Cara L Mack

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia
    Cara L Mack
    Sections of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    Gastroenterology 133:278-87. 2007
  2. pmc Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia
    Cara L Mack
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado at Denver Health Sciences Center and The Children s Hospital, Denver, USA
    Hepatology 44:1231-9. 2006
  3. pmc Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia
    Cara L Mack
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, 1056 East 19th Avenue B290, Denver, CO 80218, USA
    Clin Immunol 115:200-9. 2005
  4. pmc Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation
    Cara L Mack
    Department of Pediatric, The Children s Hospital, University of Colorado Health Science Center, Denver, CO 80218, USA
    Pediatr Res 56:79-87. 2004
  5. pmc Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia
    Barrett H Barnes
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Liver Int 29:1253-61. 2009
  6. pmc Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia
    Rebecca M Tucker
    Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Viral Immunol 20:34-43. 2007
  7. pmc B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia
    Amy G Feldman
    Department of Pediatrics, Section of Pediatric Gastroenterology, Children s Hospital, Colorado, Aurora, Colorado, USA
    PLoS ONE 8:e73644. 2013
  8. pmc α-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia
    Brandy R Lu
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Gastroenterology 139:1753-61. 2010
  9. ncbi request reprint Unraveling the pathogenesis and etiology of biliary atresia
    Cara L Mack
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver 80218, USA
    Pediatr Res 57:87R-94R. 2005
  10. ncbi request reprint Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia
    Peter F Whitington
    Department of Pediatrics, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Pediatr Res 57:837-44. 2005

