Terry R Magnuson
Affiliation: University of North Carolina
Mu W, Starmer J, Yee D, Magnuson T. EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation. Epigenetics Chromatin. 2018;11:71 pubmed publisher
..EZH2 variants determine functional specificity of PRC2 in histone methylation during cell proliferation and differentiation. ..
Pohlers M, Calabrese J, Magnuson T. Small RNA expression from the human macrosatellite DXZ4. G3 (Bethesda). 2014;4:1981-9 pubmed publisher
..Moreover, we show AGO association with DXZ4 and that the Argonaute proteins AGO-1 and PIWIL4 may play a role in DNA methylation of DXZ4. We hypothesize that the RNAs are involved in Argonaute-dependent methylation of DXZ4 DNA. ..
Runge J, Raab J, Magnuson T. Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide. G3 (Bethesda). 2018;8:1095-1102 pubmed publisher
..Moreover, our data suggest there is an important link between INO80-C and histone modifying enzymes that may have consequences in developmental and pathological contexts. ..
Fedoriw A, Menon D, Kim Y, Mu W, Magnuson T. Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes. Development. 2015;142:2972-80 pubmed publisher
..These observations support a model in which ssDNA plays a central role in the recruitment of ATR during MSUC, and provide a link to meiotic progression through activation of CHK1. ..
Chandler R, Magnuson T. The SWI/SNF BAF-A complex is essential for neural crest development. Dev Biol. 2016;411:15-24 pubmed publisher
Mu W, Starmer J, Shibata Y, Yee D, Magnuson T. EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis. Dev Biol. 2017;424:198-207 pubmed publisher
..Taken together, our findings suggest that the expression level of Ezh1 determines the restoration of H3K27 methylation in the absence of the canonical EZH2-PRC2. ..
Smith K, Starmer J, Miller S, Sethupathy P, Magnuson T. Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells. Stem Cell Reports. 2017;9:108-121 pubmed publisher
..This suggests that Cyrano functions to restrain the action of mir-7. Altogether, we provide a view into the multifaceted function of Cyrano in ESC maintenance. ..