Ram I Mahato

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc RNAi for treating hepatitis B viral infection
    Yong Chen
    Huai An 4th People s Hospital, Jiangsu, China
    Pharm Res 25:72-86. 2008
  2. pmc Gene expression and silencing for improved islet transplantation
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Control Release 140:262-7. 2009
  3. ncbi request reprint Cationic lipid and polymer-based gene delivery to human pancreatic islets
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Mol Ther 7:89-100. 2003
  4. ncbi request reprint Emerging trends in oral delivery of peptide and protein drugs
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Crit Rev Ther Drug Carrier Syst 20:153-214. 2003
  5. ncbi request reprint Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA
    Ram I Mahato
    University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, 26 South Dunlap Street, Feurt Bldg RM 406, Memphis, TN 38163, USA
    Expert Opin Drug Deliv 2:3-28. 2005
  6. ncbi request reprint Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets
    Ajit S Narang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 26 South Dunlap Street, Feurt Building RM 406, Memphis, Tennessee 38163, USA
    Pharm Res 21:15-25. 2004
  7. doi request reprint Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery
    Feng Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Biomacromolecules 11:2610-20. 2010
  8. pmc Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation
    Ravikiran Panakanti
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 S Manassas, Rm 224, Memphis, Tennessee, 38103 3308, USA
    Pharm Res 26:587-96. 2009
  9. doi request reprint Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets
    Guofeng Cheng
    Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee 38103, USA
    Mol Pharm 5:1093-102. 2008
  10. pmc Formulation and characterization of polyester/polycarbonate nanoparticles for delivery of a novel microtubule destabilizing agent
    Vaibhav Mundra
    Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, 19 South Manassas St, Memphis, Tennessee 38103, USA
    Pharm Res 29:3064-74. 2012

Research Grants

Collaborators

Detail Information

Publications67

  1. pmc RNAi for treating hepatitis B viral infection
    Yong Chen
    Huai An 4th People s Hospital, Jiangsu, China
    Pharm Res 25:72-86. 2008
    ..There is an in-depth discussion on the (1) mechanisms of RNAi, (2) methods for siRNA/shRNA production, (3) barriers to RNAi-based therapies, and (4) delivery strategies of siRNA for treating HBV infection...
  2. pmc Gene expression and silencing for improved islet transplantation
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Control Release 140:262-7. 2009
    ..In conclusion, bipartite Adv vector efficiently co-expressed both growth factor and antiapoptotic genes or shRNA targeting pro-apoptotic genes, decreases apoptosis and improves the outcome of islet transplantation...
  3. ncbi request reprint Cationic lipid and polymer-based gene delivery to human pancreatic islets
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Mol Ther 7:89-100. 2003
    ..The low transfection efficiency is due to the islets being a cluster of approximately 1000 non-dividing cells. This underscores the importance of experimentation with the actual human islets...
  4. ncbi request reprint Emerging trends in oral delivery of peptide and protein drugs
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Crit Rev Ther Drug Carrier Syst 20:153-214. 2003
    ..The roles of P-glycoprotein and CYP3A4 in controlling the extent of intestinal absorption and metabolism will also be discussed...
  5. ncbi request reprint Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA
    Ram I Mahato
    University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, 26 South Dunlap Street, Feurt Bldg RM 406, Memphis, TN 38163, USA
    Expert Opin Drug Deliv 2:3-28. 2005
    ..Furthermore, the ways to overcome the biological barriers are also discussed so that therapeutic concentrations at their target sites can be maintained for a desired period...
  6. ncbi request reprint Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets
    Ajit S Narang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 26 South Dunlap Street, Feurt Building RM 406, Memphis, Tennessee 38163, USA
    Pharm Res 21:15-25. 2004
    ..Human vascular endothelial growth factor (hVEGF) gene delivery is likely to promote islet revascularization and survival...
  7. doi request reprint Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery
    Feng Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Biomacromolecules 11:2610-20. 2010
    ..Embelin loaded PEG-PCD micelles showed significant inhibition of C4-2 prostate cancer cell proliferation, while no obvious cellular toxicity was observed for blank micelles...
