Research Topics
Species | Brion S MaherSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysisBrion S Maher
Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Psychiatr Genet 12:207-15. 2002..Overall, the meta-analyses support the involvement of the dopamine system genes in ADHD liability variation and suggest the need for studies examining interactions between these genes...
Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liabilityMichael M Vanyukov
Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 711 Salk Hall, Pittsburgh, PA 15261, USA
Behav Genet 39:233-44. 2009..The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk...- Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association resultsMary L Marazita
Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Hum Hered 68:151-70. 2009..Non-syndromic orofacial clefts, i.e. cleft lip (CL) and cleft palate (CP), are among the most common birth defects. The goal of this study was to identify genomic regions and genes for CL with or without CP (CL/P)... - The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interactionMichael M Vanyukov
Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Psychiatr Genet 17:323-32. 2007.... 
Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspectiveMichael M Vanyukov
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
Drug Alcohol Depend 123:S3-17. 2012..Two competing concepts address the development of involvement with psychoactive substances: the "gateway hypothesis" (GH) and common liability to addiction (CLA)...- Three-dimensional morphometric analysis of craniofacial shape in the unaffected relatives of individuals with nonsyndromic orofacial clefts: a possible marker for genetic susceptibilitySeth M Weinberg
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Med Genet A 146:409-20. 2008..These findings further suggest that a quantitative assessment of the craniofacial phenotype may allow for the identification of susceptible individuals within nonsyndromic cleft families... - Genome survey for loci that influence successful aging: results at 10-cM resolutionGeorge S Zubenko
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA
Am J Geriatr Psychiatry 15:184-93. 2007..A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition (successful aging)... - Pittsburgh Registry of Infant Multiplets (PRIM): an updateElizabeth A Jenkins
Department of Human Genetics, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
Twin Res Hum Genet 9:1006-8. 2006..Pilot data on the heritability of minor physical anomalies and neuropsychological characteristics (Continuous Performance Test) are reported... - Genetic segregation analysis of recurrent, early-onset major depression: evidence for single major locus transmissionBrion S Maher
Division of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania, USA
Am J Med Genet 114:214-21. 2002..Our findings illustrate the advantage of employing families identified by probands with RE-MDD in studies designed to detect susceptibility loci for unipolar MDD and related disorders... 
Identifying genomic regions for fine-mapping using genome scan meta-analysis (GSMA) to identify the minimum regions of maximum significance (MRMS) across populationsMargaret E Cooper
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
BMC Genet 6:S42. 2005..This GSMA analysis approach demonstrates the power of linkage meta-analysis to detect multiple genes simultaneously for a complex disorder. The MRMS method enhances this powerful tool to focus on more localized regions of linkage...- Methods for detecting gene x gene interaction in multiplex extended pedigreesGuy N Brock
Department of Human Genetics, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261, USA
BMC Genet 6:S144. 2005..In general, we found detection of the interacting loci to be a difficult problem, and though we experienced some modest success there is a clear need to continue developing new methods and approaches to the problem... - Liability to substance use disorders: 2. A measurement approachMichael M Vanyukov
Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
Neurosci Biobehav Rev 27:517-26. 2003..This method is also applicable to measuring liabilities to other complex disorders, especially those with relatively late onset... - Dental school applicants' use of website information during the application processHeiko Spallek
Center for Dental Informatics, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
J Dent Educ 69:1359-67. 2005..We recommend that dental schools make the most important application-related information and criteria easy to find... - Reduced age-related cataracts among elderly persons who reach age 90 with preserved cognition: a biomarker of successful aging?George S Zubenko
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 62:500-6. 2007..Our findings suggest that the progressive development of lens opacities may be reflective of degenerative events occurring more generally throughout the body... - Genetic segregation analysis of alcohol and other substance-use disorders in families with recurrent, early-onset major depressionBrion S Maher
Division of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania, USA
Am J Drug Alcohol Abuse 28:711-31. 2002..S. Mol. Psychiatry 2000, 5, 131-136]... - Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depressionGeorge S Zubenko
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pennsylvania, USA
Am J Med Genet 114:980-7. 2002..The sex-specificity of the susceptibility locus identified by our study may result from reported synergistic interactions of CREB with nuclear estrogen receptors... - Genome scan for loci involved in cleft lip with or without cleft palate, in Chinese multiplex familiesMary L Marazita
Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Am J Hum Genet 71:349-64. 2002..0; alpha=0.37) were for chromosomes 3q and 4q. Associations with P< or =.05 were found for loci on chromosomes 3, 5-7, 9, 11, 12, 16, 20, and 21. The most significant association result (P=.009) was found with D16S769 (51 cM)... - Nonsyndromic cleft lip with or without cleft palate in China: assessment of candidate regionsMary L Marazita
Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 1931, USA
