WILLIAM ROBB MACLELLAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes
    Patima Sdek
    Cardiovascular Research Laboratory, Department of Medicine and Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Cell Biol 194:407-23. 2011
  2. pmc Deducing topology of protein-protein interaction networks from experimentally measured sub-networks
    Ling Yang
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    BMC Bioinformatics 9:301. 2008
  3. ncbi request reprint Advances in the molecular mechanisms of heart failure
    W R MacLellan
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90076, USA
    Curr Opin Cardiol 15:128-35. 2000
  4. pmc Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb
    W R MacLellan
    Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 C E Young Dr, MRL 3 645, Los Angeles, CA 90095 1760, USA
    Mol Cell Biol 25:2486-97. 2005
  5. pmc A novel Rb- and p300-binding protein inhibits transactivation by MyoD
    W R MacLellan
    Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 20:8903-15. 2000
  6. pmc Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle
    Ling Yang
    Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    Biophys J 86:3432-43. 2004
  7. pmc Hysteresis and cell cycle transitions: how crucial is it?
    Zhangang Han
    Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    Biophys J 88:1626-34. 2005
  8. pmc Dynamics of the cell cycle: checkpoints, sizers, and timers
    Zhilin Qu
    Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    Biophys J 85:3600-11. 2003
  9. pmc Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy
    Katja Schenke-Layland
    Department of Medicine Cardiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1760, USA
    Exp Eye Res 90:223-37. 2010
  10. doi request reprint Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure
    Holly R Middlekauff
    Dept of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 294:H1956-62. 2008

Research Grants

  1. Genetic Analysis of Cardiac Growth
    WILLIAM ROBB MACLELLAN; Fiscal Year: 2011
  2. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2000
  3. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2003
  4. Genetic Dissection of Cardiac Growth: The Role of c-Myc
    WILLIAM MACLELLAN; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. pmc Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes
    Patima Sdek
    Cardiovascular Research Laboratory, Department of Medicine and Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Cell Biol 194:407-23. 2011
    ..Thus, Rb and p130 have overlapping roles in maintaining the postmitotic state of ACMs through their interaction with HP1-γ to direct heterochromatin formation and silencing of proliferation-promoting genes...
  2. pmc Deducing topology of protein-protein interaction networks from experimentally measured sub-networks
    Ling Yang
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    BMC Bioinformatics 9:301. 2008
    ..However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein interaction networks is unclear...
  3. ncbi request reprint Advances in the molecular mechanisms of heart failure
    W R MacLellan
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90076, USA
    Curr Opin Cardiol 15:128-35. 2000
    ..This review will focus on the recent advances that have been made and will highlight the importance they have had in our understanding and treatment of heart failure...
  4. pmc Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb
    W R MacLellan
    Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 C E Young Dr, MRL 3 645, Los Angeles, CA 90095 1760, USA
    Mol Cell Biol 25:2486-97. 2005
    ..Thus, Rb and p130 have overlapping functional roles in vivo to suppress cell cycle activators, including Myc, and maintain quiescence in postnatal cardiac muscle...
  5. pmc A novel Rb- and p300-binding protein inhibits transactivation by MyoD
    W R MacLellan
    Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 20:8903-15. 2000
    ..Inhibition of MyoD may be explained by EID-1's ability to bind and inhibit p300's histone acetylase activity, an essential MyoD coactivator. Thus, EID-1 binds both Rb and p300 and is a novel repressor of MyoD function...
  6. pmc Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle
    Ling Yang
    Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    Biophys J 86:3432-43. 2004
    ..In summary, our findings suggest that multisite phosphorylation of proteins is a critical biological mechanism in generating the essential dynamics and ensuring robust behavior of the cell cycle...
  7. pmc Hysteresis and cell cycle transitions: how crucial is it?
    Zhangang Han
    Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    Biophys J 88:1626-34. 2005
    ..Thus, although a hysteretic response is neither necessary nor sufficient, it is in general a much more robust mechanism for generating cell cycle dynamics than nonhysteretic mechanisms...