  8. pmc Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation
    Ravikiran Panakanti
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 S Manassas, Rm 224, Memphis, Tennessee, 38103 3308, USA
    Pharm Res 26:587-96. 2009
    ..Hepatocyte growth factor (HGF) increases beta-cell proliferation and promotes revascularization of islets, while interleukin-1 receptor antagonist (hIL-1Ra) inhibits islet cell apoptosis...
  9. doi request reprint Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets
    Guofeng Cheng
    Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee 38103, USA
    Mol Pharm 5:1093-102. 2008
    ..Blood glucose levels returned to > or = 325 mg/dL upon removal of the islet graft-bearing kidney at 32 days after transplantation, confirming that transplanted islets were functional...
  10. pmc Formulation and characterization of polyester/polycarbonate nanoparticles for delivery of a novel microtubule destabilizing agent
    Vaibhav Mundra
    Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, 19 South Manassas St, Memphis, Tennessee 38103, USA
    Pharm Res 29:3064-74. 2012
    ....
  11. ncbi request reprint Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells
    Ajit S Narang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Bioconjug Chem 16:156-68. 2005
    ..This hypothesis is supported by TEM observations where elongated complexes were observed and more lipid was seen associated with the DNA...
  12. doi request reprint Self-assembling methoxypoly(ethylene glycol)-b-poly(carbonate-co-L-lactide) block copolymers for drug delivery
    Michael Danquah
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 South Manassas Room 224, Memphis, TN 38103 3308, USA
    Biomaterials 31:2358-70. 2010
    ..Bicalutamide-loaded PEG-b-P(CB-co-LA) micelles showed significant inhibition of LNCaP cell growth in a dose-dependent manner which was similar to the methanol solution of free drug...
  13. doi request reprint Poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate) micelles for rapamycin delivery: in vitro characterization and biodistribution
    Wenli Lu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Pharm Sci 100:2418-29. 2011
    ..In conclusion, rapamycin formulated with PEG-b-PBC micelles showed significantly reduced toxicity on INS-1E β-cells and human islets, but had similar biodistribution profiles as those of nanosuspensions...
  14. doi request reprint Combination therapy of antiandrogen and XIAP inhibitor for treating advanced prostate cancer
    Michael Danquah
    University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, 19 South Manassas, CRB RM 226, Memphis, 38103 3308, Tennessee, USA
    Pharm Res 29:2079-91. 2012
    ..Therefore, our objective was to determine whether novel antiandrogen (CBDIV17) and XIAP inhibitor based combination therapy can treat advanced prostate cancer...
  15. pmc Mesenchymal stem cells as a gene delivery vehicle for successful islet transplantation
    Hao Wu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 S Manassas, Rm 224, Memphis, Tennessee 38103 3308, USA
    Pharm Res 28:2098-109. 2011
    ....
  16. pmc Coexpression of vascular endothelial growth factor and interleukin-1 receptor antagonist for improved human islet survival and function
    Xiangxu Jia
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Pharm 4:199-207. 2007
    ..In conclusion, our results indicated that coexpression of growth factor and antiapoptic genes can improve islet survival and function...
  17. pmc XIAP gene expression protects β-cells and human islets from apoptotic cell death
    Hao Wu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103 3308, USA
    Mol Pharm 7:1655-66. 2010
    ..These results indicate that ex vivo transduction of islets with Adv-XIAP will decrease cytokine induced apoptosis and improve the outcome of islet transplantation...
  18. doi request reprint Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100
    Feng Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
    J Control Release 143:151-8. 2010
    ..The anticancer activity of SMART-100 loaded PEG-PLA micelles was also evaluated on luciferase expressing C4-2-Luc cell lines by IVIS imaging. Our results suggest that SMART-100 has the potential to treat resistant cancers...
