S D Mahajan

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health System, Buffalo, NY 14203, USA
    J Immunol 169:3589-99. 2002
  2. ncbi request reprint Effect of maternal malnutrition and anemia on the endocrine regulation of fetal growth
    Supriya D Mahajan
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
    Endocr Res 30:189-203. 2004
  3. pmc Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 301 Multi Research Building, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    Brain Res 1203:133-48. 2008
  4. pmc Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma
    Mark F Sands
    VA Western New York Healthcare System, Buffalo, NY 14215, USA
    Clin Immunol 130:186-98. 2009
  5. pmc Nanotherapeutics Using an HIV-1 Poly A and Transactivator of the HIV-1 LTR-(TAR-) Specific siRNA
    Supriya D Mahajan
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University at Buffalo, The State University of New York, 640 Ellicott Street, Room 444 Innovation Center, Buffalo, NY 14203, USA
    Patholog Res Int 2011:719139. 2011
  6. pmc Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity: Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients
    Bindukumar Nair
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University at Buffalo, 640 Ellicott Street, Room 444 Innovation Center, Buffalo Niagara Medical Campus, 640 Ellicott Street, Buffalo, NY 14203, USA
    Int J Proteomics 2011:673618. 2011
  7. pmc Anti-HIV-1 nanotherapeutics: promises and challenges for the future
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, Buffalo Niagara Medical Campus, Buffalo, NY, USA
    Int J Nanomedicine 7:5301-14. 2012
  8. doi request reprint Suppression of MMP-9 expression in brain microvascular endothelial cells (BMVEC) using a gold nanorod (GNR)-siRNA nanoplex
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University at Buffalo, The State University of New York, Innovation Center, Buffalo, New York 14203, USA
    Immunol Invest 41:337-55. 2012
  9. ncbi request reprint Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, Buffalo, New York 14203, USA
    Mol Diagn Ther 10:257-69. 2006
  10. doi request reprint Nutritional anaemia dysregulates endocrine control of fetal growth
    S Mahajan
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Br J Nutr 100:408-17. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health System, Buffalo, NY 14203, USA
    J Immunol 169:3589-99. 2002
    ..These effects of opioids appear to be mediated through the opioid mu receptor that we demonstrated on astroglial cells...
  2. ncbi request reprint Effect of maternal malnutrition and anemia on the endocrine regulation of fetal growth
    Supriya D Mahajan
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
    Endocr Res 30:189-203. 2004
    ..Thus, these novel observations are relevant to the context of the ongoing scientific debate on Barker's hypothesis...
  3. pmc Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 301 Multi Research Building, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    Brain Res 1203:133-48. 2008
    ..An understanding of the mechanisms of BBB breakdown that lead to neurotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients...
  4. pmc Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma
    Mark F Sands
    VA Western New York Healthcare System, Buffalo, NY 14215, USA
    Clin Immunol 130:186-98. 2009
    ..Our findings support the hypothesis that TIMP-1 plays a protective role by preventing AHR and modulating inflammation, remodeling, and cytokine expression in an animal model of asthma...
  5. pmc Nanotherapeutics Using an HIV-1 Poly A and Transactivator of the HIV-1 LTR-(TAR-) Specific siRNA
    Supriya D Mahajan
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University at Buffalo, The State University of New York, 640 Ellicott Street, Room 444 Innovation Center, Buffalo, NY 14203, USA
    Patholog Res Int 2011:719139. 2011
    ..HIV-1 nanotherapeutics can thus enhance systemic bioavailability and offer multifunctionality...
  6. pmc Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity: Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients
    Bindukumar Nair
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University at Buffalo, 640 Ellicott Street, Room 444 Innovation Center, Buffalo Niagara Medical Campus, 640 Ellicott Street, Buffalo, NY 14203, USA
    Int J Proteomics 2011:673618. 2011
    ....
