Kay Macleod

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?
    Kay F Macleod
    Ben May Department for Cancer Research, Gordon Center for Integrative Sciences, University of Chicago, Chicago, Illinois, USA
    J Clin Invest 120:4179-82. 2010
  2. ncbi The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
    Kay F Macleod
    Ben May Department for Cancer Research, Committee on Cancer Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Nat Rev Cancer 8:769-81. 2008
  3. ncbi MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression
    Russell Z Szmulewitz
    Department of Medicine, Section of Hematology Oncology, The University of Chicago, Chicago, IL 60637, USA
    Int J Cancer 130:509-20. 2012
  4. ncbi The Rb tumor suppressor in stress responses and hematopoietic homeostasis
    Benjamin T Spike
    Ben May Institute for Cancer Research, Knapp Medical Research Building, University of Chicago, Chicago Illinois, USA
    Cell Cycle 4:42-5. 2005
  5. ncbi New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells
    Jennifer L Taylor
    Committee on Cancer Biology, The University of Chicago, 5841 South Maryland Avenue, MC6038, Chicago, IL 60637, United States
    Cancer Lett 272:12-22. 2008
  6. ncbi Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts
    Alexandra Dirlam
    Ben May Department for Cancer Research, Gordon Center for Integrative Sciences, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Mol Cell Biol 27:8713-28. 2007
  7. ncbi Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis
    Huiping Liu
    The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Cancer Res 7:1099-109. 2009
  8. ncbi The Rb tumor suppressor is required for stress erythropoiesis
    Benjamin T Spike
    The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    EMBO J 23:4319-29. 2004
  9. ncbi BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy
    Kristin Tracy
    The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W 338, The University of Chicago, 929 E 57th St, Chicago, IL 60637, USA
    Mol Cell Biol 27:6229-42. 2007
  10. ncbi Autophagy: cellular and molecular mechanisms
    Danielle Glick
    Ben May Department for Cancer Research, Gordon Center for Integrative Sciences, University of Chicago, IL, USA
    J Pathol 221:3-12. 2010

Research Grants

  1. Functions of pRb in Stress Erythropoiesis
    Kay Macleod; Fiscal Year: 2009
  2. Functions of BNIP3 in Mammary Tumorigenesis
    Kay F Macleod; Fiscal Year: 2010

Collaborators

  • Paul Schumacker
  • Benjamin T Spike
  • Russell Z Szmulewitz
  • Benjamin C Dibling
  • Alexandra Dirlam
  • Danielle Glick
  • Tamara Lotan
  • Huiping Liu
  • Jennifer L Taylor
  • James R Knabb
  • Kristin Tracy
  • Kristen Otto
  • Carrie Rinker-Schaeffer
  • Robert Clark
  • Jennifer Taylor Veneris
  • Sandra Barth
  • Carrie W Rinker-Schaeffer
  • Jonathan Hickson
  • Donald Vander Griend
  • Seiko Diane Yamada
  • Bart O Williams
  • Tyler Jacks
  • James Marvin

Detail Information

Publications11

  1. ncbi The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?
    Kay F Macleod
    Ben May Department for Cancer Research, Gordon Center for Integrative Sciences, University of Chicago, Chicago, Illinois, USA
    J Clin Invest 120:4179-82. 2010
    ..This unexpected function for RB1 in late-stage cancer calls upon us to reassess the significance of RB1 inactivation in other cancers in terms of its timing, function in disease etiology, and relevance for cancer therapy...
  2. ncbi The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
    Kay F Macleod
    Ben May Department for Cancer Research, Committee on Cancer Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Nat Rev Cancer 8:769-81. 2008
    ....
  3. ncbi MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression
    Russell Z Szmulewitz
    Department of Medicine, Section of Hematology Oncology, The University of Chicago, Chicago, IL 60637, USA
    Int J Cancer 130:509-20. 2012
    ..Further studies will specifically interrogate the regulation of MKK4 activation within the metastatic microenvironment and the down-stream molecular events critical for metastasis suppression...
  4. ncbi The Rb tumor suppressor in stress responses and hematopoietic homeostasis
    Benjamin T Spike
    Ben May Institute for Cancer Research, Knapp Medical Research Building, University of Chicago, Chicago Illinois, USA
    Cell Cycle 4:42-5. 2005
    ....
  5. ncbi New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells
    Jennifer L Taylor
    Committee on Cancer Biology, The University of Chicago, 5841 South Maryland Avenue, MC6038, Chicago, IL 60637, United States
    Cancer Lett 272:12-22. 2008
    ..This review will provide a historical perspective on the role of JNKK1/MKK4 in SAPK signaling, including some recent findings from our own laboratory that shed light on the complicated role for JNKK1/MKK4 in metastatic colonization...
  6. ncbi Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts
    Alexandra Dirlam
    Ben May Department for Cancer Research, Gordon Center for Integrative Sciences, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Mol Cell Biol 27:8713-28. 2007
    ..The identification of a tissue-restricted role for E2f-2 in erythropoiesis highlights the nonredundant nature of E2f transcription factor activities in cell growth and differentiation...
  7. ncbi Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis
    Huiping Liu
    The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Cancer Res 7:1099-109. 2009
    ....
  8. ncbi The Rb tumor suppressor is required for stress erythropoiesis
    Benjamin T Spike
    The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    EMBO J 23:4319-29. 2004
    ..These results demonstrate a cell intrinsic role for pRb in stress erythropoiesis and hematopoietic homeostasis that has relevance for human diseases...
  9. ncbi BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy
    Kristin Tracy
    The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W 338, The University of Chicago, 929 E 57th St, Chicago, IL 60637, USA
    Mol Cell Biol 27:6229-42. 2007
    ..These studies identify BNIP3 as a key regulator of hypoxia-induced autophagy and suggest a novel role for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3 induction in cells...
  10. ncbi Autophagy: cellular and molecular mechanisms
    Danielle Glick
    Ben May Department for Cancer Research, Gordon Center for Integrative Sciences, University of Chicago, IL, USA
    J Pathol 221:3-12. 2010
    ..This review summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease...
  11. ncbi Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse
    Benjamin T Spike
    Ben May Department for Cancer Research, Center for Integrative Sciences, Chicago, IL 60637, USA
    Blood 110:2173-81. 2007
    ....

Research Grants7

  1. Functions of pRb in Stress Erythropoiesis
    Kay Macleod; Fiscal Year: 2009
    ....
  2. Functions of BNIP3 in Mammary Tumorigenesis
    Kay F Macleod; Fiscal Year: 2010
    ....