Izumi Maezawa

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease
    Izumi Maezawa
    Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA 95616, USA
    Int J Alzheimers Dis 2012:868972. 2012
  2. ncbi request reprint Does microglial dysfunction play a role in autism and Rett syndrome?
    Izumi Maezawa
    M I N D Medical Investigation of Neurodevelopmental Disorders Institute and Department of Pathology and Laboratory Medicine, Sacramento, CA, USA
    Neuron Glia Biol 7:85-97. 2011
  3. doi request reprint Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate
    Izumi Maezawa
    Department of Pathology, Laboratory Medicine, Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Neurosci 30:5346-56. 2010
  4. pmc Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    Izumi Maezawa
    Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, California 95618, USA
    J Biol Chem 286:3693-706. 2011
  5. pmc Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro
    Makoto Horiuchi
    Department of Neurology, University of California Davis, School of Medicine, Sacramento, CA 95817, United States
    Neurobiol Aging 33:499-509. 2012
  6. pmc The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide
    Jitka Petrlova
    Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e35443. 2012
  7. pmc MeCP2 modulates gene expression pathways in astrocytes
    Dag H Yasui
    Department of Medical Microbiology and Immunology, UC Davis Genome Center, University of California Davis, 1 Shields Avenue, Davis, CA, 95616, USA
    Mol Autism 4:3. 2013
  8. pmc Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions
    Izumi Maezawa
    M I N D Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Neurosci 29:5051-61. 2009
  9. pmc Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome
    Claudia M Greco
    MIND Institute, University of California Davis Medical Center, Sacramento, CA, USA
    Mol Autism 2:2. 2011

Collaborators

Detail Information

Publications10

  1. pmc Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease
    Izumi Maezawa
    Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA 95616, USA
    Int J Alzheimers Dis 2012:868972. 2012
    ..1 blockers are well known, and a KCa3.1 blocker has been proven safe in clinical trials. It is therefore promising to reposition old or new KCa3.1 blockers for AD preclinical and clinical trials...
  2. ncbi request reprint Does microglial dysfunction play a role in autism and Rett syndrome?
    Izumi Maezawa
    M I N D Medical Investigation of Neurodevelopmental Disorders Institute and Department of Pathology and Laboratory Medicine, Sacramento, CA, USA
    Neuron Glia Biol 7:85-97. 2011
    ..We propose that ASDs provide excellent opportunities to study the influence of microglia on neurodevelopment, and this knowledge could lead to novel therapies...
  3. doi request reprint Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate
    Izumi Maezawa
    Department of Pathology, Laboratory Medicine, Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Neurosci 30:5346-56. 2010
    ..Our results suggest that microglia may influence the onset and progression of RTT and that microglia glutamate synthesis or release could be a therapeutic target for RTT...
  4. pmc Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    Izumi Maezawa
    Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, California 95618, USA
    J Biol Chem 286:3693-706. 2011
    ..Our results suggest that AβO, generally considered a neurotoxin, may more potently cause neuronal damage indirectly by activating microglia in AD...
  5. pmc Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro
    Makoto Horiuchi
    Department of Neurology, University of California Davis, School of Medicine, Sacramento, CA 95817, United States
    Neurobiol Aging 33:499-509. 2012
    ....
  6. pmc The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide
    Jitka Petrlova
    Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e35443. 2012
    ..Several lines of evidence point to the soluble Aβ oligomer (AβO) as the primary neurotoxic species in the etiology of AD. Recently, we have demonstrated that a class of fluorene molecules specifically disrupts the AβO species...
  7. pmc MeCP2 modulates gene expression pathways in astrocytes
    Dag H Yasui
    Department of Medical Microbiology and Immunology, UC Davis Genome Center, University of California Davis, 1 Shields Avenue, Davis, CA, 95616, USA
    Mol Autism 4:3. 2013
    ..abstract:..
  8. pmc Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions
    Izumi Maezawa
    M I N D Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Neurosci 29:5051-61. 2009
    ..Our results suggest that astrocytes are viable therapeutic targets for RTT and perhaps regressive forms of autism...
  9. pmc Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome
    Claudia M Greco
    MIND Institute, University of California Davis Medical Center, Sacramento, CA, USA
    Mol Autism 2:2. 2011
    ..abstract:..