Research Topics
| Louis J MagnottiSummaryAffiliation: University of Tennessee Country: USA Publications
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Publications
Reduction in inadequate empiric antibiotic therapy for ventilator-associated pneumonia: impact of a unit-specific treatment pathwayLouis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Am Surg 74:516-22; discussion 522-3. 2008..Adherence to a unit-specific pathway for the empiric management of VAP reduces multiple IEAT episodes. By limiting IEAT episodes, resource utilization and hospital mortality are significantly decreased...
Improved survival after hemostatic resuscitation: does the emperor have no clothes?Louis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 70:97-102. 2011..To help resolve this controversy, we evaluated the temporal relationship between blood product administration and mortality in civilian trauma patients receiving MT...- Admission ionized calcium levels predict the need for multiple transfusions: a prospective study of 591 critically ill trauma patientsLouis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 70:391-5; discussion 395-7. 2011..We hypothesized that admission iCa levels could potentially predict the need for multiple transfusions in critically ill trauma patients... - Causative pathogen dictates optimal duration of antimicrobial therapy for ventilator-associated pneumonia in trauma patientsLouis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 212:476-84; discussion 484-6. 2011..The purpose of this study was to determine the appropriate duration of antimicrobial therapy for VAP in trauma patients secondary to hospital-acquired pathogens... - Efficacy of monotherapy in the treatment of Pseudomonas ventilator-associated pneumonia in patients with traumaLouis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 66:1052-8; discussion 1058-9. 2009..The relevance of such "synergy" is commonly supposed but poorly supported. The purpose of this study was to evaluate the efficacy of monotherapy in the treatment of Pseudomonas VAP as measured by microbiological resolution... - Impact of gender on outcomes after blunt injury: a definitive analysis of more than 36,000 trauma patientsLouis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 206:984-91; discussion 991-2. 2008..In an attempt to resolve this ongoing dispute, we evaluated the effect of gender on various outcomes in the largest single institutional series of trauma patients reported in the literature after blunt injury... - Accounting for differences in transfusion volume: Are all massive transfusions created equal?John P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Trauma Acute Care Surg 72:1536-40. 2012..We sought to evaluate the effect of the number of RBC units transfused on both plasma:RBC and platelet:RBC and their association with mortality in MT patients... - A reappraisal of nitrogen requirements for patients with critical illness and traumaRoland N Dickerson
Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma Acute Care Surg 73:549-57. 2012.... - Identifying life-threatening shock in the older injured patient: an analysis of the National Trauma Data BankBen L Zarzaur
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 68:1134-8. 2010..We hypothesized that age x SI would be a better predictor of 48-hour mortality in old patients (age, >55 years) compared with TVS, whereas for young patients (age, <or=55 years), SI would be a better predictor than TVS... - Beta-adrenergic blockade and traumatic brain injury: protective?Thomas J Schroeppel
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Trauma 69:776-82. 2010..We hypothesize that suppression of the catecholamine surge in multiple-injured TBI patients with beta-adrenergic blockade decreases mortality... - A ten-year review of enterocutaneous fistulas after laparotomy for traumaPeter E Fischer
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 67:924-8. 2009..This study is the largest series of ECFs reported exclusively caused by trauma and examines the characteristics unique to this population... - Initial chest CT obviates the need for repeat chest radiograph after penetrating thoracic traumaLouis J Magnotti
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Am Surg 73:569-72; discussion 572-3. 2007.... - Angiographic embolization for liver injuries: low mortality, high morbidityAlicia M Mohr
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medcial School, Newark, 07103, USA
J Trauma 55:1077-81; discussion 1081-2. 2003..This study examines further the role of AE in both blunt and penetrating liver injuries and the outcomes of its use... - Temporary abdominal closure techniques: a prospective randomized trial comparing polyglactin 910 mesh and vacuum-assisted closureTiffany K Bee
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 65:337-42; discussion 342-4. 2008..Some advocate polyglactin mesh (MESH), while others favor vacuum-assisted closure (VAC). We performed a single institution prospective randomized trial comparing morbidity and mortality differences between MESH and VAC... - Antibiotic-coated ePTFE decreases graft colonization and neointimal hyperplasiaPeter E Fischer
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Surg Res 156:199-204. 2009..Thus, we hypothesized that the coated grafts would resist infection and have decreased neointimal hyperplasia when used in vivo in a large animal model... - Impact of airbags on a Level I trauma center: injury patterns, infectious morbidity, and hospital costsRegan F Williams
