N Mackman

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration
    Julie C Williams
    Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    J Signal Transduct 2011:415195. 2011
  2. ncbi request reprint Tissue-specific hemostasis: role of tissue factor
    N Mackman
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA
    J Thromb Haemost 6:303-5. 2008
  3. pmc Role of tissue factor in thrombosis in antiphospholipid antibody syndrome
    J Boles
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7005, USA
    Lupus 19:370-8. 2010
  4. pmc Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity
    R D Lee
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Thromb Res 129:80-5. 2012
  5. doi request reprint Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet
    F Li
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    J Thromb Haemost 8:2122-32. 2010
  6. pmc Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis
    M R Cronan
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Oncogene 31:3889-900. 2012
  7. pmc Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule
    G Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA
    Lupus 17:931-6. 2008
  8. pmc Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice
    J G Wang
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Thromb Haemost 7:1092-8. 2009
  9. pmc The many faces of tissue factor
    N Mackman
    Division of Hematology and Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Thromb Haemost 7:136-9. 2009
  10. pmc Venous thromboembolism in malignant gliomas
    E O Jenkins
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Thromb Haemost 8:221-7. 2010

Collaborators

Detail Information

Publications34

  1. pmc Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration
    Julie C Williams
    Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    J Signal Transduct 2011:415195. 2011
    ..Infiltration of neutrophils and macrophages into the lung following LPS administration was not affected by an absence of PAR-2. Our results support the notion that PAR-2 plays a role in LPS activation of TLR4 signaling in macrophages...
  2. ncbi request reprint Tissue-specific hemostasis: role of tissue factor
    N Mackman
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA
    J Thromb Haemost 6:303-5. 2008
  3. pmc Role of tissue factor in thrombosis in antiphospholipid antibody syndrome
    J Boles
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7005, USA
    Lupus 19:370-8. 2010
    ..In this review we provide an overview of TF, describe mouse models used in the evaluation of the role of TF in thrombosis, as well as summarize recent work on TF and APS...
  4. pmc Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity
    R D Lee
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Thromb Res 129:80-5. 2012
    ..The aim of this study was to investigate the effects of pre-analytical and analytical variables on TF activity of MPs isolated from blood of healthy volunteers either untreated or treated ex vivo with bacterial lipopolysaccharide...
  5. doi request reprint Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet
    F Li
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    J Thromb Haemost 8:2122-32. 2010
    ..Diabetes is associated with fibrin deposition. Lack of nitric oxide and fatty acids stimulates the NF-kB pathway, which increases tissue factor (TF)...
  6. pmc Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis
    M R Cronan
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Oncogene 31:3889-900. 2012
    ....
  7. pmc Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule
    G Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA
    Lupus 17:931-6. 2008
    ..The identification of TF, acting as an important pro-inflammatory mediator in aPL-induced fetal injury, provides a new target for therapy to prevent pregnancy loss in the aPL syndrome...
  8. pmc Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice
    J G Wang
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Thromb Haemost 7:1092-8. 2009
    ..Elevated levels of these MPs appear to play a role in the pathogenesis of thrombosis in a variety of diseases, including sepsis...
  9. pmc The many faces of tissue factor
    N Mackman
    Division of Hematology and Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Thromb Haemost 7:136-9. 2009
    ..In endotoxemia and sepsis, TF-dependent thrombin generation and activation of PAR1 on dendritic cells enhance inflammation. Finally, the TF:FVIIa complex contributes to tumor growth by activating PAR2...
  10. pmc Venous thromboembolism in malignant gliomas
    E O Jenkins
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Thromb Haemost 8:221-7. 2010
    ..Recent studies exploring disordered coagulation, such as increased expression of tissue factor (TF), and tumorigenic molecular signaling may help to explain the increased risk of VTE in patients with malignant gliomas...
  11. ncbi request reprint Role of cardiac myocyte tissue factor in heart hemostasis
    R Pawlinski
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    J Thromb Haemost 5:1693-700. 2007
    ..Hemosiderosis and fibrosis are observed in the hearts of all low TF mice as early as 3 months of age. In contrast, TF(+/-) mice expressing approximately 50% of wild-type levels of TF had no detectable hemostatic defects...
  12. pmc In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis
    I K Mullarky
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Thromb Haemost 4:1580-7. 2006
    ..Inflammatory cytokines potently impact hemostatic pathways during infection, but the tissue-specific regulation of coagulation and fibrinolysis complicates studies of the underlying mechanisms...
  13. ncbi request reprint Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice
    M Hayashi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    J Thromb Haemost 4:177-85. 2006
    ..We previously reported that the targeted disruption of murine antithrombin (AT) gene resulted in embryonic lethality before 16.5 gestational days (gd) because of severe cardiac and hepatic thrombosis...
  14. pmc Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction
    R Pawlinski
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:15333-8. 2002
    ..We propose that TF expression by cardiac myocytes provides a secondary hemostatic barrier to protect the heart from hemorrhage...