Cleft Palate Craniofac J 39:149-56. 2002..Therefore, the objective of this study of Chinese families was to evaluate linkage and association between CL/P and 10 genetic markers in five chromosomal regions that have shown positive results in Caucasians... - Liability to substance use disorders: 1. Common mechanisms and manifestationsMichael M Vanyukov
Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
Neurosci Biobehav Rev 27:507-15. 2003..An accompanying paper describes an approach to the quantitative estimation of this trait... - Orbicularis oris muscle defects as an expanded phenotypic feature in nonsyndromic cleft lip with or without cleft palateKatherine Neiswanger
Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, and Department of Pediatric Radiology, Children s Hospital of Pittsburgh, Pennsylvania 15219, USA
Am J Med Genet A 143:1143-9. 2007..Furthermore, the expansion of the cleft lip+/-cleft palate phenotypic spectrum should improve the power of genetic studies... - Minor physical anomalies in schizophrenia: a meta-analysisSeth M Weinberg
Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Schizophr Res 89:72-85. 2007..05), although the pooled odds ratios for these regions did not differ significantly from one another. These results suggest a lack of regional specificity for MPAs in schizophrenia... - Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depressionGeorge S Zubenko
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 129:47-54. 2004.... - Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35Mary L Marazita
Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Am J Hum Genet 75:161-73. 2004..0004). These are the first genomewide significant linkage results ever reported for CL/P, and they represent an unprecedented demonstration of the power of linkage analysis to detect multiple genes simultaneously for a complex disorder... - Approaches to detecting gene x gene interaction in Genetic Analysis Workshop 14 pedigreesBrion S Maher
Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Genet Epidemiol 29:S116-9. 2005..Overall, most of the groups found limited success in consistently detecting all of the simulated interactions due, in large part, to the nature of the generating model... - Haplotypes of the monoamine oxidase genes and the risk for substance use disordersMichael M Vanyukov
Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
Am J Med Genet B Neuropsychiatr Genet 125:120-5. 2004..Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems... - Genetic analysis of candidate loci in non-syndromic cleft lip families from Antioquia-Colombia and OhioLina M Moreno
Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
Am J Med Genet A 125:135-44. 2004..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html... - Idiopathic congenital central hypoventilation syndrome: analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2bDebra E Weese-Mayer
Department of Pediatrics, Rush Children s Hospital at Rush Presbyterian St Luke s Medical Center, Rush University, Chicago, Illinois 60612, USA
Am J Med Genet A 123:267-78. 2003.... - Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic developmentDebra E Weese-Mayer
Department of Pediatrics, Rush Children s Hospital at Rush University Medical Center, Chicago, IL 60612, USA
Pediatr Res 56:391-5. 2004..These data represent further refinement of the genetic profile that might place an infant at risk for SIDS... - MEGF10 association with schizophreniaXiangning Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
Biol Psychiatry 63:441-8. 2008..In this study, we carried out independent replication and expression studies of the MEGF10 gene... - Impaired FGF signaling contributes to cleft lip and palateBridget M Riley
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 104:4512-7. 2007..The data suggest that the FGF signaling pathway may contribute to as much as 3-5% of NS CLP and will be a consideration in the clinical management of CLP... - Sudden infant death syndrome: association with a promoter polymorphism of the serotonin transporter geneDebra E Weese-Mayer
Department of Pediatrics, Rush University, Rush Children s Hospital at Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
Am J Med Genet A 117:268-74. 2003.... - Association of the serotonin transporter gene with sudden infant death syndrome: a haplotype analysisDebra E Weese-Mayer
Department of Pediatrics, Rush Children s Hospital at Rush Presbyterian St Luke s Medical Center, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
Am J Med Genet A 122:238-45. 2003.... - Sudden infant death syndrome: Case-control frequency differences in paired like homeobox (PHOX) 2B geneCasey M Rand
Department of Pediatrics, Rush Children's Hospital at Rush University Medical Center, Chicago, Illinois 60612, USA
Am J Med Genet A 140:1687-91. 2006 - 3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysisBrion S Maher
Am J Med Genet A 140:1453-7. 2006 - Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palateTheresa M Zucchero
University of Iowa, Iowa City 52242, USA
N Engl J Med 351:769-80. 2004..We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene... - Facial phenotype in children and young adults with PHOX2B-determined congenital central hypoventilation syndrome: quantitative pattern of dysmorphologyEmily S Todd
Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612, USA
Pediatr Res 59:39-45. 2006..These results suggest a characteristic facial phenotype in children and young adults with CCHS, due to an expansion mutation in PHOX2B... - Gene by environment interactionsROBERT C CULVERHOUSE
Department of Medicine, Washington University School of Medicine, 600 South Euclid, St Louis, MO 63110, USA
Genet Epidemiol 31:S68-74. 2007..A related but distinct goal is to characterize an interaction (e.g. to determine if the interaction is significant)... - Nicotine metabolizing genes GSTT1 and CYP1A1 in sudden infant death syndromeCasey M Rand
Department of Pediatrics, Rush Children s Hospital at Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
Am J Med Genet A 140:1447-52. 2006..A prospective study of SIDS cases with nicotine exposure history is necessary to resolve the relationship between nicotine metabolizing genes and SIDS...