Research Topics
| Feilim Mac GabhannSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Systems biology of vascular endothelial growth factorsFeilim Mac Gabhann
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Microcirculation 15:715-38. 2008....- Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment modelsFlorence T H Wu
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Methods Enzymol 467:461-97. 2009..g., vascular permeability and lymphatic drainage). The given examples will demonstrate the utility of computational models in aiding both basic science and clinical research on VEGF systems biology... - A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic useFlorence T H Wu
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Cell Mol Med 14:528-52. 2010..Finally, we present the need for a systems biology perspective in interpreting circulating VEGF and sVEGFR1 concentrations as surrogate markers of angiogenic status in angiogenesis-dependent diseases... - Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic modelMarianne O Stefanini
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
Cancer Res 70:9886-94. 2010..Diffusible molecules extravasate, intravasate, are removed from the healthy tissue through the lymphatics, and are cleared from the blood... 
Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exerciseJames W Ji
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore MD 21205, USA
Am J Physiol Heart Circ Physiol 293:H3740-9. 2007....- Module-based multiscale simulation of angiogenesis in skeletal muscleGang Liu
Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Theor Biol Med Model 8:6. 2011..Integration of models at different scales is a challenging and currently unsolved problem... - Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysisPrakash Vempati
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
BMC Syst Biol 5:59. 2011..However, computational models have predicted that HSPG binding alone does not affect VEGF localization or gradients at steady state... - Monte Carlo simulations of VEGF binding to cell surface receptors in vitroFeilim Mac Gabhann
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
Biochim Biophys Acta 1746:95-107. 2005..The variability is expected to be more prominent in in vivo situations where the number of ligand molecules available for binding is less... 
Computational models of VEGF-associated angiogenic processes in cancerMarianne O Stefanini
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Math Med Biol 29:85-94. 2012....- A compartment model of VEGF distribution in blood, healthy and diseased tissuesMarianne O Stefanini
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
BMC Syst Biol 2:77. 2008..We analyze the sensitivity of this distribution to the secretion rate, clearance rate and vascular permeability of VEGF... - Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transportFlorence T H Wu
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Physiol Genomics 38:29-41. 2009..sVEGFR1's interactions with cell surface receptors such as NRP1 are also expected to affect its molecular interplay with VEGF... - Dimerization of VEGF receptors and implications for signal transduction: a computational studyFeilim Mac Gabhann
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biophys Chem 128:125-39. 2007..These results have significant implications for VEGF signal transduction and interpretation of experimental studies. These results may be applicable to other ligand-receptor pairs, in particular PDGF... - The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signalingMarianne O Stefanini
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS Comput Biol 5:e1000622. 2009.... - Gene therapy from the perspective of systems biologyFeilim Mac Gabhann
Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 720 Rutland Avenue, Baltimore, MD 21205, USA
Curr Opin Mol Ther 12:570-7. 2010..In addition, the opportunities for systems biology and in silico modeling to improve on current outcomes are highlighted... - Collateral capillary arterialization following arteriolar ligation in murine skeletal muscleFeilim Mac Gabhann
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
Microcirculation 17:333-47. 2010..We quantify the spatio-temporal patterns of microvascular network remodeling following arteriolar ligation in different mouse strains to better understand inter-individual variability... - Multi-scale computational models of pro-angiogenic treatments in peripheral arterial diseaseFeilim Mac Gabhann
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Ann Biomed Eng 35:982-94. 2007.... - Multiscale models of angiogenesisAmina A Qutub
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
IEEE Eng Med Biol Mag 28:14-31. 2009..As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia... - Integration of experimental and computational approaches to sprouting angiogenesisShayn M Peirce
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
Curr Opin Hematol 19:184-91. 2012..Using recent examples, we show how new understanding results from bridging computational and experimental approaches... - Protein transport to choroid and retina following periocular injection: theoretical and experimental studyFeilim Mac Gabhann
Department of Biomedical Engineering, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
Ann Biomed Eng 35:615-30. 2007..This is the first model of ocular drug delivery to explicitly account for transport properties of each eye layer... - Systems analysis of small signaling modules relevant to eight human diseasesKelly F Benedict
Department of Biomedical Engineering, University of Virginia Health System, One Boar s Head Pointe, Charlottesville, VA 22908, USA
Ann Biomed Eng 39:621-35. 2011..This work supports the future use of this approach for informing the next generation of experimental roadmaps for known diseases... - Vascular morphogenesis of adipose-derived stem cells is mediated by heterotypic cell-cell interactionsDaphne L Hutton
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Tissue Eng Part A 18:1729-40. 2012..Together, these findings underscore the potential use of ASCs in forming mature vessels in vitro as well as the need for a further understanding of the heterotypic interactions among ASC subpopulations... - Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cellsFeilim Mac Gabhann
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Traylor 613, 720 Rutland Ave, Baltimore, MD 21205, USA
Am J Physiol Heart Circ Physiol 286:H153-64. 2004..These results suggest that VEGFR1 signaling can be functional in adult-derived endothelial cells...