R MacLaren

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Critical care pharmacy services in United States hospitals
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann Pharmacother 40:612-8. 2006
  2. doi request reprint Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    JPEN J Parenter Enteral Nutr 32:412-9. 2008
  3. ncbi request reprint Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 27:351-9. 2007
  4. ncbi request reprint Economic evaluation of sustained sedation/analgesia in the intensive care unit
    Robert MacLaren
    University of Colorado at Denver and Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Expert Opin Pharmacother 7:2047-68. 2006
  5. doi request reprint Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 36:3184-9. 2008
  6. ncbi request reprint Pharmacoeconomic modeling of lorazepam, midazolam, and propofol for continuous sedation in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 25:1319-28. 2005
  7. ncbi request reprint A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomes
    Robert MacLaren
    University of Colorado Health Sciences Center, School of Pharmacy, Department of Clinical Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Transfusion 45:1434-42. 2005
  8. doi request reprint Effects of pharmacist participation in intensive care units on clinical and economic outcomes of critically ill patients with thromboembolic or infarction-related events
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacotherapy 29:761-8. 2009
  9. ncbi request reprint Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients
    Robert MacLaren
    School of Pharmacy, C238, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Value Health 8:105-16. 2005
  10. ncbi request reprint Key concepts in the management of difficult hemorrhagic cases
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 27:93S-102S. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Critical care pharmacy services in United States hospitals
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann Pharmacother 40:612-8. 2006
    ..Critical care pharmacy activities have been described as fundamental, desirable, and optimal, but actual services provided have not been evaluated...
  2. doi request reprint Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    JPEN J Parenter Enteral Nutr 32:412-9. 2008
    ..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)...
  3. ncbi request reprint Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 27:351-9. 2007
    ..To determine if adjunctive dexmedetomidine therapy in intensive care patients alters requirements for and levels of sedation and analgesia, and to describe hemodynamic and ventilatory parameters...
  4. ncbi request reprint Economic evaluation of sustained sedation/analgesia in the intensive care unit
    Robert MacLaren
    University of Colorado at Denver and Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Expert Opin Pharmacother 7:2047-68. 2006
    ....
  5. doi request reprint Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 36:3184-9. 2008
    ....
  6. ncbi request reprint Pharmacoeconomic modeling of lorazepam, midazolam, and propofol for continuous sedation in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 25:1319-28. 2005
    ..To compare the expected costs of short-, intermediate-, and long-term sedation (< 24, 24-72, and > 72 hrs, respectively) with propofol, lorazepam, and midazolam in an intensive care unit...
  7. ncbi request reprint A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomes
    Robert MacLaren
    University of Colorado Health Sciences Center, School of Pharmacy, Department of Clinical Pharmacy, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Transfusion 45:1434-42. 2005
    ..Off-label use of recombinant factor VIIa (rFVIIa) occurs despite minimal data. The purpose of this study was to describe prescribing practices and clinical outcomes for off-label rFVIIa use...
  8. doi request reprint Effects of pharmacist participation in intensive care units on clinical and economic outcomes of critically ill patients with thromboembolic or infarction-related events
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacotherapy 29:761-8. 2009
    ..To assess the effects of clinical pharmacist participation in the care of critically ill Medicare patients with thromboembolic or infarction-related events (TIE) on clinical and economic outcomes...
  9. ncbi request reprint Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients
    Robert MacLaren
    School of Pharmacy, C238, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Value Health 8:105-16. 2005
    ..To examine the cost-effectiveness of using recombinant human erythropoietin (rHuEPO) to reduce red blood cells (RBC) transfusions in intensive care unit (ICU) patients...
  10. ncbi request reprint Key concepts in the management of difficult hemorrhagic cases
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 27:93S-102S. 2007
    ..To maximize therapy, the clinician must be aware of how best to clinically apply hemostatic agents, their comparative benefits and disadvantages, and the optimal methods for monitoring their effectiveness and toxicities...
  11. ncbi request reprint Comparison of cisapride and metoclopramide for facilitating gastric emptying and improving tolerance to intragastric enteral nutrition in critically III, mechanically ventilated adults
    R MacLaren
    School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Clin Ther 23:1855-66. 2001
    ....
