NIGEL contact MACKMAN

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
    Nigel Mackman
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Code SP30 3040, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 27:1687-93. 2007
  2. pmc Triggers, targets and treatments for thrombosis
    Nigel Mackman
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 451:914-8. 2008
  3. doi request reprint Roles of PAR1 and PAR2 in viral myocarditis
    Nigel Mackman
    Department of Medicine, Division of Hematology and Oncology, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, 98 Manning Drive Campus Box 7035, Chapel Hill, NC, USA Electronic address
    Thromb Res 133:S18-20. 2014
  4. ncbi request reprint New players in haemostasis and thrombosis
    Julia E Geddings
    Nigel Mackman, PhD, Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA, Tel 1 919 843 3961, Fax 1 919 966 7639, E mail
    Thromb Haemost 111:570-4. 2014
  5. doi request reprint The antithrombotic effects of statins
    A Phillip Owens
    Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 email
    Annu Rev Med 65:433-45. 2014
  6. pmc New insights into the mechanisms of venous thrombosis
    Nigel Mackman
    Division of Hematology Oncology, Department of Medicine, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Invest 122:2331-6. 2012
  7. pmc The many faces of tissue factor
    N Mackman
    Division of Hematology and Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Thromb Haemost 7:136-9. 2009
  8. doi request reprint Tissue factor and its measurement in whole blood, plasma, and microparticles
    Nigel S Key
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Semin Thromb Hemost 36:865-75. 2010
  9. pmc Venous thromboembolism: a need for more public awareness and research into mechanisms
    Stephan Moll
    Division of Hematology Oncology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7035, USA
    Arterioscler Thromb Vasc Biol 28:367-9. 2008
  10. pmc Tissue factor and thrombosis: The clot starts here
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, USA
    Thromb Haemost 104:432-9. 2010

Research Grants

  1. BLOOD COAGULATION & FIBRINOLYSIS
    Nigel Mackman; Fiscal Year: 2004
  2. Thrombin-PAR-1 Signaling in Cardiac I/R Injury
    Nigel Mackman; Fiscal Year: 2005
  3. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2005
  4. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
  5. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2004
  6. Thrombin-PAR-1 Signaling in Cardiac I/R Injury
    Nigel Mackman; Fiscal Year: 2004
  7. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
  8. Role of PAR-1 and PAR-2 in Cardiac Remodeling
    Nigel Mackman; Fiscal Year: 2007
  9. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
  10. Role of PAR-1 and PAR-2 in Cardiac Remodeling
    Nigel Mackman; Fiscal Year: 2009

Collaborators

  • Nigel S Key
  • A Phillip Owens
  • G Girardi
  • Sabina A Murphy
  • D A Morrow
  • Stephan Moll
  • E M Antman
  • Cheng Liu
  • Bruce Furie
  • J I Weitz
  • Daniel D Myers
  • Rolf Dario Frank
  • THOMAS WILLIAM contact WAKEFIELD
  • Brian Pedersen
  • Rafal Pawlinski
  • James P Luyendyk
  • Julia E Geddings
  • Raj S Kasthuri
  • Surya V Seshan
  • Chirag Amin
  • Patricia E Ganey
  • Jacob Sevastos
  • Janusz Rak
  • Rachel Tilley
  • Rachel E Tilley
  • Sharlene M Day
  • Deborah D Motton
  • Gourab Bhattacharjee
  • Janet Chou
  • Albert J Chong
  • Patricia Redecha
  • Mark B Taubman
  • Marc Monestier
  • Claus Werner Franzke
  • Darren R Davis
  • Melissa Sam
  • Jonathan H Erlich
  • Robert A Roth
  • Jane F Maddox
  • Theresa M Eagle
  • Sandra W Newport
  • Sean E Kennedy
  • Philip W Peake
  • John A Charlesworth
  • Joanne L Yu
  • James Luyendyk
  • John C Rutledge
  • Wolfram Ruf
  • Jennifer L Reeve
  • William P Fay
  • Diana M Farris
  • Jasimuddin Ahamed
  • Michael Im
  • Thomas S Edgington
  • Amr El-Sheikh
  • Jonathan Erlich
  • Glenn Merrill-Skoloff
  • Timothy H Pohlman
  • Akira Shimamoto
  • Craig R Hampton
  • Edward D Verrier