  7. pmc Anti-HIV-1 nanotherapeutics: promises and challenges for the future
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, Buffalo Niagara Medical Campus, Buffalo, NY, USA
    Int J Nanomedicine 7:5301-14. 2012
    ....
  8. doi request reprint Suppression of MMP-9 expression in brain microvascular endothelial cells (BMVEC) using a gold nanorod (GNR)-siRNA nanoplex
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University at Buffalo, The State University of New York, Innovation Center, Buffalo, New York 14203, USA
    Immunol Invest 41:337-55. 2012
    ....
  9. ncbi request reprint Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, Buffalo, New York 14203, USA
    Mol Diagn Ther 10:257-69. 2006
    ..This suggests that methamphetamine has a role as a cofactor in the pathogenesis of HIV-1...
  10. doi request reprint Nutritional anaemia dysregulates endocrine control of fetal growth
    S Mahajan
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Br J Nutr 100:408-17. 2008
    ....
  11. ncbi request reprint Endocrine regulation in asymmetric intrauterine fetal growth retardation
    S D Mahajan
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India, 110029
    J Matern Fetal Neonatal Med 19:615-23. 2006
    ..IUGR is a significant risk factor for adult disease. In this study, we have investigated the endocrine adaptation by the fetus to overcome the growth disadvantage caused due to poor nutritional status of the mother...
  12. pmc Enhancing the delivery of anti retroviral drug "Saquinavir" across the blood brain barrier using nanoparticles
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
    Curr HIV Res 8:396-404. 2010
    ..These observations indicate that drug-loaded nanoparticles can deliver therapeutics across the BBB. These results highlight the potential of this nanoformulation in the treatment of Neuro-AIDS and other neurological disorders...
  13. ncbi request reprint Thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemia
    S D Mahajan
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Horm Metab Res 37:633-40. 2005
    ..These observations lead us to speculate that alterations in the pituitary-thyroid function result in beneficial adaptations to the hostile intrauterine environment in malnutrition related growth retardation and anemia...
  14. pmc Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, State University of New York, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    Biochem Biophys Res Commun 396:348-52. 2010
    ..Our results demonstrate that gene polymorphisms for CCR5-Delta32, CCR2b-641, RANTES In1.1C, SDF-1 3'A, IL-10-5'-592A and IL-4-589T may be used as clinical markers to predict progression of HIV-1 infections...
  15. doi request reprint Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
    Supriya D Mahajan
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Buffalo General Hospital, 301 Multi Research Bldg, 100 High Street, Buffalo, NY 14203, USA
    J Clin Immunol 28:528-41. 2008
    ..These studies may lead to the development of novel anti-HIV-1 therapeutics that target specific TJ proteins, thus preventing TJ disruption in opiate using HIV-1 patients...
  16. ncbi request reprint Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
    Curr HIV Res 3:277-88. 2005
    ....
  17. pmc Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes
    B Bindukumar
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, University at Buffalo, State University of NY, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
    Brain Res 1191:1-11. 2008
    ..Our results show that the expression of more than 20 translated protein gene products from NHA was differentially dysregulated by treatment with Delta(9)-THC compared to untreated, control NHA...
  18. pmc Proteomic analyses of the effects of drugs of abuse on monocyte-derived mature dendritic cells
    Jessica L Reynolds
    Departments of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, New York, USA
    Immunol Invest 38:526-50. 2009
    ..These proteins may predispose immunocompetent cells, including dendritic cells, to infection with viruses such as HCV and HIV-1, which are associated with drug abuse...
  19. pmc Proteomic analyses of methamphetamine (METH)-induced differential protein expression by immature dendritic cells (IDC)
    Jessica L Reynolds
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
    Biochim Biophys Acta 1774:433-42. 2007
    ..Identification of unique, METH-induced proteins may help to develop novel markers for diagnostic, preventive and therapeutic targeting in METH using subjects...
