Robert MacLaren

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint A randomized, double-blind pilot study of dexmedetomidine versus midazolam for intensive care unit sedation: patient recall of their experiences and short-term psychological outcomes
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA
    J Intensive Care Med 30:167-75. 2015
  2. doi request reprint Proton pump inhibitors and histamine-2 receptor antagonists in the intensive care setting: focus on therapeutic and adverse events
    Robert MacLaren
    University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Clinical Pharmacy, C238, 12850 East Montview Blvd, Aurora, CO 80045, USA 1 303 724 2622 1 303 724 0979
    Expert Opin Drug Saf 14:269-80. 2015
  3. doi request reprint Clinical and financial impact of pharmacy services in the intensive care unit: pharmacist and prescriber perceptions
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045, USA
    Pharmacotherapy 33:401-10. 2013
  4. doi request reprint A case-based approach to the practical application of dexmedetomidine in critically ill adults
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado 80045, USA
    Pharmacotherapy 33:165-86. 2013
  5. pmc Immunosedation: a consideration for sepsis
    Robert MacLaren
    University of Colorado Denver School of Pharmacy, Academic Office 1, C238 L15, 12631 East 17th Avenue, Aurora, CO 80045, USA
    Crit Care 13:191. 2009
  6. doi request reprint A randomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal
    Scott W Mueller
    1Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 2Department of Pharmacy, Denver Health Medical Center, Denver, CO 3Division of Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO
    Crit Care Med 42:1131-9. 2014
  7. doi request reprint Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 36:3184-9. 2008
  8. doi request reprint Bivalirudin versus unfractionated heparin for prevention of hemofilter occlusion during continuous renal replacement therapy
    Tyree H Kiser
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado, Aurora, Colorado 80045, USA
    Pharmacotherapy 30:1117-26. 2010
  9. doi request reprint Prefilter bivalirudin for preventing hemofilter occlusion in continuous renal replacement therapy
    Scott W Mueller
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
    Ann Pharmacother 43:1360-5. 2009
  10. doi request reprint Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions
    Erica L Horinek
    Department of Pharmacy, Sky Ridge Medical Center, Lone Tree, CO, USA
    Ann Pharmacother 43:1964-71. 2009

