Research Topics
Genomes and Genes | WILLIAM ROBB MACLELLANSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Deducing topology of protein-protein interaction networks from experimentally measured sub-networksLing Yang
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
BMC Bioinformatics 9:301. 2008..However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein interaction networks is unclear...
Advances in the molecular mechanisms of heart failureW R MacLellan
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90076, USA
Curr Opin Cardiol 15:128-35. 2000..This review will focus on the recent advances that have been made and will highlight the importance they have had in our understanding and treatment of heart failure...- A novel Rb- and p300-binding protein inhibits transactivation by MyoDW R MacLellan
Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Mol Cell Biol 20:8903-15. 2000..Inhibition of MyoD may be explained by EID-1's ability to bind and inhibit p300's histone acetylase activity, an essential MyoD coactivator. Thus, EID-1 binds both Rb and p300 and is a novel repressor of MyoD function... - Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of RbW R MacLellan
Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 C E Young Dr, MRL 3 645, Los Angeles, CA 90095 1760, USA
Mol Cell Biol 25:2486-97. 2005..Thus, Rb and p130 have overlapping functional roles in vivo to suppress cell cycle activators, including Myc, and maintain quiescence in postnatal cardiac muscle... - Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycleLing Yang
Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
Biophys J 86:3432-43. 2004..In summary, our findings suggest that multisite phosphorylation of proteins is a critical biological mechanism in generating the essential dynamics and ensuring robust behavior of the cell cycle... - Hysteresis and cell cycle transitions: how crucial is it?Zhangang Han
Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
Biophys J 88:1626-34. 2005..Thus, although a hysteretic response is neither necessary nor sufficient, it is in general a much more robust mechanism for generating cell cycle dynamics than nonhysteretic mechanisms... - Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndromeKatja Schenke-Layland
Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles CA 90095 1760, USA
Matrix Biol 27:53-66. 2008..These new insights into the involvement of ECM degradation in SS may lead to novel therapies for patients suffering from dry eye disease... - Muscle mechanoreceptor sensitivity in heart failureHolly R Middlekauff
Div of Cardiology, 47 123 CHS, UCLA Dept of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 287:H1937-43. 2004..Finally, muscle mechanoreceptors in patients with HF have heightened basal sensitivity to mechanical stimuli resulting in exaggerated early increases in MSNA... - Coordination of cell growth and cell division: a mathematical modeling studyZhilin Qu
Cardiovascular Research Laboratory, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
J Cell Sci 117:4199-207. 2004..The model also accounts for the cell cycle delay seen in restriction point experiments performed in HeLa cells... - Dynamics of the cell cycle: checkpoints, sizers, and timersZhilin Qu
Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
Biophys J 85:3600-11. 2003..This model successfully reproduces sizer, timer, and the restriction point features of the eukaryotic cell cycle, in addition to other experimental findings... 
Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failureHolly R Middlekauff
Dept of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 294:H1956-62. 2008....- Regulation of the mammalian cell cycle: a model of the G1-to-S transitionZhilin Qu
Cardiovascular Research Laboratory, Department of Medicine, University of California, Los Angeles, California 90095, USA
Am J Physiol Cell Physiol 284:C349-64. 2003..In addition, we found that multisite phosphorylation of CDC25A, Rb, and CKI was critical for the generation of dynamics required for cell cycle progression... - Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathyKatja Schenke-Layland
Department of Medicine Cardiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1760, USA
Exp Eye Res 90:223-37. 2010.... - A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardiumEkaterini Angelis
The Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1760, USA
Circ Res 102:1222-9. 2008.... - Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cellsKatja Schenke-Layland
Cardiovascular Research Laboratory, UCLA School of Medicine, 675 C E Young Dr, MRL 3 645, Los Angeles, California 90095 1760, USA
Stem Cells 25:1529-38. 2007..Our data suggest that, given the appropriate extracellular stimuli, mouse embryonic stem cells can differentiate into trophoectoderm. Disclosure of potential conflicts of interest is found at the end of this article... - Influence of systematically varied nano-scale topography on cell morphology and adhesionSepideh Heydarkhan Hagvall
Department of Surgery, Regenerative Bioengineering and Repair Laboratory, University of California Los Angeles, Los Angeles, California 90095 1741, USA
Cell Commun Adhes 14:181-94. 2007..The presented nano-structures offer interesting opportunities to study the interaction of cells with topographical features comparable to the size of extracellular matrix components... - Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathwayWeiguang Zhong
The Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
EMBO J 25:3869-79. 2006..These data suggest that Myc is required for a normal hypertrophic response and that its growth-promoting effects are also mediated through a CycD2-dependent pathway... - Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineagesKatja Schenke-Layland
