Thomas J MacVittie

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Hematopoietic recovery following autologous bone marrow transplantation in a nonhuman primate: effect of variation in treatment schedule with PEG-rHuMGDF
    Ann M Farese
    University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Stem Cells 21:79-89. 2003
  2. ncbi request reprint The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation
    Thomas J MacVittie
    Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Health Phys 103:427-53. 2012
  3. ncbi request reprint The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model
    Thomas J MacVittie
    Department of Radiation Oncology, University of Maryland, School of Medicine, MD, USA
    Health Phys 103:411-26. 2012
  4. ncbi request reprint The MCART Consortium animal models series
    Thomas J MacVittie
    Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD, USA
    Health Phys 103:340-2. 2012
  5. doi request reprint The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model
    Michael Garofalo
    University of Maryland, School of Medicine, Department of Radiation Oncology Statistician, Rockville, MD
    Health Phys 106:56-72. 2014
  6. doi request reprint Filgrastim improves survival in lethally irradiated nonhuman primates
    Ann M Farese
    Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    Radiat Res 179:89-100. 2013
  7. pmc The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent
    Ann M Farese
    Radiation Oncology Department, University of Maryland, School of Medicine, Baltimore, Md Department of Biostatistics, Indiana University, Indianapolis, IN
    Health Phys 106:39-47. 2014
  8. pmc A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management
    Ann M Farese
    Department of Radiation Oncology, University of Maryland, School of Medicine, Ft Detrick, MD, USA
    Health Phys 103:367-82. 2012
  9. ncbi request reprint Mass spectrometry imaging enriches biomarker discovery approaches with candidate mapping
    Alison J Scott
    University of Maryland, School of Dentistry, Baltimore, MD University of Maryland, School of Pharmacy, Baltimore, MD Indiana University, School of Medicine, Indianapolis, IN University of Maryland, School of Medicine, Baltimore, MD
    Health Phys 106:120-8. 2014
  10. ncbi request reprint Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species
    Jace W Jones
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 20 N Pine Street, Room 721N, Baltimore, MD, 21201, USA
    Anal Bioanal Chem 406:4663-75. 2014