  12. ncbi request reprint Use of enteral nutrition for stress ulcer prophylaxis
    R MacLaren
    School of Pharmacy, C238, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262 0001, USA
    Ann Pharmacother 35:1614-23. 2001
    ..To review the controversies involving the use of enteral nutrition support for stress ulcer prophylaxis and formulate recommendations...
  13. ncbi request reprint Use of exogenous erythropoietin in critically ill patients
    R MacLaren
    School of Pharmacy, University of Colorado Health Services Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Clin Pharm Ther 29:195-208. 2004
    ..Review the literature regarding the use of recombinant human erythropoietin (rHuEPO) to prevent red blood cell (RBC) transfusion in critically ill patients...
  14. ncbi request reprint Stress-dose corticosteroid therapy for sepsis and acute lung injury or acute respiratory distress syndrome in critically ill adults
    Robert MacLaren
    Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Science Center, Denver 80262, USA
    Pharmacotherapy 22:1140-56. 2002
    ..Stress-dose methylprednisolone therapy for ALI-ARDS requires further study but may be warranted in cases of refractory infection-induced ARDS when impending mortality is likely...
  15. doi request reprint Reliability and accuracy of practitioner-calculated Acute Physiology and Chronic Health Evaluation II scores for determining the appropriateness of drotrecogin alfa (activated)
    Phillip S Owen
    Department of Pharmacy Practice, College of Pharmacy and Health Sciences Center, Mercer University MU, Atlanta, GA, USA
    Am J Health Syst Pharm 67:136-43. 2010
    ..The reliability and accuracy of practitioner-calculated Acute Physiology and Chronic Health Evaluation (APACHE) II scores for determining the appropriateness of drotrecogin alfa (activated) in critically ill patients were evaluated...
  16. ncbi request reprint Surveillance of multi-drug resistant Pseudomonas aeruginosa in an urban tertiary-care teaching hospital
    R Jung
    Antimicrobial Research Laboratory, Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C 238 Denver, CO 80262, USA
    J Hosp Infect 57:105-11. 2004
    ..On-going surveillance within individual institutions is critical for the selection of appropriate empiric antimicrobial therapy...
  17. doi request reprint Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions
    Erica L Horinek
    Department of Pharmacy, Sky Ridge Medical Center, Lone Tree, CO, USA
    Ann Pharmacother 43:1964-71. 2009
    ..Intravenous lorazepam contains propylene glycol, which has been associated with toxicity when high doses of lorazepam are administered...
  18. pmc Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome
    Robert MacLaren
    Departments of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80260, USA
    Pharmacotherapy 27:860-73. 2007
    ..Although clinical data are less convincing than these findings, results from clinical trials may influence the design of future studies...
  19. pmc Immunosedation: a consideration for sepsis
    Robert MacLaren
    University of Colorado Denver School of Pharmacy, Academic Office 1, C238 L15, 12631 East 17th Avenue, Aurora, CO 80045, USA
    Crit Care 13:191. 2009
    ..Perhaps one day the choice of sedative in septic patients will not be based solely on sedative properties but rather immunosedative profiles...
  20. ncbi request reprint Enteral glutamine supplementation in critically ill patients with burn injuries: a retrospective case-control evaluation
    Paul Juang
    Department of Pharmacy Practice, St Louis College of Pharmacy, St Louis, Missouri 63110 1088, USA
    Pharmacotherapy 27:11-9. 2007
    ....
  21. ncbi request reprint Duration of antimicrobial therapy for nosocomial pneumonia: possible strategies for minimizing antimicrobial use in intensive care units
    H A Dugan
    School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Clin Pharm Ther 28:123-9. 2003
    ..To review published data evaluating shorter courses of antibiotic therapy for nosocomial pneumonia and provide recommendations for minimizing antimicrobial use in intensive care units...
  22. ncbi request reprint Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU
    R A Lugo
    Department of Pharmacy Practice, College of Pharmacy, University of Utah, Salt Lake City 84112 5820, USA
    Pharmacotherapy 21:1566-73. 2001
    ..To determine if enterally administered methadone can facilitate fentanyl discontinuation and prevent withdrawal in children at high risk for opioid abstinence syndrome...
