Paul MacLean

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Exercise-induced transcription of the muscle glucose transporter (GLUT 4) gene
    Paul S MacLean
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Biochem Biophys Res Commun 292:409-14. 2002
  2. ncbi request reprint Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, University of Colorado at Denver and Health Sciences Center, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1577-88. 2006
  3. ncbi request reprint Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitus
    Paul S MacLean
    University of Colorado Health Sciences Center, Center for Human Nutrition, 4200 East 9th Avenue, C225, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:2250-8. 2005
  4. ncbi request reprint Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1306-15. 2004
  5. ncbi request reprint Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R288-97. 2004
  6. ncbi request reprint Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice
    Paul S MacLean
    Department of Biochemistry, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Arterioscler Thromb Vasc Biol 23:1412-5. 2003
  7. doi request reprint Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia
    Matthew R Jackman
    University of Colorado Denver, Center for Human Nutrition, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1117-29. 2008
  8. pmc Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 297:R793-802. 2009
  9. pmc Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet
    Matthew R Jackman
    Univ of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1097-105. 2010
  10. ncbi request reprint Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002

Research Grants

Detail Information

Publications19

  1. ncbi request reprint Exercise-induced transcription of the muscle glucose transporter (GLUT 4) gene
    Paul S MacLean
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
    Biochem Biophys Res Commun 292:409-14. 2002
    ....
  2. ncbi request reprint Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, University of Colorado at Denver and Health Sciences Center, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1577-88. 2006
    ..These metabolic adjustments to weight reduction are discussed in the context of a homeostatic feedback system that controls body weight...
  3. ncbi request reprint Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitus
    Paul S MacLean
    University of Colorado Health Sciences Center, Center for Human Nutrition, 4200 East 9th Avenue, C225, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:2250-8. 2005
    ..Thus, the suppressive effects of type 2 diabetes in obese subjects are observed in both men and women and may be due, at least in part, to a suppression of hepatic CETP expression...
  4. ncbi request reprint Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1306-15. 2004
    ....
  5. ncbi request reprint Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats
    Paul S MacLean
    Center for Human Nutrition, and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 287:R288-97. 2004
    ....
  6. ncbi request reprint Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice
    Paul S MacLean
    Department of Biochemistry, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Arterioscler Thromb Vasc Biol 23:1412-5. 2003
    ..We have examined the effect of CETP expression on vascular health in the db/db model of diabetic obesity...
  7. doi request reprint Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia
    Matthew R Jackman
    University of Colorado Denver, Center for Human Nutrition, PO Box 6511, F 8305, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1117-29. 2008
    ..These observations provide evidence of adaptations in the oxidation and trafficking of dietary fat that extend beyond the energy imbalance, which facilitate rapid, efficient regain during the relapse to obesity...
  8. pmc Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss
    Paul S MacLean
    Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 297:R793-802. 2009
    ..These observations indicate that regimented exercise altered several metabolic adaptations to weight reduction in a manner that would coordinately attenuate the propensity to regain lost weight...
  9. pmc Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet
    Matthew R Jackman
    Univ of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1097-105. 2010
    ..Changes in TEE appear to be triggered by overconsumption of the HFD and not simply the diet composition...
  10. ncbi request reprint Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ....
  11. doi request reprint A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats
    Paul S MacLean
    Center for Human Nutrition, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:696-703. 2010
    ....
  12. ncbi request reprint Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats
    Michael E Bizeau
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
    J Nutr 133:1787-92. 2003
    ..This effect could not be explained by plasma glucose or insulin concentration. In conclusion, SREBP-1c RNA and SREBP-1 protein levels respond to nutritional status in skeletal muscle...
  13. pmc Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?
    Dalan R Jensen
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado at Denver, Aurora, CO, USA
    J Lipid Res 49:870-9. 2008
    ....
  14. ncbi request reprint Trafficking of dietary fat in obesity-prone and obesity-resistant rats
    Matthew R Jackman
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Am J Physiol Endocrinol Metab 291:E1083-91. 2006
    ....
  15. pmc When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals
    Edward L Melanson
    Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
    J Appl Physiol 107:1847-56. 2009
    ..e., energy balance is maintained), 24-h fat oxidation does not increase and in fact, may be slightly decreased. It appears that the state of energy balance is an underappreciated factor determining the impact of exercise on fat oxidation...
  16. pmc Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidation
    Edward L Melanson
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Denver, CO 80045, USA
    Exerc Sport Sci Rev 37:93-101. 2009
    ..Although exercise improves the capacity of muscle to oxidize fat, our studies suggest that moderate duration exercise (< or =1 h) has little impact on 24-h fat oxidation...
  17. ncbi request reprint A peripheral perspective of weight regain
    Paul S MacLean
    Am J Physiol Regul Integr Comp Physiol 288:R1447-9. 2005
  18. ncbi request reprint knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice
    Liping Qiao
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Endocrinology 147:3060-9. 2006
    ..Taken together, these results indicate that C/EBPalpha plays an important role in maintaining glucose and lipid homeostasis in the liver...
  19. ncbi request reprint C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer
    Liping Qiao
    Graduate Center for Nutritional Sciences, University of Kentucky, 900 S Limestone, Lexington, KY 40536, USA
    Diabetes 54:1744-54. 2005
    ..Thus, C/EBPalpha is a key transcription factor for full activation of human adiponectin gene transcription in mature adipocytes through interaction with response elements in the intronic enhancer...

Research Grants6

  1. Utilization of Ingested Engery During Underfeeding
    Paul S MacLean; Fiscal Year: 2010
    ..These studies may provide important evidence on which to base strategies that will facilitate sustained weight reduction in obese individuals. ..
  2. Functional aspects of SREBP1c in intact skeletal muscle
    Paul MacLean; Fiscal Year: 2007
    ....
  3. UTILIZATION OF INGESTED ENERGY DURING UNDERFEEDING
    Paul MacLean; Fiscal Year: 2007
    ..These studies may provide important evidence on which to base strategies that will facilitate sustained weight reduction in obese individuals. ..