Research Topics
Genomes and Genes | Paul S MacLeanSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Publications
A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese ratsPaul S MacLean
Center for Human Nutrition, University of Colorado Denver, Aurora, Colorado, USA
Obesity (Silver Spring) 18:696-703. 2010....
Regular exercise attenuates the metabolic drive to regain weight after long-term weight lossPaul S MacLean
Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
Am J Physiol Regul Integr Comp Physiol 297:R793-802. 2009..These observations indicate that regimented exercise altered several metabolic adaptations to weight reduction in a manner that would coordinately attenuate the propensity to regain lost weight...- Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regainAmy J Steig
Center for Human Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 301:R656-67. 2011..The attenuation of the biological drive to regain weight, involving both central and peripheral aspects of energy homeostasis, may explain, in part, the utility of regular exercise in preventing weight regain after weight loss... - Biology's response to dieting: the impetus for weight regainPaul S MacLean
University of Colorado Anschutz Medical Campus, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, Denver, Colorado, USA
Am J Physiol Regul Integr Comp Physiol 301:R581-600. 2011..To be successful in the long term, our strategies for preventing weight regain may need to be just as comprehensive, persistent, and redundant, as the biological adaptations they are attempting to counter... - Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasiaMatthew R Jackman
University of Colorado Denver, Center for Human Nutrition, PO Box 6511, F 8305, Aurora, CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 294:R1117-29. 2008..These observations provide evidence of adaptations in the oxidation and trafficking of dietary fat that extend beyond the energy imbalance, which facilitate rapid, efficient regain during the relapse to obesity... 
Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone ratsPaul S MacLean
Center for Human Nutrition, Department of Medicine, University of Colorado at Denver and Health Sciences Center, PO Box 6511, F 8305, Aurora, CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 290:R1577-88. 2006..These metabolic adjustments to weight reduction are discussed in the context of a homeostatic feedback system that controls body weight...- Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humansAudrey Bergouignan
Center for Human Nutrition, School of Medicine, University of Colorado Denver, Denver, Colorado, United States of America
PLoS ONE 7:e30164. 2012.... - Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat dietMatthew R Jackman
Univ of Colorado Denver, Aurora, 80045, USA
Am J Physiol Regul Integr Comp Physiol 299:R1097-105. 2010..Changes in TEE appear to be triggered by overconsumption of the HFD and not simply the diet composition... - When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individualsEdward L Melanson
Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
J Appl Physiol 107:1847-56. 2009..e., energy balance is maintained), 24-h fat oxidation does not increase and in fact, may be slightly decreased. It appears that the state of energy balance is an underappreciated factor determining the impact of exercise on fat oxidation... - Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone ratsPaul S MacLean
Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Physiol Regul Integr Comp Physiol 287:R1306-15. 2004.... - Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female ratsErin D Giles
Center for Human Nutrition, Univ of Colorado Denver, 12800 East 19 Ave, Aurora, CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 299:R1634-42. 2010..These observations reveal a dominant effect of obesity on EB, fuel utilization, and activity levels in cycling rats, which has implications for studies focused on obesity and EB in female rodents... - Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone ratsPaul S MacLean
Center for Human Nutrition, and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Regul Integr Comp Physiol 287:R288-97. 2004.... - Trafficking of dietary fat in obesity-prone and obesity-resistant ratsMatthew R Jackman
Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Am J Physiol Endocrinol Metab 291:E1083-91. 2006.... - Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancerErin D Giles
Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA
Cancer Res 72:6490-501. 2012..Our findings have potential explanative power in understanding why obese, postmenopausal women display an increased risk of breast cancer... - Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesityJanine A Higgins
Center for Human Nutrition, Anschutz Medical Campus, University of Colorado Denver 13001 E 17th Place, Campus Box C263, Aurora, CO 80045, USA
Nutr Metab (Lond) 8:49. 2011..abstract:.. - Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitusPaul S MacLean
University of Colorado Health Sciences Center, Center for Human Nutrition, 4200 East 9th Avenue, C225, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 90:2250-8. 2005..Thus, the suppressive effects of type 2 diabetes in obese subjects are observed in both men and women and may be due, at least in part, to a suppression of hepatic CETP expression... - Impact of high-fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactationJessica L Wahlig
Department of Obstetrics and Gynecology, Division of Basic Reproductive Sciences, University of Colorado, Denver, Colorado, USA
Obesity (Silver Spring) 20:65-75. 2012..05). Collectively these data show that consumption of a HF diet significantly affects maternal and neonatal metabolism and that maternal obesity can independently alter these responses... - Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?Dalan R Jensen
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado at Denver, Aurora, CO, USA
J Lipid Res 49:870-9. 2008.... - Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in ratsMichael E Bizeau
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
J Nutr 133:1787-92. 2003..This effect could not be explained by plasma glucose or insulin concentration. In conclusion, SREBP-1c RNA and SREBP-1 protein levels respond to nutritional status in skeletal muscle... - Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese miceCarrie E McCurdy
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
Diabetes 61:2495-505. 2012.... - Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in miceTakuji Ishimoto
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 109:4320-5. 2012..These studies provide insights into the mechanisms by which fructose causes obesity and metabolic syndrome... - Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidationEdward L Melanson
Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Denver, CO 80045, USA
Exerc Sport Sci Rev 37:93-101. 2009..Although exercise improves the capacity of muscle to oxidize fat, our studies suggest that moderate duration exercise (< or =1 h) has little impact on 24-h fat oxidation... - Lactation and neonatal nutrition: defining and refining the critical questionsMargaret C Neville
University of Colorado School of Medicine, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 17:167-88. 2012..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond... - Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR deltaDeborah M Muoio
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:26089-97. 2002.... - Exercise-induced transcription of the muscle glucose transporter (GLUT 4) genePaul S MacLean
Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
Biochem Biophys Res Commun 292:409-14. 2002....