Research Topics
Genomes and Genes | S D MahajanSummaryAffiliation: University at Buffalo Country: USA Publications
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Publications
Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptorSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health System, Buffalo, NY 14203, USA
J Immunol 169:3589-99. 2002..These effects of opioids appear to be mediated through the opioid mu receptor that we demonstrated on astroglial cells...- Effect of maternal malnutrition and anemia on the endocrine regulation of fetal growthSupriya D Mahajan
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
Endocr Res 30:189-203. 2004..Thus, these novel observations are relevant to the context of the ongoing scientific debate on Barker's hypothesis... 
Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuseSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 301 Multi Research Building, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
Brain Res 1203:133-48. 2008..An understanding of the mechanisms of BBB breakdown that lead to neurotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients...- Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthmaMark F Sands
VA Western New York Healthcare System, Buffalo, NY 14215, USA
Clin Immunol 130:186-98. 2009..Our findings support the hypothesis that TIMP-1 plays a protective role by preventing AHR and modulating inflammation, remodeling, and cytokine expression in an animal model of asthma... - Anti-HIV-1 nanotherapeutics: promises and challenges for the futureSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, Buffalo Niagara Medical Campus, Buffalo, NY, USA
Int J Nanomedicine 7:5301-14. 2012.... 
Suppression of MMP-9 expression in brain microvascular endothelial cells (BMVEC) using a gold nanorod (GNR)-siRNA nanoplexSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University at Buffalo, The State University of New York, Innovation Center, Buffalo, New York 14203, USA
Immunol Invest 41:337-55. 2012....- Nutritional anaemia dysregulates endocrine control of fetal growthS Mahajan
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Br J Nutr 100:408-17. 2008.... - Role of chemokine and cytokine polymorphisms in the progression of HIV-1 diseaseSupriya D Mahajan
Department of Medicine, Division of Allergy, State University of New York, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
Biochem Biophys Res Commun 396:348-52. 2010..Our results demonstrate that gene polymorphisms for CCR5-Delta32, CCR2b-641, RANTES In1.1C, SDF-1 3'A, IL-10-5'-592A and IL-4-589T may be used as clinical markers to predict progression of HIV-1 infections... - Endocrine regulation in asymmetric intrauterine fetal growth retardationS D Mahajan
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India, 110029
J Matern Fetal Neonatal Med 19:615-23. 2006..IUGR is a significant risk factor for adult disease. In this study, we have investigated the endocrine adaptation by the fetus to overcome the growth disadvantage caused due to poor nutritional status of the mother... - Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesisSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, Buffalo, New York 14203, USA
Mol Diagn Ther 10:257-69. 2006..This suggests that methamphetamine has a role as a cofactor in the pathogenesis of HIV-1... - Thyroid hormone dysregulation in intrauterine growth retardation associated with maternal malnutrition and/or anemiaS D Mahajan
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Horm Metab Res 37:633-40. 2005..These observations lead us to speculate that alterations in the pituitary-thyroid function result in beneficial adaptations to the hostile intrauterine environment in malnutrition related growth retardation and anemia... - Enhancing the delivery of anti retroviral drug "Saquinavir" across the blood brain barrier using nanoparticlesSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
Curr HIV Res 8:396-404. 2010..These observations indicate that drug-loaded nanoparticles can deliver therapeutics across the BBB. These results highlight the potential of this nanoformulation in the treatment of Neuro-AIDS and other neurological disorders... - Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeabilitySupriya D Mahajan
Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Buffalo General Hospital, 301 Multi Research Bldg, 100 High Street, Buffalo, NY 14203, USA
J Clin Immunol 28:528-41. 2008..These studies may lead to the development of novel anti-HIV-1 therapeutics that target specific TJ proteins, thus preventing TJ disruption in opiate using HIV-1 patients... - Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cellsSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
Curr HIV Res 3:277-88. 2005.... - Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytesB Bindukumar
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, University at Buffalo, State University of NY, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
Brain Res 1191:1-11. 2008..Our results show that the expression of more than 20 translated protein gene products from NHA was differentially dysregulated by treatment with Delta(9)-THC compared to untreated, control NHA... - Proteomic analyses of the effects of drugs of abuse on monocyte-derived mature dendritic cellsJessica L Reynolds