Collaborators

Detail Information

Publications22

  1. pmc Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia
    Cara L Mack
    Sections of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    Gastroenterology 133:278-87. 2007
    ..We hypothesized that the T cells in biliary atresia tissue expressed related TCRs, suggesting that the expansion was in direct response to antigenic stimulation...
  2. pmc Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia
    Cara L Mack
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado at Denver Health Sciences Center and The Children s Hospital, Denver, USA
    Hepatology 44:1231-9. 2006
    ..The role of cellular and humoral autoimmunity in human biliary atresia and possible interventional strategies therefore should be the focus of future research...
  3. pmc Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia
    Cara L Mack
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, 1056 East 19th Avenue B290, Denver, CO 80218, USA
    Clin Immunol 115:200-9. 2005
    ..Utilization of the murine model of BA yielded mechanistic data that can provide much needed insight into the role played by different arms of the immune system related to the pathogenesis of human BA...
  4. pmc Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation
    Cara L Mack
    Department of Pediatric, The Children s Hospital, University of Colorado Health Science Center, Denver, CO 80218, USA
    Pediatr Res 56:79-87. 2004
    ....
  5. pmc Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia
    Barrett H Barnes
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Liver Int 29:1253-61. 2009
    ....
  6. pmc Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia
    Rebecca M Tucker
    Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Viral Immunol 20:34-43. 2007
    ..In summary, although RRV-inoculated BALB/c mice have highly elevated expression of TNF-alpha, this cytokine does not play an obligate role in disease progression...
  7. pmc B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia
    Amy G Feldman
    Department of Pediatrics, Section of Pediatric Gastroenterology, Children s Hospital, Colorado, Aurora, Colorado, USA
    PLoS ONE 8:e73644. 2013
    ..The mechanism of protection may involve lack of B cell antigen presentation, which impairs T-cell activation and Th1 inflammation. Immune modulators that inhibit B cell function may be a new strategy for treatment of BA. ..
  8. pmc α-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia
    Brandy R Lu
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Gastroenterology 139:1753-61. 2010
    ..We aimed to identify autoantigens recognized by serum antibodies in the Rhesus rotavirus (RRV)-induced mouse model of BA; findings were correlated with BA in humans...
  9. ncbi request reprint Unraveling the pathogenesis and etiology of biliary atresia
    Cara L Mack
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver 80218, USA
    Pediatr Res 57:87R-94R. 2005
    ..Future investigations combining animal model work and evaluation of clinical specimens holds the promise of identifying the etiology of BA and providing a scientific basis for treatment and preventative interventions...
  10. ncbi request reprint Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia
    Peter F Whitington
    Department of Pediatrics, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Pediatr Res 57:837-44. 2005
    ..These findings suggest a role for OPN in the pathogenesis of biliary atresia...
  11. pmc Clues to the etiology of bile duct injury in biliary atresia
    Cara L Mack
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, and Digestive Health Institute, Children s Hospital Colorado, Aurora, Colorado 80045, USA
    Semin Liver Dis 32:307-16. 2012
    ..What controls the coordination of these events, why the disease only occurs in the first few months of life, and why a minority of infants with perinatal viral infections develop BA are remaining questions to be answered...
  12. ncbi request reprint Inflammation and biliary tract injury
    Brandy R Lu
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Curr Opin Gastroenterol 25:260-4. 2009
    ..Primary biliary cirrhosis, primary sclerosing cholangitis and biliary atresia are thought to be immune-mediated cholangiopathies, however, gaps in knowledge remain with regard to the immunopathogenesis of these diseases...
  13. pmc High-dose IgG therapy mitigates bile duct-targeted inflammation and obstruction in a mouse model of biliary atresia
    Erika K Fenner
    1 Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 2 Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado School of Medicine and the Digestive Health Institute, Children s Hospital Colorado, Aurora, Colorado
    Pediatr Res 76:72-80. 2014
    ..This study lends support for consideration of IVIg clinical trials in infants with BA, to diminish the progressive intrahepatic bile duct injury. ..
  14. doi request reprint Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin
    Elizabeth B Rand
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr 155:566-71. 2009
    ....
  15. pmc Biliary atresia: cellular dynamics and immune dysregulation
    Amy G Feldman
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Semin Pediatr Surg 21:192-200. 2012
    ..This review will focus solely on human studies pertaining to a potential viral trigger of bile duct injury at diagnosis and provide insight into the interplay of the innate and adaptive immune responses in the pathogenesis of disease...
  16. pmc The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease
    Cara L Mack
    Pediatric Liver Center and Liver Transplant Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, University of Colorado at Denver Health Sciences Center, Denver, Colorado 80218, USA
    Semin Liver Dis 27:233-42. 2007
    ....
  17. pmc Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease
    Rebecca M Tucker
    Department of Medicine, University of Colorado, Denver Department of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Colorado, Aurora, Colorado, USA
    Hepatol Res 42:502-7. 2012
    ..The cholangiocyte-specific cDNA library is a powerful tool for the identification of target antigens in murine inflammatory cholangiopathies and is available as a shared resource...
  18. ncbi request reprint Acute hepatitis and liver failure associated with influenza A infection in children
    John R Whitworth
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Pediatric Liver Center, Denver, CO, USA
    J Pediatr Gastroenterol Nutr 43:536-8. 2006
  19. ncbi request reprint Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis
    Cara L Mack
    Immunology and Interdepartmental Immunobiology Center, Department of Microbiology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Neuroimmunol 144:68-79. 2003
    ....
  20. ncbi request reprint Serum cytokines as biomarkers of disease and clues to pathogenesis
    Cara L Mack
    Hepatology 46:6-8. 2007
  21. ncbi request reprint Optimizing outcomes and bridging biliary atresia into adulthood
    Ronald J Sokol
    Hepatology 41:231-3. 2005
  22. ncbi request reprint Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis
    Cara L Mack
    Departments of Pediatrics and Surgery, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA
    J Pediatr 142:197-9. 2003
    ..Coagulation factors had returned to normal by one year. The data suggest that portal venous flow is essential for maintaining normal coagulation...

Research Grants3

  1. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
  2. Immunologic Mechanism/Destruction/Biliary Artesia
    Cara Mack; Fiscal Year: 2006
    ..Cytokine profiles will be characterized by cytokine mRNA expression. ..
  3. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    Cara Mack; Fiscal Year: 2007
    ..The overall goal of this research program is to use these molecular and immunological insights as a basis for development of future therapeutic and preventative strategies for this important disease. ..