Collaborators

Detail Information

Publications33

  1. doi request reprint A randomized, double-blind pilot study of dexmedetomidine versus midazolam for intensive care unit sedation: patient recall of their experiences and short-term psychological outcomes
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA
    J Intensive Care Med 30:167-75. 2015
    ..This pilot study evaluated whether transitioning benzodiazepine sedation to dexmedetomidine alters patient recall and the incidence of anxiety, depression, or acute stress disorder (ASD)...
  2. doi request reprint Proton pump inhibitors and histamine-2 receptor antagonists in the intensive care setting: focus on therapeutic and adverse events
    Robert MacLaren
    University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Clinical Pharmacy, C238, 12850 East Montview Blvd, Aurora, CO 80045, USA 1 303 724 2622 1 303 724 0979
    Expert Opin Drug Saf 14:269-80. 2015
    ..A paucity of data implicates these agents with pneumonia and Clostridium difficile infection (CDI)...
  3. doi request reprint Clinical and financial impact of pharmacy services in the intensive care unit: pharmacist and prescriber perceptions
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045, USA
    Pharmacotherapy 33:401-10. 2013
    ..To compare pharmacist and prescriber perceptions of the clinical and financial outcomes of pharmacy services in the intensive care unit (ICU)...
  4. doi request reprint A case-based approach to the practical application of dexmedetomidine in critically ill adults
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado 80045, USA
    Pharmacotherapy 33:165-86. 2013
    ....
  5. pmc Immunosedation: a consideration for sepsis
    Robert MacLaren
    University of Colorado Denver School of Pharmacy, Academic Office 1, C238 L15, 12631 East 17th Avenue, Aurora, CO 80045, USA
    Crit Care 13:191. 2009
    ..Perhaps one day the choice of sedative in septic patients will not be based solely on sedative properties but rather immunosedative profiles...
  6. doi request reprint A randomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal
    Scott W Mueller
    1Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 2Department of Pharmacy, Denver Health Medical Center, Denver, CO 3Division of Pulmonary and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO
    Crit Care Med 42:1131-9. 2014
    ..To evaluate dexmedetomidine as adjunctive therapy to lorazepam for severe alcohol withdrawal...
  7. doi request reprint Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 36:3184-9. 2008
    ....
  8. doi request reprint Bivalirudin versus unfractionated heparin for prevention of hemofilter occlusion during continuous renal replacement therapy
    Tyree H Kiser
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado, Aurora, Colorado 80045, USA
    Pharmacotherapy 30:1117-26. 2010
    ..To evaluate the safety and efficacy of bivalirudin compared with heparin for preventing hemofilter occlusion during continuous venovenous hemofiltration (CVVH)...
  9. doi request reprint Prefilter bivalirudin for preventing hemofilter occlusion in continuous renal replacement therapy
    Scott W Mueller
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
    Ann Pharmacother 43:1360-5. 2009
    ..To describe a case of successful bivalirudin use as a prefilter anticoagulant in continuous venovenous hemofiltration (CVVH)...
  10. doi request reprint Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions
    Erica L Horinek
    Department of Pharmacy, Sky Ridge Medical Center, Lone Tree, CO, USA
    Ann Pharmacother 43:1964-71. 2009
    ..Intravenous lorazepam contains propylene glycol, which has been associated with toxicity when high doses of lorazepam are administered...
  11. ncbi request reprint Key concepts in the management of difficult hemorrhagic cases
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 27:93S-102S. 2007
    ..To maximize therapy, the clinician must be aware of how best to clinically apply hemostatic agents, their comparative benefits and disadvantages, and the optimal methods for monitoring their effectiveness and toxicities...
  12. ncbi request reprint Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 27:351-9. 2007
    ..To determine if adjunctive dexmedetomidine therapy in intensive care patients alters requirements for and levels of sedation and analgesia, and to describe hemodynamic and ventilatory parameters...
  13. doi request reprint Efflux pump contribution to multidrug resistance in clinical isolates of Pseudomonas aeruginosa
    Tyree H Kiser
    Department of Clinical Pharmacy, University of Colorado Denver, Aurora, Colorado, USA
    Pharmacotherapy 30:632-8. 2010
    ..To determine if increased expression of efflux pumps, mutations in the genes encoding regulatory proteins for efflux pumps, or the combination is associated with multidrug-resistant (MDR) Pseudomonas aeruginosa isolates...
  14. doi request reprint Effects of pharmacist participation in intensive care units on clinical and economic outcomes of critically ill patients with thromboembolic or infarction-related events
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacotherapy 29:761-8. 2009
    ..To assess the effects of clinical pharmacist participation in the care of critically ill Medicare patients with thromboembolic or infarction-related events (TIE) on clinical and economic outcomes...
  15. ncbi request reprint Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study
    Tyree H Kiser
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Nephrol Dial Transplant 20:1813-20. 2005
    ..This study aims to evaluate the effects of AVP and OCT on renal function, systemic haemodynamics and clinical outcomes in HRS...
  16. ncbi request reprint Pharmacoeconomic modeling of lorazepam, midazolam, and propofol for continuous sedation in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 25:1319-28. 2005
    ..To compare the expected costs of short-, intermediate-, and long-term sedation (< 24, 24-72, and > 72 hrs, respectively) with propofol, lorazepam, and midazolam in an intensive care unit...
  17. ncbi request reprint Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia
    Tyree H Kiser
    Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 25:1736-45. 2005
    ....
  18. doi request reprint Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit
    Robert MacLaren
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora
    JAMA Intern Med 174:564-74. 2014
    ..Numerous other risk factors are apparent. These data warrant confirmation in comparative prospective studies. ..
  19. doi request reprint Cost-effectiveness of histamine receptor-2 antagonist versus proton pump inhibitor for stress ulcer prophylaxis in critically ill patients*
    Robert MacLaren
    Both authors Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO
    Crit Care Med 42:809-15. 2014
    ..To examine the cost-effectiveness of using histamine receptor-2 antagonist or proton pump inhibitor for stress ulcer prophylaxis...
  20. doi request reprint Management of extravasation injuries: a focused evaluation of noncytotoxic medications
    Paul M Reynolds
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado Department of Pharmacy, University of Colorado Hospital, Aurora, Colorado
    Pharmacotherapy 34:617-32. 2014
    ..More research is needed to improve knowledge of patient risk, prompt recognition of the extravasation, and time course for tissue injury, and to develop prevention and treatment strategies for extravasation injuries. ..
  21. doi request reprint Treatment of hepatorenal syndrome
    Tyree H Kiser
    Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Pharmacotherapy 29:1196-211. 2009
    ..The role of renal replacement therapies or the newer artificial hepatic support therapies need further evaluation before they can be routinely recommended...
  22. doi request reprint Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    JPEN J Parenter Enteral Nutr 32:412-9. 2008
    ..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)...
  23. doi request reprint Stability of dexmedetomidine in polyvinyl chloride bags containing 0.9% sodium chloride injection
    Candice R Preslaski
    Surgical Intensive Care Unit, Denver Health Medical Center, Denver, CO, USA
    Am J Health Syst Pharm 70:1336-41. 2013
    ..The stability of dexmedetomidine in polyvinyl chloride (PVC) bags containing 0.9% sodium chloride injection was studied...
  24. ncbi request reprint Economic evaluation of sustained sedation/analgesia in the intensive care unit
    Robert MacLaren
    University of Colorado at Denver and Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Expert Opin Pharmacother 7:2047-68. 2006
    ....
  25. doi request reprint Neuromuscular blockade resistance during therapeutic hypothermia
    Scott W Mueller
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
    Ann Pharmacother 45:e15. 2011
    ..To report a case of neuromuscular blockade resistance to multiple agents during therapeutic hypothermia and discuss possible mechanisms of this resistance...
  26. ncbi request reprint Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients
    Robert MacLaren
    School of Pharmacy, C238, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Value Health 8:105-16. 2005
    ..To examine the cost-effectiveness of using recombinant human erythropoietin (rHuEPO) to reduce red blood cells (RBC) transfusions in intensive care unit (ICU) patients...
  27. doi request reprint A comparison of dexmedetomidine and placebo on the plasma concentrations of NGF, BDNF, GDNF, and epinephrine during severe alcohol withdrawal
    Paul M Reynolds
    Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado 80045, USA University of Colorado Hospital, Aurora, Colorado 80045, USA
    Alcohol 49:15-9. 2015
    ..DEX administration and higher DEX concentrations attenuated lorazepam administration in the short-term and suppressed EPI...
  28. ncbi request reprint Critical care pharmacy services in United States hospitals
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann Pharmacother 40:612-8. 2006
    ..Critical care pharmacy activities have been described as fundamental, desirable, and optimal, but actual services provided have not been evaluated...
  29. doi request reprint Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care
    Gina D Moore
    School of Pharmacy, University of Colorado Denver, 12631 E 17th Ave, Mail Stop C238 L15, Aurora, CO 80045, USA
    Ann Pharmacother 43:1802-8. 2009
    ..To summarize the published clinical data on fospropofol, critically review the safety and efficacy information, and provide pertinent information for formulary review...
  30. ncbi request reprint A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomes
    Robert MacLaren
    University of Colorado Health Sciences Center, School of Pharmacy, Department of Clinical Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Transfusion 45:1434-42. 2005
    ..Off-label use of recombinant factor VIIa (rFVIIa) occurs despite minimal data. The purpose of this study was to describe prescribing practices and clinical outcomes for off-label rFVIIa use...
  31. pmc National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002
    Marilee D Obritsch
    Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Antimicrob Agents Chemother 48:4606-10. 2004
    ..Ongoing surveillance studies are crucial in monitoring antimicrobial susceptibility patterns and selecting empirical treatment regimens...
  32. pmc Lactoferrin protects against acetaminophen-induced liver injury in mice
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado, Denver, CO 80045, USA
    Hepatology 51:1007-16. 2010
    ..This protective effect of Lac appeared to be dependent on hepatic resident macrophages (Kupffer cells [KCs])...
  33. ncbi request reprint Implementing and assessing an evidence-based electrolyte dosing order form in the medical ICU
    Phillip Owen
    School of Pharmacy C238, Department of Clinical Pharmacy, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Intensive Crit Care Nurs 24:8-19. 2008
    ..The purpose of this study was to evaluate the efficacy, safety, and nursing acceptability of a nursing initiated, evidence-based order form to replace potassium, magnesium, and phosphate in the MICU...