Paul S MacLean

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 297:R793-802. 2009
  2. pmc Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain
    Amy J Steig
    Center for Human Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 301:R656-67. 2011
  3. pmc Biology's response to dieting: the impetus for weight regain
    Paul S MacLean
    University of Colorado Anschutz Medical Campus, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 301:R581-600. 2011
  4. doi request reprint A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats
    Paul S MacLean
    Center for Human Nutrition, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:696-703. 2010
  5. doi request reprint Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia
    Matthew R Jackman
    University of Colorado Denver, Center for Human Nutrition, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1117-29. 2008
  6. ncbi request reprint Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, University of Colorado at Denver and Health Sciences Center, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1577-88. 2006
  7. pmc Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans
    Audrey Bergouignan
    Center for Human Nutrition, School of Medicine, University of Colorado Denver, Denver, Colorado, United States of America
    PLoS ONE 7:e30164. 2012
  8. pmc When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals
    Edward L Melanson
    Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
    J Appl Physiol (1985) 107:1847-56. 2009
  9. pmc Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet
    Matthew R Jackman
    Univ of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1097-105. 2010
  10. pmc High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO
    Hepatology 58:1632-43. 2013

Detail Information

Publications30

  1. pmc Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 297:R793-802. 2009
    ..These observations indicate that regimented exercise altered several metabolic adaptations to weight reduction in a manner that would coordinately attenuate the propensity to regain lost weight...
  2. pmc Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain
    Amy J Steig
    Center for Human Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 301:R656-67. 2011
    ..The attenuation of the biological drive to regain weight, involving both central and peripheral aspects of energy homeostasis, may explain, in part, the utility of regular exercise in preventing weight regain after weight loss...
  3. pmc Biology's response to dieting: the impetus for weight regain
    Paul S MacLean
    University of Colorado Anschutz Medical Campus, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 301:R581-600. 2011
    ..To be successful in the long term, our strategies for preventing weight regain may need to be just as comprehensive, persistent, and redundant, as the biological adaptations they are attempting to counter...
  4. doi request reprint A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats
    Paul S MacLean
    Center for Human Nutrition, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:696-703. 2010
    ....
  5. doi request reprint Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia
    Matthew R Jackman
    University of Colorado Denver, Center for Human Nutrition, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1117-29. 2008
    ..These observations provide evidence of adaptations in the oxidation and trafficking of dietary fat that extend beyond the energy imbalance, which facilitate rapid, efficient regain during the relapse to obesity...
  6. ncbi request reprint Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, University of Colorado at Denver and Health Sciences Center, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1577-88. 2006
    ..These metabolic adjustments to weight reduction are discussed in the context of a homeostatic feedback system that controls body weight...
  7. pmc Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans
    Audrey Bergouignan
    Center for Human Nutrition, School of Medicine, University of Colorado Denver, Denver, Colorado, United States of America
    PLoS ONE 7:e30164. 2012
    ....
  8. pmc When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals
    Edward L Melanson
    Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
    J Appl Physiol (1985) 107:1847-56. 2009
    ..e., energy balance is maintained), 24-h fat oxidation does not increase and in fact, may be slightly decreased. It appears that the state of energy balance is an underappreciated factor determining the impact of exercise on fat oxidation...
  9. pmc Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet
    Matthew R Jackman
    Univ of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1097-105. 2010
    ..Changes in TEE appear to be triggered by overconsumption of the HFD and not simply the diet composition...
  10. pmc High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO
    Hepatology 58:1632-43. 2013
    ..These studies emphasize the important role of fructose in the development of fatty liver and nonalcoholic steatohepatitis...
  11. pmc Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats
    Erin D Giles
    Center for Human Nutrition, Univ of Colorado Denver, 12800 East 19 Ave, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1634-42. 2010