  23. ncbi request reprint Proton-pump inhibitors for stress ulcer prophylaxis in critically ill patients
    Rose Jung
    Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Ann Pharmacother 36:1929-37. 2002
    ..To evaluate the use of proton-pump inhibitors (PPIs) for stress ulcer prophylaxis in critically ill adults...
  24. ncbi request reprint Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia
    Tyree H Kiser
    Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pharmacotherapy 25:1736-45. 2005
    ....
  25. ncbi request reprint Evaluation and survey of intravenous vitamin K1 for treatment of coagulopathy in critically ill patients
    R MacLaren
    School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Pharmacotherapy 21:175-82. 2001
    ..Randomized, placebo-controlled studies are necessary to confirm the effectiveness of vitamin K1...
  26. doi request reprint Prefilter bivalirudin for preventing hemofilter occlusion in continuous renal replacement therapy
    Scott W Mueller
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045, USA
    Ann Pharmacother 43:1360-5. 2009
    ..To describe a case of successful bivalirudin use as a prefilter anticoagulant in continuous venovenous hemofiltration (CVVH)...
  27. ncbi request reprint Implementing and assessing an evidence-based electrolyte dosing order form in the medical ICU
    Phillip Owen
    School of Pharmacy C238, Department of Clinical Pharmacy, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Intensive Crit Care Nurs 24:8-19. 2008
    ..The purpose of this study was to evaluate the efficacy, safety, and nursing acceptability of a nursing initiated, evidence-based order form to replace potassium, magnesium, and phosphate in the MICU...
  28. doi request reprint Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care
    Gina D Moore
    School of Pharmacy, University of Colorado Denver, 12631 E 17th Ave, Mail Stop C238 L15, Aurora, CO 80045, USA
    Ann Pharmacother 43:1802-8. 2009
    ..To summarize the published clinical data on fospropofol, critically review the safety and efficacy information, and provide pertinent information for formulary review...
  29. ncbi request reprint Effects of continuous vasopressin infusion in patients with septic shock
    Marilee D Obritsch
    University of Colorado Hospital, Denver, CO 80262, USA
    Ann Pharmacother 38:1117-22. 2004
    ..Small studies have reported that vasopressin improves hemodynamic instability in patients with septic shock...
  30. ncbi request reprint The role of vasopressin in vasodilatory septic shock
    Marilee D Obritsch
    Department of Pharmacy, University of Colorado Hospital, Denver, Colorado, USA
    Pharmacotherapy 24:1050-63. 2004
    ..A multicenter, comparative study of vasopressin 0.03 U/minute as add-on therapy is under way and should provide mortality data...
  31. pmc National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002
    Marilee D Obritsch
    Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Antimicrob Agents Chemother 48:4606-10. 2004
    ..Ongoing surveillance studies are crucial in monitoring antimicrobial susceptibility patterns and selecting empirical treatment regimens...
  32. pmc Lactoferrin protects against acetaminophen-induced liver injury in mice
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado, Denver, CO 80045, USA
    Hepatology 51:1007-16. 2010
    ..These findings reveal the significant therapeutic potential of Lac during AILI and other types of liver diseases...
  33. ncbi request reprint Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study
    Tyree H Kiser
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Nephrol Dial Transplant 20:1813-20. 2005
    ..This study aims to evaluate the effects of AVP and OCT on renal function, systemic haemodynamics and clinical outcomes in HRS...
  34. doi request reprint Formulary management of recombinant factor VIIa at an academic medical center
    Phillip S Owen
    Department of Pharmacy Practice Clinical Assistant Professor, College of Pharmacy and Health Sciences Center, Mercer University, Atlanta, GA, USA
    Ann Pharmacother 42:771-6. 2008
    ..Concerns of potentially inappropriate use, safety, and cost of rVIIa led to efforts to standardize use of this agent...
  35. ncbi request reprint Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition
    James Landzinski
    Department of Pharmacy, Georgetown University Hospital, Washington, DC, USA
    JPEN J Parenter Enteral Nutr 32:45-50. 2008
    ..This study evaluated gastric emptying in patients with limited GRV (tolerant group) vs volumes > or =150 mL (intolerant group) and whether prokinetic therapy improves gastric motility in intolerant patients...