Research Topics
Species | Lillian Maggio-PriceSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancerLillian Maggio-Price
Department of Comparative Medicine, University of Washington, School of Medicine, Seattle, Washington 98195, USA
Am J Pathol 174:317-29. 2009....
Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasiaLillian Maggio-Price
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Pathol 166:1793-806. 2005..This animal model may have particular relevance to human IBD and colorectal cancer because certain human MDR1 polymorphisms have been linked to ulcerative colitis and increased risk for colorectal cancer...
Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient miceLillian Maggio-Price
Department of Comparative Medicine, University of Washington, 1959 Northeast Pacific Avenue, Seattle, WA 98195, USA
Cancer Res 66:828-38. 2006....
Lack of effect of murine norovirus infection on a mouse model of bacteria-induced colon cancerKaren C Lencioni
Department of Comparative Medicine, University of Washington, Seattle, Washington, USA
Comp Med 61:219-26. 2011..In addition, MNV infection alone did not result in IBD or colon cancer. Therefore MNV infection alone or in conjunction with Helicobacter does not alter the development or progression of IBD or colon cancer in Smad3(-/-) mice...
Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr(-/-) miceJisun Paik
Department of Comparative Medicine, University of Washington, Seattle, Washington, USA
Comp Med 61:330-8. 2011..Increased lesion size was associated with increased macrophages, suggesting that MNV may influence macrophage activation or accumulation in the lesion area...
Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel diseaseAnne E Torrence
Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
Inflamm Bowel Dis 14:480-90. 2008..Currently, there are limited noninvasive biomarkers for monitoring disease progression in animal IBD models, which are used extensively to develop new therapies and to understand IBD pathogenesis...
Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) miceLillian Maggio-Price
Department of Comparative Medicine, School of Medicine, University of Washington, Box 357190, Seattle, WA 981295, USA
Am J Pathol 160:739-51. 2002..mdr1a-/- mice infected with Helicobacter spp. may provide a useful tool to explore the pathogenesis of microbial-induced IBD in a model with a presumed epithelial cell "barrier" defect...
Effects of murine norovirus infection on a mouse model of diet-induced obesity and insulin resistanceJisun Paik
Department of Comparative Medicine, The University of Washington, Seattle, Washington, USA
Comp Med 60:189-95. 2010..Further studies using other models of metabolic diseases are needed to provide additional information on the potential role this 'subclinical' virus might have on disease progression in mouse models of inflammatory diseases...
Changes in pharmacokinetics of anti-HIV protease inhibitors during pregnancy: the role of CYP3A and P-glycoproteinAnita A Mathias
Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
J Pharmacol Exp Ther 316:1202-9. 2006..If such upregulation of hepatic CYP3A activity occurs in pregnant women, it has important implications for dose adjustment of a variety of drugs ingested by pregnant women and cleared predominately via CYP3A metabolism...
Vascular leak syndrome of Sprague-Dawley rats in a mandibular distraction osteogenesis studyCarole R Baskin
Department of Comparative Medicine, University of Washington, Seattle 98195, USA
Comp Med 53:207-12. 2003..Hence, the rat may be a useful animal model to h elp characterize the physiologic and molecular events that accompany this syndrome...
Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenograftsPiper M Treuting
Department of Pathology, University of Washington, Seattle 98195, USA
Breast Cancer Res Treat 72:79-88. 2002..000001). Our findings suggest that RARbeta2 may play a role in inhibiting the metastatic cascade in a mouse mammary gland xenograft tumor model and is a potential candidate for therapeutic intervention in human breast cancer...
Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) miceLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Helicobacter 12:598-604. 2007..However, the long lead time required before development of inflammation-associated colon neoplasia in commonly used murine models of IBD slows the development of effective chemopreventative therapies...
