Murty V V S Madiraju

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Replacement of Mycobacterium smegmatis dnaA gene by Mycobacterium tuberculosis homolog results in temperature sensitivity
    Murty Madiraju
    The University of Texas Health Science Center, 11937 US Hwy 271, Tyler, TX 75703, United States
    Tuberculosis (Edinb) 91:S136-41. 2011
  2. ncbi request reprint The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC
    Murty V V S Madiraju
    Biomedical Research, The University of Texas Health Center at Tyler, 75708 3154, USA
    Mol Microbiol 59:1876-90. 2006
  3. ncbi request reprint Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase
    Ashwini Chauhan
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 62:132-47. 2006
  4. ncbi request reprint Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator
    Marek Fol
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 60:643-57. 2006
  5. ncbi request reprint Conditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene
    Rebecca Greendyke
    Biomedical Research, 11937 US The University of Texas Health Center at Tyler, Tyler, TX 75708 3154, USA
    Microbiology 148:3887-900. 2002
  6. pmc Mycobacterium tuberculosis cells growing in macrophages are filamentous and deficient in FtsZ rings
    Ashwini Chauhan
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708 3154, USA
    J Bacteriol 188:1856-65. 2006
  7. pmc Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome
    Jaroslaw Dziadek
    Department of Biochemistry, The University of Texas Health Center at Tyler, 75708 3154, USA
    J Bacteriol 184:3848-55. 2002
  8. ncbi request reprint Genetic evidence that mycobacterial FtsZ and FtsW proteins interact, and colocalize to the division site in Mycobacterium smegmatis
    Malini Rajagopalan
    The University of Texas Health Center at Tyler, Biomedical Research, 11937 US Hwy 271, Tyler, TX 75708, United States
    FEMS Microbiol Lett 250:9-17. 2005
  9. ncbi request reprint Physiological consequences associated with overproduction of Mycobacterium tuberculosis FtsZ in mycobacterial hosts
    Jaroslaw Dziadek
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708 3154, USA
    Microbiology 148:961-71. 2002
  10. pmc Modulation of Mycobacterium tuberculosis DnaA protein-adenine-nucleotide interactions by acidic phospholipids
    Kohji Yamamoto
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, U S A
    Biochem J 363:305-11. 2002