  19. pmc HPMA polymer-based site-specific delivery of oligonucleotides to hepatic stellate cells
    Ningning Yang
    Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, Tennessee 38103, USA
    Bioconjug Chem 20:213-21. 2009
    ..Almost 80% of the total liver uptake in fibrotic rats was contributed by HSCs. In conclusion, conjugation with M6P-HPMA-GFLG significantly increased TFO delivery to the HSCs and could be potentially used for treating liver fibrosis...
  20. ncbi request reprint Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function
    Ajit S Narang
    Department of Pharmaceutical Sciences, University of Tennesee Health Science Center, 26 S Dunlap St, Feurt Bldg RM 413, Memphis, Tennessee 38163, USA
    Pharm Res 23:1970-82. 2006
    ..We determined whether there is an additive effect of hVEGF and human interleukin-1 receptor antagonist (hIL-1Ra) gene expression in human islets...
  21. ncbi request reprint Enhanced hepatic uptake and bioactivity of type alpha1(I) collagen gene promoter-specific triplex-forming oligonucleotides after conjugation with cholesterol
    Kun Cheng
    University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, 26 South Dunlap Street, Feurt 413, Memphis, TN 38163, USA
    J Pharmacol Exp Ther 317:797-805. 2006
    ..More importantly, the nuclear uptake of TFO-Chol was higher than TFO in cell culture system and in vivo studies. In conclusion, TFO-Chol is a potential antifibrotic agent...
  22. ncbi request reprint RGD peptide-modified adenovirus expressing hepatocyte growth factor and X-linked inhibitor of apoptosis improves islet transplantation
    Hao Wu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
    J Gene Med 13:658-69. 2011
    ..Islet transplantation has the potential for treating type I diabetes; however, its widespread clinical application is limited by the massive apoptotic cell death and poor revascularization of transplanted islet grafts...
  23. pmc Genetically modified mesenchymal stem cells for improved islet transplantation
    Hao Wu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States
    Mol Pharm 8:1458-70. 2011
    ..This review aims to gain a thorough understanding of the current obstacles to successful islet transplantation and discusses the potential role of primary MSCs before or after genetic modification in islet transplantation...
  24. ncbi request reprint Receptor-mediated hepatic uptake of M6P-BSA-conjugated triplex-forming oligonucleotides in rats
    Zhaoyang Ye
    Department of Pharmaceutical, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Bioconjug Chem 17:823-30. 2006
    ..Almost 82% of the total liver uptake in fibrotic rats was contributed by HSCs. In conclusion, by conjugation with M6P-BSA, the TFO could be potentially used for the treatment of liver fibrosis...
  25. doi request reprint GFAP promoter-driven RNA interference on TGF-β1 to treat liver fibrosis
    Ningning Yang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 South Manassas, Memphis, Tennessee 38103 3308, USA
    Pharm Res 28:752-61. 2011
    ..This is expected to avoid the side effect of non-specific TGF-β1 gene silencing...
  26. pmc TGF-beta1 gene silencing for treating liver fibrosis
    Kun Cheng
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    Mol Pharm 6:772-9. 2009
    ..In conclusion, both siRNA and shRNA showed sequence-specific and dose dependent TGF-beta1 gene silencing and have the potential to treat liver fibrosis...
  27. doi request reprint Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling
    Akshay Pratap
    Division of Solid Organ Transplantation, Methodist University Hospital, Memphis, TN, USA
    J Drug Target 20:770-82. 2012
    ..Thus, GDC has the potential to serve as a new therapeutic agent for treating early liver fibrosis...
  28. pmc Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation
    Ravikiran Panakanti
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Biochem Pharmacol 80:1718-26. 2010
    ..These results suggests that TFO can be used to downregulate type 1 collagen gene expression and can alleviate liver fibrosis induced by common bile duct ligation...
  29. pmc Cyclopamine attenuates acute warm ischemia reperfusion injury in cholestatic rat liver: hope for marginal livers
    Akshay Pratap
    Division of Solid Organ Transplantation, Methodist University Hospital, Memphis, Tennessee 38140, USA
    Mol Pharm 8:958-68. 2011
    ..Endogenous Hh signaling in cholestasis exacerbates inflammatory injury during liver I/R. Blockade of Hh pathway represents a clinically relevant novel approach to limit I/R injury in cholestatic marginal liver...
