Scott Mackler

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat
    S A Mackler
    Departments of Medicine and Psychiatry, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 20:6210-7. 2000
  2. ncbi Cloning and functional expression of the mouse epithelial sodium channel
    Y J Ahn
    Departments of Medicine and Physiology, University of Pennsylvania, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol 277:F121-9. 1999
  3. ncbi The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 68:291-9. 2001
  4. ncbi Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, 19104, Philadelphia, PA, USA
    Alcohol 23:109-16. 2001
  5. ncbi NAC-1, a rat brain mRNA, is increased in the nucleus accumbens three weeks after chronic cocaine self-administration
    X Y Cha
    Department of Medicine, Philadelphia Veterans Administration Medical Center and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 17:6864-71. 1997
  6. ncbi The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures
    L Korutla
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 94:786-93. 2005
  7. ncbi The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1
    S A Mackler
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Neuroscience 121:355-61. 2003
  8. ncbi Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat
    Michael F Stromberg
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Alcohol 28:169-79. 2002
  9. ncbi A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats
    Michael F Stromberg
    Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 72:483-90. 2002
  10. ncbi The effect of cocaine on the expression of motor activity and conditioned place preference in high and low alcohol-preferring Wistar rats
    Michael F Stromberg
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Pharmacol Biochem Behav 82:314-9. 2005

Research Grants

  1. NAC1, A cocaine regulated mRNA in the rat brain
    Scott Mackler; Fiscal Year: 2007
  2. NAC-1 A Cocaine Regulated MRNA in the Rat Brain
    Scott Mackler; Fiscal Year: 2005
  3. NAC-1, A COCAINE-REGULATED MRNA IN THE RAT BRAIN
    Scott Mackler; Fiscal Year: 2002
  4. NAC1, A cocaine regulated mRNA in the rat brain
    Scott A Mackler; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. ncbi NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat
    S A Mackler
    Departments of Medicine and Psychiatry, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 20:6210-7. 2000
    ..Thus, NAC-1 may modify the long-term behaviors of psychostimulant abuse by regulating gene transcription in the mammalian brain...
  2. ncbi Cloning and functional expression of the mouse epithelial sodium channel
    Y J Ahn
    Departments of Medicine and Physiology, University of Pennsylvania, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol 277:F121-9. 1999
    ....
  3. ncbi The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 68:291-9. 2001
    ..These data suggest that GVG has potential for clinical use in populations that abuse either alcohol or cocaine alone or in combination...
  4. ncbi Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption
    M F Stromberg
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, 19104, Philadelphia, PA, USA
    Alcohol 23:109-16. 2001
    ..From these findings, it is suggested that a combination approach of these drugs may not be any more effective than monotherapy...
  5. ncbi NAC-1, a rat brain mRNA, is increased in the nucleus accumbens three weeks after chronic cocaine self-administration
    X Y Cha
    Department of Medicine, Philadelphia Veterans Administration Medical Center and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 17:6864-71. 1997
    ..Regulation of NAC-1 mRNA in the nucleus accumbens demonstrates a long-term effect of cocaine use on cellular function that may be relevant in behavioral sensitization or cocaine self-administration...
  6. ncbi The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures
    L Korutla
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 94:786-93. 2005
    ..Taken together, the results of these experiments indicate sNAC1 and lNAC1 recruit histone deacetylases for transcriptional repression, further enhancing POZ/BTB protein mediated repression...
  7. ncbi The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1
    S A Mackler
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Neuroscience 121:355-61. 2003
    ..Identification of drug induced alterations in gene expression is key to understanding the types of molecular adaptations underlying addiction...
  8. ncbi Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat
    Michael F Stromberg
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Alcohol 28:169-79. 2002
    ..The implications of these findings for the clinical use of naltrexone in populations with comorbid ethanol and cocaine abuse are discussed...
  9. ncbi A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats
    Michael F Stromberg
    Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 72:483-90. 2002
    ..The implications of these data for the development of pharmacotherapeutic agents capable of reducing drinking in recovering alcoholics are discussed...
  10. ncbi The effect of cocaine on the expression of motor activity and conditioned place preference in high and low alcohol-preferring Wistar rats
    Michael F Stromberg
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Pharmacol Biochem Behav 82:314-9. 2005
    ....
  11. ncbi The relationship between cocaine-induced increases in NAC1 and behavioral sensitization
    P J Wang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacol Biochem Behav 75:49-54. 2003
    ..Furthermore, these data suggest that NAC1 may function as an endogenous inhibitor of behavioral sensitization. NAC1 represents a target for future studies examining cocaine-induced behavioral changes...

Research Grants14

  1. NAC1, A cocaine regulated mRNA in the rat brain
    Scott Mackler; Fiscal Year: 2007
    ....
  2. NAC-1 A Cocaine Regulated MRNA in the Rat Brain
    Scott Mackler; Fiscal Year: 2005
    ..The hnman NAC 1 proteinis similar to that of rat and mouse, therefore these experiments may provide important insights into cocaine abuse in humans. ..
  3. NAC-1, A COCAINE-REGULATED MRNA IN THE RAT BRAIN
    Scott Mackler; Fiscal Year: 2002
    ..NAC-1 is one mRNA that demonstrates a long-term adaptation to cocaine use. Results from studies of NAC-1 function in the rat may be helpful in future studies of human subjects who abuse cocaine. ..
  4. NAC1, A cocaine regulated mRNA in the rat brain
    Scott A Mackler; Fiscal Year: 2010
    ....