Research Topics
Genomes and Genes | S B MaggirwarSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Publications
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapyPauline Chugh
Department of Microbiology and Immunology, School of Medicine, University of Rochester Medical Center 601 Elmwood Avenue Box 672 Rochester, New York 14742 USA
Retrovirology 5:11. 2008..Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs...- Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDSShengbo Cao
Department of Public Health Sciences, University of Hawai i, Honolulu, Hawai i 96822, USA
J Neuroinflammation 8:48. 2011..We therefore hypothesized that a soluble TNF-α antagonist might have potential utility as a neuroprotective effecter molecule, and conducted proof-of-concept studies to test this hypothesis... 
Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cellsS B Maggirwar
Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
J Neurochem 74:527-39. 2000..Together, these studies demonstrate a functional interaction between NF-kappaB and c-Jun and suggest a novel mechanism of NF-kappaB-mediated neuroprotection...- Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neuronsN Tong
Center for Ageing and Developmental Biology, Aab Biomedical Institute, University of Rochester Medical Center, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA
Eur J Neurosci 13:1913-22. 2001..Abnormal PAF signalling that results in GSK-3beta overactivation may represent a common mechanism for pathological defects in neuronal migration in the prenatal period and neuronal apoptosis in the postnatal period... - Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementiaS M Fine
Department of Medicine, University of Rochester Medical Center, NY 14642, USA
J Neuroimmunol 95:55-64. 1999..Thus, blockade of NF-kappaB activation in microglia in vitro can decrease production of TNF-alpha and may prove to be a novel strategy for treating HIV-1 dementia... - HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicityS B Maggirwar
Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
J Neurochem 73:578-86. 1999..These findings are consistent with the existence of one or more pathways that can lead to GSK-3beta activation in neurons, and they suggest that the dysregulation of this enzyme could contribute to HIV-induced neuronal apoptosis... - Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanismS H Ramirez
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
J Neurochem 78:874-89. 2001..These findings suggest that the activation of NF-kappaB by neurotrophic factors may promote survival of neurons exposed to Tat, via regulation of anti-apoptotic genes including Bcl-2... - Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and VmaxSeth W Perry
Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, Graduate Program in Pathology, and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 30:14153-64. 2010..Finally, we provide key translational relevance for these findings by highlighting published human data of increased DAT levels in striata of HAND patients and by demonstrating similar findings in Tat-expressing transgenic mice... - Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinaseHarris A Gelbard
Center for Neural Development and Disease, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Neurotherapeutics 7:392-8. 2010.... - Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cellsEmily A Desmet
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Virology 400:224-32. 2010..These findings support a role for MLK3 in viral production during influenza infection... - Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairmentGiovanni Schifitto
Department of Neurology, University of Rochester, Rochester, New York, USA
J Neurovirol 15:176-86. 2009.... - Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factorsS B Maggirwar
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
Mol Cell Biol 17:2605-14. 1997..Together, these results suggest that activation of IL-2 gene transcription by the TCR- and CD28-mediated signals involves the interaction of CD28RE with NF-ATp and various NF-kappaB/Rel transcription factors... - Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell linePauline Chugh
Department of Microbiology and Immunology, School of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14742, USA
J Mol Biol 366:67-81. 2007..We propose that the expression of Tat may enable HIV-1 infected microglia to survive throughout the course of infection, leading to persistent HIV-1 production and infection in the central nervous system... - HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanismD R New
Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York, 14642, USA
J Biol Chem 273:17852-8. 1998.... - Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDSStephen Dewhurst
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Neuroimmune Pharmacol 2:93-6. 2007..These findings highlight the therapeutic potential of GSK-3beta blockade... - The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelBCarolyn J Baglole
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 283:28944-57. 2008..The association between RelB and AhR may represent a new therapeutic and more selective target with which to combat inflammation-associated diseases... - Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell deathNing Jin
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
Neuropharmacology 48:576-83. 2005..Collectively, these results show that VPA is not a universal inhibitor of neuronal GSK-3, and that instead of being neuroprotective, VPA can even exacerbate neuronal death under some conditions... - Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelBThomas H Thatcher
Department of Medicine, University of Rochester, Rochester, New York 14642, USA
Am J Pathol 170:855-64. 2007.... - Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neuronsAttila D Kovács
