Thomas J MacVittie
Affiliation: University of Maryland
- Hematopoietic recovery following autologous bone marrow transplantation in a nonhuman primate: effect of variation in treatment schedule with PEG-rHuMGDFAnn M Farese
University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
Stem Cells 21:79-89. 2003..These data confirm predictions from PK/PD modeling of PEG-rHuMGDF that thrombocytopenia is preventable following AuBMT...
- The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiationThomas J MacVittie
Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Health Phys 103:427-53. 2012..Specific and multi-organ medical countermeasures can be assessed for efficacy and interaction during the concomitant evolution of acute and delayed key organ-specific subsyndromes...
- The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque modelThomas J MacVittie
Department of Radiation Oncology, University of Maryland, School of Medicine, MD, USA
Health Phys 103:411-26. 2012..The model defines the dose response relationship and time course of acute gastrointestinal syndrome-induced morbidity and mortality in the rhesus macaque...
- The MCART Consortium animal models seriesThomas J MacVittie
Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD, USA
Health Phys 103:340-2. 2012....
- The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque modelMichael Garofalo
University of Maryland, School of Medicine, Department of Radiation Oncology Statistician, Rockville, MD
Health Phys 106:56-72. 2014..Therefore, it may provide an effective platform for the efficacy testing of candidate medical countermeasures against the delayed pulmonary syndrome. ..
- Filgrastim improves survival in lethally irradiated nonhuman primatesAnn M Farese
Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland, USA
Radiat Res 179:89-100. 2013..418). Survival was significantly increased by 38.3% over controls. Filgrastim, administered at this dose and schedule, effectively mitigated the lethality of the hematopoietic subsyndrome of the acute radiation syndrome...
- The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependentAnn M Farese
Radiation Oncology Department, University of Maryland, School of Medicine, Baltimore, Md Department of Biostatistics, Indiana University, Indianapolis, IN
Health Phys 106:39-47. 2014....
- A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical managementAnn M Farese
Department of Radiation Oncology, University of Maryland, School of Medicine, Ft Detrick, MD, USA
Health Phys 103:367-82. 2012..Furthermore, following a nuclear terrorist event, medical management may be the only treatment administered at its optimal schedule...
- Mass spectrometry imaging enriches biomarker discovery approaches with candidate mappingAlison J Scott
University of Maryland, School of Dentistry, Baltimore, MD University of Maryland, School of Pharmacy, Baltimore, MD Indiana University, School of Medicine, Indianapolis, IN University of Maryland, School of Medicine, Baltimore, MD
Health Phys 106:120-8. 2014..This paper will discuss the application of MALDI-MSI for use in a larger biomarker discovery pipeline. ..
- Pegfilgrastim Improves Survival of Lethally Irradiated Nonhuman PrimatesKim G Hankey
a Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland
Radiat Res 183:643-55. 2015..These data demonstrate that pegfilgrastim is an additional medical countermeasure capable of increasing survival and neutrophil-related parameters when administered in an abbreviated schedule to a NHP model of lethal H-ARS...
- Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple speciesJace W Jones
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 20 N Pine Street, Room 721N, Baltimore, MD, 21201, USA
Anal Bioanal Chem 406:4663-75. 2014..The results demonstrated that circulating citrulline can be confidently quantified from plasma. Additionally, circulating citrulline displayed a time-dependent response for radiological doses covering GI-ARS across multiple species. ..
- A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damageMichael C Garofalo
University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD 21201
Health Phys 106:73-83. 2014....
- Linking the human response to unplanned radiation and treatment to the nonhuman primate response to controlled radiation and treatmentHarald Dörr
Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, Germany University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD U S Food and Drug Administration FDA, Silver Spring, MD
Health Phys 106:129-34. 2014....
- Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSFThomas J MacVittie
Marlene and Stewart Greenebaum Cancer Center, Bressler Research Building, Room 7 039, University of Maryland Baltimore, 655 West Baltimore Street, Baltimore, MD 21201, USA
Health Phys 89:546-55. 2005..Clearly, the use of supportive care and G-CSF enhanced recovery of myelopoiesis and survival after lethal doses of irradiation...
- Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometryJace W Jones
University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD University of Maryland, School of Dentistry, Department of Microbial Pathogenesis, Baltimore, MD Epistem Ltd, Manchester, UK University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD
Health Phys 106:106-19. 2014..Going forward, the use of mass spectrometry-based metabolomics coupled to well defined animal models provides the unique opportunity for comprehensive biomarker discovery. ..
- Immune cell reconstitution after exposure to potentially lethal doses of radiation in the nonhuman primateThomas J MacVittie
University of Maryland, School of Medicine, Dept of Radiation Oncology, Baltimore, MD Integrated Research Facility, Frederick, MD Naval Medical Research Center, Silver Spring, MD
Health Phys 106:84-96. 2014....
- Animal models for medical countermeasures to radiation exposureJacqueline P Williams
Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
Radiat Res 173:557-78. 2010..Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings...
- The MCART radiation physics core: the quest for radiation dosimetry standardizationAbdul M Kazi
University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD
Health Phys 106:97-105. 2014..It is appropriate to report a summary of initial activities with the intent of reporting the full implementation at a later date. ..
- Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkeyRoy M Vigneulle
Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
Dig Dis Sci 47:1480-91. 2002..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
- Cytokine-based treatment of radiation injury: potential benefits after low-level radiation exposureThomas J MacVittie
Departments of Radiation Oncology and Pathology, University of Maryland, Greenebaum Cancer Center, 655 West Baltimore Street, Baltimore, MD 21201, USA
Mil Med 167:68-70. 2002....
- Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cellsSebastian Brenner
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Ther 14:202-11. 2006..Some inserts landed in the vicinity of genes controlling cell cycle and proliferation. Statistical analyses of insertion sites 1 year posttransplant suggest a high diversity of insertion sites despite low marking...
- Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003Helen B Stone
National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 162:711-28. 2004....
- Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working GroupJamie K Waselenko
Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
Ann Intern Med 140:1037-51. 2004..For terrorist or accidental events involving exposure to radioiodines, prophylaxis against malignant disease of the thyroid is also recommended, particularly for children and adolescents...
- Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacyGerrit Koopman
Biomedical Primate Research Center, Department of Virology, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
Vaccine 23:4195-202. 2005..We conclude that besides mobilization of dendritic cells additional stimuli to induce dendritic cell maturation may be needed for avid boosting of antigen specific immune activation...
- Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaquesGerrit Koopman
BPRC, Rijswijk, The Netherlands
Hum Immunol 65:303-16. 2004..In conclusion, ProGP-1 may be used to generate a transient increase in DC as well as CD4 T-cell numbers, thereby creating a window of opportunity for immunotherapeutic intervention...
- The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 actionDirk E Smith
Amgen Corporation, 51 University Street, Seattle, WA 98101, USA
Immunity 18:87-96. 2003..These findings suggest that the soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action...
- Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001C Norman Coleman
Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 159:812-34. 2003..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...
- Immune Reconstitution in Nonhuman PrimatesThomas Macvittie; Fiscal Year: 2005..Clearly the ability to colonize mucosal surfaces in the respiratory, intestinal, and genital tracts also require the orchestrated synthesis of fimbriae for adherence and flagella for motility. ..