  20. pmc Proteomic analysis of the effects of cocaine on the enhancement of HIV-1 replication in normal human astrocytes (NHA)
    Jessica L Reynolds
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    Brain Res 1123:226-36. 2006
    ..Further, our results show for the first time that cocaine differentially regulates the expression of a number of proteins by NHA that may play a role in the neuropathogenesis of HIV-1 disease...
  21. pmc RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapy
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    AAPS J 7:E572-8. 2005
    ..This effect may be mediated by modulation of p38 mitogen activated protein kinase (MAPK)...
  22. ncbi request reprint Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 14203, USA
    J Immunol 174:6617-26. 2005
    ..A better understanding of the role of DC-SIGN in HIV infection may help to design novel therapeutic strategies against the progression of HIV disease in the drug-using population...
  23. ncbi request reprint Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology and State University of New York and Buffalo General Hospital, Kaleida Health System 100 High Street, Buffalo, NY 14203, USA
    J Neuroimmunol 157:56-60. 2004
    ....
  24. pmc Modulation of the proteome of peripheral blood mononuclear cells from HIV-1-infected patients by drugs of abuse
    Jessica L Reynolds
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, University at Buffalo, State University of New York at Buffalo, 311 MultiLab Research Building, Buffalo, NY, 14203, USA
    J Clin Immunol 29:646-56. 2009
    ..We used proteomic analyses to assess how drug abuse modulates immunologic responses to infections with the human immunodeficiency virus type 1 (HIV-1)...
  25. pmc MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier
    Adela Bonoiu
    Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York, Buffalo, New York, 14260 3000, USA
    Brain Res 1282:142-55. 2009
    ..This will prevent neuroinflammation and maintain the integrity of the BBB...
  26. pmc Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons
    Adela C Bonoiu
    Institute for Lasers Photonics and Biophotonics, The State University of New York, Buffalo, NY 14260, USA
    Proc Natl Acad Sci U S A 106:5546-50. 2009
    ..Therefore, these nanoplexes appear to be suited for brain-specific delivery of appropriate siRNA for therapy of drug addiction and other brain diseases...
  27. ncbi request reprint Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and light
    Zale P Bernstein
    RPCI, Buffalo, NY 14263, USA
    Curr HIV Res 6:152-63. 2008
    ..Area under the curve for viral load showed a significant decrease from pre- to post-therapy (p 0.007). No associated toxicities were observed...
  28. pmc Therapeutic targeting of "DARPP-32": a key signaling molecule in the dopiminergic pathway for the treatment of opiate addiction
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, State University of New York, Buffalo, New York 14203, USA
    Int Rev Neurobiol 88:199-222. 2009
    ..These findings have the potential to facilitate the development of DARPP32 siRNA-based therapeutics against drug addiction...
  29. pmc The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
    Ravikumar Aalinkeel
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Kaleida Health, Buffalo, New York, USA
    Prostate 68:1773-89. 2008
    ..The aim of this study is to evaluate the effect(s) of quercetin on normal and malignant prostate cells and to identify the target(s) of quercetin's action...
  30. ncbi request reprint Morphine modulates chemokine gene regulation in normal human astrocytes
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 310 Multi Research Building, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
    Clin Immunol 115:323-32. 2005
    ..These results support our hypothesis that opiates act as co-factors in the neuropathogenesis of HIV infection...
  31. pmc SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-kappaB pathway in human monocyte macrophages in vitro
    Susan F Dosch
    Department of Microbiology and Immunology, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo, NY, United States
    Virus Res 142:19-27. 2009
    ..The results further suggested that released or secreted S protein could activate blood monocytes through recognition by toll-like receptor (TLR)2 ligand...
  32. ncbi request reprint Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier
    Gaixia Xu
    Institute for Lasers, Photonics and Biophotonics, The State University of New York, Buffalo, New York 14260 3000, USA
    Bioconjug Chem 19:1179-85. 2008
    ....