Detail Information

Publications33

  1. ncbi request reprint Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
    Nigel Mackman
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Code SP30 3040, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 27:1687-93. 2007
    ..Understanding how the extrinsic pathway of blood coagulation contributes to hemostasis and thrombosis may lead to the development of safe and effective hemostatic agents and antithrombotic drugs...
  2. pmc Triggers, targets and treatments for thrombosis
    Nigel Mackman
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 451:914-8. 2008
    ..The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs...
  3. doi request reprint Roles of PAR1 and PAR2 in viral myocarditis
    Nigel Mackman
    Department of Medicine, Division of Hematology and Oncology, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, 98 Manning Drive Campus Box 7035, Chapel Hill, NC, USA Electronic address
    Thromb Res 133:S18-20. 2014
    ..Our studies support the notion that PARs modulate the innate immune response and can have both positive and negative effects on TLR-dependent responses. ..
  4. ncbi request reprint New players in haemostasis and thrombosis
    Julia E Geddings
    Nigel Mackman, PhD, Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA, Tel 1 919 843 3961, Fax 1 919 966 7639, E mail
    Thromb Haemost 111:570-4. 2014
    ..NETs can capture platelets and increase fibrin deposition. The recent advances in our understanding of the factors contributing to thrombosis in animal models provide new opportunities for the development of safer anticoagulant drugs. ..
  5. doi request reprint The antithrombotic effects of statins
    A Phillip Owens
    Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 email
    Annu Rev Med 65:433-45. 2014
    ..These antithrombotic activities of statins likely contribute to the ability of statins to reduce the incidence of cardiovascular death. ..
  6. pmc New insights into the mechanisms of venous thrombosis
    Nigel Mackman
    Division of Hematology Oncology, Department of Medicine, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Invest 122:2331-6. 2012
    ..Subsequent activation of the leukocytes induces expression of the potent procoagulant protein tissue factor that triggers thrombosis. Understanding the mechanisms of venous thrombosis may lead to the development of new treatments...
  7. pmc The many faces of tissue factor
    N Mackman
    Division of Hematology and Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Thromb Haemost 7:136-9. 2009
    ..In endotoxemia and sepsis, TF-dependent thrombin generation and activation of PAR1 on dendritic cells enhance inflammation. Finally, the TF:FVIIa complex contributes to tumor growth by activating PAR2...
  8. doi request reprint Tissue factor and its measurement in whole blood, plasma, and microparticles
    Nigel S Key
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Semin Thromb Hemost 36:865-75. 2010
    ..We comment on some of the crucial preanalytical and analytical variables that influence the results and their interpretation...
  9. pmc Venous thromboembolism: a need for more public awareness and research into mechanisms
    Stephan Moll
    Division of Hematology Oncology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7035, USA
    Arterioscler Thromb Vasc Biol 28:367-9. 2008
  10. pmc Tissue factor and thrombosis: The clot starts here
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, USA
    Thromb Haemost 104:432-9. 2010
    ..Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis...
  11. pmc Role of tissue factor in cancer
    Raj S Kasthuri
    Division of Hematology and Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Oncol 27:4834-8. 2009
    ..Nevertheless, additional studies are needed to determine if this strategy can be successfully translated to the treatment of cancer patients...
  12. pmc Microparticles in hemostasis and thrombosis
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina, USA
