R R MacGregor
Affiliation: University of Pennsylvania
- Clinical protocol. A phase 1 open-label clinical trial of the safety and tolerability of single escalating doses of autologous CD4 T cells transduced with VRX496 in HIV-positive subjectsR R MacGregor
Division of Infectious Diseases, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Gene Ther 12:2028-9. 2001..Follow-up examinations will be conducted 1, 3, and 6 months post-injection. Long term follow-up including RCR testing will be performed...
- Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG studyRob Roy MacGregor
Infectious Diseases Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
AIDS Res Hum Retroviruses 21:689-95. 2005..MAC-specific T cell responses apparently develop and persist during DMAC, but are dysfunctional or too infrequent to prevent persistence...
- First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host responseR R MacGregor
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6073, USA
J Infect Dis 178:92-100. 1998..The safety and potential immunogenicity of an HIV-directed DNA-based vaccine was demonstrated, a finding that should encourage further studies...
- Use of PCR in detection of Mycobacterium avium complex (MAC) bacteremia: sensitivity of the assay and effect of treatment for MAC infection on concentrations of human immunodeficiency virus in plasmaR R MacGregor
Infectious Diseases Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6073, USA
J Clin Microbiol 37:90-4. 1999..HIV viremia was unaffected by 8 weeks of MAC therapy...
- Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: results of AIDS clinical trials group protocol 853R D MacArthur
Wayne State University, Department of Medicine, Division of Infectious Diseases, Detroit, MI 48201, USA
J Infect Dis 181:1486-90. 2000..Nonsignificant decreases in plasma levels of TNF-alpha, IL-1beta, IL-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study...
- Management of potential neurocysticercosis in patients with HIV infectionSashank Prasad
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Clin Infect Dis 42:e30-4. 2006..We report 3 cases and suggest including the CD4+ T lymphocyte count as an important factor in the proper diagnosis and treatment of patients with human immunodeficiency virus and potential neurocysticercosis...
- Identifying the vector of Lyme diseaseVincent Lo Re
Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Am Fam Physician 69:1935-7. 2004..Administration of amoxicillin is appropriate for pregnant women or children younger than eight years. For those who are allergic to these medications, cefuroxime axetil may be used...
- Cryptococcus and lymphocytic meningitis in BotswanaGregory P Bisson
Infectious Diseases Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
S Afr Med J 98:724-5. 2008..Moreover, almost 70% of CSF samples with significant lymphocytosis did not yield a pathogen, suggesting that many causes of lymphocytic meningitis go undiagnosed...
- Tuberculous meningitis in HIV-infected individualsChristopher Vinnard
Division of Infectious Disease, Hospital of the University of Pennsylvania, 3400 Spruce Street, 3 Silverstein, Suite E, Philadelphia, PA 19104, USA
Curr HIV/AIDS Rep 6:139-45. 2009..Additional treatment considerations for HIV-infected individuals include the timing of initiation of antiretroviral therapy, the potential for drug-drug interactions, and the role of adjunctive corticosteroid therapy...
- Isoniazid resistance and death in patients with tuberculous meningitis: retrospective cohort studyChristopher Vinnard
Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, 502 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
BMJ 341:c4451. 2010..To determine whether initial isoniazid resistance is associated with death during the treatment of tuberculous meningitis...
- Impact of the human immunodeficiency virus on early multidrug-resistant tuberculosis treatment outcomes in BotswanaJ Hafkin
Botswana UPenn Partnership, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Int J Tuberc Lung Dis 17:348-53. 2013....
- A study of discontinuing maintenance therapy in human immunodeficiency virus-infected subjects with disseminated Mycobacterium avium complex: AIDS Clinical Trial Group 393 Study TeamJudith A Aberg
Department of Medicine, Division of Infectious Disease, University of California San Francisco, San Francisco, CA, USA
J Infect Dis 187:1046-52. 2003..44/100 person-years (95% confidence interval, 0.04-8.01). Withdrawal of anti-MAC therapy appears to be safe in patients who have been treated with a macrolide-based regimen for at least 1 year and have an immunologic response on HAART...