  30. pmc Lipid and polymeric carrier-mediated nucleic acid delivery
    Lin Zhu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 South Manassas St, Cancer Research Building RM 226, Memphis, TN 38103, USA
    Expert Opin Drug Deliv 7:1209-26. 2010
    ....
  31. pmc Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation
    Lin Zhu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38103, United States
    Bioconjug Chem 21:2119-27. 2010
    ..In conclusion, these siRNA conjugates have the potential for targeted delivery of siRNAs to hepatocytes and hepatic stellate cells for efficient gene silencing in vivo...
  32. ncbi request reprint Biological and biomaterial approaches for improved islet transplantation
    Ajit S Narang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 26 S Dunlap St, Feurt Building, Room 413, Memphis, TN 38163, USA
    Pharmacol Rev 58:194-243. 2006
    ..This review will critically address various insights developed in each individual strategy and for multipronged approaches, which will be helpful in achieving better outcomes...
  33. pmc Structural and formulation factors influencing pyridinium lipid-based gene transfer
    Lin Zhu
    University of Tennessee Health Science Center, Memphis, Tennessee 38103 3308, USA
    Bioconjug Chem 19:2499-512. 2008
    ..In conclusion, pyridinium lipids showed high transfection efficiency and have the potential to be used as transfection reagents in vitro and in vivo...
  34. pmc Site-specific delivery of oligonucleotides to hepatocytes after systemic administration
    Lin Zhu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Bioconjug Chem 19:290-8. 2008
    ..In conclusion, Gal-PEG-ODN conjugate may be used for treating a variety of liver diseases...
  35. pmc Bioconjugation of oligonucleotides for treating liver fibrosis
    Zhaoyang Ye
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Oligonucleotides 17:349-404. 2007
    ..Various insights developed in individual strategy and the need for multipronged approaches will also be discussed...
  36. pmc Chemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathway
    Saurabh Singh
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e40021. 2012
    ..We have shown that supplementing mitotic stabilizer drugs such as PTX with Hh-inhibitor CYA can reverse PTX chemoresistance and eliminate SP fraction in androgen independent, metastatic prostate cancer cell lines...
  37. pmc Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene
    Feng Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103 3308, USA
    J Gene Med 11:764-71. 2009
    ..Expression of a growth factor gene to promote revascularization and silencing of pro-apoptotic genes before transplantation may improve the outcome of islet transplantation...
  38. pmc Sequence-specific triple helix formation with genomic DNA
    Zhaoyang Ye
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Biochemistry 46:11240-52. 2007
    ..3% of triplex formation was observed, which was correlated with a 73.6% of transcription inhibition. These findings will further strengthen the therapeutic applications of APS165...
  39. doi request reprint Micellar delivery of cyclopamine and gefitinib for treating pancreatic cancer
    Deepak Chitkara
    Department of Pharmaceutical Sciences, and Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States
    Mol Pharm 9:2350-7. 2012
    ..6pl-derived xenograft mouse tumors. These data suggest the applicability of our micellar system to effectively load and deliver cyclopamine and gefitinib for combination chemotherapy...
  40. doi request reprint miRNA profiling in pancreatic cancer and restoration of chemosensitivity
    Saurabh Singh
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, United States
    Cancer Lett 334:211-20. 2013
    ....
  41. doi request reprint Self-assembling, amphiphilic polymer-gemcitabine conjugate shows enhanced antitumor efficacy against human pancreatic adenocarcinoma
    Deepak Chitkara
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Bioconjug Chem 24:1161-73. 2013
    ....
  42. pmc Targeted TFO delivery to hepatic stellate cells
    Ningning Yang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, United States
    J Control Release 155:326-30. 2011
    ..This TFO conjugate shows negligible immunogenicity owing to the use of HPMA, one of the least immunogenic copolymers, thereby making it a suitable and more effective candidate for antifibrotic therapy...