    ..These observations reveal a dominant effect of obesity on EB, fuel utilization, and activity levels in cycling rats, which has implications for studies focused on obesity and EB in female rodents...
  12. ncbi request reprint Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1306-15. 2004
    ....
  13. pmc Dynamic regulation of hepatic lipid droplet properties by diet
    Amanda E Crunk
    Graduate Program of Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 8:e67631. 2013
    ..These findings implicate CLD in the regulation of hepatic metabolic processes, and suggest that their properties undergo reorganization in response to hepatic metabolic demands. ..
  14. ncbi request reprint Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R288-97. 2004
    ....
  15. ncbi request reprint Trafficking of dietary fat in obesity-prone and obesity-resistant rats
    Matthew R Jackman
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Am J Physiol Endocrinol Metab 291:E1083-91. 2006
    ....
  16. pmc Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer
    Erin D Giles
    Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Cancer Res 72:6490-501. 2012
    ..Our findings have potential explanative power in understanding why obese, postmenopausal women display an increased risk of breast cancer...
  17. pmc Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity
    Janine A Higgins
    Center for Human Nutrition, Anschutz Medical Campus, University of Colorado Denver 13001 E 17th Place, Campus Box C263, Aurora, CO 80045, USA
    Nutr Metab (Lond) 8:49. 2011
    ..abstract:..
  18. ncbi request reprint Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitus
    Paul S MacLean
    University of Colorado Health Sciences Center, Center for Human Nutrition, 4200 East 9th Avenue, C225, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:2250-8. 2005
    ..Thus, the suppressive effects of type 2 diabetes in obese subjects are observed in both men and women and may be due, at least in part, to a suppression of hepatic CETP expression...
  19. pmc Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease
    James L McManaman
    Division of Basic Reproductive Sciences, University of Colorado School of Medicine, Aurora, CO, USA
    J Lipid Res 54:1346-59. 2013
    ..Our study provides the first evidence that Plin2 contributes to HFD-induced obesity by modulating food intake, and that its absence prevents obesity-associated adipose tissue inflammatory foci and liver steatosis...
  20. doi request reprint Impact of high-fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation
    Jessica L Wahlig
    Department of Obstetrics and Gynecology, Division of Basic Reproductive Sciences, University of Colorado, Denver, Colorado, USA
    Obesity (Silver Spring) 20:65-75. 2012
    ..05). Collectively these data show that consumption of a HF diet significantly affects maternal and neonatal metabolism and that maternal obesity can independently alter these responses...
  21. ncbi request reprint Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats
    Michael E Bizeau
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
    J Nutr 133:1787-92. 2003
    ..This effect could not be explained by plasma glucose or insulin concentration. In conclusion, SREBP-1c RNA and SREBP-1 protein levels respond to nutritional status in skeletal muscle...
  22. pmc Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?
    Dalan R Jensen
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado at Denver, Aurora, CO, USA
    J Lipid Res 49:870-9. 2008
    ....
  23. pmc Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis
    Jessica L Saben
    Division of Basic Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America Graduate Program in Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 9:e98066. 2014
    ....
  24. pmc Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Diabetes 61:2495-505. 2012
    ....
  25. pmc Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:4320-5. 2012
    ..These studies provide insights into the mechanisms by which fructose causes obesity and metabolic syndrome...
  26. pmc Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidation
    Edward L Melanson
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Denver, CO 80045, USA
    Exerc Sport Sci Rev 37:93-101. 2009
    ..Although exercise improves the capacity of muscle to oxidize fat, our studies suggest that moderate duration exercise (< or =1 h) has little impact on 24-h fat oxidation...
  27. pmc N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training
    Catherine M Jankowski
    College of Nursing, University of Colorado Anschutz Medical Campus, Mail Stop C288 19, 13120 East 19th Avenue, Aurora, CO 80045 2527, USA
    Eur J Appl Physiol 113:1127-36. 2013
    ..40) in both groups. The administration of ACET (1,000 mg) prior to each exercise session did not impair PRT-induced increases in FFM or significantly alter bone formation markers in middle aged and older men...
  28. pmc Lactation and neonatal nutrition: defining and refining the critical questions
    Margaret C Neville
    University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 17:167-88. 2012
    ..In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond...
  29. ncbi request reprint Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ....
  30. ncbi request reprint Exercise-induced transcription of the muscle glucose transporter (GLUT 4) gene
    Paul S MacLean
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Biochem Biophys Res Commun 292:409-14. 2002
    ....