K Mackie

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Cannabinoid receptor homo- and heterodimerization
    Ken Mackie
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, WA 98195 6540, USA
    Life Sci 77:1667-73. 2005
  2. ncbi request reprint Cannabinoid receptors as therapeutic targets
    Ken Mackie
    Department of Anesthesiology and Physiology, University of Washington School of Medicine, Seattle, WA 98195 6540, USA
    Annu Rev Pharmacol Toxicol 46:101-22. 2006
  3. ncbi request reprint Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength
    K Mackie
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195 6540, USA
    Int J Obes (Lond) 30:S19-23. 2006
  4. ncbi request reprint Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current
    M S Shapiro
    Department of Physiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 20:1710-21. 2000
  5. ncbi request reprint Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor
    D E Garcia
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 18:2834-41. 1998
  6. ncbi request reprint Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
    W Twitchell
    Department of Anesthesiology, School of Medicine, University of Washington, Seattle 98195, USA
    J Neurophysiol 78:43-50. 1997

Research Grants

  1. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Cannabinoid receptor homo- and heterodimerization
    Ken Mackie
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, WA 98195 6540, USA
    Life Sci 77:1667-73. 2005
    ..In this review, the evidence for CB1 multimerization will be presented, the implications for cannabinoid signaling discussed, and possible future directions for this research considered...
  2. ncbi request reprint Cannabinoid receptors as therapeutic targets
    Ken Mackie
    Department of Anesthesiology and Physiology, University of Washington School of Medicine, Seattle, WA 98195 6540, USA
    Annu Rev Pharmacol Toxicol 46:101-22. 2006
    ..This review considers the components of the endocannabinoid system and discusses some of the most promising endocannabinoid-based therapies...
  3. ncbi request reprint Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength
    K Mackie
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195 6540, USA
    Int J Obes (Lond) 30:S19-23. 2006
    ..The behavioral consequences of these changes are many, but some of the most striking and relevant to the current symposium are those associated with endogenous reward and consumptive behavior...
  4. ncbi request reprint Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current
    M S Shapiro
    Department of Physiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 20:1710-21. 2000
    ..Our data further rule out Ca(2+) as the diffusible messenger. The reconstitution of muscarinic modulation of the M current that uses cloned components should facilitate the elucidation of the muscarinic signaling mechanism...
  5. ncbi request reprint Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor
    D E Garcia
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 18:2834-41. 1998
    ..Mutating this serine to alanine did not affect the ability of CB1 to modulate currents, but it eliminated disruption by PMA, demonstrating that PKC can disrupt ion channel modulation by receptor phosphorylation...
  6. ncbi request reprint Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
    W Twitchell
    Department of Anesthesiology, School of Medicine, University of Washington, Seattle 98195, USA
    J Neurophysiol 78:43-50. 1997
    ....

Research Grants1

  1. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..4. To determine whether increased spinal cord bioavailability of methylprednisolone decreases secondary damage following spinal cord injury. ..