  15. ncbi request reprint Tissue factor in the heart. Multiple roles in hemostasis, thrombosis, and inflammation
    T Luther
    Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 11:307-12. 2001
    ..This review discusses the roles of TF in hemostasis, thrombosis, and inflammation in the heart as well as other potential roles of TF in the maintenance of cardiac muscle...
  16. ncbi request reprint Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development
    E Melis
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven, B 3000, Belgium
    Biochem Biophys Res Commun 286:580-6. 2001
    ....
  17. pmc Low levels of tissue factor are compatible with development and hemostasis in mice
    G C Parry
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 101:560-9. 1998
    ..These studies establish a novel mouse model system that can be used to examine the regulation of the human TF gene in vivo and the impact of low TF levels on the hemostatic balance in various thrombotic diseases...
  18. pmc Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation
    J Erlich
    Departments of Immunology and Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:8138-43. 1999
    ..This study demonstrated that TF is required for uterine hemostasis and revealed an unexpected role of TF in the maintenance of the placental labyrinth...
  19. ncbi request reprint Conservation of tissue factor primary sequence among three mammalian species
    B S Andrews
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Gene 98:265-9. 1991
    ....
  20. pmc Functional analysis of the human tissue factor promoter and induction by serum
    N Mackman
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 87:2254-8. 1990
    ..Based on this functional map, we propose that the elaborate pattern of TF expression by cells results from a relatively complex promoter...
  21. ncbi request reprint Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade
    N Mackman
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Biochemistry 28:1755-62. 1989
    ..These factors included AP-1 and AP-2 which can mediate the effects of phorbol esters, agonists known to induce TF expression in monocytes and vascular endothelial cells...
  22. ncbi request reprint Regulation of the tissue factor gene
    N Mackman
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    FASEB J 9:883-9. 1995
    ..Sp1 also mediates basal promoter activity. Thus, TF gene expression is complex and is regulated by a number of transcription factors that bind to distinct regions of the TF promoter...
  23. ncbi request reprint Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers
    N Mackman
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    J Biol Chem 269:26363-7. 1994
    ..Taken together, these data indicated that inhibiting nuclear translocation of c-Rel/p65 heterodimers prevented LPS induction of TF gene transcription in monocytic cells...
  24. pmc Tissue factor expression during human and mouse development
    T Luther
    Institute of Pathology, Technical University Dresden, Dresden, Germany
    Am J Pathol 149:101-13. 1996
    ..The temporal and spatial pattern of TF expression during murine and human development supports the contention that TF serves as an important morphogenic factor during embryogenesis...
  25. ncbi request reprint Role of tissue factor in embryonic blood vessel development
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 383:73-5. 1996
    ..Vitelline vessels from null mice were deficient in smooth-muscle alpha-actin-expressing mesenchymal cells, which participate in organization of the vessel wall. This implies that tissue factor has a role in blood vessel development...
  26. ncbi request reprint Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression
    M Guha
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 98:1429-39. 2001
    ..The data indicate that LPS induction of Egr-1 gene expression is required for maximal induction of the TNF-alpha and TF genes in human monocytic cells...
  27. pmc Regulation of an essential innate immune response by the p50 subunit of NF-kappaB
    J Bohuslav
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 102:1645-52. 1998
    ..Thus, p50 expression plays a key role in the development of LPS tolerance...
  28. pmc RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts
    Y Xia
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Biol 19:7688-96. 1999
    ..Our findings suggest a novel transcription suppression function of RelB in fibroblasts...
  29. ncbi request reprint Protein kinase C-beta and oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature
    S F Yan
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 275:11921-8. 2000
    ....
  30. ncbi request reprint The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia-reperfusion injury
    R D Frank
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Thromb Haemost 3:531-40. 2005
    ..Our data suggest that fondaparinux reduces kidney I/R injury primarily by inhibiting the recruitment of neutrophils...
  31. pmc Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain
    G C Parry
    Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 105:1547-54. 2000
    ..We propose that TF/FVIIa-dependent extracellular protease activity is required for embryogenesis...
  32. ncbi request reprint Mechanism of resveratrol-mediated suppression of tissue factor gene expression
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 75708, USA
    Thromb Haemost 87:155-62. 2002
    ..In summary, our results indicate that resveratrol does not inhibit the activation or translocation of NF-kappaB/Rel proteins but inhibits NF-kappaB/Rel-dependent transcription by impairing the transactivation potential of p65...
  33. ncbi request reprint Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
    L Arbibe
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 1:533-40. 2000
    ..Thus Rac1 controls a second, I kappa B-independent, pathway to NF-kappa B activation and is essential in innate immune cell signaling via TLR2...
  34. ncbi request reprint Structure of the murine tissue factor gene. Chromosome location and conservation of regulatory elements in the promoter
    N Mackman
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Arterioscler Thromb 12:474-83. 1992
    ....