T M Mack

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint The ghost of pandemics past
    Thomas M Mack
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90089, USA
    Lancet 365:1370-2. 2005
  2. pmc Heritable breast cancer in twins
    T M Mack
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MC9175, Los Angeles, California, CA 90089 9175, USA
    Br J Cancer 87:294-300. 2002
  3. ncbi request reprint Use of twins as mutual proxy respondents in a case-control study of breast cancer: effect of item nonresponse and misclassification
    A S Hamilton
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles 90089 9175, USA
    Am J Epidemiol 152:1093-103. 2000
  4. ncbi request reprint An estimate of physical activity prevalence in a large population-based cohort
    Steven A Hawkins
    Department of Kinesiology and Nutritional Science, California State University Los Angeles, 5151 State University Drive, Los Angeles, CA 90032 8162, USA
    Med Sci Sports Exerc 36:253-60. 2004
  5. ncbi request reprint Evidence of genetic susceptibility to infectious mononucleosis: a twin study
    A E Hwang
    Department of Preventive Medicine and Norris Comprehensive Cancer Centre, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Epidemiol Infect 140:2089-95. 2012
  6. ncbi request reprint Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus
    Yan Cui
    Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int J Cancer 118:714-20. 2006
  7. doi request reprint Use of an electrostatic dust cloth for self-administered home allergen collection
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
    Twin Res Hum Genet 11:150-5. 2008
  8. pmc Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
    Blood 111:3377-82. 2008
  9. pmc A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
    Yuan Chin Amy Lee
    Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Int J Cancer 122:1630-8. 2008
  10. ncbi request reprint Gender differences in determinants of smoking initiation and persistence in California twins
    Ann S Hamilton
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Cancer Epidemiol Biomarkers Prev 15:1189-97. 2006