  8. pmc Dynamics of the cell cycle: checkpoints, sizers, and timers
    Zhilin Qu
    Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    Biophys J 85:3600-11. 2003
    ..This model successfully reproduces sizer, timer, and the restriction point features of the eukaryotic cell cycle, in addition to other experimental findings...
  9. pmc Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy
    Katja Schenke-Layland
    Department of Medicine Cardiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1760, USA
    Exp Eye Res 90:223-37. 2010
    ....
  10. doi request reprint Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure
    Holly R Middlekauff
    Dept of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 294:H1956-62. 2008
    ....
  11. pmc Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome
    Katja Schenke-Layland
    Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles CA 90095 1760, USA
    Matrix Biol 27:53-66. 2008
    ..These new insights into the involvement of ECM degradation in SS may lead to novel therapies for patients suffering from dry eye disease...
  12. ncbi request reprint Regulation of the mammalian cell cycle: a model of the G1-to-S transition
    Zhilin Qu
    Cardiovascular Research Laboratory, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Cell Physiol 284:C349-64. 2003
    ..In addition, we found that multisite phosphorylation of CDC25A, Rb, and CKI was critical for the generation of dynamics required for cell cycle progression...
  13. ncbi request reprint Muscle mechanoreceptor sensitivity in heart failure
    Holly R Middlekauff
    Div of Cardiology, 47 123 CHS, UCLA Dept of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 287:H1937-43. 2004
    ..Finally, muscle mechanoreceptors in patients with HF have heightened basal sensitivity to mechanical stimuli resulting in exaggerated early increases in MSNA...
  14. ncbi request reprint Coordination of cell growth and cell division: a mathematical modeling study
    Zhilin Qu
    Cardiovascular Research Laboratory, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Cell Sci 117:4199-207. 2004
    ..The model also accounts for the cell cycle delay seen in restriction point experiments performed in HeLa cells...
  15. pmc A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium
    Ekaterini Angelis
    The Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1760, USA
    Circ Res 102:1222-9. 2008
    ....
  16. ncbi request reprint Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells
    Katja Schenke-Layland
    Cardiovascular Research Laboratory, UCLA School of Medicine, 675 C E Young Dr, MRL 3 645, Los Angeles, California 90095 1760, USA
    Stem Cells 25:1529-38. 2007
    ..Our data suggest that, given the appropriate extracellular stimuli, mouse embryonic stem cells can differentiate into trophoectoderm. Disclosure of potential conflicts of interest is found at the end of this article...
  17. pmc Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway
    Weiguang Zhong
    The Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    EMBO J 25:3869-79. 2006
    ..These data suggest that Myc is required for a normal hypertrophic response and that its growth-promoting effects are also mediated through a CycD2-dependent pathway...
  18. ncbi request reprint Influence of systematically varied nano-scale topography on cell morphology and adhesion
    Sepideh Heydarkhan-Hagvall
    Department of Surgery, Regenerative Bioengineering and Repair Laboratory, University of California Los Angeles, Los Angeles, California 90095 1741, USA
    Cell Commun Adhes 14:181-94. 2007
    ..The presented nano-structures offer interesting opportunities to study the interaction of cells with topographical features comparable to the size of extracellular matrix components...
  19. ncbi request reprint EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD
    Aimin Ji
    Cardiovascular Research Laboratories, Department of Medicine, David Geffen School of Medicine at UCLA, MRL 3 645, 675 C E Young Dr, Los Angeles, CA 90095 1760, USA
    Gene 318:35-43. 2003
    ..These data suggest that EID-1 and -2 represent a novel family of proteins that negatively regulate differentiation through a p300-dependent mechanism...
  20. doi request reprint Human adipose stem cells: a potential cell source for cardiovascular tissue engineering
    Sepideh Heydarkhan-Hagvall
    Regenerative Bioengineering and Repair Laboratory, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
    Cells Tissues Organs 187:263-74. 2008
    ..The objective of this study was to identify the exogenous and endogenous parameters that are critical for the differentiation of human adipose stem cells (hASCs) into cardiovascular cells...