- A randomized, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study GJ E Feinberg
Department of Medicine, University of Cincinnati, Ohio 45267 0405, USA
J Infect Dis 177:48-56. 1998..06). Toxicity and earlier medication discontinuation were more common in this group. Valaciclovir significantly reduces the risk of CMV disease. Further exploration of a better-tolerated dose is warranted...
- Stavudine entry into cerebrospinal fluid after single and multiple doses in patients infected with human immunodeficiency virusKathleen A Brady
Infectious Diseases Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pharmacotherapy 25:10-7. 2005..To establish the pharmacokinetics of stavudine within the cerebrospinal fluid (CSF) of patients infected with human immunodeficiency virus (HIV)...
- A tale of 2 epidemics: the intersection between obesity and HIV infection in PhiladelphiaValerianna Amorosa
Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104 6073, USA
J Acquir Immune Defic Syndr 39:557-61. 2005..Obesity and HIV infection are ongoing epidemics in the United States. Obesity predisposes to diabetes and cardiovascular disease, which are complications also associated with HIV and/or its treatment...
- IL-13 acutely augments HIV-specific and recall responses from HIV-1-infected subjects in vitro by modulating monocytesEmmanouil Papasavvas
The Wistar Institute, Philadelphia, PA 19104, USA
J Immunol 175:5532-40. 2005..Our data show that IL-13 is able to acutely enhance the function of the CD14(+) cell subset toward supporting Ag-specific cell-mediated responses in chronic HIV-1 infection...
- A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndromeConstance A Benson
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Clin Infect Dis 37:1234-43. 2003..057). Subjects in the C+E+R group had improved survival, compared with the C+E group (hazard ratio [HR], 0.44; 95% confidence interval [CI], 0.23-0.83) and the C+R group (HR, 0.49; 95% CI, 0.26-0.92)...
- Increased plasma tryptophan in HIV-infected patients treated with pharmacologic doses of nicotinamideM F Murray
Department of Medicine, Brigham and Women s Hospital, Harvard University, Boston, Massachusetts, USA
Nutrition 17:654-6. 2001....
- Induced sputum improves the diagnosis of pulmonary tuberculosis in hospitalized patients in Gaborone, BotswanaM Morse
Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6073, USA
Int J Tuberc Lung Dis 12:1279-85. 2008..Low sensitivity of acid-fast bacilli (AFB) sputum smears and absence of productive cough are obstacles to the diagnosis of pulmonary tuberculosis (PTB) in hospitals that lack access to bronchoscopy...
- Plasmid vaccination of stable HIV-positive subjects on antiviral treatment results in enhanced CD8 T-cell immunity and increased control of viral "blips"Rob Roy MacGregor
Department of Medicine, University of Pennsylvania School of Medicine, 502 Johnson Pavilion, 36th and Hamilton Walk, Philadelphia, PA 19104 6073, USA
Vaccine 23:2066-73. 2005..04). The decrease in the frequency of transient viremia and failure suggests that DNA immunization with CD8-generating vaccines in HAART-controlled HIV-positive subjects may have therapeutic potential...
- Endemic babesiosis in another eastern state: New JerseyBarbara L Herwaldt
Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Emerg Infect Dis 9:184-8. 2003..Babesiosis, a potentially serious zoonosis, is endemic in New Jersey and should be considered in the differential diagnosis of patients with fever and hemolytic anemia, particularly in the spring, summer, and early fall...
- Differential virulence of Mycobacterium avium strains isolated from HIV-infected patients with disseminated M. avium complex diseaseKiyofumi Ohkusu
Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles and University of Southern California, Los Angeles, California 90027, USA
J Infect Dis 190:1347-54. 2004..There were significant differences in the virulence properties, and these differences may provide insight into the interplay between microbial pathogenesis and host defense...
- Serological evidence of HIV-associated infection among HIV-1-infected adults in BotswanaC William Wester
Botswana Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana
Clin Infect Dis 43:1612-5. 2006..A paucity of data exist from sub-Saharan Africa describing the prevalence of these pathogens. We report data for HIV-1-infected adults referred for initiation of highly active antiretroviral therapy in Botswana...