    Circ Res 108:1284-97. 2011
    ..This review will summarize our current knowledge of the role of procoagulant MPs in hemostasis and thrombosis...
  13. pmc Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies
    Surya V Seshan
    Department of Pathology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Blood 114:1675-83. 2009
    ..Treatment with pravastatin, which down-regulates glomerular TF synthesis, prevents aPL-induced TMA in this mouse model, thus emphasizing that targeting TF might be a good therapeutic intervention in patients with TMA...
  14. pmc The role of tissue factor and factor VIIa in hemostasis
    Nigel Mackman
    Department of Medicine, Division of Hematology Oncology, University of North Carolina at Chapel Hill, NC 27599 7035, USA
    Anesth Analg 108:1447-52. 2009
    ..However, the mechanism by which recombinant FVIIa restores hemostasis has not been clearly defined. In conclusion, the TF:FVIIa complex is essential for hemostasis and recombinant FVIIa is an effective hemostatic drug...
  15. doi request reprint Microparticles and cancer
    Chirag Amin
    Department of Medicine and Program in Hemostasis and Thrombosis, Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Pathophysiol Haemost Thromb 36:177-83. 2008
    ....
  16. ncbi request reprint Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial
    David A Morrow
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 26:682-8. 2005
    ..Sunol-cH36, a chimaeric monoclonal antibody to TF, blocks binding of factor X to the TF:VIIa complex. This report describes the first completed trial of Sunol-cH36 in humans...
  17. ncbi request reprint Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice
    Patricia E Ganey
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hepatology 46:1177-86. 2007
    ..CONCLUSION: Activation of the coagulation system and PAR-1 signaling contribute significantly to APAP-induced liver injury...
  18. ncbi request reprint A non-anticoagulant synthetic pentasaccharide reduces inflammation in a murine model of kidney ischemia-reperfusion injury
    Rolf Dario Frank
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Thromb Haemost 96:802-6. 2006
    ..These findings indicate that the anti-inflammatory activity of fondaparinux can be dissociated from its anticoagulant activity and that NAC-pentasaccharide is protective in kidney I/R injury...
  19. ncbi request reprint Role of tissue factor in hemostasis, thrombosis, and vascular development
    Nigel Mackman
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, Calif 92037, USA
    Arterioscler Thromb Vasc Biol 24:1015-22. 2004
    ..This review focuses on the roles of TF in hemostasis, thrombosis, and vascular development...
  20. ncbi request reprint Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis
    Rafal Pawlinski
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Crit Care Med 32:S293-7. 2004
    ..Taken together, our results suggest that activation of multiple PARs by coagulation proteases enhances inflammation during endotoxemia...
  21. ncbi request reprint Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation
    Janet Chou
    Center for Hemostasis and Thrombosis Research, Vascular Biology Center, 330 Brookline Ave, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 104:3190-7. 2004
    ..This demonstrates that blood-borne TF associated with hematopoietic cell-derived microparticles contributes to thrombus propagation...
  22. ncbi request reprint Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 105:192-8. 2005
    ..Therefore, our results suggest that thrombus formation in the arterial and venous macrovasculature is driven primarily by TF derived from the blood vessel wall as opposed to leukocytes...
  23. ncbi request reprint Mouse models in haemostasis and thrombosis
    Nigel Mackman
    Thromb Haemost 92:440-3. 2004
  24. ncbi request reprint Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice
    Rafal Pawlinski
    The Scripps Research Institute, 10550 North Torrey Pines Road, CVN 18, La Jolla, CA 92017, USA