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 206:962-8; discussion 968-9. 2008..We hypothesized that airbag use would be related to decreased injury severity of motor vehicle collision survivors admitted to a Level I trauma center, leading to a decrease in infectious morbidity and hospital resource use... - Functional outcomes following blunt cerebrovascular injuryJennifer M DiCocco
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Trauma Acute Care Surg 74:955-60. 2013..This study was conducted to address those long-term outcomes... - Use of the clinical pulmonary infection score to guide therapy for ventilator-associated pneumonia risks antibiotic overexposure in patients with traumaNancy A Parks
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA
J Trauma Acute Care Surg 73:52-8; discussion 58-9. 2012..This study evaluates the use of CPIS in determining the appropriate duration of antimicrobial therapy for VAP in patients with critical illness and trauma... - Adherence to a simplified management algorithm reduces morbidity and mortality after penetrating colon injuries: a 15-year experienceJohn P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA
J Am Coll Surg 214:591-7; discussion 597-8. 2012..The purpose of this study was to evaluate the validity of this algorithm in the face of an increased incidence of destructive injuries observed in recent years... - The "July phenomenon": is trauma the exception?Thomas J Schroeppel
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 209:378-84. 2009..The objective of this study was to determine if a July phenomenon existed in a Level I trauma center with an attending present at all times... - Impact of intracranial pressure monitor prophylaxis on central nervous system infections and bacterial multi-drug resistanceNathaniel F Stoikes
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Surg Infect (Larchmt) 9:503-8. 2008..We tested the hypothesis that prophylactic antibiotics do not reduce the incidence of central nervous system (CNS) infections but instead are associated with the acquisition of multi-drug resistant (MDR) bacterial infections... - The futility of the clinical pulmonary infection score in trauma patientsMartin A Croce
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 60:523-7; discussion 527-8. 2006..In this study, we evaluated the potential use of CPIS as the sole means for diagnosis of VAP in critically injured patients... - Diagnostic laparoscopy for the evaluation of occult diaphragmatic injury following penetrating thoracoabdominal traumaBenjamin S Powell
Department of Surgery, University of Tennessee Health Science Centre, Memphis, Tennessee
Injury 39:530-4. 2008.... - Necessity of repeat head CT and ICU monitoring in patients with minimal brain injuryTiffany K Bee
Critical Care Trauma Division, Department of General Surgery, University of Tennessee, Memphis, Tennessee 38163, USA
J Trauma 66:1015-8. 2009..In an attempt to better allocate scarce resources, we hypothesized that not only was repeat head CT unnecessary but also routine intensive care unit (ICU) monitoring of these patients with MBI and stable examinations were unnecessary... - Is ventilator-associated pneumonia in trauma patients an epiphenomenon or a cause of death?Louis J Magnotti
Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
Surg Infect (Larchmt) 5:237-42. 2004..We studied patients with less severe injuries (Injury Severity Score, ISS < 25) to determine the impact of VAP on outcomes... - Changes in pulmonary cytokines during antibiotic therapy for ventilator-associated pneumoniaJoseph M Swanson
Department of Clinical Pharmacy, University of Tennessee, Memphis, Tennessee 38163, USA
Surg Infect (Larchmt) 11:161-7. 2010..A major unanswered question in ventilator-associated pneumonia (VAP) management relates to patient response to therapy. We investigated the use of pulmonary cytokines as biomarkers for response to antibiotic therapy for VAP... - Long-term survival and return on investment after nonneurologic injury: implications for the elderly trauma patientBen L Zarzaur
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 69:93-8. 2010..The purpose of this study was to evaluate the cost per 2-year survivor stratified by age after moderate- to severe-nonneurologic injury... - Applicability of an established management algorithm for colon injuries following blunt traumaJohn P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma Acute Care Surg 74:419-24; discussion 424-5. 2013..The purpose of this study was to evaluate the applicability of the ALG to blunt colon injuries... - Impact of a defined management algorithm on outcome after traumatic pancreatic injuryJohn P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Trauma Acute Care Surg 72:100-5. 2012..Consequently, a management algorithm (ALG) was developed and implemented. The purpose of this study was to evaluate the impact of this ALG on outcomes... - Components separation for abdominal wall reconstruction: the Memphis modificationJennifer M DiCocco
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Surgery 151:118-25. 2012..The purpose of this manuscript is to describe in detail how to perform a modification of the components separation technique that has been shown to have one of the lowest recurrence rates in the literature... - New vitals after injury: shock index for the young and age x shock index for the oldBen L Zarzaur
Department of Surgery at The University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Surg Res 147:229-36. 2008..Because age negatively impacts physiological reserve, we hypothesized that age multiplied by SI (Age x SI) would be a better predictor of 48 h mortality (48 MORT) compared to heart rate (HR), systolic blood pressure (SBP), or SI... 