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Eur J Neurosci 20:345-52. 2004..Our findings suggest a novel mode of initiation of neuronal apoptosis wherein survival signal withdrawal induces NF-kappaB to lethally turn itself off... - Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawalServio H Ramirez
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci Res 77:258-69. 2004..Taken together, these findings provide evidence that endogenous adenosine may be important in mediating protection of sympathetic neurons and that it may act via the A2A receptor subtype... - Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cellsE W Harhaj
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hersey 17033, USA
Oncogene 12:2385-92. 1996..However, the inducible degradation of p105 is not coupled with the generation of p50. Together, these studies demonstrate that the processing and inducible degradation of p105 are differentially regulated... - Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanismJing Wang
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 292:L1495-505. 2007..carinii-stimulated AECs. These data demonstrate that AECs respond to P. carinii in a proinflammatory manner that may contribute to the generation of immune-mediated lung injury... - Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signalingLynn F Sniderhan
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Cell Neurosci 38:404-16. 2008..The results shown here identify ARMS as a major factor that links neurotrophin signaling to NF-kappaB... - Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survivalTatiana M Garcia-Bates
Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Cancer Immunol Immunother 58:1071-83. 2009..These findings further suggest the potential of PPARgamma as a therapeutic target for B cell malignancy... - HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1Lingbing Zeng
Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
J Gene Med 8:18-28. 2006..Lentiviral vector-mediated gene delivery to the CNS by monocytes/macrophages is a promising, emerging strategy for treating neuro-AIDS... - Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementiaZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Immunol 178:3226-36. 2007..Taken together, our results show that CD40 signaling in microglia and monocytes can synergize with the effects of Tat, further amplifying inflammatory processes within the CNS and influencing neuronal survival... - Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signalingJoseph F Sanchez
Program in Genetics, Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mol Cell Biol 23:4649-62. 2003..These findings therefore implicate GSK-3beta as a regulator of NF-kappaB activation in astrocytes and suggest that the pro-apoptotic effects of GSK-3beta may be mediated at least in part through the inhibition of NF-kappaB pathway... - Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitisHuanyu Dou
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198-5215, USA
J Neurosci 23:9162-70. 2003..We conclude that VPA protects neurons against HIV-1 infected MDM neurotoxicity, possibly through its effects on the phosphorylation of tau and beta-catenin. The use of VPA as an adjuvant in treatment of human HAD is being pursued... - Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophagesSe-Ran Yang
Dept. of Environmental Medicine, Lung Biology and Disease Program, Univ. of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 291:L46-57. 2006..Moreover, cigarette smoke-mediated proinflammatory events are regulated by the redox status of the cells... - Recruitment of active glycogen synthase kinase-3 into neuronal lipid raftsZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Biochem Biophys Res Commun 345:1643-8. 2006..Our observations reveal novel interaction of GSK-3beta and raft domains, and suggest that such interaction could contribute to neuronal apoptosis... - Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neuronsZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
Eur J Neurosci 23:2623-34. 2006..These findings may have important therapeutic implications for the management of HIV-1-associated dementia... - Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthaseSandeep C Pingle
Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
Mol Pharmacol 72:856-67. 2007..Taken together, our results demonstrate that the A(1)AR protects against HIV-1 toxicity by inhibiting NF-kappaB, thereby reducing the expression of iNOS and NO radicals and neuronal apoptosis... - Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activationZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 177:702-11. 2006..In aggregate, our data define MLK3 as a promising therapeutic target for intervention in HAD...
Research Grants
- ROLE OF NF-KAPPA B IN MEDIATING SURVIVAL OF NEURONSSanjay Maggirwar; Fiscal Year: 2002..It is expected that these studies will provide new insights into the pathogenesis of neurodegenerative diseases, and that they may ultimately contribute to the identification of pharmacological inhibitors of neuronal cell death. ..
- Inflammatory mechanisms associated with HIV-1 dementiaSanjay Maggirwar; Fiscal Year: 2007..Collectively, these investigations will identify novel therapeutic strategies that may enhance neuronal function and survival in neuroAIDS. ..
- Inflammatory mechanisms associated with HIV-1 dementiaSanjay B Maggirwar; Fiscal Year: 2010..Collectively, these investigations will identify novel therapeutic strategies that may enhance neuronal function and survival in neuroAIDS. ..
- Platelet-mediated neuroinflammatory response to HIVSanjay B Maggirwar; Fiscal Year: 2010..The outcome of these studies is expected to further our understanding of disease, which ultimately will lead to new therapeutic strategies. ..