Kenneth N Maclean

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi request reprint CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Hepatology 45:1108-17. 2007
  2. doi request reprint Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
    Mol Genet Metab 105:395-403. 2012
  3. pmc Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States
    Mol Genet Metab 101:163-71. 2010
  4. pmc A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment
    Kenneth N Maclean
    Departments of Pediatrics and Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Genet Metab 101:153-62. 2010
  5. pmc Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis
    Colin T Shearn
    Department of Pharmaceutical Sciences, University of Colorado Denver Anchutz Medical Campus, Aurora, CO 80045, USA
    J Nutr Biochem 24:1436-45. 2013
  6. pmc Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 287:31994-2005. 2012
  7. doi request reprint Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes
    Hua Jiang
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
    Mol Genet Metab 107:55-65. 2012
  8. ncbi request reprint Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria
    Amy K Keating
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    Mol Genet Metab 103:330-7. 2011
  9. ncbi request reprint Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation
    Jana Oliveriusova
    Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
    J Biol Chem 277:48386-94. 2002
  10. ncbi request reprint Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Cell Physiol 192:81-92. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    Shaikh Mizanoor Rahman
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Hepatology 45:1108-17. 2007
    ..Conversely, C/EBPbeta over-expression in livers of WT mice increased steatosis, nuclear factor-kappaB, and endoplasmic reticulum stress, similar to MCD diet-fed mice...
  2. doi request reprint Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
    Mol Genet Metab 105:395-403. 2012
    ....
  3. pmc Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States
    Mol Genet Metab 101:163-71. 2010
    ....
  4. pmc A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment
    Kenneth N Maclean
    Departments of Pediatrics and Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Genet Metab 101:153-62. 2010
    ..Our findings indicate that this mouse model will be a valuable tool in the study of pathogenesis in classical homocystinuria and the rational design of novel treatments...
  5. pmc Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis
    Colin T Shearn
    Department of Pharmaceutical Sciences, University of Colorado Denver Anchutz Medical Campus, Aurora, CO 80045, USA
    J Nutr Biochem 24:1436-45. 2013
    ....
  6. pmc Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Biol Chem 287:31994-2005. 2012
    ....
  7. doi request reprint Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes
    Hua Jiang
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
    Mol Genet Metab 107:55-65. 2012
    ....
  8. ncbi request reprint Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria
    Amy K Keating
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    Mol Genet Metab 103:330-7. 2011
    ..Our findings indicate that anti-inflammatory strategies could serve as a useful adjuvant therapy for this disease...
  9. ncbi request reprint Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation
    Jana Oliveriusova
    Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
    J Biol Chem 277:48386-94. 2002
    ....
  10. ncbi request reprint Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Cell Physiol 192:81-92. 2002
    ..Our data indicates that screening compounds for the ability to affect transsulfuration in cultured cell models must take proliferation status into account to avoid masking regulatory interactions that may be of significance in vivo...
  11. ncbi request reprint Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding
    Nina Frank
    Department of Pediatrics, University of Colorado School of Medicine at Fitzsimons, 12800 East 19th Avenue, Mail Stop 8313, P O Box 6511, Aurora, Colorado 80045 0511, USA
    Biochemistry 45:11021-9. 2006
    ....
  12. ncbi request reprint High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Hum Mutat 19:641-55. 2002
    ....
  13. doi request reprint Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells
    Angela L Rachubinski
    Department of Pediatrics, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    Exp Gerontol 47:723-33. 2012
    ....
  14. ncbi request reprint The dominant role of Sp1 in regulating the cystathionine beta-synthase -1a and -1b promoters facilitates potential tissue-specific regulation by Kruppel-like factors
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Biol Chem 279:8558-66. 2004
    ....
  15. doi request reprint Mouse model of fragile X syndrome: behavioral and hormonal response to stressors
    Darci M Nielsen
    Department of Pediatrics, University of Colorado Denver Medical School, Aurora, CO 80045, USA
    Behav Neurosci 123:677-86. 2009
    ..The knockout mice's increased responsiveness to footshock in the extended test may be an indication of increased vulnerability to stress or enhanced emotional reactivity...
  16. pmc Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome
    Fabio M Simões de Souza
    Cell and Developmental Biology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    Sci Rep 1:137. 2011
    ..Collectively, our study indicates that olfactory learning can be a sensitive tool for evaluating deficits in associative learning in mouse models of DS and that galantamine has therapeutic potential for improving cognitive abilities...
  17. pmc Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease
    James J Galligan
    Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    J Toxicol 2012:207594. 2012
    ..Collectively, our results indicate a primary pathogenic role for oxidative stress in the early initiating stages of ALD that precedes the involvement of the ER stress response...
  18. pmc Effects of neonatal neural progenitor cell implantation on adult neuroanatomy and cognition in the Ts65Dn model of Down syndrome
    Angela L Rachubinski
    Department of Pediatrics, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    PLoS ONE 7:e36082. 2012
    ..To the best of our knowledge, these results constitute the first assessment of mNPC as an early intervention on cognitive ability in a DS model...