Collaborators

Detail Information

Publications17

  1. pmc Replacement of Mycobacterium smegmatis dnaA gene by Mycobacterium tuberculosis homolog results in temperature sensitivity
    Murty Madiraju
    The University of Texas Health Science Center, 11937 US Hwy 271, Tyler, TX 75703, United States
    Tuberculosis (Edinb) 91:S136-41. 2011
    ..Our results suggest that Mtb DnaA functions as a partially active protein in M. smegmatis, hence is not as proficient as M. smegmatis counterpart in optimally driving the M. smegmatis oriC replication machinery...
  2. ncbi request reprint The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC
    Murty V V S Madiraju
    Biomedical Research, The University of Texas Health Center at Tyler, 75708 3154, USA
    Mol Microbiol 59:1876-90. 2006
    ..We propose that ATPase activity enables the DnaA protomers on oriC to rapidly form oligomeric complexes competent for replication initiation...
  3. ncbi request reprint Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase
    Ashwini Chauhan
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 62:132-47. 2006
    ....
  4. ncbi request reprint Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator
    Marek Fol
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 60:643-57. 2006
    ..We propose that proliferation of M. tuberculosis in vivo depends, in part, on the optimal ratio of phosphorylated to non-phosphorylated MtrA response regulator...
  5. ncbi request reprint Conditional expression of Mycobacterium smegmatis dnaA, an essential DNA replication gene
    Rebecca Greendyke
    Biomedical Research, 11937 US The University of Texas Health Center at Tyler, Tyler, TX 75708 3154, USA
    Microbiology 148:3887-900. 2002
    ..It is concluded that DNA replication and cell-division processes in M. smegmatis are linked, and it is proposed that DnaA has a role in both of these processes...
  6. pmc Mycobacterium tuberculosis cells growing in macrophages are filamentous and deficient in FtsZ rings
    Ashwini Chauhan
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708 3154, USA
    J Bacteriol 188:1856-65. 2006
    ..Our results suggest that the intraphagosomal milieu alters the expression of M. tuberculosis genes affecting Z-ring formation and thereby cell division...
  7. pmc Mutations in the CCGTTCACA DnaA box of Mycobacterium tuberculosis oriC that abolish replication of oriC plasmids are tolerated on the chromosome
    Jaroslaw Dziadek
    Department of Biochemistry, The University of Texas Health Center at Tyler, 75708 3154, USA
    J Bacteriol 184:3848-55. 2002
    ..tuberculosis strains have evolved mechanisms to tolerate mutations in the oriC region and that functional requirements for M. tuberculosis oriC replication are different for chromosomes and plasmids...
  8. ncbi request reprint Genetic evidence that mycobacterial FtsZ and FtsW proteins interact, and colocalize to the division site in Mycobacterium smegmatis
    Malini Rajagopalan
    The University of Texas Health Center at Tyler, Biomedical Research, 11937 US Hwy 271, Tyler, TX 75708, United States
    FEMS Microbiol Lett 250:9-17. 2005
    ..Our results suggest that mycobacterial FtsZ can localize to the septum independent of FtsW, and that interactions of FtsW with FtsZ are critical for the formation of productive FtsZ-rings and the cell division process in mycobacteria...
  9. ncbi request reprint Physiological consequences associated with overproduction of Mycobacterium tuberculosis FtsZ in mycobacterial hosts
    Jaroslaw Dziadek
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708 3154, USA
    Microbiology 148:961-71. 2002
    ..Together these results suggest that the intracellular concentration of FtsZ protein is critical for productive septum formation in mycobacteria...
  10. pmc Modulation of Mycobacterium tuberculosis DnaA protein-adenine-nucleotide interactions by acidic phospholipids
    Kohji Yamamoto
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, U S A
    Biochem J 363:305-11. 2002
    ..tuberculosis oriC involves intimate interactions between DnaA, adenine nucleotides and membrane phospholipids, and the latter helps to ensure that only the ATP form of the DnaA protein interacts continuously with oriC...
  11. ncbi request reprint Mutations in the GTP-binding and synergy loop domains of Mycobacterium tuberculosis ftsZ compromise its function in vitro and in vivo
    Malini Rajagopalan
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    Biochem Biophys Res Commun 331:1171-7. 2005
    ..Together, our results indicate that optimal GTPase and polymerization activities of FtsZ are required to sustain cell division in mycobacteria and that the same conserved mutations in different bacterial species have distinct phenotypes...
  12. ncbi request reprint Conditional expression of Mycobacterium smegmatis ftsZ, an essential cell division gene
    Jaroslaw Dziadek
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
    Microbiology 149:1593-603. 2003
    ..It is concluded that optimal levels of M. smegmatis FtsZ are required to sustain cell division and that the cell division initiation mechanisms are similar in mycobacteria...
  13. pmc The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides
    Erin Maloney
    Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, TX, USA
    PLoS Pathog 5:e1000534. 2009
    ..Together, our results suggest that LysX-mediated production of L-PG is necessary for the maintenance of optimal membrane integrity and for survival of the pathogen upon infection...
  14. pmc Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator
    Malini Rajagopalan
    Biomedical Research, University of Texas Health Science Center, Tyler, Texas 75708 3154, USA
    J Biol Chem 285:15816-27. 2010
    ..e. oriC and fbpB, reflects its main role as a coordinator between the proliferative and pathogenic functions of Mtb...
  15. pmc Synchronous replication initiation in novel Mycobacterium tuberculosis dnaA cold-sensitive mutants
    Naveen Nair
    Biomedical Research, Department of Biochemistry, The University of Texas Health Science Center at Tyler, Tyler, TX 75708 3154, USA
    Mol Microbiol 71:291-304. 2009
    ..tuberculosis requires that the dnaA promoter remains active during the replication period and that the DnaA protein is able to interact with ATP...
  16. pmc Facilitation of dissociation reaction of nucleotides bound to Mycobacterium tuberculosis DnaA
    Kohji Yamamoto
    Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812 8581, Japan
    J Biochem 143:759-64. 2008
    ..We suggest that the outcome of intra-cellular DnaA(TB)-nucleotide interactions, hence DnaA(TB) activity, is influenced by phospholipids...