Departments of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, New York, USA
Immunol Invest 38:526-50. 2009..These proteins may predispose immunocompetent cells, including dendritic cells, to infection with viruses such as HCV and HIV-1, which are associated with drug abuse... - Modulation of the proteome of peripheral blood mononuclear cells from HIV-1-infected patients by drugs of abuseJessica L Reynolds
Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, University at Buffalo, State University of New York at Buffalo, 311 MultiLab Research Building, Buffalo, NY, 14203, USA
J Clin Immunol 29:646-56. 2009..We used proteomic analyses to assess how drug abuse modulates immunologic responses to infections with the human immunodeficiency virus type 1 (HIV-1)... - Proteomic analyses of methamphetamine (METH)-induced differential protein expression by immature dendritic cells (IDC)Jessica L Reynolds
Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
Biochim Biophys Acta 1774:433-42. 2007..Identification of unique, METH-induced proteins may help to develop novel markers for diagnostic, preventive and therapeutic targeting in METH using subjects... - Proteomic analysis of the effects of cocaine on the enhancement of HIV-1 replication in normal human astrocytes (NHA)Jessica L Reynolds
Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
Brain Res 1123:226-36. 2006..Further, our results show for the first time that cocaine differentially regulates the expression of a number of proteins by NHA that may play a role in the neuropathogenesis of HIV-1 disease... - RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapyMadhavan P N Nair
Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
AAPS J 7:E572-8. 2005..This effect may be mediated by modulation of p38 mitogen activated protein kinase (MAPK)... - Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patientsMadhavan P N Nair
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 14203, USA
J Immunol 174:6617-26. 2005..A better understanding of the role of DC-SIGN in HIV infection may help to design novel therapeutic strategies against the progression of HIV disease in the drug-using population... - Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDOMadhavan P N Nair
Department of Medicine, Division of Allergy, Immunology, and Rheumatology and State University of New York and Buffalo General Hospital, Kaleida Health System 100 High Street, Buffalo, NY 14203, USA
J Neuroimmunol 157:56-60. 2004.... - MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrierAdela Bonoiu
Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York, Buffalo, New York, 14260 3000, USA
Brain Res 1282:142-55. 2009..This will prevent neuroinflammation and maintain the integrity of the BBB... - Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neuronsAdela C Bonoiu
Institute for Lasers Photonics and Biophotonics, The State University of New York, Buffalo, NY 14260, USA
Proc Natl Acad Sci U S A 106:5546-50. 2009..Therefore, these nanoplexes appear to be suited for brain-specific delivery of appropriate siRNA for therapy of drug addiction and other brain diseases... - Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and lightZale P Bernstein
RPCI, Buffalo, NY 14263, USA
Curr HIV Res 6:152-63. 2008..Area under the curve for viral load showed a significant decrease from pre- to post-therapy (p 0.007). No associated toxicities were observed... - Therapeutic targeting of "DARPP-32": a key signaling molecule in the dopiminergic pathway for the treatment of opiate addictionSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, State University of New York, Buffalo, New York 14203, USA
Int Rev Neurobiol 88:199-222. 2009..These findings have the potential to facilitate the development of DARPP32 siRNA-based therapeutics against drug addiction... - The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90Ravikumar Aalinkeel
Division of Allergy, Immunology and Rheumatology, Department of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Kaleida Health, Buffalo, New York, USA
Prostate 68:1773-89. 2008..The aim of this study is to evaluate the effect(s) of quercetin on normal and malignant prostate cells and to identify the target(s) of quercetin's action... - Morphine modulates chemokine gene regulation in normal human astrocytesSupriya D Mahajan
Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 310 Multi Research Building, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
Clin Immunol 115:323-32. 2005..These results support our hypothesis that opiates act as co-factors in the neuropathogenesis of HIV infection... - SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-kappaB pathway in human monocyte macrophages in vitroSusan F Dosch
Department of Microbiology and Immunology, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo, NY, United States
Virus Res 142:19-27. 2009..The results further suggested that released or secreted S protein could activate blood monocytes through recognition by toll-like receptor (TLR)2 ligand... - Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrierGaixia Xu
Institute for Lasers, Photonics and Biophotonics, The State University of New York, Buffalo, New York 14260 3000, USA
Bioconjug Chem 19:1179-85. 2008....