Research Topics
| R MacLarenSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Critical care pharmacy services in United States hospitalsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann Pharmacother 40:612-8. 2006..Critical care pharmacy activities have been described as fundamental, desirable, and optimal, but actual services provided have not been evaluated...
Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patientsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
JPEN J Parenter Enteral Nutr 32:412-9. 2008..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)...- Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parametersRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
Pharmacotherapy 27:351-9. 2007..To determine if adjunctive dexmedetomidine therapy in intensive care patients alters requirements for and levels of sedation and analgesia, and to describe hemodynamic and ventilatory parameters... - Economic evaluation of sustained sedation/analgesia in the intensive care unitRobert MacLaren
University of Colorado at Denver and Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
Expert Opin Pharmacother 7:2047-68. 2006.... - Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infectionsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
Crit Care Med 36:3184-9. 2008.... - Pharmacoeconomic modeling of lorazepam, midazolam, and propofol for continuous sedation in critically ill patientsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Pharmacotherapy 25:1319-28. 2005..To compare the expected costs of short-, intermediate-, and long-term sedation (< 24, 24-72, and > 72 hrs, respectively) with propofol, lorazepam, and midazolam in an intensive care unit... - A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomesRobert MacLaren
University of Colorado Health Sciences Center, School of Pharmacy, Department of Clinical Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
Transfusion 45:1434-42. 2005..Off-label use of recombinant factor VIIa (rFVIIa) occurs despite minimal data. The purpose of this study was to describe prescribing practices and clinical outcomes for off-label rFVIIa use... - Effects of pharmacist participation in intensive care units on clinical and economic outcomes of critically ill patients with thromboembolic or infarction-related eventsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, Colorado 80045, USA
Pharmacotherapy 29:761-8. 2009..To assess the effects of clinical pharmacist participation in the care of critically ill Medicare patients with thromboembolic or infarction-related events (TIE) on clinical and economic outcomes... - Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patientsRobert MacLaren
School of Pharmacy, C238, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Value Health 8:105-16. 2005..To examine the cost-effectiveness of using recombinant human erythropoietin (rHuEPO) to reduce red blood cells (RBC) transfusions in intensive care unit (ICU) patients... - Key concepts in the management of difficult hemorrhagic casesRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
Pharmacotherapy 27:93S-102S. 2007..To maximize therapy, the clinician must be aware of how best to clinically apply hemostatic agents, their comparative benefits and disadvantages, and the optimal methods for monitoring their effectiveness and toxicities... - Comparison of cisapride and metoclopramide for facilitating gastric emptying and improving tolerance to intragastric enteral nutrition in critically III, mechanically ventilated adultsR MacLaren
School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Clin Ther 23:1855-66. 2001.... - Use of enteral nutrition for stress ulcer prophylaxisR MacLaren
School of Pharmacy, C238, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262 0001, USA
Ann Pharmacother 35:1614-23. 2001..To review the controversies involving the use of enteral nutrition support for stress ulcer prophylaxis and formulate recommendations... - Use of exogenous erythropoietin in critically ill patientsR MacLaren
School of Pharmacy, University of Colorado Health Services Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Clin Pharm Ther 29:195-208. 2004..Review the literature regarding the use of recombinant human erythropoietin (rHuEPO) to prevent red blood cell (RBC) transfusion in critically ill patients... - Stress-dose corticosteroid therapy for sepsis and acute lung injury or acute respiratory distress syndrome in critically ill adultsRobert MacLaren
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Science Center, Denver 80262, USA
Pharmacotherapy 22:1140-56. 2002..Stress-dose methylprednisolone therapy for ALI-ARDS requires further study but may be warranted in cases of refractory infection-induced ARDS when impending mortality is likely... - Reliability and accuracy of practitioner-calculated Acute Physiology and Chronic Health Evaluation II scores for determining the appropriateness of drotrecogin alfa (activated)Phillip S Owen
Department of Pharmacy Practice, College of Pharmacy and Health Sciences Center, Mercer University MU, Atlanta, GA, USA
Am J Health Syst Pharm 67:136-43. 2010..The reliability and accuracy of practitioner-calculated Acute Physiology and Chronic Health Evaluation (APACHE) II scores for determining the appropriateness of drotrecogin alfa (activated) in critically ill patients were evaluated... - Surveillance of multi-drug resistant Pseudomonas aeruginosa in an urban tertiary-care teaching hospitalR Jung
Antimicrobial Research Laboratory, Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C 238 Denver, CO 80262, USA
J Hosp Infect 57:105-11. 2004..On-going surveillance within individual institutions is critical for the selection of appropriate empiric antimicrobial therapy... - Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusionsErica L Horinek
Department of Pharmacy, Sky Ridge Medical Center, Lone Tree, CO, USA
Ann Pharmacother 43:1964-71. 2009..Intravenous lorazepam contains propylene glycol, which has been associated with toxicity when high doses of lorazepam are administered... 
Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndromeRobert MacLaren
Departments of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80260, USA
Pharmacotherapy 27:860-73. 2007..Although clinical data are less convincing than these findings, results from clinical trials may influence the design of future studies...- Immunosedation: a consideration for sepsisRobert MacLaren
University of Colorado Denver School of Pharmacy, Academic Office 1, C238 L15, 12631 East 17th Avenue, Aurora, CO 80045, USA
Crit Care 13:191. 2009..Perhaps one day the choice of sedative in septic patients will not be based solely on sedative properties but rather immunosedative profiles... - Enteral glutamine supplementation in critically ill patients with burn injuries: a retrospective case-control evaluationPaul Juang
Department of Pharmacy Practice, St Louis College of Pharmacy, St Louis, Missouri 63110 1088, USA
Pharmacotherapy 27:11-9. 2007.... - Duration of antimicrobial therapy for nosocomial pneumonia: possible strategies for minimizing antimicrobial use in intensive care unitsH A Dugan
School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Clin Pharm Ther 28:123-9. 2003..Further research is needed to determine the optimal duration of therapy in patients with nosocomial pneumonia... - Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICUR A Lugo
Department of Pharmacy Practice, College of Pharmacy, University of Utah, Salt Lake City 84112 5820, USA
Pharmacotherapy 21:1566-73. 2001..To determine if enterally administered methadone can facilitate fentanyl discontinuation and prevent withdrawal in children at high risk for opioid abstinence syndrome... - Proton-pump inhibitors for stress ulcer prophylaxis in critically ill patientsRose Jung
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Ann Pharmacother 36:1929-37. 2002..Additional comparative studies with adequate patient numbers and pharmacoeconomic analyses are needed before PPIs are considered the agents of choice for stress ulcer prophylaxis... - Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopeniaTyree H Kiser
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Pharmacotherapy 25:1736-45. 2005..Platelet-aggregation tests were least useful for evaluating HIT. Appropriate diagnostic strategies should be used to avoid unnecessary drug use... - Evaluation and survey of intravenous vitamin K1 for treatment of coagulopathy in critically ill patientsR MacLaren
School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Pharmacotherapy 21:175-82. 2001..Randomized, placebo-controlled studies are necessary to confirm the effectiveness of vitamin K1... - Prefilter bivalirudin for preventing hemofilter occlusion in continuous renal replacement therapyScott W Mueller
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
Ann Pharmacother 43:1360-5. 2009..To describe a case of successful bivalirudin use as a prefilter anticoagulant in continuous venovenous hemofiltration (CVVH)... - Implementing and assessing an evidence-based electrolyte dosing order form in the medical ICUPhillip Owen
School of Pharmacy C238, Department of Clinical Pharmacy, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Intensive Crit Care Nurs 24:8-19. 2008..The purpose of this study was to evaluate the efficacy, safety, and nursing acceptability of a nursing initiated, evidence-based order form to replace potassium, magnesium, and phosphate in the MICU... - Fospropofol: a new sedative-hypnotic agent for monitored anesthesia careGina D Moore
School of Pharmacy, University of Colorado Denver, 12631 E 17th Ave, Mail Stop C238 L15, Aurora, CO 80045, USA
Ann Pharmacother 43:1802-8. 2009..To summarize the published clinical data on fospropofol, critically review the safety and efficacy information, and provide pertinent information for formulary review... - Effects of continuous vasopressin infusion in patients with septic shockMarilee D Obritsch
University of Colorado Hospital, Denver, CO 80262, USA
Ann Pharmacother 38:1117-22. 2004..In the meantime, vasopressin infusion at <or=0.03 units/min should be considered only if response to 1 or 2 catecholamine vasopressors is inadequate or as a method to reduce the dose of these therapies... - The role of vasopressin in vasodilatory septic shockMarilee D Obritsch
Department of Pharmacy, University of Colorado Hospital, Denver, Colorado, USA
Pharmacotherapy 24:1050-63. 2004..A multicenter, comparative study of vasopressin 0.03 U/minute as add-on therapy is under way and should provide mortality data... - National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002Marilee D Obritsch
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Antimicrob Agents Chemother 48:4606-10. 2004..Ongoing surveillance studies are crucial in monitoring antimicrobial susceptibility patterns and selecting empirical treatment regimens... - Lactoferrin protects against acetaminophen-induced liver injury in miceHao Yin
Department of Pharmaceutical Sciences, University of Colorado, Denver, CO 80045, USA
Hepatology 51:1007-16. 2010..These findings reveal the significant therapeutic potential of Lac during AILI and other types of liver diseases... - Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective studyTyree H Kiser
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
Nephrol Dial Transplant 20:1813-20. 2005..No adverse effects related to AVP therapy were observed. CONCLUSION: When compared with OCT, HRS patients treated with AVP had significantly higher recovery rates, improved survival and were more likely to receive a liver transplant... - Formulary management of recombinant factor VIIa at an academic medical centerPhillip S Owen
Department of Pharmacy Practice Clinical Assistant Professor, College of Pharmacy and Health Sciences Center, Mercer University, Atlanta, GA, USA
Ann Pharmacother 42:771-6. 2008..Concerns of potentially inappropriate use, safety, and cost of rVIIa led to efforts to standardize use of this agent... - Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutritionJames Landzinski
Department of Pharmacy, Georgetown University Hospital, Washington, DC, USA
JPEN J Parenter Enteral Nutr 32:45-50. 2008..This study evaluated gastric emptying in patients with limited GRV (tolerant group) vs volumes > or =150 mL (intolerant group) and whether prokinetic therapy improves gastric motility in intolerant patients...