    Thromb Haemost 92:444-50. 2004
    ..Low TF mice are also a useful tool to study the role of TF and the coagulation cascade in other processes, such as thrombosis, inflammation and angiogenesis...
  25. ncbi request reprint Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78
    Gourab Bhattacharjee
    Department of Immunology, The Scripps Research Institute, SP258, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 25:1737-43. 2005
    ..To test the hypothesis that Grp78 negatively regulates cell surface tissue factor (TF) procoagulant activity and whether this is mediated by physical interaction...
  26. ncbi request reprint Tissue-specific hemostasis in mice
    Nigel Mackman
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 25:2273-81. 2005
    ..These observations, together with the phenotypes of mice that have defects in the procoagulant, anticoagulant, and fibrinolytic pathways, indicate that hemostasis is regulated in a tissue-specific manner...
  27. ncbi request reprint Postprandial elevation of tissue factor antigen in the blood of healthy adults
    Deborah D Motton
    Division of Endocrinology, Clinical Nutrition and Vascular Medicine, Department of Internal Medicine, Suite 5303, Genomics and Biomedical Sciences Facility, University of California, Davis, California 95616, USA
    Thromb Haemost 94:504-9. 2005
    ..These results demonstrate increased tissue factor levels in individuals who consumed a moderate fat diet. This suggests that the typical western diet may play a larger role in cardiovascular disease than merely altering lipid profiles...
  28. ncbi request reprint Role of tissue factor in hemostasis and thrombosis
    Nigel Mackman
    Departments of Immunology and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CVN 18, La Jolla, CA 92037, USA
    Blood Cells Mol Dis 36:104-7. 2006
    ..Inhibition of TF activity in patients with TF expression in vascular cells and with elevated levels of circulating TF may decrease thrombosis associated with a variety of diseases...
  29. ncbi request reprint Tissue factor in hemostasis and thrombosis
    Rachel Tilley
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Semin Thromb Hemost 32:5-10. 2006
    ..TF expression in these diseases is associated with thrombotic events. Future therapeutic strategies may prove beneficial in the treatment of thrombosis. However, these strategies should be designed to avoid compromising hemostasis...
  30. ncbi request reprint Genetic susceptibility to thrombosis
    James P Luyendyk
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, CVN 18, La Jolla, CA 92037, USA
    Curr Atheroscler Rep 8:193-7. 2006
    ..Tissue factor is the primary cellular initiator of blood coagulation and is a major contributor to thrombosis. In this review, we discuss the association between various polymorphisms and the risk for thrombosis...
  31. ncbi request reprint Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury
    Jacob Sevastos
    Prince of Wales Clinical School, University of New South Wales, Sydney, and Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia
    Blood 109:577-83. 2007
    ..These experiments indicate that increased TF activity after renal IR leads to increased CXC chemokine expression and subsequent neutrophil-mediated injury predominantly by thrombin-dependent PAR-1 signaling...
  32. ncbi request reprint Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans
    Janusz Rak
    Montreal Children s Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    Cancer Res 66:10643-6. 2006
    ....
  33. ncbi request reprint Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury
    Albert J Chong
    Division of Cardiothoracic Surgery, The University of Washington, Seattle, Washington 98104, USA
    Ann Thorac Surg 75:S649-55. 2003
    ..However, defibrinogenating rabbits with ancrod had no effect on infarct size, suggesting a requirement of thrombin generation but not fibrin deposition in myocardial I/R injury...