  43. doi request reprint Subcellular fate and off-target effects of siRNA, shRNA, and miRNA
    Saurabh Singh
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 S Manassas, Rm 224, Memphis, Tennessee 38103 3308, USA
    Pharm Res 28:2996-3015. 2011
    ..We also discuss approaches that increase the specificity and metabolic stability and reduce the off-target effects of RNAi strategy...
  44. ncbi request reprint Targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells
    Zhaoyang Ye
    Department of Pharmaceutical, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Biochemistry 44:4466-76. 2005
    ..Therefore, this TFO conjugate may be used for the treatment of liver fibrosis...
  45. ncbi request reprint Biodistribution and hepatic uptake of triplex-forming oligonucleotides against type alpha1(I) collagen gene promoter in normal and fibrotic rats
    Kun Cheng
    Department of Pharmaceutical, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Pharm 2:206-17. 2005
    ..In conclusion, systemic delivery of the TFO against type alpha1(I) collagen gene promoter may be used for the treatment of liver fibrosis...
  46. pmc Bipartite vector encoding hVEGF and hIL-1Ra for ex vivo transduction into human islets
    Ravikiran Panakanti
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    Mol Pharm 6:274-84. 2009
    ..These results indicate that the bipartite Adv vector efficiently expresses both growth factor and antiapoptotic genes, decreases apoptosis and improves the outcome of islet transplantation...
  47. ncbi request reprint Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery
    Dong An Wang
    Department of Pharmaceutical Sciences, University of Tennessee, Memphis, Tennessee 38163, USA
    Biomacromolecules 3:1197-207. 2002
    ....
  48. pmc RNA interference for improving the outcome of islet transplantation
    Feng Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Adv Drug Deliv Rev 63:47-68. 2011
    ..Last but not the least, several delivery strategies for enhanced gene silencing are discussed, including chemical modification of siRNA, complex formation, bioconjugation, and viral vectors...
  49. doi request reprint Extravasation of polymeric nanomedicines across tumor vasculature
    Michael K Danquah
    Department of Pharmaceutical Sciences, 19 South Manassas St, Memphis, TN 38103 3308, USA
    Adv Drug Deliv Rev 63:623-39. 2011
    ..Special attention is given to utilizing polymeric nanomedicines to facilitate extravasation of anticancer drugs for future cancer therapy...
  50. pmc Gene modulation for treating liver fibrosis
    Kun Cheng
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Crit Rev Ther Drug Carrier Syst 24:93-146. 2007
    ..This review critically addresses various insights developed with each individual strategy and for multipronged approaches, which will be helpful in achieving more effective outcomes...
  51. ncbi request reprint Micellar delivery of bicalutamide and embelin for treating prostate cancer
    Michael Danquah
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38103 3308, USA
    Pharm Res 26:2081-92. 2009
    ..To examine the effect of bicalutamide and embelin on the growth of prostate cancer cells in vitro and in vivo..
  52. doi request reprint Inhibition of endogenous hedgehog signaling protects against acute liver injury after ischemia reperfusion
    Akshay Pratap
    Division of Solid Organ Transplantation, Methodist University Hospital Transplant Institute, Memphis, Tennessee 38104, USA
    Pharm Res 27:2492-504. 2010
    ..Therefore, we determined the expression pattern of Hh signaling and its role in liver injury following I/R using Hh antagonist cyclopamine (CYA)...
  53. pmc Third-party mesenchymal stem cells improved human islet transplantation in a humanized diabetic mouse model
    Hao Wu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Mol Ther 21:1778-86. 2013
    ..Taken together, our studies demonstrated that transplantation of islets with hBMSCs is a promising strategy to improve the outcome of human islet transplantation...
  54. doi request reprint iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis
    Feng Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Mol Pharm 5:407-17. 2008
    ..Nevertheless, these results suggest that siRNA may penetrate beyond the periphery into a larger percentage of an islet mass than previously thought...
