Amalia S Magaret

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: results of analyses from a multicenter randomized trial
    Guy de Bruyn
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 12:277. 2012
  2. pmc Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa
    Amalia S Magaret
    Department of Laboratory Medicine, University of Washington, 600 Broadway, Suite 400, Seattle, WA 98122, USA
    J Clin Microbiol 45:1618-20. 2007
  3. pmc Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling
    A S Magaret
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Sex Transm Infect 85:270-5. 2009
  4. pmc Incorporating validation subsets into discrete proportional hazards models for mismeasured outcomes
    Amalia S Magaret
    Department of Laboratory Medicine, University of Washington, P O Box 359928, Seattle, WA 98195, USA
    Stat Med 27:5456-70. 2008
  5. pmc Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
  6. pmc Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
  7. pmc Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
  8. pmc Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    J Infect Dis 205:358-65. 2012
  9. pmc Detailed characterization of T cell responses to herpes simplex virus-2 in immune seronegative persons
    Christine M Posavad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    J Immunol 184:3250-9. 2010
  10. ncbi request reprint Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:1324-31. 2007

Detail Information

Publications21

  1. pmc Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: results of analyses from a multicenter randomized trial
    Guy de Bruyn
    Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 12:277. 2012
    ....
  2. pmc Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa
    Amalia S Magaret
    Department of Laboratory Medicine, University of Washington, 600 Broadway, Suite 400, Seattle, WA 98122, USA
    J Clin Microbiol 45:1618-20. 2007
    ..We found that a cutoff of 50 HSV DNA copies/ml of swab specimen, a level 10-fold lower than our previous cutoff, minimizes misclassification...
  3. pmc Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling
    A S Magaret
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Sex Transm Infect 85:270-5. 2009
    ..We evaluated two methods to describe detection of herpes simplex virus (HSV) from the genital mucosa...
  4. pmc Incorporating validation subsets into discrete proportional hazards models for mismeasured outcomes
    Amalia S Magaret
    Department of Laboratory Medicine, University of Washington, P O Box 359928, Seattle, WA 98195, USA
    Stat Med 27:5456-70. 2008
    ..We also compare the performance of the validation methods proposed using an example data set...
  5. pmc Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
    ..To determine whether rapidly cleared episodes of herpes simplex virus (HSV) reactivation occur in HIV-infected adults...
  6. pmc Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
    ..Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated...
  7. pmc Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  8. pmc Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    J Infect Dis 205:358-65. 2012
    ..Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1...
  9. pmc Detailed characterization of T cell responses to herpes simplex virus-2 in immune seronegative persons
    Christine M Posavad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    J Immunol 184:3250-9. 2010
    ..Understanding the mechanism(s) by which such responses are elicited may provide important insights in developing novel strategies for preventing acquisition of sexually acquired HSV-2...
  10. ncbi request reprint Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:1324-31. 2007
    ..In animal models, induction of Th1-specific responses modifies experimental herpes simplex virus (HSV) infection...
  11. pmc Case-crossover analysis of condom use and herpes simplex virus type 2 acquisition
    Jeffrey D Stanaway
    Departments of Epidemiology, University of Washington, Seattle, WA, USA
    Sex Transm Dis 39:388-93. 2012
    ..The case-crossover design offers increased control of individual-level confounders, and was thus used with the aim of producing a more accurate estimate of the effect of condom use on HSV-2 acquisition...
  12. pmc Diversity in CD8(+) T cell function and epitope breadth among persons with genital herpes
    Kerry J Laing
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Clin Immunol 30:703-22. 2010
    ..The diversity in T cell response in these ex vivo assessments offers the potential of defining immune correlates of HSV-2 reactivation in humans...
  13. ncbi request reprint Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
    J Infect Dis 196:505-9. 2007
    ..02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection...
  14. pmc Development of an interferon-gamma ELISPOT assay to detect human T cell responses to HSV-2
    Christine M Posavad
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Vaccine 29:7058-66. 2011
    ..A sensitive and specific assay to measure HSV-specific T cell responses is a necessary part of vaccine development and thus we undertook the development of an interferon-γ (IFN-γ) ELISPOT assay to measure T cell responses to HSV-2...
  15. pmc A pooled analysis of the effect of condoms in preventing HSV-2 acquisition
    Emily T Martin
    Departments of Epidemiology, University of Washington, Seattle, USA
    Arch Intern Med 169:1233-40. 2009
    ..The degree of effectiveness of condom use in preventing the transmission of herpes simplex virus 2 (HSV-2) is uncertain. To address this issue, we performed a large pooled analysis...
  16. ncbi request reprint Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    ..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
  17. pmc Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case-control study
    Marcel E Curlin
    Vaccine and Infectious Diseases Institute, Fred Hutchinson Cancer Research Center, USA
    AIDS 25:153-8. 2011
    ..We examined the association between adenovirus serostatus and the rate of incident HIV infection in populations at elevated risk of HIV acquisition...
  18. pmc Predictors of survival after a diagnosis of non-Hodgkin lymphoma in a resource-limited setting: a retrospective study on the impact of HIV infection and its treatment
    Moses H Bateganya
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 56:312-9. 2011
    ..We examined factors associated with survival among patients with newly diagnosed non-Hodgkin lymphoma (NHL) in Uganda...
  19. pmc Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected Persons
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, WA, USA
    BMC Res Notes 4:64. 2011
    ..abstract:..
  20. pmc Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response
    Huong Q Nguyen
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 22:937-45. 2008
    ..To evaluate the role of highly active antiretroviral therapy and chemotherapy on tumor response among persons with AIDS-related Kaposi sarcoma and identify factors associated with response in a clinic setting...
  21. ncbi request reprint Prenatal herpes simplex virus serologic screening beliefs and practices among obstetricians
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98119, USA
    Obstet Gynecol 110:1364-70. 2007
    ..To describe the beliefs and practices of obstetricians related to prenatal serologic testing for HSV infection...