A population-based analysis of neighborhood socioeconomic status and injury admission rates and in-hospital mortalityBen L Zarzaur
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 211:216-23. 2010..We hypothesized that injury-related hospitalization rates would vary by N-SES and that N-SES would be related to in-hospital mortality...- "Awake" laparoscopy for the evaluation of equivocal penetrating abdominal woundsJordan A Weinberg
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
Injury 38:60-4. 2007..We hypothesised that, in appropriate patients, diagnostic "awake" laparoscopy (AL) could be performed under local anaesthesia in the emergency department (ED), allowing for expedited discharge and potential cost savings... - Quality of life after abdominal wall reconstruction following open abdomenBen L Zarzaur
Department of Surgery and School of Nursing, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 70:285-91. 2011..Results after DAWR demonstrate acceptable recurrence, morbidity, and mortality rates. However, little is known about quality of life (QOL) after DAWR. The purpose of this study was to analyze QOL after DAWR... - Injury location dictates utility of digital rectal examination and rigid sigmoidoscopy in the evaluation of penetrating rectal traumaM Brinson Hargraves
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Am Surg 75:1069-72. 2009..RS proved better than DRE for diagnosis. The greatest benefit was observed with EP injuries. The possibility of a missed IP injury associated with a negative screen should prompt exploration if clinical suspicion is high... - Penetrating rectal trauma: management by anatomic distinction improves outcomeJordan A Weinberg
University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 60:508-13; discussion 513-14. 2006..Management by anatomic distinction allows for omission of colostomy in most IP injuries and select EP injuries, while diminishing the risk of retrorectal abscess in EP injuries with the judicious application of presacral drainage... - Comparison of intravenous ethanol versus diazepam for alcohol withdrawal prophylaxis in the trauma ICU: results of a randomized trialJordan A Weinberg
Section of Trauma, Burns, and Surgical Critical Care, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Trauma 64:99-104. 2008..The purpose of this study was to prospectively evaluate the efficacy of intravenous ethanol compared with benzodiazepines for the prevention of AWS with particular emphasis on the sedative effects of each therapy... - The real risk of splenectomy after discharge home following nonoperative management of blunt splenic injuryBen L Zarzaur
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Trauma 66:1531-6; discussion 1536-8. 2009..The purpose of this study was to analyze, using population-based data, the 180-day risk of splenectomy in a clinically relevant sample... - Impact of location on outcome after penetrating colon injuriesJohn P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Trauma Acute Care Surg 73:1428-32; discussion 1433. 2012..diversion) are based on a defined management algorithm regardless of injury location. The purpose of this study was to evaluate the effect of injury location on outcomes after penetrating colon injuries... - Current issues in traumaTimothy C Fabian
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Curr Probl Surg 39:1160-244. 2002 - Minor trauma is an unrecognized contributor to poor fetal outcomes: a population-based study of 78,552 pregnanciesPeter E Fischer
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA
J Trauma 71:90-3. 2011..The purpose of this study was to determine the association of both minor and severe injury on fetal demise and prematurity/low birth weight (LBW) in a large population-based study using robust state databases... - Impact of decompressive craniectomy on functional outcome after severe traumatic brain injuryRegan F Williams
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Trauma 66:1570-4; discussion 1574-6. 2009..The purpose of this study was to evaluate the efficacy of DC on functional outcome after severe TBI in the largest single institutional series reported in the literature... - The utility of serial computed tomography imaging of blunt splenic injury: still worth a second look?Jordan A Weinberg
Department of Surgery, University of Alabama at Birmingham, USA
J Trauma 62:1143-7; discussion 1147-8. 2007..The purpose of this study was to reevaluate the clinical practice of serial CT imaging within the context of an institutional protocol for the nonoperative management (NOM) of BSI... - Long-term follow-up of abdominal wall reconstruction after planned ventral hernia: a 15-year experienceJennifer M DiCocco
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38162, USA
J Am Coll Surg 210:686-95, 695-8. 2010.... - Emergent pelvic fixation in patients with exsanguinating pelvic fracturesMartin A Croce
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 204:935-9; discussion 940-2. 2007..Little published information is available about its effectiveness. This study evaluated the efficacy of the POD compared with EPF in patients with life-threatening pelvic fractures... - Outcomes of operations performed by attending surgeons after overnight trauma shiftsJohn P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA
J Am Coll Surg 216:791-7; discussion 797-9. 2013..The purpose of this study was to investigate the impact of working an overnight trauma shift on outcomes of general surgery operations performed the next day by the post-call attending physician... - Relationship between disruption of the unstirred mucus layer and intestinal restitution in loss of gut barrier function after trauma hemorrhagic shockBobby Rupani
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, USA
Surgery 141:481-9. 2007..The factors involved in shock-induced loss of gut barrier function remain to be defined fully and studies investigating gut injury have focused primarily on the systemic side of the intestine... - Descending necrotizing mediastinitis: unique complication of central venous catheterizationFrancis J Caputo
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
Surg Infect (Larchmt) 8:611-4. 2007..However, these devices are not without complications. We describe the first reported case of descending necrotizing mediastinitis secondary to central venous catheterization without evidence of associated vascular perforation... - Prophylactic antibiotic days as a predictor of sensitivity patterns in Acinetobacter pneumoniaParth B Amin
Department of Surgery, University of Tennessee Health Science Center, 910 Madison Avenue, Memphis, TN 38163, USA
Surg Infect (Larchmt) 12:33-8. 2011..The purpose of this study was to evaluate the change in Acinetobacter sensitivity over time and determine which risk factors predict resistance in trauma patients... - Prosthetic vascular conduit in contaminated fields: a new technology to decrease ePTFE infectionsPeter E Fischer
College of Medicine, Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Am Surg 74:524-8; discussion 528-9. 2008..In vitro, the grafts provide a slow elution of antibiotics that provide resistance from infection by SA and SE for up to 2 weeks after graft insertion... - Insurance type is a determinant of 2-year mortality after non-neurologic traumaBen L Zarzaur
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Surg Res 160:196-201. 2010..Less is known about the influence of insurance type and long-term mortality following non-NEURO-TRA. We hypothesized that NO-INS would be associated with 2-y mortality after moderate to severe injury... - Optimal outcomes for patients with blunt cerebrovascular injury (BCVI): tailoring treatment to the lesionJennifer M DiCocco
Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Am Coll Surg 212:549-57; discussion 557-9. 2011..Endovascular therapy in these lesions has increased without reports of outcomes. We sought to determine ischemic stroke and death rates after BCVI with and without endovascular treatment... - Toward a better definition of massive transfusion: focus on the interval of hemorrhage controlJohn P Sharpe
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Trauma Acute Care Surg 73:1553-7. 2012..In this study, we evaluated whether patients who reach the MT threshold during hemorrhage control differ clinically from those who reach it after hemorrhage control (i.e., after intensive care unit [ICU] arrival) but before 24 hours... - Improving outcomes following penetrating colon wounds: application of a clinical pathwayPreston R Miller
Department of Surgery, The University of Tennessee Health Science Center, Memphis, 38163, USA
Ann Surg 235:775-81. 2002..The data demonstrated the need for colostomy in the face of shock and comorbidities. Institution of this pathway results in colostomy for only 7% of all colon wounds... - Impact of motorcycle helmets and state laws on society's burden: a national studyMartin A Croce
Department of Surgery University of Tennessee Health Science Center Memphis, TN, USA
Ann Surg 250:390-4. 2009..To analyze a large national database, the National Trauma Data Bank, regarding the contribution of motorcycle helmet use to outcome and the efficacy of state helmet laws... - Microvascular response to red blood cell transfusion in trauma patientsJordan A Weinberg
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
Shock 37:276-81. 2012..Bedside sublingual imaging may have the potential to detect subtle perfusion defects and ultimately inform clinical decision making with respect to transfusion... - Pancreatic duct ligation reduces lung injury following trauma and hemorrhagic shockDavid B Cohen
Department of Surgery, University of Medicine, and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Ann Surg 240:885-91. 2004..Thus, the presence of pancreatic digestive enzymes in the ischemic gut appears to be involved in gut-induced lung and RBC injury... - Burns, bacterial translocation, gut barrier function, and failureLouis J Magnotti
Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey 07103, USA
J Burn Care Rehabil 26:383-91. 2005..Thus, the goal of this review will be to provide a perspective on the evolution of the gut hypothesis of systemic inflammation and distant organ dysfunction... - Influence of gut microflora on mesenteric lymph cytokine production in rats with hemorrhagic shockWeidun Guo
Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103-2714, USA
J Trauma 52:1178-85; disciussion 1185. 2002..CONCLUSION: Changes in the gut microflora modulate the gut cytokine production after tissue injury with or without hemorrhagic shock, with intestinal bacterial overgrowth leading to the greatest increase in mesenteric lymph IL-6 levels... - The evolution of blunt splenic injury: resolution and progressionStephanie A Savage
Department of General Surgery, Wilford Hall Medical Center, Lackland AFB, Texas, USA
J Trauma 64:1085-91; discussion 1091-2. 2008..Our hypothesis was that time to healing is related to severity of BSI...