  55. ncbi request reprint Water insoluble and soluble lipids for gene delivery
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 26 South Dunlap Street, Feurt Bldg RM 413, Memphis, TN 38163, United States
    Adv Drug Deliv Rev 57:699-712. 2005
    ..This review provides a critical discussion on how the components of water insoluble and soluble lipids affect their transfection efficiency and biodistribution of lipid/plasmid complexes...
  56. ncbi request reprint Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer
    Anupama Mittal
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biomaterials 35:7077-87. 2014
    ..Immuno-hiostochemical analysis revealed decreased tumor cell proliferation with increased apoptosis in the animals treated with miR-205 and gemcitabine combination. ..
  57. ncbi request reprint Emerging trends in cell-based therapies. Preface
    Zhaoyang Ye
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 S Manassas, Rm 224, Memphis, TN 38103 3308, USA
    Adv Drug Deliv Rev 60:89-90. 2008
  58. ncbi request reprint Nanomedicines of Hedgehog Inhibitor and PPAR-γ Agonist for Treating Liver Fibrosis
    Virender Kumar
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA
    Pharm Res 31:1158-69. 2014
    ..Since Hh inhibitor, vismodegib (GDC) and PPAR-γ agonist, rosiglitazone (RSG) have poor water solubility, our objective was to formulate biodegradable polymeric nanoparticles encapsulating GDC and RSG for treating liver fibrosis...
  59. pmc Genetically modified human bone marrow derived mesenchymal stem cells for improving the outcome of human islet transplantation
    Vaibhav Mundra
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 8:e77591. 2013
    ..In conclusion, our results have demonstrated that hBMSCs may be used as gene carriers and nursing cells to improve the outcome of islet transplantation. ..
  60. pmc Mesenchymal stem cell-based therapy
    Vaibhav Mundra
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38103, United States
    Mol Pharm 10:77-89. 2013
    ..This review focuses on the clinical applications of MSC-based cell therapy, with particular emphasis on islet transplantation for treating type I diabetes...
  61. pmc Synthesis and characterization of an anti-apoptotic immunosuppressive compound for improving the outcome of islet transplantation
    Hao Wu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States
    Bioconjug Chem 24:2036-44. 2013
    ..Taken together, our results demonstrated that JP-3-110 can be a safer immunosuppressive agent for human islet transplantation. ..
  62. ncbi request reprint Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function
    Daniel de Paula
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    J Drug Target 15:358-69. 2007
    ..Therefore, we investigated the effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function...
  63. pmc Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
    Daniel de Paula
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP Brazil
    RNA 13:431-56. 2007
    ....
  64. pmc siRNA pool targeting different sites of human hepatitis B surface antigen efficiently inhibits HBV infection
    Yong Chen
    Huaian 4th People s Hospital, Jiangsu, PR China
    J Drug Target 16:140-8. 2008
    ..In conclusion, a pool of chemically synthesised siRNAs as well as the shRNA expression plasmid encoding multiple shRNAs targeting different regions of HBsAg showed high gene silencing in HepG2.2.15 cells...
  65. ncbi request reprint Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine
    Jonathan M Benns
    Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, 30 South 2000 East, Rm 201, Salt Lake City, UT 84112 5820, USA
    J Control Release 79:255-69. 2002
    ..There was little increase in toxicity when FPF-5.2g-PEI/pLuc complex concentrations increased...
  66. ncbi request reprint Novel water insoluble lipoparticulates for gene delivery
    Darin Y Furgeson
    Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, Salt Lake City, Utah 84112 5820, USA
    Pharm Res 19:382-90. 2002
    ..The objective was to design and prepare water insoluble lipoparticulates (ISLPs) for efficient gene delivery to lung tissue...
  67. doi request reprint Role of nanomedicines in cell-based therapeutics
    Zhaoyang Ye
    Nanomedicine (Lond) 3:5-8. 2008

Research Grants1

  1. Targeted Delivery of TFOs for Treatment of Liver Fibrosis
    RAM MAHATO; Fiscal Year: 2007
    ..The data will also be beneficial to successful treatment of other organ fibrosis. ..