Feilim Mac Gabhann

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Systems biology of vascular endothelial growth factors
    Feilim Mac Gabhann
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Microcirculation 15:715-38. 2008
  2. pmc Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 467:461-97. 2009
  3. pmc A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 14:528-52. 2010
  4. ncbi request reprint Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise
    James W Ji
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore MD 21205, USA
    Am J Physiol Heart Circ Physiol 293:H3740-9. 2007
  5. pmc Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 70:9886-94. 2010
  6. pmc Module-based multiscale simulation of angiogenesis in skeletal muscle
    Gang Liu
    Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Theor Biol Med Model 8:6. 2011
  7. pmc Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    BMC Syst Biol 5:59. 2011
  8. ncbi request reprint Monte Carlo simulations of VEGF binding to cell surface receptors in vitro
    Feilim Mac Gabhann
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1746:95-107. 2005
  9. doi request reprint Computational models of VEGF-associated angiogenic processes in cancer
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Math Med Biol 29:85-94. 2012
  10. pmc A compartment model of VEGF distribution in blood, healthy and diseased tissues
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    BMC Syst Biol 2:77. 2008

Collaborators

Detail Information

Publications25

  1. pmc Systems biology of vascular endothelial growth factors
    Feilim Mac Gabhann
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Microcirculation 15:715-38. 2008
    ....
  2. pmc Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 467:461-97. 2009
    ..g., vascular permeability and lymphatic drainage). The given examples will demonstrate the utility of computational models in aiding both basic science and clinical research on VEGF systems biology...
  3. pmc A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 14:528-52. 2010
    ..Finally, we present the need for a systems biology perspective in interpreting circulating VEGF and sVEGFR1 concentrations as surrogate markers of angiogenic status in angiogenesis-dependent diseases...
  4. ncbi request reprint Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise
    James W Ji
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore MD 21205, USA
    Am J Physiol Heart Circ Physiol 293:H3740-9. 2007
    ....
  5. pmc Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 70:9886-94. 2010
    ..Diffusible molecules extravasate, intravasate, are removed from the healthy tissue through the lymphatics, and are cleared from the blood...
  6. pmc Module-based multiscale simulation of angiogenesis in skeletal muscle
    Gang Liu
    Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Theor Biol Med Model 8:6. 2011
    ..Integration of models at different scales is a challenging and currently unsolved problem...
  7. pmc Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    BMC Syst Biol 5:59. 2011
    ..However, computational models have predicted that HSPG binding alone does not affect VEGF localization or gradients at steady state...
  8. ncbi request reprint Monte Carlo simulations of VEGF binding to cell surface receptors in vitro
    Feilim Mac Gabhann
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1746:95-107. 2005
    ..The variability is expected to be more prominent in in vivo situations where the number of ligand molecules available for binding is less...
  9. doi request reprint Computational models of VEGF-associated angiogenic processes in cancer
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Math Med Biol 29:85-94. 2012
    ....
  10. pmc A compartment model of VEGF distribution in blood, healthy and diseased tissues
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    BMC Syst Biol 2:77. 2008
    ..We analyze the sensitivity of this distribution to the secretion rate, clearance rate and vascular permeability of VEGF...
  11. pmc Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
    Florence T H Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Physiol Genomics 38:29-41. 2009
    ..sVEGFR1's interactions with cell surface receptors such as NRP1 are also expected to affect its molecular interplay with VEGF...
  12. pmc Dimerization of VEGF receptors and implications for signal transduction: a computational study
    Feilim Mac Gabhann
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biophys Chem 128:125-39. 2007
    ..These results have significant implications for VEGF signal transduction and interpretation of experimental studies. These results may be applicable to other ligand-receptor pairs, in particular PDGF...
  13. pmc The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
    Marianne O Stefanini
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Comput Biol 5:e1000622. 2009
    ....
  14. pmc Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
    ..As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia...
  15. pmc Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle
    Feilim Mac Gabhann
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Microcirculation 17:333-47. 2010
    ..We quantify the spatio-temporal patterns of microvascular network remodeling following arteriolar ligation in different mouse strains to better understand inter-individual variability...
  16. pmc Gene therapy from the perspective of systems biology
    Feilim Mac Gabhann
    Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Opin Mol Ther 12:570-7. 2010
    ..In addition, the opportunities for systems biology and in silico modeling to improve on current outcomes are highlighted...
  17. ncbi request reprint Multi-scale computational models of pro-angiogenic treatments in peripheral arterial disease
    Feilim Mac Gabhann
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann Biomed Eng 35:982-94. 2007
    ....
  18. doi request reprint Integration of experimental and computational approaches to sprouting angiogenesis
    Shayn M Peirce
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Curr Opin Hematol 19:184-91. 2012
    ..Using recent examples, we show how new understanding results from bridging computational and experimental approaches...
  19. ncbi request reprint Protein transport to choroid and retina following periocular injection: theoretical and experimental study
    Feilim Mac Gabhann
    Department of Biomedical Engineering, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
    Ann Biomed Eng 35:615-30. 2007
    ..This is the first model of ocular drug delivery to explicitly account for transport properties of each eye layer...
  20. doi request reprint Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning
    Prakash Vempati
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cytokine Growth Factor Rev 25:1-19. 2014
    ..A better understanding of the control of angiogenesis is necessary to improve upon limitations of current angiogenic therapies. ..
  21. pmc APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study
    Iraj Hosseini
    Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS ONE 8:e63984. 2013
    ..We extended our model to simulate the combination of APOBEC3G therapy with other biological activities, to estimate the likelihood of improved outcomes...
  22. pmc Systems analysis of small signaling modules relevant to eight human diseases
    Kelly F Benedict
    Department of Biomedical Engineering, University of Virginia Health System, One Boar s Head Pointe, Charlottesville, VA 22908, USA
    Ann Biomed Eng 39:621-35. 2011
    ..This work supports the future use of this approach for informing the next generation of experimental roadmaps for known diseases...
  23. pmc Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking
    Wan Hua Tan
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Cell Signal 25:2496-510. 2013
    ..Fourth, different endothelial cell types appear to have different trafficking rates, which result in different levels of endosomal receptor localization and different ERK response profiles. ..
  24. pmc Vascular morphogenesis of adipose-derived stem cells is mediated by heterotypic cell-cell interactions
    Daphne L Hutton
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Tissue Eng Part A 18:1729-40. 2012
    ..Together, these findings underscore the potential use of ASCs in forming mature vessels in vitro as well as the need for a further understanding of the heterotypic interactions among ASC subpopulations...
  25. ncbi request reprint Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells
    Feilim Mac Gabhann
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Traylor 613, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 286:H153-64. 2004
    ..These results suggest that VEGFR1 signaling can be functional in adult-derived endothelial cells...