Research Topics
| Paul MacLeanSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Exercise-induced transcription of the muscle glucose transporter (GLUT 4) genePaul S MacLean
Center for Human Nutrition, University of Colorado Health Sciences Center, Denver 80262, USA
Biochem Biophys Res Commun 292:409-14. 2002....- Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone ratsPaul S MacLean
Center for Human Nutrition, Department of Medicine, University of Colorado at Denver and Health Sciences Center, PO Box 6511, F 8305, Aurora, CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 290:R1577-88. 2006..These metabolic adjustments to weight reduction are discussed in the context of a homeostatic feedback system that controls body weight... - Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitusPaul S MacLean
University of Colorado Health Sciences Center, Center for Human Nutrition, 4200 East 9th Avenue, C225, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 90:2250-8. 2005..Thus, the suppressive effects of type 2 diabetes in obese subjects are observed in both men and women and may be due, at least in part, to a suppression of hepatic CETP expression... - Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone ratsPaul S MacLean
Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Physiol Regul Integr Comp Physiol 287:R1306-15. 2004.... - Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone ratsPaul S MacLean
Center for Human Nutrition, and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Regul Integr Comp Physiol 287:R288-97. 2004.... - Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db micePaul S MacLean
Department of Biochemistry, Brody School of Medicine, East Carolina University, Greenville, NC, USA
Arterioscler Thromb Vasc Biol 23:1412-5. 2003..We have examined the effect of CETP expression on vascular health in the db/db model of diabetic obesity... 
Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasiaMatthew R Jackman
University of Colorado Denver, Center for Human Nutrition, PO Box 6511, F 8305, Aurora, CO 80045, USA
Am J Physiol Regul Integr Comp Physiol 294:R1117-29. 2008..These observations provide evidence of adaptations in the oxidation and trafficking of dietary fat that extend beyond the energy imbalance, which facilitate rapid, efficient regain during the relapse to obesity...
Regular exercise attenuates the metabolic drive to regain weight after long-term weight lossPaul S MacLean
Center for Human Nutrition, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver, Denver, Colorado, USA
Am J Physiol Regul Integr Comp Physiol 297:R793-802. 2009..These observations indicate that regimented exercise altered several metabolic adaptations to weight reduction in a manner that would coordinately attenuate the propensity to regain lost weight...- Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat dietMatthew R Jackman
Univ of Colorado Denver, Aurora, 80045, USA
Am J Physiol Regul Integr Comp Physiol 299:R1097-105. 2010..Changes in TEE appear to be triggered by overconsumption of the HFD and not simply the diet composition... - Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR deltaDeborah M Muoio
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:26089-97. 2002.... - A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese ratsPaul S MacLean
Center for Human Nutrition, University of Colorado Denver, Aurora, Colorado, USA
Obesity (Silver Spring) 18:696-703. 2010.... - Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in ratsMichael E Bizeau
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Science Center, Denver, CO 80262, USA
J Nutr 133:1787-92. 2003..This effect could not be explained by plasma glucose or insulin concentration. In conclusion, SREBP-1c RNA and SREBP-1 protein levels respond to nutritional status in skeletal muscle... - Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?Dalan R Jensen
Division of Endocrinology, Diabetes, and Metabolism, University of Colorado at Denver, Aurora, CO, USA
J Lipid Res 49:870-9. 2008.... - Trafficking of dietary fat in obesity-prone and obesity-resistant ratsMatthew R Jackman
Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Am J Physiol Endocrinol Metab 291:E1083-91. 2006.... - When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individualsEdward L Melanson
Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
J Appl Physiol 107:1847-56. 2009..e., energy balance is maintained), 24-h fat oxidation does not increase and in fact, may be slightly decreased. It appears that the state of energy balance is an underappreciated factor determining the impact of exercise on fat oxidation... - Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidationEdward L Melanson
Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, School of Medicine, Denver, CO 80045, USA
Exerc Sport Sci Rev 37:93-101. 2009..Although exercise improves the capacity of muscle to oxidize fat, our studies suggest that moderate duration exercise (< or =1 h) has little impact on 24-h fat oxidation... - A peripheral perspective of weight regainPaul S MacLean
Am J Physiol Regul Integr Comp Physiol 288:R1447-9. 2005 - knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db miceLiping Qiao
Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536-0200, USA
Endocrinology 147:3060-9. 2006..Taken together, these results indicate that C/EBPalpha plays an important role in maintaining glucose and lipid homeostasis in the liver... - C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancerLiping Qiao
Graduate Center for Nutritional Sciences, University of Kentucky, 900 S Limestone, Lexington, KY 40536, USA
Diabetes 54:1744-54. 2005..Thus, C/EBPalpha is a key transcription factor for full activation of human adiponectin gene transcription in mature adipocytes through interaction with response elements in the intronic enhancer...
Research Grants
- Utilization of Ingested Engery During UnderfeedingPaul S MacLean; Fiscal Year: 2010..These studies may provide important evidence on which to base strategies that will facilitate sustained weight reduction in obese individuals. ..
- Functional aspects of SREBP1c in intact skeletal musclePaul MacLean; Fiscal Year: 2007....
- UTILIZATION OF INGESTED ENERGY DURING UNDERFEEDINGPaul MacLean; Fiscal Year: 2007..These studies may provide important evidence on which to base strategies that will facilitate sustained weight reduction in obese individuals. ..