- Regulatory T cell suppression of Gag-specific CD8 T cell polyfunctional response after therapeutic vaccination of HIV-1-infected patients on ARTBernard J C Macatangay
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e9852. 2010..The Treg suppressive effect masked an increase in the vaccine-induced anti-HIV-1-specific polyfunctional response. The role of Treg should be considered in immunotherapeutic trials of HIV-1 infection...
- Comparison of immunologic assays for detecting immune responses in HIV immunotherapeutic studies: AIDS Clinical Trials Group Trial A5181Bernard J C Macatangay
Division of Infectious Diseases HIV AIDS Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Clin Vaccine Immunol 17:1452-9. 2010..These studies highlight complexities of immunologic monitoring of T-cell responses in multisite clinical trials in HIV infection and outline considerations for optimizing these efforts...
- CD4⁺CD73⁺ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppressionPatrick J Schuler
Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
AIDS 27:1545-55. 2013..The role of the adenosine (ADO) suppression pathway, specifically CD39-expressing and CD73-expressing CD4⁺ T cells in HIV-1 infection is unclear...