Research Topics
Genomes and Genes | Kenneth N MacleanSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Publications
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitisShaikh Mizanoor Rahman
Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Hepatology 45:1108-17. 2007....
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic riskKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
Mol Genet Metab 105:395-403. 2012....
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatmentKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States
Mol Genet Metab 101:163-71. 2010....- A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatmentKenneth N Maclean
Departments of Pediatrics and Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
Mol Genet Metab 101:153-62. 2010..Our findings indicate that this mouse model will be a valuable tool in the study of pathogenesis in classical homocystinuria and the rational design of novel treatments... - Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomesHua Jiang
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045 0511, USA
Mol Genet Metab 107:55-65. 2012.... - Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell deathKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Biol Chem 287:31994-2005. 2012.... - Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuriaAmy K Keating
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
Mol Genet Metab 103:330-7. 2011..Our findings indicate that anti-inflammatory strategies could serve as a useful adjuvant therapy for this disease... - Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulationJana Oliveriusova
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
J Biol Chem 277:48386-94. 2002.... - Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine bindingNina Frank
Department of Pediatrics, University of Colorado School of Medicine at Fitzsimons, 12800 East 19th Avenue, Mail Stop 8313, P O Box 6511, Aurora, Colorado 80045 0511, USA
Biochemistry 45:11021-9. 2006.... - Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiaeKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Cell Physiol 192:81-92. 2002..Our data indicates that screening compounds for the ability to affect transsulfuration in cultured cell models must take proliferation status into account to avoid masking regulatory interactions that may be of significance in vivo... - Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cellsAngela L Rachubinski
Department of Pediatrics, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
Exp Gerontol 47:723-33. 2012.... - High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutationsKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
Hum Mutat 19:641-55. 2002.... - The dominant role of Sp1 in regulating the cystathionine beta-synthase -1a and -1b promoters facilitates potential tissue-specific regulation by Kruppel-like factorsKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Biol Chem 279:8558-66. 2004.... - Mouse model of fragile X syndrome: behavioral and hormonal response to stressorsDarci M Nielsen
Department of Pediatrics, University of Colorado Denver Medical School, Aurora, CO 80045, USA
Behav Neurosci 123:677-86. 2009..The knockout mice's increased responsiveness to footshock in the extended test may be an indication of increased vulnerability to stress or enhanced emotional reactivity... - Effects of neonatal neural progenitor cell implantation on adult neuroanatomy and cognition in the Ts65Dn model of Down syndromeAngela L Rachubinski
Department of Pediatrics, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
PLoS ONE 7:e36082. 2012..To the best of our knowledge, these results constitute the first assessment of mNPC as an early intervention on cognitive ability in a DS model... - Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver DiseaseJames J Galligan
Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
J Toxicol 2012:207594. 2012..Collectively, our results indicate a primary pathogenic role for oxidative stress in the early initiating stages of ALD that precedes the involvement of the ER stress response...