steatohepatitis
    JACQUELYN MAHER; Fiscal Year: 2007
    ..Because lipoapoptosis can be regulated by dietary nutrients, some individuals at risk of steatohepatitis may be able to reduce their risk by modifying their diet. ..
  3. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2007
    ..If chemokines have significant cytoprotective effects, then anti-chemokine therapy may be complicated by unwanted side effects. ..
  4. NRSA Hepatology Training Grant
    JACQUELYN MAHER; Fiscal Year: 2007
    ..Graduates of this research training in hepatology will be ready to assume a faculty-level position and to compete for individual extramural funding. ..
  5. LIVER CENTER
    JACQUELYN MAHER; Fiscal Year: 2006
    ..The opportunities in basic biology and in the application of basic science to clinical liver disease have never been greater, and the Center is poised to catalyze discovery in these areas. ..
  6. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2006
    ..If chemokines have significant cytoprotective effects, then anti-chemokine therapy may be complicated by unwanted side effects. ..
  7. Dietary factors in the pathogenesis of steatohepatitis
    Jacquelyn J Maher; Fiscal Year: 2010
    ..Because lipoapoptosis can be regulated by dietary nutrients, some individuals at risk of steatohepatitis may be able to reduce their risk by modifying their diet. ..