  21. pmc Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages
    Katja Schenke-Layland
    Department of Medicine and Physiology, Cardiovascular Research Laboratory, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1760, USA
    Stem Cells 26:1537-46. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  22. pmc Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice
    Preeti Ahuja
    Department of Medicine, The Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1760, USA
    J Clin Invest 120:1494-505. 2010
    ..Our data suggest that Myc directly regulates glucose metabolism and mitochondrial biogenesis in cardiac myocytes and is an important regulator of energy metabolism in the heart in response to pathologic stress...
  23. pmc Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury
    David A Liem
    Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Mol Cell Cardiol 45:610-6. 2008
    ..These data suggest that Cdk2 signaling pathways are critical regulators of cardiac I/R injury in vivo and support a cardioprotective role for Rb...
  24. pmc Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells
    Denis Evseenko
    Department of Pathology and Laboratory Medicine, and Broad Stem Cell Research Center and Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:13742-7. 2010
    ..These findings present a unique approach to study how germ layer specification is regulated and offer a promising target for tissue engineering...
  25. doi request reprint Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly
    Denis Evseenko
    Division of Research Immunology and Bone Marrow Transplantation, Childrens Hospital of Los Angeles, Los Angeles, CA 90095 1732, USA
    Stem Cells Dev 18:919-28. 2009
    ..These data reveal for the first time the crucial role of the ECM proteins laminin-511 and nidogen-1 in hESC assembly, and provide a novel practical tool to investigate hESC differentiation in a xenogen-free microenvironment...
  26. ncbi request reprint Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue
    David A Brown
    Bioengineering, University of California, Los Angeles, CA, USA
    Biotechnol Bioeng 97:962-75. 2007
    ..Based on the sensitivity analysis in the present study, it is concluded that diffusion-reaction models may offer relatively precise predictions of oxygen concentrations in diffusion-limited tissue constructs...
  27. ncbi request reprint Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability
    Katja Schenke-Layland
    Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1760, USA
    Ann Thorac Surg 83:1641-50. 2007
    ..In the present study we used these novel imaging modalities to compare the effects of vitreous and frozen cryopreservation on the extracellular matrix (ECM) of cardiac tissues...
  28. pmc Cardiac myocyte cell cycle control in development, disease, and regeneration
    Preeti Ahuja
    Division of Cardiology, University of California at Los Angeles, The Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine 90095 1760, USA
    Physiol Rev 87:521-44. 2007
    ..In addition, we also discuss the potential usefulness of cardiomyocyte self-renewal as well as feasibility of therapeutic manipulation of the cardiac myocyte cell cycle for cardiac regeneration...
  29. pmc Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger
    Kenneth P Roos
    Department of Physiology, The Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1751, USA
    J Card Fail 13:318-29. 2007
    ..Because heart failure is associated with increased expression of NCX1, heterozygous (HET) and homozygous (HOM) transgenic mice overexpressing NCX1 were developed and evaluated...
  30. doi request reprint Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue
    David A Brown
    Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
    Artif Cells Blood Substit Immobil Biotechnol 36:94-113. 2008
    ..In this report, we tested the ability of HEPES-buffered culture medium to reduce acidotic cell death in hypoxic monolayer cell cultures and in a diffusion-limited model of engineered heart tissue (EHT)...
  31. ncbi request reprint Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates
    David A Brown
    Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, 7523 Boelter Hall, University of California, Los Angeles, California 90095, USA
    J Biomed Mater Res A 74:419-29. 2005
    ..Conclusions from this study are that surface energy and protein adsorption influence the gene expression of adherent NRVMs, and may be important for modulating the function of engineered myocardium...
  32. ncbi request reprint Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue
    David A Brown
    Department of Bioengineering, University of California, Los Angeles, 7523 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    Ann Biomed Eng 35:1885-97. 2007
    ....

Research Grants9

  1. Genetic Analysis of Cardiac Growth
    WILLIAM ROBB MACLELLAN; Fiscal Year: 2011
    ..The studies in this application will address critical deficiencies in our current knowledge of cardiac growth and will identify specific molecular pathways amenable to directed therapies. ..
  2. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2000
    ..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
  3. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2003
    ..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
  4. Genetic Dissection of Cardiac Growth: The Role of c-Myc
    WILLIAM MACLELLAN; Fiscal Year: 2007
    ..abstract_text> ..