Research Grants33

  1. BLOOD COAGULATION & FIBRINOLYSIS
    Nigel Mackman; Fiscal Year: 2004
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  2. Thrombin-PAR-1 Signaling in Cardiac I/R Injury
    Nigel Mackman; Fiscal Year: 2005
    ..Our studies should increase the fundamental knowledge of the role of the thrombin-PAR-1 signaling pathway in myocardial I/R injury and may lead to the development of novel therapies to preserve ischemic myocardium. ..
  3. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2005
    ..The clinical relevance of these studies is that they may provide new insight that can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  4. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
    ..These studies will provide new insight into the role of TF and the PI3K-Akt pathway in endotoxemia. This information can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  5. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2004
    ..The clinical relevance of these studies is that they may provide new insight that can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  6. Thrombin-PAR-1 Signaling in Cardiac I/R Injury
    Nigel Mackman; Fiscal Year: 2004
    ..Our studies should increase the fundamental knowledge of the role of the thrombin-PAR-1 signaling pathway in myocardial I/R injury and may lead to the development of novel therapies to preserve ischemic myocardium. ..
  7. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
    ..These studies will provide new insight into the role of TF and the PI3K-Akt pathway in endotoxemia. This information can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  8. Role of PAR-1 and PAR-2 in Cardiac Remodeling
    Nigel Mackman; Fiscal Year: 2007
    ..The results may lead to the development of PAR-1 and PAR-2 inhibitors that may be used as novel therapies for the treatment of pathological cardiac remodeling and hypertrophy in humans. ..
  9. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..These studies will provide new insight into the role of TF and the PI3K-Akt pathway in endotoxemia. This information can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  10. Role of PAR-1 and PAR-2 in Cardiac Remodeling
    Nigel Mackman; Fiscal Year: 2009
    ..The results may lead to the development of PAR-1 and PAR-2 inhibitors that may be used as novel therapies for the treatment of pathological cardiac remodeling and hypertrophy in humans. ..
  11. Mechanisms of Venous Thromboembolism in Cancer
    Nigel Mackman; Fiscal Year: 2009
    ..This is of enormous importance as physicians will be able to institute measures to prevent thrombosis in high-risk patients and improve clinical outcomes. ..
  12. Role of PAR-1 and PAR-2 in Cardiac Remodeling
    Nigel Mackman; Fiscal Year: 2010
    ..The results may lead to the development of PAR-1 and PAR-2 inhibitors that may be used as novel therapies for the treatment of pathological cardiac remodeling and hypertrophy in humans. ..
  13. Thrombin-PAR-1 Signaling in Cardiac I/R Injury
    Nigel Mackman; Fiscal Year: 2003
    ..Our studies should increase the fundamental knowledge of the role of the thrombin-PAR-1 signaling pathway in myocardial I/R injury and may lead to the development of novel therapies to preserve ischemic myocardium. ..
  14. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2003
    ..The clinical relevance of these studies is that they may provide new insight that can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  15. BLOOD COAGULATION & FIBRINOLYSIS
    Nigel Mackman; Fiscal Year: 2003
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  16. TISSUE FACTOR GENE REGULATION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 1992
    ..Understanding the transcriptional control of the TF gene should allow the development of effective strategies for the prevention and treatment of thrombotic and vascular diseases...
  17. TISSUE FACTOR GENE REGULATION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 1993
    ..Understanding the transcriptional control of the TF gene should allow the development of effective strategies for the prevention and treatment of thrombotic and vascular diseases...
  18. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 1999
    ..Finally the applicant will use proteasome inhibitors to block NF-(B /Rel activity in a novel mouse sepsis model humanized for TF. ..
  19. BLOOD COAGULATION & FIBRINOLYSIS
    Nigel Mackman; Fiscal Year: 2000
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  20. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2000
    ..Finally the applicant will use proteasome inhibitors to block NF-(B /Rel activity in a novel mouse sepsis model humanized for TF. ..
  21. INHIBITION OF GENE EXPRESSION IN ENDOTHELIAL CELLS
    Nigel Mackman; Fiscal Year: 2001
    ..The effects of intracellular cAMP on the functional activity and phosphorylation of NFKB/Rel proteins will be investigated. A yeast two hybrid system will be used to identify additional factors which interact with NFKB. ..
  22. BLOOD COAGULATION & FIBRINOLYSIS
    Nigel Mackman; Fiscal Year: 2001
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  23. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2002
    ..The clinical relevance of these studies is that they may provide new insight that can be used to develop improved therapeutic strategies for the treatment of patients with severe sepsis. ..
  24. Thrombin-PAR-1 Signaling in Cardiac I/R Injury
    Nigel Mackman; Fiscal Year: 2002
    ..Our studies should increase the fundamental knowledge of the role of the thrombin-PAR-1 signaling pathway in myocardial I/R injury and may lead to the development of novel therapies to preserve ischemic myocardium. ..
  25. BLOOD COAGULATION & FIBRINOLYSIS
    Nigel Mackman; Fiscal Year: 2002
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  26. Mechanisms of Venous Thromboembolism in Cancer
    NIGEL contact MACKMAN; Fiscal Year: 2010
    ..This is of enormous importance as physicians will be able to institute measures to prevent thrombosis in high-risk patients and improve clinical outcomes. ..