Research Topics
Species | T M MackSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Heritable breast cancer in twinsT M Mack
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MC9175, Los Angeles, California, CA 90089 9175, USA
Br J Cancer 87:294-300. 2002..The resultant class of disease accounts for a larger proportion of all breast cancers than previously thought, with a rather high overall penetrance. Some of the biological characteristics differ from those of breast cancer generally...
The ghost of pandemics pastThomas M Mack
Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90089, USA
Lancet 365:1370-2. 2005- Use of twins as mutual proxy respondents in a case-control study of breast cancer: effect of item nonresponse and misclassificationA S Hamilton
Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles 90089 9175, USA
Am J Epidemiol 152:1093-103. 2000..These findings demonstrate that, for these variables in this population, twins are reliable proxies for each other and that results from single-respondent pairs should be included... - An estimate of physical activity prevalence in a large population-based cohortSteven A Hawkins
Department of Kinesiology and Nutritional Science, California State University Los Angeles, 5151 State University Drive, Los Angeles, CA 90032 8162, USA
Med Sci Sports Exerc 36:253-60. 2004.... - Evidence of genetic susceptibility to infectious mononucleosis: a twin studyA E Hwang
Department of Preventive Medicine and Norris Comprehensive Cancer Centre, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Epidemiol Infect 140:2089-95. 2012..When the analysis was restricted to same-sex twin pairs, that estimate was 2·5 (95% CI 1·2-5·3, P=0·02). The results are compatible with a heritable contribution to the risk of infectious mononucleosis... - A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancersYuan Chin Amy Lee
Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
Int J Cancer 122:1630-8. 2008..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers... - Gender differences in determinants of smoking initiation and persistence in California twinsAnn S Hamilton
Department of Preventive Medicine, University of Southern California, Los Angeles, USA
Cancer Epidemiol Biomarkers Prev 15:1189-97. 2006..To determine the effects of genetic versus environmental influences on smoking initiation (SI) and smoking persistence (SP)... - Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
Blood 111:3377-82. 2008..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility... - Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagusYan Cui
Department of Epidemiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
Int J Cancer 118:714-20. 2006..7, 38). In conclusion, our study suggests that the XPG Asp1104Asp genotype may be associated with decreased susceptibility to lung cancer and SCCOLE... - Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumptionWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
J Clin Immunol 24:617-22. 2004..4 pg/mL; p=0.03). No statistically significant differences in INF-gamma, IL-4, or IgE levels were observed. Smoking appears to be associated with increased levels of IL-13... - IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 103:3216-21. 2004..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma... 
Use of an electrostatic dust cloth for self-administered home allergen collectionWendy Cozen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
Twin Res Hum Genet 11:150-5. 2008....- Puberty and genetic susceptibility to breast cancer in a case-control study in twinsAnn S Hamilton
Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
N Engl J Med 348:2313-22. 2003..Different predictors of hereditary and sporadic breast cancer suggest different pathogenic mechanisms. Affected twin pairs may help to illustrate such differences... - The occurrence of chronic disease and other conditions in a large population-based cohort of native Californian twinsMyles Cockburn
University of Southern California Keck School of Medicine, California, USA
Twin Res 5:460-7. 2002..We outline our plans for cohort expansion, additional studies using the cohort, and future plans for inviting collaboration... - A protective role for early oral exposures in the etiology of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Blood 114:4014-20. 2009..Our observations support a protective role for increased early oral exposure to the microbiome, suggesting that factors associated with increased Th2 and decreased Th1 cytokines are etiologically relevant to YAHL... - Twins as willing research participants: successes from studies nested within the California Twin ProgramMyles G Cockburn
Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Twin Res Hum Genet 9:927-32. 2006..However, in most analyses, the participating sample of twins does not differ substantially from the underlying sample from the CTP. Future work will focus on improving methods of re-contacting cohort members... - Differential twin concordance for multiple sclerosis by latitude of birthplaceTalat Islam
Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, 90089, USA
Ann Neurol 60:56-64. 2006..INTERPRETATION: Multiple sclerosis is similarly heritable by sex, and the apparent variation in MZ concordance by latitude is influenced by environmental and genetic factors... - Development and representativeness of a large population-based cohort of native Californian twinsM G Cockburn
University of Southern California Keck School of Medicine, USA
Twin Res 4:242-50. 2001..We provide a brief synopsis of studies nested within this cohort. We also elucidate our plans for expanding the cohort in the near future... - Associations between NBS1 polymorphisms, haplotypes and smoking-related cancersSungshim L Park
Department of Epidemiology, School of Public Health, University of California, Los Angeles, 71 225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA 90095 1772, USA
Carcinogenesis 31:1264-71. 2010..These hypotheses should be further examined in functional studies... - The risk of angiosarcoma following primary breast cancerW Cozen
University of Southern California School of Medicine, Department of Preventive Medicine, Los Angeles 90033, USA
Br J Cancer 81:532-6. 1999..9-152.8). A strong increase in risk after breast cancer was also observed for angiosarcoma of the chest and breast (OR = 11.6, 95% CI = 4.3-26.1) and for other sarcomas of the chest and breast (OR = 3.3, 95% CI = 1.1-1.7)... - Childhood sun exposure influences risk of multiple sclerosis in monozygotic twinsTalat Islam
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
Neurology 69:381-8. 2007.... - Dietary flavonoid intake and lung cancer--a population-based case-control studyYan Cui
Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California, USA
Cancer 112:2241-8. 2008..To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case-control study of 558 lung cancer cases and a group of 837 controls... - Diverticulitis in the United States: 1998-2005: changing patterns of disease and treatmentDavid A Etzioni
Departments of Colorectal Surgery, University of Southern California, Los Angeles, 90033, USA
Ann Surg 249:210-7. 2009..We analyzed whether these changes are reflected in patterns of practice in a nationally-representative patient cohort... - Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control studyMia Hashibe
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006.... - Risk factors for anal cancer: results of a population-based case--control studyHung Fu Tseng
Department of Healthcare Administration, Fooyin University, Kaohsiung, Taiwan, ROC
Cancer Causes Control 14:837-46. 2003..Although the incidence of anal cancer is higher in women than in men, the reasons for this gender difference are not clear. The purpose of this study was to identify risk factors for anal cancer in both men and women...
Research Grants
- DNA methylation differences between identical twinsThomas Mack; Fiscal Year: 2009..Finally, any evidence of a heritable propensity to change methylation status, based on identical and like sex fraternal twins having the least evidence of cumulative toxic exposure, will be investigated. ..
- ACQUIRED & GENETIC DETERMINANTS OF MULTIPLE SCLEROSISThomas Mack; Fiscal Year: 2006..Additional descriptive evidence of environmental etiology will also be sought. ..
- DNA methylation differences between identical twinsThomas Mack; Fiscal Year: 2009..Finally, any evidence of a heritable propensity to change methylation status, based on identical and like sex fraternal twins having the least evidence of cumulative toxic exposure, will be investigated. ..