T J MacVittie

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates
    T J MacVittie
    Greenebaum Cancer Center, Baltimore, MD 21201, USA
    Exp Hematol 27:1557-68. 1999
  2. ncbi Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF
    Thomas J MacVittie
    Marlene and Stewart Greenebaum Cancer Center, Bressler Research Building, Room 7 039, University of Maryland Baltimore, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Health Phys 89:546-55. 2005
  3. ncbi Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: effect of schedule, dose, and route of administration
    A M Farese
    University of Maryland, Greenebaum Cancer Center, 655 West Baltimore Street, BRB 7 049, Baltimore, MD 21201, USA
    Stem Cells 19:522-33. 2001
  4. ncbi A single dose of pegylated leridistim significantly improves neutrophil recovery in sublethally irradiated rhesus macaques
    A M Farese
    University of Maryland, Greenebaum Cancer Center, 655 West Baltimore Street, BRB 7 049, Baltimore, MD 21201, USA
    Stem Cells 19:514-21. 2001
  5. ncbi Promegapoietin-1a, an engineered chimeric IL-3 and Mpl-L receptor agonist, stimulates hematopoietic recovery in conventional and abbreviated schedules following radiation-induced myelosuppression in nonhuman primates
    A M Farese
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    Stem Cells 19:329-38. 2001
  6. ncbi Pegfilgrastim, a sustained-duration form of filgrastim, significantly improves neutrophil recovery after autologous marrow transplantation in rhesus macaques
    A M Farese
    Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Bone Marrow Transplant 32:399-404. 2003
  7. ncbi Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Ther 14:202-11. 2006
  8. ncbi Hematopoietic recovery following autologous bone marrow transplantation in a nonhuman primate: effect of variation in treatment schedule with PEG-rHuMGDF
    Ann M Farese
    University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Stem Cells 21:79-89. 2003
  9. ncbi The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
    Dirk E Smith
    Amgen Corporation, 51 University Street, Seattle, WA 98101, USA
    Immunity 18:87-96. 2003
  10. ncbi Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques
    Gerrit Koopman
    BPRC, Rijswijk, The Netherlands
    Hum Immunol 65:303-16. 2004

Detail Information

Publications15

  1. ncbi Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates
    T J MacVittie
    Greenebaum Cancer Center, Baltimore, MD 21201, USA
    Exp Hematol 27:1557-68. 1999
    ....
  2. ncbi Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF
    Thomas J MacVittie
    Marlene and Stewart Greenebaum Cancer Center, Bressler Research Building, Room 7 039, University of Maryland Baltimore, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Health Phys 89:546-55. 2005
    ..Clearly, the use of supportive care and G-CSF enhanced recovery of myelopoiesis and survival after lethal doses of irradiation...
  3. ncbi Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: effect of schedule, dose, and route of administration
    A M Farese
    University of Maryland, Greenebaum Cancer Center, 655 West Baltimore Street, BRB 7 049, Baltimore, MD 21201, USA
    Stem Cells 19:522-33. 2001
    ..Leridistim, a novel engineered hematopoietic growth factor administered at the appropriate dose, route and schedule, stimulates multilineage hematopoietic reconstitution in radiation-myelosuppressed nonhuman primates...
  4. ncbi A single dose of pegylated leridistim significantly improves neutrophil recovery in sublethally irradiated rhesus macaques
    A M Farese
    University of Maryland, Greenebaum Cancer Center, 655 West Baltimore Street, BRB 7 049, Baltimore, MD 21201, USA
    Stem Cells 19:514-21. 2001
    ....
  5. ncbi Promegapoietin-1a, an engineered chimeric IL-3 and Mpl-L receptor agonist, stimulates hematopoietic recovery in conventional and abbreviated schedules following radiation-induced myelosuppression in nonhuman primates
    A M Farese
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    Stem Cells 19:329-38. 2001
    ....
  6. ncbi Pegfilgrastim, a sustained-duration form of filgrastim, significantly improves neutrophil recovery after autologous marrow transplantation in rhesus macaques
    A M Farese
    Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Bone Marrow Transplant 32:399-404. 2003
    ..Enhanced pharmacokinetics in AuBMT cohorts are consistent with self-regulating, neutrophil-mediated clearance...
  7. ncbi Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Ther 14:202-11. 2006
    ..Some inserts landed in the vicinity of genes controlling cell cycle and proliferation. Statistical analyses of insertion sites 1 year posttransplant suggest a high diversity of insertion sites despite low marking...
  8. ncbi Hematopoietic recovery following autologous bone marrow transplantation in a nonhuman primate: effect of variation in treatment schedule with PEG-rHuMGDF
    Ann M Farese
    University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Stem Cells 21:79-89. 2003
    ..These data confirm predictions from PK/PD modeling of PEG-rHuMGDF that thrombocytopenia is preventable following AuBMT...
  9. ncbi The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
    Dirk E Smith
    Amgen Corporation, 51 University Street, Seattle, WA 98101, USA
    Immunity 18:87-96. 2003
    ..These findings suggest that the soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action...
  10. ncbi Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques
    Gerrit Koopman
    BPRC, Rijswijk, The Netherlands
    Hum Immunol 65:303-16. 2004
    ..In conclusion, ProGP-1 may be used to generate a transient increase in DC as well as CD4 T-cell numbers, thereby creating a window of opportunity for immunotherapeutic intervention...
  11. ncbi Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group
    Jamie K Waselenko
    Walter Reed Army Medical Center and Catholic University of America, Washington, DC 20307, USA
    Ann Intern Med 140:1037-51. 2004
    ..For terrorist or accidental events involving exposure to radioiodines, prophylaxis against malignant disease of the thyroid is also recommended, particularly for children and adolescents...
  12. ncbi Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
    Helen B Stone
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 162:711-28. 2004
    ....
  13. ncbi Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy
    Gerrit Koopman
    Biomedical Primate Research Center, Department of Virology, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 23:4195-202. 2005
    ..We conclude that besides mobilization of dendritic cells additional stimuli to induce dendritic cell maturation may be needed for avid boosting of antigen specific immune activation...
  14. ncbi Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey
    Roy M Vigneulle
    Department of Radiation Oncology, Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Dig Dis Sci 47:1480-91. 2002
    ..Our integrated approach allowed a comprehensive study of the relationship between postirradiation tissue injury and changes in function over time in the gastrointestinal tract of the nonhuman primate...
  15. ncbi Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...