Department of Medicine and Physiology, Cardiovascular Research Laboratory, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1760, USA
Stem Cells 26:1537-46. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - Human adipose stem cells: a potential cell source for cardiovascular tissue engineeringSepideh Heydarkhan-Hagvall
Regenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
Cells Tissues Organs 187:263-74. 2008..The objective of this study was to identify the exogenous and endogenous parameters that are critical for the differentiation of human adipose stem cells (hASCs) into cardiovascular cells... - EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoDAimin Ji
Cardiovascular Research Laboratories, Department of Medicine, David Geffen School of Medicine at UCLA, MRL 3 645, 675 C E Young Dr, Los Angeles, CA 90095 1760, USA
Gene 318:35-43. 2003..These data suggest that EID-1 and -2 represent a novel family of proteins that negatively regulate differentiation through a p300-dependent mechanism... - Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in micePreeti Ahuja
Department of Medicine, The Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1760, USA
J Clin Invest 120:1494-505. 2010..Our data suggest that Myc directly regulates glucose metabolism and mitochondrial biogenesis in cardiac myocytes and is an important regulator of energy metabolism in the heart in response to pathologic stress... - Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injuryDavid A Liem
Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Mol Cell Cardiol 45:610-6. 2008..These data suggest that Cdk2 signaling pathways are critical regulators of cardiac I/R injury in vivo and support a cardioprotective role for Rb... - Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assemblyDenis Evseenko
Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital of Los Angeles, Los Angeles, CA 90095 1732, USA
Stem Cells Dev 18:919-28. 2009..These data reveal for the first time the crucial role of the ECM proteins laminin-511 and nidogen-1 in hESC assembly, and provide a novel practical tool to investigate hESC differentiation in a xenogen-free microenvironment... - Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchangerKenneth P Roos
Department of Physiology, The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1751, USA
J Card Fail 13:318-29. 2007..Because heart failure is associated with increased expression of NCX1, heterozygous (HET) and homozygous (HOM) transgenic mice overexpressing NCX1 were developed and evaluated... - Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durabilityKatja Schenke Layland
Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1760, USA
Ann Thorac Surg 83:1641-50. 2007..In the present study we used these novel imaging modalities to compare the effects of vitreous and frozen cryopreservation on the extracellular matrix (ECM) of cardiac tissues... - Cardiac myocyte cell cycle control in development, disease, and regenerationPreeti Ahuja
Division of Cardiology, University of California at Los Angeles, The Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine 90095 1760, USA
Physiol Rev 87:521-44. 2007..In addition, we also discuss the potential usefulness of cardiomyocyte self-renewal as well as feasibility of therapeutic manipulation of the cardiac myocyte cell cycle for cardiac regeneration... - Analysis of oxygen transport in a diffusion-limited model of engineered heart tissueDavid A Brown
Bioengineering, University of California, Los Angeles, CA, USA
Biotechnol Bioeng 97:962-75. 2007..Based on the sensitivity analysis in the present study, it is concluded that diffusion-reaction models may offer relatively precise predictions of oxygen concentrations in diffusion-limited tissue constructs... - Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cellsDenis Evseenko
Department of Pathology and Laboratory Medicine, and Broad Stem Cell Research Center and Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:13742-7. 2010..These findings present a unique approach to study how germ layer specification is regulated and offer a promising target for tissue engineering... - Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissueDavid A Brown
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
Artif Cells Blood Substit Immobil Biotechnol 36:94-113. 2008..In this report, we tested the ability of HEPES-buffered culture medium to reduce acidotic cell death in hypoxic monolayer cell cultures and in a diffusion-limited model of engineered heart tissue (EHT)... - Analysis of pH gradients resulting from mass transport limitations in engineered heart tissueDavid A Brown
Department of Bioengineering, University of California, Los Angeles, 7523 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA
Ann Biomed Eng 35:1885-97. 2007.... - Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substratesDavid A Brown
Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, 7523 Boelter Hall, University of California, Los Angeles, California 90095, USA
J Biomed Mater Res A 74:419-29. 2005..Conclusions from this study are that surface energy and protein adsorption influence the gene expression of adherent NRVMs, and may be important for modulating the function of engineered myocardium...
Research Grants
- Genetic Analysis of Cardiac GrowthWILLIAM ROBB MACLELLAN; Fiscal Year: 2011..The studies in this application will address critical deficiencies in our current knowledge of cardiac growth and will identify specific molecular pathways amenable to directed therapies. ..
- GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATIONW MacLellan; Fiscal Year: 2003..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
- Genetic Dissection of Cardiac Growth: The Role of c-MycWILLIAM MACLELLAN; Fiscal Year: 2007..abstract_text> ..