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The ghost of pandemics past
    Thomas M Mack
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90089, USA
    Lancet 365:1370-2. 2005
  2. pmc Heritable breast cancer in twins
    T M Mack
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MC9175, Los Angeles, California, CA 90089 9175, USA
    Br J Cancer 87:294-300. 2002
    ..The resultant class of disease accounts for a larger proportion of all breast cancers than previously thought, with a rather high overall penetrance. Some of the biological characteristics differ from those of breast cancer generally...
  3. ncbi request reprint Use of twins as mutual proxy respondents in a case-control study of breast cancer: effect of item nonresponse and misclassification
    A S Hamilton
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles 90089 9175, USA
    Am J Epidemiol 152:1093-103. 2000
    ..These findings demonstrate that, for these variables in this population, twins are reliable proxies for each other and that results from single-respondent pairs should be included...
  4. ncbi request reprint An estimate of physical activity prevalence in a large population-based cohort
    Steven A Hawkins
    Department of Kinesiology and Nutritional Science, California State University Los Angeles, 5151 State University Drive, Los Angeles, CA 90032 8162, USA
    Med Sci Sports Exerc 36:253-60. 2004
    ....
  5. ncbi request reprint Evidence of genetic susceptibility to infectious mononucleosis: a twin study
    A E Hwang
    Department of Preventive Medicine and Norris Comprehensive Cancer Centre, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Epidemiol Infect 140:2089-95. 2012
    ..When the analysis was restricted to same-sex twin pairs, that estimate was 2·5 (95% CI 1·2-5·3, P=0·02). The results are compatible with a heritable contribution to the risk of infectious mononucleosis...
  6. ncbi request reprint Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus
    Yan Cui
    Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int J Cancer 118:714-20. 2006
    ..7, 38). In conclusion, our study suggests that the XPG Asp1104Asp genotype may be associated with decreased susceptibility to lung cancer and SCCOLE...
  7. doi request reprint Use of an electrostatic dust cloth for self-administered home allergen collection
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
    Twin Res Hum Genet 11:150-5. 2008
    ....
  8. pmc Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
    Blood 111:3377-82. 2008
    ..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility...
  9. pmc A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
    Yuan Chin Amy Lee
    Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
    Int J Cancer 122:1630-8. 2008
    ..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers...
  10. ncbi request reprint Gender differences in determinants of smoking initiation and persistence in California twins
    Ann S Hamilton
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Cancer Epidemiol Biomarkers Prev 15:1189-97. 2006
    ..To determine the effects of genetic versus environmental influences on smoking initiation (SI) and smoking persistence (SP)...
  11. ncbi request reprint Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
    J Clin Immunol 24:617-22. 2004
    ..4 pg/mL; p=0.03). No statistically significant differences in INF-gamma, IL-4, or IgE levels were observed. Smoking appears to be associated with increased levels of IL-13...
  12. ncbi request reprint IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 103:3216-21. 2004
    ..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma...
  13. pmc A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
    Blood 114:4014-20. 2009
    ..Our observations support a protective role for increased early oral exposure to the microbiome, suggesting that factors associated with increased Th2 and decreased Th1 cytokines are etiologically relevant to YAHL...
  14. ncbi request reprint Puberty and genetic susceptibility to breast cancer in a case-control study in twins
    Ann S Hamilton
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
    N Engl J Med 348:2313-22. 2003
    ..Different predictors of hereditary and sporadic breast cancer suggest different pathogenic mechanisms. Affected twin pairs may help to illustrate such differences...
  15. ncbi request reprint The occurrence of chronic disease and other conditions in a large population-based cohort of native Californian twins
    Myles Cockburn
    University of Southern California Keck School of Medicine, California, USA
    Twin Res 5:460-7. 2002
    ..We outline our plans for cohort expansion, additional studies using the cohort, and future plans for inviting collaboration...
  16. ncbi request reprint Twins as willing research participants: successes from studies nested within the California Twin Program
    Myles G Cockburn
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Twin Res Hum Genet 9:927-32. 2006
    ..However, in most analyses, the participating sample of twins does not differ substantially from the underlying sample from the CTP. Future work will focus on improving methods of re-contacting cohort members...
  17. pmc Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins
    W Cozen
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Br J Cancer 108:1163-7. 2013
    ..Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity...
  18. ncbi request reprint Differential twin concordance for multiple sclerosis by latitude of birthplace
    Talat Islam
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, 90089, USA
    Ann Neurol 60:56-64. 2006
    ..To address the inconsistency in the reported concordance of multiple sclerosis (MS) among twins by zygosity, sex, and latitude...
  19. ncbi request reprint Development and representativeness of a large population-based cohort of native Californian twins
    M G Cockburn
    University of Southern California Keck School of Medicine, USA
    Twin Res 4:242-50. 2001
    ..We provide a brief synopsis of studies nested within this cohort. We also elucidate our plans for expanding the cohort in the near future...
  20. pmc Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers
    Sungshim L Park
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, 71 225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA 90095 1772, USA
    Carcinogenesis 31:1264-71. 2010
    ..These hypotheses should be further examined in functional studies...
  21. pmc The risk of angiosarcoma following primary breast cancer
    W Cozen
    University of Southern California School of Medicine, Department of Preventive Medicine, Los Angeles 90033, USA
    Br J Cancer 81:532-6. 1999
    ..9-152.8). A strong increase in risk after breast cancer was also observed for angiosarcoma of the chest and breast (OR = 11.6, 95% CI = 4.3-26.1) and for other sarcomas of the chest and breast (OR = 3.3, 95% CI = 1.1-1.7)...
  22. doi request reprint Diverticulitis in the United States: 1998-2005: changing patterns of disease and treatment
    David A Etzioni
    Departments of Colorectal Surgery, University of Southern California, Los Angeles, 90033, USA
    Ann Surg 249:210-7. 2009
    ..We analyzed whether these changes are reflected in patterns of practice in a nationally-representative patient cohort...
  23. doi request reprint Dietary flavonoid intake and lung cancer--a population-based case-control study
    Yan Cui
    Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
    Cancer 112:2241-8. 2008
    ..To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls...
  24. ncbi request reprint Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins
    Talat Islam
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Neurology 69:381-8. 2007
    ....
  25. ncbi request reprint Risk factors for anal cancer: results of a population-based case--control study
    Hung Fu Tseng
    Department of Healthcare Administration, Fooyin University, Kaohsiung, Taiwan, ROC
    Cancer Causes Control 14:837-46. 2003
    ..Although the incidence of anal cancer is higher in women than in men, the reasons for this gender difference are not clear. The purpose of this study was to identify risk factors for anal cancer in both men and women...
  26. ncbi request reprint Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study
    Mia Hashibe
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006
    ..We conducted a population-based case-control study of the association between marijuana use and the risk of lung and upper aerodigestive tract cancers in Los Angeles...

Research Grants10

  1. DNA methylation differences between identical twins
    Thomas Mack; Fiscal Year: 2009
    ..Finally, any evidence of a heritable propensity to change methylation status, based on identical and like sex fraternal twins having the least evidence of cumulative toxic exposure, will be investigated. ..
  2. ACQUIRED & GENETIC DETERMINANTS OF MULTIPLE SCLEROSIS
    Thomas Mack; Fiscal Year: 2006
    ..Additional descriptive evidence of environmental etiology will also be sought. ..
  3. DNA methylation differences between identical twins
    Thomas Mack; Fiscal Year: 2009
    ..Finally, any evidence of a heritable propensity to change methylation status, based on identical and like sex fraternal twins having the least evidence of cumulative toxic exposure, will be investigated. ..