Research Grants

  1. Immune Reconstitution in Nonhuman Primates
    Thomas Macvittie; Fiscal Year: 2005

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Hematopoietic recovery following autologous bone marrow transplantation in a nonhuman primate: effect of variation in treatment schedule with PEG-rHuMGDF
    Ann M Farese
    University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Stem Cells 21:79-89. 2003
    ..These data confirm predictions from PK/PD modeling of PEG-rHuMGDF that thrombocytopenia is preventable following AuBMT...
  2. ncbi request reprint The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation
    Thomas J MacVittie
    Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Health Phys 103:427-53. 2012
    ..Specific and multi-organ medical countermeasures can be assessed for efficacy and interaction during the concomitant evolution of acute and delayed key organ-specific subsyndromes...
  3. ncbi request reprint The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model
    Thomas J MacVittie
    Department of Radiation Oncology, University of Maryland, School of Medicine, MD, USA
    Health Phys 103:411-26. 2012
    ..The model defines the dose response relationship and time course of acute gastrointestinal syndrome-induced morbidity and mortality in the rhesus macaque...
  4. ncbi request reprint The MCART Consortium animal models series
    Thomas J MacVittie
    Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD, USA
    Health Phys 103:340-2. 2012
    ....
  5. doi request reprint The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model
    Michael Garofalo
    University of Maryland, School of Medicine, Department of Radiation Oncology Statistician, Rockville, MD
    Health Phys 106:56-72. 2014
    ..Therefore, it may provide an effective platform for the efficacy testing of candidate medical countermeasures against the delayed pulmonary syndrome. ..
  6. doi request reprint Filgrastim improves survival in lethally irradiated nonhuman primates
    Ann M Farese
    Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    Radiat Res 179:89-100. 2013
    ..418). Survival was significantly increased by 38.3% over controls. Filgrastim, administered at this dose and schedule, effectively mitigated the lethality of the hematopoietic subsyndrome of the acute radiation syndrome...
  7. pmc The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent
    Ann M Farese
    Radiation Oncology Department, University of Maryland, School of Medicine, Baltimore, Md Department of Biostatistics, Indiana University, Indianapolis, IN
    Health Phys 106:39-47. 2014
    ....
  8. pmc A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management
    Ann M Farese
    Department of Radiation Oncology, University of Maryland, School of Medicine, Ft Detrick, MD, USA
    Health Phys 103:367-82. 2012
    ..Furthermore, following a nuclear terrorist event, medical management may be the only treatment administered at its optimal schedule...
  9. ncbi request reprint Mass spectrometry imaging enriches biomarker discovery approaches with candidate mapping
    Alison J Scott
    University of Maryland, School of Dentistry, Baltimore, MD University of Maryland, School of Pharmacy, Baltimore, MD Indiana University, School of Medicine, Indianapolis, IN University of Maryland, School of Medicine, Baltimore, MD
    Health Phys 106:120-8. 2014
    ..This paper will discuss the application of MALDI-MSI for use in a larger biomarker discovery pipeline. ..
  10. ncbi request reprint Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species
    Jace W Jones
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 20 N Pine Street, Room 721N, Baltimore, MD, 21201, USA
    Anal Bioanal Chem 406:4663-75. 2014
    ..The results demonstrated that circulating citrulline can be confidently quantified from plasma. Additionally, circulating citrulline displayed a time-dependent response for radiological doses covering GI-ARS across multiple species. ..
  11. doi request reprint A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage
    Michael C Garofalo
    University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD 21201
    Health Phys 106:73-83. 2014
    ....
  12. pmc Linking the human response to unplanned radiation and treatment to the nonhuman primate response to controlled radiation and treatment
    Harald Dörr
    Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, Germany University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD U S Food and Drug Administration FDA, Silver Spring, MD
    Health Phys 106:129-34. 2014
    ....
  13. ncbi request reprint Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF
    Thomas J MacVittie
    Marlene and Stewart Greenebaum Cancer Center, Bressler Research Building, Room 7 039, University of Maryland Baltimore, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Health Phys 89:546-55. 2005
    ..Clearly, the use of supportive care and G-CSF enhanced recovery of myelopoiesis and survival after lethal doses of irradiation...
  14. pmc Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry
    Jace W Jones
    University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD University of Maryland, School of Dentistry, Department of Microbial Pathogenesis, Baltimore, MD Epistem Ltd, Manchester, UK University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD
    Health Phys 106:106-19. 2014
    ..Going forward, the use of mass spectrometry-based metabolomics coupled to well defined animal models provides the unique opportunity for comprehensive biomarker discovery. ..
  15. doi request reprint Immune cell reconstitution after exposure to potentially lethal doses of radiation in the nonhuman primate
    Thomas J MacVittie
    University of Maryland, School of Medicine, Dept of Radiation Oncology, Baltimore, MD Integrated Research Facility, Frederick, MD Naval Medical Research Center, Silver Spring, MD
    Health Phys 106:84-96. 2014
    ....
  16. pmc Animal models for medical countermeasures to radiation exposure
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Radiat Res 173:557-78. 2010
    ..Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings...
  17. doi request reprint The MCART radiation physics core: the quest for radiation dosimetry standardization
    Abdul M Kazi
    University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore, MD
    Health Phys 106:97-105. 2014
    ..It is appropriate to report a summary of initial activities with the intent of reporting the full implementation at a later date. ..
  18. ncbi request reprint Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey
    Roy M Vigneulle
    Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Dig Dis Sci 47:1480-91. 2002
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  19. ncbi request reprint Cytokine-based treatment of radiation injury: potential benefits after low-level radiation exposure
    Thomas J MacVittie
    Departments of Radiation Oncology and Pathology, University of Maryland, Greenebaum Cancer Center, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Mil Med 167:68-70. 2002
    ....
  20. ncbi request reprint Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Ther 14:202-11. 2006
    ..Some inserts landed in the vicinity of genes controlling cell cycle and proliferation. Statistical analyses of insertion sites 1 year posttransplant suggest a high diversity of insertion sites despite low marking...
  21. ncbi request reprint Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...
  22. ncbi request reprint Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques
    Gerrit Koopman
    BPRC, Rijswijk, The Netherlands
    Hum Immunol 65:303-16. 2004
    ..In conclusion, ProGP-1 may be used to generate a transient increase in DC as well as CD4 T-cell numbers, thereby creating a window of opportunity for immunotherapeutic intervention...
  23. ncbi request reprint Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group
    Jamie K Waselenko
    Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
    Ann Intern Med 140:1037-51. 2004
    ..For terrorist or accidental events involving exposure to radioiodines, prophylaxis against malignant disease of the thyroid is also recommended, particularly for children and adolescents...
  24. ncbi request reprint Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
    Helen B Stone
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 162:711-28. 2004
    ....
  25. ncbi request reprint Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy
    Gerrit Koopman
    Biomedical Primate Research Center, Department of Virology, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 23:4195-202. 2005
    ..We conclude that besides mobilization of dendritic cells additional stimuli to induce dendritic cell maturation may be needed for avid boosting of antigen specific immune activation...
  26. ncbi request reprint The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
    Dirk E Smith
    Amgen Corporation, 51 University Street, Seattle, WA 98101, USA
    Immunity 18:87-96. 2003
    ..These findings suggest that the soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action...

Research Grants1

  1. Immune Reconstitution in Nonhuman Primates
    Thomas Macvittie; Fiscal Year: 2005
    ..Clearly the ability to colonize mucosal surfaces in the respiratory, intestinal, and genital tracts also require the orchestrated synthesis of fimbriae for adherence and flagella for motility. ..